| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Hefti, E Melamed, R J Wurtma. The site of dopamine formation in rat striatum after L-dopa administration. The Journal of pharmacology and experimental therapeutics. vol 217. issue 1. 1981-05-26. PMID:7205652. |
unilateral nigrostriatal lesions produced by injecting 6-hydroxydopamine stereotaxically into both the substantia nigra and the medial forebrain bundle reduced striatal tyrosine hydroxylase activity and dopamine (da) concentrations by 95% (compared with the intact, contralateral striata) but lowered dopa decarboxylase (ddc) activity by only 80%. |
1981-05-26 |
2023-08-12 |
rat |
| M Radulovacki, W J Wojcik, C Fornal, R Miletic. Elimination of REM sleep rebound in rats by alpha-adrenoreceptor blockers, phentolamine and phenoxybenzamine. Pharmacology, biochemistry, and behavior. vol 13. issue 1. 1980-10-27. PMID:7403221. |
the hypothesis was based on results from our previous studies which showed that administration to rats of diethyldithiocarbamate (ddc), a dopamine beta hydroxylase inhibitor, decreased the concentration of brain norepinephrine and reduced rem sleep permanently without the subsequent appearance of rem sleep rebound. |
1980-10-27 |
2023-08-12 |
rat |
| A A Verhofstad, T Hökfelt, M Goldstein, H W Steinbusch, H W Jooste. Appearance of tyrosine hydroxylase, aromatic amino-acid decarboxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase during the ontogenesis of the adrenal medulla: an immunohistochemical study in the rat. Cell and tissue research. vol 200. issue 1. 1980-01-24. PMID:40700. |
the cellular localization of the enzymes tyrosine hydroxylase (th), aromatic amino-acid decarboxylase (or dopa decarboxylase, ddc), dopamine beta-hydroxylase (dbh) and phenylethanolamine n-methyltransferase (pnmt) in the adrenal medulla of adult rats and rat fetuses (14th, 17th, 18th, 19th and 21st day) was examined. |
1980-01-24 |
2023-08-11 |
rat |
| N Halász, A Ljungdahl, T Hökfelt, O Johansson, M Goldstein, D Park, P Biberfel. Transmitter histochemistry of the rat olfactory bulb. I. Immunohistochemical localization of monoamine synthesizing enzymes. Support for intrabulbar, periglomerular dopamine neurons. Brain research. vol 126. issue 3. 1977-07-18. PMID:16685. |
in the principal bulb the first two enzymes, tyrosine hydroxylase (th) and dopa decarboxylase (ddc), but not dopamine-beta-hydroxylase (dbh), were present in a proportion of periglomerular cell bodies and dendrites indicating that these neurons synthesize dopamine (da). |
1977-07-18 |
2023-08-11 |
rat |
| T Nagatsu, T Kato, Y Numata, K Ikuta, M San. Phenylethanolamine N-methyltransferase and other enzymes of catecholamine metabolism in human brain. Clinica chimica acta; international journal of clinical chemistry. vol 75. issue 2. 1977-05-20. PMID:14798. |
the activities of tyrosine hydroxylase (th), dopa decarboxylase (ddc), dopamine beta-hydroxylase (dbh), phenylethanolamine n-methyltransferase (pnmt), and monoamine oxidase (mao) with serotonin and phenylethylamine as substrates were measured in catecholaminergic regions of human brain from 10 controls and 3 patients with parkinsonism. |
1977-05-20 |
2023-08-11 |
human |
| J W Haycock, R van Buskirk, J L McGaug. Facilitation of retention performance in mice by posttraining diethyldithiocarbamate. Pharmacology, biochemistry, and behavior. vol 5. issue 5. 1977-04-25. PMID:190619. |
ddc (900 mg/kg) produced a large but transient increase in whole brain dopamine (da) levels while norepinephrine (ne) levels were lowered. |
1977-04-25 |
2023-08-11 |
mouse |
| M D Hamburg, A Ker. DDC-induced retrograde amnesias prevented by injections of dl-DOPS. Pharmacology, biochemistry, and behavior. vol 5. issue 4. 1977-02-26. PMID:188054. |
injection of a dopamine beta-hydroxylate inhibitor, diethyldithiocarbamate (ddc) in rats 30 min prior to training of a step-down passive avoidance task impaired performance of the task 24 hr later. |
1977-02-26 |
2023-08-11 |
rat |
| A Szmigielsk. Effect of disulfiram and sodium diethyldithiocarbamate on tyrosine and dopamine-beta-hydroxylases activities in rat brain and heart. Polish journal of pharmacology and pharmacy. vol 27. issue 2. 1975-10-28. PMID:239395. |
tyrosine hydroxylase and dopamine (da)-beta-hydroxylase activities in rat brain and heart after disulfiram (ds) or diethyldithiocarbamate (ddc) administration have been determined in vitro and in vivo. |
1975-10-28 |
2023-08-11 |
rat |
| O L Chan, R A Webste. Importance of noradrenaline found in a functional pool in maintaining spontaneous locomotor activity in rats. British journal of pharmacology. vol 41. issue 4. 1971-07-22. PMID:5579467. |
the dopamine beta hydroxylase inhibitor, diethyldithiocarbamate (ddc), suppressed activity as well as the concentrations of na and da at high doses (750 mg/kg) but smaller doses (400 mg/kg) plus l-dopa gave high da concentrations without activity.6. |
1971-07-22 |
2023-08-11 |
rat |