| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Qin, M A Kurpaku. The role of laminin-5 in TGF alpha/EGF-mediated corneal epithelial cell motility. Experimental eye research. vol 66. issue 5. 1998-07-24. PMID:9628804. |
from these results, it is hypothesized that endogenously secreted laminin-5 functions to promote migration in corneal epithelial cells which have been treated with tgf alpha or egf. |
1998-07-24 |
2023-08-12 |
human |
| M E Christense. The EGF receptor system in head and neck carcinomas and normal tissues. Immunohistochemical and quantitative studies. Danish medical bulletin. vol 45. issue 2. 1998-07-17. PMID:9587699. |
the egf receptor (egf receptor) and two of the ligands, transforming growth factor alpha (tgf-alpha) and epidermal growth factor (egf), exert mitogenic activities in epithelial cells. |
1998-07-17 |
2023-08-12 |
human |
| L J McCawley, P O'Brien, L G Hudso. Epidermal growth factor (EGF)- and scatter factor/hepatocyte growth factor (SF/HGF)- mediated keratinocyte migration is coincident with induction of matrix metalloproteinase (MMP)-9. Journal of cellular physiology. vol 176. issue 2. 1998-07-09. PMID:9648913. |
multiple ligands were mitogenic for keratinocytes, but only epidermal growth factor (egf), transforming growth factor alpha (tgfalpha), and scatter factor/hepatocyte growth factor (sf/hgf) promoted cell motility as assessed by colony dispersion (scattering) and in vitro reepithelialization. |
1998-07-09 |
2023-08-12 |
Not clear |
| G Mincione, A Piccirelli, D Lazzereschi, D S Salomon, G Collett. Heregulin-dependent autocrine loop regulates growth of K-ras but not erbB-2 transformed rat thyroid epithelial cells. Journal of cellular physiology. vol 176. issue 2. 1998-07-09. PMID:9648926. |
the egf-like family of proteins, such as epidermal growth factor (egf), transforming growth factor alpha (tgfalpha), amphiregulin (ar), betacellulin (btc), cripto-1 (cr-1), and heregulin (hrg), plays an important role in the pathogenesis of several human carcinomas as autocrine growth factors. |
1998-07-09 |
2023-08-12 |
human |
| H Waterman, I Sabanai, B Geiger, Y Yarde. Alternative intracellular routing of ErbB receptors may determine signaling potency. The Journal of biological chemistry. vol 273. issue 22. 1998-07-01. PMID:9593726. |
concentrating on erbb-1 and two of its ligands, epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha), and the neu differentiation factor (ndf/neuregulin) and one of its receptors, erbb-3, we show that ligand binding variably accelerates endocytosis of the respective ligand-receptor complex. |
1998-07-01 |
2023-08-12 |
Not clear |
| S Kitano, V A Bohr, T D Reed, C M Haggerty, A May, G S Rot. Effect of aging on EGF-stimulated replication of specific genes in rat hepatocytes. Journal of cellular physiology. vol 176. issue 1. 1998-07-01. PMID:9618142. |
although [3h]thymidine incorporation, dna polymerase alpha activity, total cellular dna, dhfr, and c-myc gene specific dna replication stimulated by egf are reduced with age, mt dna replication is not affected by either egf or age. |
1998-07-01 |
2023-08-12 |
rat |
| C Blanco-Aparicio, M A Molina, E Fernández-Salas, M L Frazier, J M Mas, E Querol, F X Avilés, R de Lloren. Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth. The Journal of biological chemistry. vol 273. issue 20. 1998-06-12. PMID:9575190. |
pci has a special disulfide scaffold called a t-knot that is also present in several growth factors including egf and transforming growth factor alpha. |
1998-06-12 |
2023-08-12 |
mouse |
| J T Jones, M D Ballinger, P I Pisacane, J A Lofgren, V D Fitzpatrick, W J Fairbrother, J A Wells, M X Sliwkowsk. Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis. The Journal of biological chemistry. vol 273. issue 19. 1998-06-05. PMID:9565587. |
many residues important for hrg binding to its receptors correspond to critical residues for epidermal growth factor (egf) and transforming growth factor alpha binding to the egf receptor. |
1998-06-05 |
2023-08-12 |
Not clear |
| P C Konturek, T Brzozowski, S J Konturek, A Taut, Z Sliwowski, J Stachura, E G Hah. Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage. European journal of pharmacology. vol 342. issue 1. 1998-06-03. PMID:9544793. |
we evaluated gastric mucosa lesions, gastric blood flow, mucosal generation of prostaglandin e2 and mucosal gene expression of epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) as well as constitutive prostaglandin cyclooxygenase-1 and inducible cyclooxygenase-2 and the effect of the inhibition of these enzymes on the recovery of mucosa from the stress-induced lesions. |
1998-06-03 |
2023-08-12 |
rat |
| P C Konturek, T Brzozowski, S J Konturek, A Taut, Z Sliwowski, J Stachura, E G Hah. Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage. European journal of pharmacology. vol 342. issue 1. 1998-06-03. PMID:9544793. |
gastric mucosa biopsies were taken for determination of immunoreactive egf and tgf alpha. |
1998-06-03 |
2023-08-12 |
rat |
| P C Konturek, T Brzozowski, S J Konturek, A Taut, Z Sliwowski, J Stachura, E G Hah. Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage. European journal of pharmacology. vol 342. issue 1. 1998-06-03. PMID:9544793. |
expression of egf and tgf alpha mrna and cyclooxygenase-1 and cyclooxygenase-2 mrna was also determined by reverse-transcriptase polymerase chain reaction. |
1998-06-03 |
2023-08-12 |
rat |
| P C Konturek, T Brzozowski, S J Konturek, A Taut, Z Sliwowski, J Stachura, E G Hah. Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage. European journal of pharmacology. vol 342. issue 1. 1998-06-03. PMID:9544793. |
the number of gastric lesions induced by 3.5 h stress averaged approximately 20 per rat and declined significantly at 2, 4, 6, 8 and 12 h, to disappear almost completely after 24 h. this was accompanied by a gradual rise in gastric blood flow, mucosal generation of prostaglandin e2 and mucosal egf and tgf alpha contents, while the increased gastric acid secretion returned to normal. |
1998-06-03 |
2023-08-12 |
rat |
| P C Konturek, T Brzozowski, S J Konturek, A Taut, Z Sliwowski, J Stachura, E G Hah. Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage. European journal of pharmacology. vol 342. issue 1. 1998-06-03. PMID:9544793. |
in the intact mucosa, egf mrna was not detected but tgf alpha mrna was found in measurable amounts. |
1998-06-03 |
2023-08-12 |
rat |
| P C Konturek, T Brzozowski, S J Konturek, A Taut, Z Sliwowski, J Stachura, E G Hah. Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage. European journal of pharmacology. vol 342. issue 1. 1998-06-03. PMID:9544793. |
we conclude that healing of stress lesions results in the restoration gastric blood flow and mucosal prostaglandin generation and that these effects are accompanied by overexpression of egf and tgf alpha as well as cyclooxygenase-1 and cyclooxygenase-2 mrna and by increased biosynthesis of gastroprotective prostaglandin. |
1998-06-03 |
2023-08-12 |
rat |
| F Ciardiello, G Tortor. Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 4. issue 4. 1998-05-28. PMID:9563874. |
in fact, overexpression of egf-related growth factors such as transforming growth factor alpha and amphiregulin and/or their specific receptor, the egf receptor (egfr), has been detected in several types of human cancers, including breast, lung, and colorectal cancers. |
1998-05-28 |
2023-08-12 |
human |
| S Gibbs, E Boelsma, J Kempenaar, M Pone. Temperature-sensitive regulation of epidermal morphogenesis and the expression of cornified envelope precursors by EGF and TGF alpha. Cell and tissue research. vol 292. issue 1. 1998-05-26. PMID:9506918. |
temperature-sensitive regulation of epidermal morphogenesis and the expression of cornified envelope precursors by egf and tgf alpha. |
1998-05-26 |
2023-08-12 |
Not clear |
| C A Hazzalin, R Le Panse, E Cano, L C Mahadeva. Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction. Molecular and cellular biology. vol 18. issue 4. 1998-05-21. PMID:9528756. |
anisomycin desensitization of a panel of ie genes (c-fos, fosb, c-jun, junb, and jund), using epidermal growth factor (egf), basic fibroblast growth factor, (bfgf), tumor necrosis factor alpha (tnf-alpha), anisomycin, tetradecanoyl phorbol acetate (tpa), and uv radiation as secondary stimuli, was found to be extremely specific both with respect to the secondary stimuli and at the level of individual genes. |
1998-05-21 |
2023-08-12 |
Not clear |
| A E Lenferink, R H Kramer, M J van Vugt, M Königswieser, P P Di Fiore, E J van Zoelen, M L van de Pol. Superagonistic behaviour of epidermal growth factor/transforming growth factor-alpha chimaeras: correlation with receptor routing after ligand-induced internalization. The Biochemical journal. vol 327 ( Pt 3). 1998-05-20. PMID:9581567. |
human epidermal growth factor (egf) and human transforming growth factor alpha (tgf-alpha) are structurally related polypeptide growth factors that exert their mitogenic activity through interaction with a common cell-surface receptor, the epidermal growth factor receptor (egfr). |
1998-05-20 |
2023-08-12 |
human |
| E van der Zee, I Jansen, K Hoeben, W Beertsen, V Evert. EGF and IL-1 alpha modulate the release of collagenase, gelatinase and TIMP-1 as well as the release of calcium by rabbit calvarial bone explants. Journal of periodontal research. vol 33. issue 1. 1998-05-14. PMID:9524323. |
egf and il-1 alpha modulate the release of collagenase, gelatinase and timp-1 as well as the release of calcium by rabbit calvarial bone explants. |
1998-05-14 |
2023-08-12 |
rabbit |
| E van der Zee, I Jansen, K Hoeben, W Beertsen, V Evert. EGF and IL-1 alpha modulate the release of collagenase, gelatinase and TIMP-1 as well as the release of calcium by rabbit calvarial bone explants. Journal of periodontal research. vol 33. issue 1. 1998-05-14. PMID:9524323. |
as both production of these enzymes and bone resorption appear to be mediated by cytokines, we investigated the effects of two cytokines, il-1 alpha and egf, on the release of collagenase, gelatinase a (mmp-2), gelatinase b (mmp-9), timp-1 and calcium by rabbit calvariae. |
1998-05-14 |
2023-08-12 |
rabbit |