| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michail Pavlidis, Maria Sundvik, Yu-Chia Chen, Pertti Panul. Adaptive changes in zebrafish brain in dominant-subordinate behavioral context. Behavioural brain research. vol 225. issue 2. 2012-01-24. PMID:21875623. |
expression of genes encoding proteins involved in the functioning of the hypothalamus-hypophysis-interrenal axis (corticotropin releasing factor, crf; glucocorticoid receptor, gr; mineralocorticoid receptor, mr); arginine vasotocin, avt), in the biosynthesis and catabolism of catecholamines (tyrosine hydroxylase, th1 and th2; dopa decarboxylase, ddc), dopamine β-hydroxylase, dbh; catechol-o-methyl transferase, comt), in the biosynthesis of histamine (histidine decarboxylase, hdc) and in the general stress response (galanin, gal; hypocretin/orexin, hcrt) was examined. |
2012-01-24 |
2023-08-12 |
zebrafish |
| Keisuke Matsubara, Hiroshi Watabe, Yoshitaka Kumakura, Takuya Hayashi, Christopher J Endres, Kotaro Minato, Hidehiro Iid. Sensitivity of kinetic macro parameters to changes in dopamine synthesis, storage, and metabolism: a simulation study for [¹⁸F]FDOPA PET by a model with detailed dopamine pathway. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21190220. |
simple kinetic macro parameters are often utilized to quantitatively evaluate metabolic and physiological processes of interest, which may include ddc activity, vesicular storage, and catabolism from (18) f-labeled dopamine to dopac and hva. |
2011-10-18 |
2023-08-12 |
Not clear |
| Zhi Zhou, Jialong Yang, Lingling Wang, Huan Zhang, Yang Gao, Xiaowei Shi, Mengqiang Wang, Pengfei Kong, Limei Qiu, Linsheng Son. A dopa decarboxylase modulating the immune response of scallop Chlamys farreri. PloS one. vol 6. issue 4. 2011-08-30. PMID:21533240. |
dopa decarboxylase (ddc) is a pyridoxal 5-phosphate (plp)-dependent enzyme that catalyzes the decarboxylation of l-dopa to dopamine, and involved in complex neuroendocrine-immune regulatory network. |
2011-08-30 |
2023-08-12 |
Not clear |
| Huaifang Fang, Trisha L Vickrey, B Jill Vento. Analysis of biogenic amines in a single Drosophila larva brain by capillary electrophoresis with fast-scan cyclic voltammetry detection. Analytical chemistry. vol 83. issue 6. 2011-06-09. PMID:21322586. |
when flies are fed nsd-1015, which inhibits dopamine decarboxylase (ddc) a synthesis enzyme in the dopamine and serotonin pathways, dopamine significantly decreases by 52%. |
2011-06-09 |
2023-08-12 |
drosophila_melanogaster |
| C K Kontos, I N Papadopoulos, E G Fragoulis, A Scorila. Quantitative expression analysis and prognostic significance of L-DOPA decarboxylase in colorectal adenocarcinoma. British journal of cancer. vol 102. issue 9. 2010-05-28. PMID:20424616. |
l-dopa decarboxylase (ddc) is an enzyme that catalyses, mainly, the decarboxylation of l-dopa to dopamine and was found to be involved in many malignancies. |
2010-05-28 |
2023-08-12 |
Not clear |
| Qian Han, Haizhen Ding, Howard Robinson, Bruce M Christensen, Jianyong L. Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase. PloS one. vol 5. issue 1. 2010-05-20. PMID:20098687. |
physiologically, ddc is responsible for the production of dopamine and serotonin through the decarboxylation of 3,4-dihydroxyphenylalanine and 5-hydroxytryptophan, respectively. |
2010-05-20 |
2023-08-12 |
drosophila_melanogaster |
| Ioanna Kokkinou, Emmanuel G Fragoulis, Dido Vassilacopoulo. The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase. Journal of neuroimmunology. vol 216. issue 1-2. 2010-01-11. PMID:19800137. |
the expression of enzymatically active ddc shows the endogenous production of dopamine in u937 cells and raises new questions about the enzyme's involvement in immune responses. |
2010-01-11 |
2023-08-12 |
human |
| Shizuma Ishikawa, Takahiro Taira, Takeshi Niki, Kazuko Takahashi-Niki, Chinatsu Maita, Hiroshi Maita, Hiroyoshi Ariga, Sanae M M Iguchi-Arig. Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. The Journal of biological chemistry. vol 284. issue 42. 2009-11-24. PMID:19703902. |
parkinson disease (pd) is caused by loss of dopamine, which is synthesized from tyrosine by two enzymes, tyrosine hydroxylase (th) and 4-dihydroxy-l-phenylalanine decarboxylase (ddc). |
2009-11-24 |
2023-08-12 |
human |
| Roser Corominas, Marta Ribases, Montserrat Camiña, Ester Cuenca-León, Julio Pardo, Susana Boronat, María-Jesús Sobrido, Bru Cormand, Alfons Macay. Two-stage case-control association study of dopamine-related genes and migraine. BMC medical genetics. vol 10. 2009-10-07. PMID:19772578. |
we previously reported risk haplotypes for two genes related with serotonin and dopamine metabolism: maoa in migraine without aura and ddc in migraine with aura. |
2009-10-07 |
2023-08-12 |
Not clear |
| Andrés J López-Contreras, Jesús D Galindo, Carlos López-García, Maria T Castells, Asunción Cremades, Rafael Peñafie. Opposite sexual dimorphism of 3,4-dihydroxyphenylalanine decarboxylase in the kidney and small intestine of mice. The Journal of endocrinology. vol 196. issue 3. 2009-10-01. PMID:18310457. |
3,4-dihydroxyphenylalanine decarboxylase (ddc; also known as l-amino acid decarboxylase) is involved in the synthesis of dopamine, norepinephrine, and serotonin, and also acts as an androgen receptor co-regulator protein. |
2009-10-01 |
2023-08-12 |
mouse |
| Yasuyuki Arakane, Joseph Lomakin, Richard W Beeman, Subbaratnam Muthukrishnan, Stevin H Gehrke, Michael R Kanost, Karl J Krame. Molecular and functional analyses of amino acid decarboxylases involved in cuticle tanning in Tribolium castaneum. The Journal of biological chemistry. vol 284. issue 24. 2009-08-20. PMID:19366687. |
aspartate 1-decarboxylase (adc) and 3,4-dihydroxyphenylalanine decarboxylase (ddc) provide beta-alanine and dopamine used in insect cuticle tanning. |
2009-08-20 |
2023-08-12 |
Not clear |
| Kazuhiro E Fujimor. Characterization of the regulatory region of the dopa decarboxylase gene in Medaka: an in vivo green fluorescent protein reporter assay combined with a simple TA-cloning method. Molecular biotechnology. vol 41. issue 3. 2009-08-03. PMID:18987999. |
as an application of this method, i focused on the dopa decarboxylase (ddc) gene, an essential enzyme for production of neurotransmitters, dopamine, and serotonin. |
2009-08-03 |
2023-08-12 |
Not clear |
| Stephen T Brown, Kevin F Kelly, Juliet M Daniel, Colin A Nurs. Hypoxia inducible factor (HIF)-2 alpha is required for the development of the catecholaminergic phenotype of sympathoadrenal cells. Journal of neurochemistry. vol 110. issue 2. 2009-07-31. PMID:19457096. |
this was correlated with a marked reduction in the expression of dopa decarboxylase (ddc) and dopamine beta hydroxylase (dbetah) but not th. |
2009-07-31 |
2023-08-12 |
rat |
| Ioanna Kokkinou, Eleftheria Nikolouzou, Alexandros Hatzimanolis, Emmanuel G Fragoulis, Dido Vassilacopoulo. Expression of enzymatically active L-DOPA decarboxylase in human peripheral leukocytes. Blood cells, molecules & diseases. vol 42. issue 1. 2009-02-09. PMID:19041269. |
l-dopa decarboxylase (ddc) is a pyridoxal 5-phosphate (plp)-dependent enzyme that catalyses the decarboxylation of l-dopa to dopamine. |
2009-02-09 |
2023-08-12 |
human |
| Claude Wicker-Thomas, Mickael Haman. Interaction of dopamine, female pheromones, locomotion and sex behavior in Drosophila melanogaster. Journal of insect physiology. vol 54. issue 10-11. 2009-01-07. PMID:18762189. |
ddc mutants and wild-type female flies treated with tyrosine hydroxylase inhibitors (alpha-methyltyrosine or 3-iodotyrosine) had fewer diene hydrocarbons (female pheromones) and there was a total (ddc), partial (alpha-methyltyrosine) or no (3-iodotyrosine) rescue of hydrocarbon pattern after dopamine ingestion. |
2009-01-07 |
2023-08-12 |
drosophila_melanogaster |
| Regina C C Kubrusly, Rogerio Panizzutti, Patricia F Gardino, Bernardo Stutz, Ricardo A M Reis, Ana Lucia M Ventura, Maria Christina F de Mello, Fernando G de Mell. Expression of functional dopaminergic phenotype in purified cultured Müller cells from vertebrate retina. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18582514. |
müller cells purified from developing chick and mouse retinas express l-dopa decarboxylase (ddc; aromatic-l-amino-acid decarboxylase; ec 4.1.1.28) and the dopamine transporter dat. |
2008-11-06 |
2023-08-12 |
mouse |
| Regina C C Kubrusly, Rogerio Panizzutti, Patricia F Gardino, Bernardo Stutz, Ricardo A M Reis, Ana Lucia M Ventura, Maria Christina F de Mello, Fernando G de Mell. Expression of functional dopaminergic phenotype in purified cultured Müller cells from vertebrate retina. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18582514. |
the synthesis of dopamine from l-dopa supplied to müller cultures is inhibited by m-hydroxybenzylhydrazine, a ddc inhibitor. |
2008-11-06 |
2023-08-12 |
mouse |
| Monica M Davis, David A Primrose, Ross B Hodgett. A member of the p38 mitogen-activated protein kinase family is responsible for transcriptional induction of Dopa decarboxylase in the epidermis of Drosophila melanogaster during the innate immune response. Molecular and cellular biology. vol 28. issue 15. 2008-08-12. PMID:18519585. |
we propose that the involvement of ddc in a new pathway involved in drosophila immunity increases the levels of dopamine, which is metabolized to produce reactive quinones that exert an antimicrobial effect on invading bacteria. |
2008-08-12 |
2023-08-12 |
drosophila_melanogaster |
| Yosuke Ninomiya, Maiko Kurakake, Yasunori Oda, Seiji Tsuzuki, Yoichi Hayakaw. Insect cytokine growth-blocking peptide signaling cascades regulate two separate groups of target genes. The FEBS journal. vol 275. issue 5. 2008-04-11. PMID:18215168. |
gbp also enhances expression of the tyrosine hydroxylase (th, ec 1.14.16.2) and 3,4-dihydroxy-l-phenylalanine (dopa) decarboxylase (ddc, ec 4.1.1.26) genes, which elevate dopamine levels in insect epidermal cells. |
2008-04-11 |
2023-08-12 |
drosophila_melanogaster |
| Chiu-Ming Wen, Yeong-Hsiang Cheng, Ya-Fen Huang, Chung-Shung Wan. Isolation and characterization of a neural progenitor cell line from tilapia brain. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 149. issue 2. 2008-03-06. PMID:18096421. |
on a poly-l-lysine-coated substrate in vitro, tb2 cells showed increases in neuronal dopamine decarboxylase (ddc) and microtubule-associated protein 2 (map2), indicating that they can initiate differentiation into neurons. |
2008-03-06 |
2023-08-12 |
cattle |