| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R E Robert. Alpha 2 adrenoceptor-mediated vasoconstriction in porcine palmar lateral vein: role of phosphatidylinositol 3-kinase and EGF receptor transactivation. British journal of pharmacology. vol 138. issue 1. 2003-07-15. PMID:12522079. |
2 alpha(2) adrenoceptor-mediated vasoconstriction and erk2 activation in the porcine palmar lateral vein was inhibited in the presence of either the pi 3-kinase inhibitor ly294002, or the egf receptor tyrosine kinase inhibitor ag1478 suggesting the involvement of both pi 3-kinase and egf receptor transactivation. |
2003-07-15 |
2023-08-12 |
Not clear |
| S Saxena, A K Jain, D Bhatnaga. Study of events leading cellular senescence to human mammary epithelial cancer cells in vitro. Indian journal of cancer. vol 38. issue 2-4. 2003-05-29. PMID:12593448. |
the role of epidermal growth factors (egf) and transforming growth factors (tgf) alpha and beta as autocrine factors in inducing senescence of cultured hmec cells were also investigated. |
2003-05-29 |
2023-08-12 |
human |
| Jianzheng Zhou, Robert N Fariss, Peggy S Zelenk. Synergy of epidermal growth factor and 12(S)-hydroxyeicosatetraenoate on protein kinase C activation in lens epithelial cells. The Journal of biological chemistry. vol 278. issue 7. 2003-04-30. PMID:12464613. |
the 12-lipoxygenase blocker, baicalein, prevents epidermal growth factor (egf)-induced activation of protein kinase c (pkc) alpha and beta in lens epithelial cells, whereas supplementation with 12(s)hete reverses this effect, suggesting that egf and 12(s)hete may work together to activate pkc. |
2003-04-30 |
2023-08-12 |
Not clear |
| Bukhtiar H Shah, Jae-Won Soh, Kevin J Cat. Dependence of gonadotropin-releasing hormone-induced neuronal MAPK signaling on epidermal growth factor receptor transactivation. The Journal of biological chemistry. vol 278. issue 5. 2003-04-03. PMID:12446705. |
gnrh stimulation caused translocation of pkc alpha and -epsilon to the cell membrane and enhanced the association of src with pkc alpha and pkc epsilon, pyk2, and the egf receptor. |
2003-04-03 |
2023-08-12 |
Not clear |
| A Shobokshi, M Shaaraw. Maternal serum and amniotic fluid cytokines in patients with preterm premature rupture of membranes with and without intrauterine infection. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. vol 79. issue 3. 2003-03-26. PMID:12445984. |
to evaluate the role of interleukins (il-1, il-6), tumor necrosis factor alpha (tnfalpha) and for the first time interferon gamma (ifngamma) and epidermal growth factor (egf) in the pathogenesis of premature rupture of membranes (prom) with and without confirmed intrauterine infection. |
2003-03-26 |
2023-08-12 |
Not clear |
| Masumi Katane, Eiko Takao, Yoshinao Kubo, Rika Fujita, Hiroshi Amanum. Factors affecting the direct targeting of murine leukemia virus vectors containing peptide ligands in the envelope protein. EMBO reports. vol 3. issue 9. 2003-03-20. PMID:12189179. |
we found a site in the variable region a, where the insertion of ligands, epidermal growth factor (egf) and stromal-derived factor-1 alpha (sdf-1 alpha), was possible without abolishing virion incorporation of the env protein and its ecotropic entry function. |
2003-03-20 |
2023-08-12 |
human |
| E Moré, T Fellner, H Doppelmayr, C Hauser-Kronberger, N Dandachi, P Obrist, F Sandhofer, B Paulwebe. Activation of the MAP kinase pathway induces chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) expression in human breast cancer cell lines. The Journal of endocrinology. vol 176. issue 1. 2003-03-03. PMID:12525252. |
in the present study we investigated the effect of epidermal growth factor (egf), transforming growth factor alpha (tgfalpha) and phorbol myristate acetate (pma) on chicken ovalbumin upstream promoter-transcription factor (coup-tf) expression in human breast cancer cells. |
2003-03-03 |
2023-08-12 |
human |
| T Futamura, K Toyooka, S Iritani, K Niizato, R Nakamura, K Tsuchiya, T Someya, A Kakita, H Takahashi, H Naw. Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients. Molecular psychiatry. vol 7. issue 7. 2003-02-25. PMID:12192610. |
epidermal growth factor (egf) comprises a structurally related family of proteins containing heparin-binding egf-like growth factor (hb-egf) and transforming growth factor alpha (tgfalpha) that regulates the development of dopaminergic neurons as well as monoamine metabolism. |
2003-02-25 |
2023-08-12 |
human |
| Arindam Dhar, Mathew R Young, Nancy H Colbur. The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive. Molecular and cellular biochemistry. vol 234-235. issue 1-2. 2003-02-14. PMID:12162432. |
clonal variants of jb6 cells are differentially responsive to transformation induced by tumor promoters such as phorbol esters (tpa), epidermal growth factor (egf) and tumor necrosis factor alpha (tnf-alpha), as well as oxidative stress. |
2003-02-14 |
2023-08-12 |
mouse |
| Theingi M Thway, Michael W Wolf. An activator protein-1 complex mediates epidermal growth factor regulation of equine glycoprotein alpha subunit expression in trophoblast cells. Biology of reproduction. vol 67. issue 3. 2003-02-13. PMID:12193410. |
previously, we have reported that epidermal growth factor (egf) regulates the equine glycoprotein hormone alpha subunit promoter through a protein kinase c (pkc)/mitogen-activated protein kinase (mapk) signal transduction pathway in trophoblasts. |
2003-02-13 |
2023-08-12 |
Not clear |
| Theingi M Thway, Michael W Wolf. An activator protein-1 complex mediates epidermal growth factor regulation of equine glycoprotein alpha subunit expression in trophoblast cells. Biology of reproduction. vol 67. issue 3. 2003-02-13. PMID:12193410. |
the current study investigates the regulatory element/factors involved in the induction of equine glycoprotein alpha subunit gene expression by egf. |
2003-02-13 |
2023-08-12 |
Not clear |
| Rosa-Maria Canet-Aviles, Mark Anderton, Nigel M Hooper, Anthony J Turner, Peter F T Vaugha. Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C. Brain research. Molecular brain research. vol 102. issue 1-2. 2003-02-11. PMID:12191495. |
muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma sh-sy5y by a pathway dependent on protein kinase c(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase c. the signalling pathways by which muscarine and epidermal growth factor (egf) regulate the secretion of the alpha-secretase cleavage product (sappalpha) of the amyloid precursor protein (app) were examined in the human neuroblastoma sh-sy5y. |
2003-02-11 |
2023-08-12 |
human |
| W D Ni, H An, D M Jian. [Comparative study on osteogenesis of three types growth factors recombination artificial bones]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. vol 13. issue 5. 2003-01-24. PMID:12080826. |
to compare the osteogenesis of recombination artificial bones, which are bovine deproteined bone (bdpb) and bovine bone morphogenetic protein (bbmp), combined with tumor necrosis factor alpha (tnf alpha), basic fibroblast growth factor (bfgf), epidermal growth factor (egf) respectively. |
2003-01-24 |
2023-08-12 |
cattle |
| Helena Domeij, Tülay Yucel-Lindberg, Thomas Modée. Signal pathways involved in the production of MMP-1 and MMP-3 in human gingival fibroblasts. European journal of oral sciences. vol 110. issue 4. 2002-12-26. PMID:12206592. |
the aim of this study was to investigate the production and regulation of mmp-1 and mmp-3 in human gingival fibroblasts challenged with the cytokines interleukin-lbeta (il-1beta), tumor necrosis factor alpha (tnfalpha) or epidermal growth factor (egf). |
2002-12-26 |
2023-08-12 |
human |
| Karen Schlüter, Maciej Figiel, Joanna Rozyczka, Jürgen Engel. CNS region-specific regulation of glial glutamate transporter expression. The European journal of neuroscience. vol 16. issue 5. 2002-12-09. PMID:12372019. |
together these findings identify pacap, tgf alpha and egf as potent regulators of glutamate transporter expression in striatal glia. |
2002-12-09 |
2023-08-12 |
rat |
| M Richter, D Jurek, F Wrba, K Kaserer, G Wurzer, J Karner-Hanusch, B Maria. Cells obtained from colorectal microadenomas mirror early premalignant growth patterns in vitro. European journal of cancer (Oxford, England : 1990). vol 38. issue 14. 2002-11-18. PMID:12204677. |
however, in spite of autocrine tgf(alpha) production, growth was strongly dependent on exogenous growth factors--mainly egf, insulin and hgf. |
2002-11-18 |
2023-08-12 |
Not clear |
| Takafumi Arai, Hiroko Matsumoto, Yoshiaki Akimoto, Hitoshi Nishimura, Makiko Ono, Akira Fuji. Behavior of HO-1-N-1, buccal mucosa carcinoma derived cells, on [Ca2+]i responses to stimulants. Journal of oral science. vol 44. issue 2. 2002-11-18. PMID:12227494. |
buccal mucosa carcinoma-derived cell line, ho-1-n-1, epithelial-like cells, was obtained in order to investigate the characteristics of oral cancer cells and examine the [ca2+]i responses to stimulants, such as bradykinin (bk), histamine (hist), thapsigargin (tg), epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha ). |
2002-11-18 |
2023-08-12 |
Not clear |
| Silvia Gogg, Ulf Smit. Epidermal growth factor and transforming growth factor alpha mimic the effects of insulin in human fat cells and augment downstream signaling in insulin resistance. The Journal of biological chemistry. vol 277. issue 39. 2002-11-13. PMID:12138086. |
no effects were found in rat fat cells, whereas egf (ec(50) for glucose transport approximately 0.02 nm) and transforming growth factor alpha (ec(50) approximately 0.2 nm), but not platelet-derived growth factor, mimicked the effects of insulin (ec(50) approximately 0.2 nm) on both pathways. |
2002-11-13 |
2023-08-12 |
human |
| Kazumi Suzukawa, Thomas J Weber, Nancy H Colbur. AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model. Environmental health perspectives. vol 110. issue 9. 2002-10-29. PMID:12204819. |
because treatment by tumor promoters [12-o-tetradecanoylphorbol-13-acetate (tpa), epidermal growth factor (egf), or tumor necrosis factor alpha (tnf-alpha)] transforms clone 41 cells to anchorage-independent and tumorigenic phenotypes, they are considered to be undergoing late-stage tumor promotion. |
2002-10-29 |
2023-08-12 |
mouse |
| Shengliang Zhang, Masaya Fukushi, Shinichi Hashimoto, Chongfeng Gao, Lin Huang, Yayoi Fukuyo, Takuma Nakajima, Teruo Amagasa, Shoji Enomoto, Katsuro Koike, Osamu Miura, Naoki Yamamoto, Nobuo Tsuchid. A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling. Biochemical and biophysical research communications. vol 297. issue 1. 2002-10-29. PMID:12220502. |
upon egf treatment, naf1 alpha was phosphorylated by the egf/mek/erk2 signal transduction pathway. |
2002-10-29 |
2023-08-12 |
human |