| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Vaccari, P L Saba, S Ruiu, M Collu, P Devot. Disulfiram and diethyldithiocarbamate intoxication affects the storage and release of striatal dopamine. Toxicology and applied pharmacology. vol 139. issue 1. 1996-08-21. PMID:8685891. |
the intraperitoneal injection of a high dose of disulfiram and ddc into rats, mimicking acute intoxication, induced in vivo overflow of striatal dopamine from both a reserpine-sensitive (vesicular) and an alpha-methyl-p-tyrosine-sensitive (cytoplasmic) pool. |
1996-08-21 |
2023-08-12 |
rat |
| A Vaccari, P L Saba, S Ruiu, M Collu, P Devot. Disulfiram and diethyldithiocarbamate intoxication affects the storage and release of striatal dopamine. Toxicology and applied pharmacology. vol 139. issue 1. 1996-08-21. PMID:8685891. |
ddc acted poorly at the vesicle membrane, and the in vivo releasing effect of dopamine was only partially prevented by the inhibition of 5-ht3 receptors, thus suggesting the role of additional mechanisms. |
1996-08-21 |
2023-08-12 |
rat |
| W Kura. [The role of enzymatic systems in pathophysiology and pharmacotherapy of Parkinson's disease]. Neurologia i neurochirurgia polska. vol 29. issue 4. 1996-02-14. PMID:8544935. |
in the metabolism of one of the main cns neurotransmitters dopamine very important roles are played by four enzymes: two synthetizing dopamine: th and ddc, and two enzymes breaking down dopamine: mao-b and comt. |
1996-02-14 |
2023-08-12 |
Not clear |
| P Cumming, H Kuwabara, A Ase, A Gjedd. Regulation of DOPA decarboxylase activity in brain of living rat. Journal of neurochemistry. vol 65. issue 3. 1995-09-18. PMID:7643116. |
to test the hypothesis that l-dopa decarboxylase (ddc) is a regulated enzyme in the synthesis of dopamine (da), we developed a model of the cerebral uptake and metabolism of [3h]dopa. |
1995-09-18 |
2023-08-12 |
rat |
| F Vaglini, C Pardini, R Maggio, G U Corsin. Role of excitatory amino-acids in diethyldithiocarbamate-induced cell death in mesencephalic cultures. Brain research. vol 674. issue 1. 1995-07-11. PMID:7773680. |
ddc 10 microm was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [3h]dopamine uptake. |
1995-07-11 |
2023-08-12 |
Not clear |
| X H Zhong, J W Haycock, K Shannak, Y Robitaille, J Fratkin, A H Koeppen, O Hornykiewicz, S J Kis. Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 1. 1995-04-13. PMID:7885342. |
we measured the levels of dopamine, tyrosine hydroxylase (th) protein, and dihydroxyphenylalanine (dopa) decarboxylase (ddc) protein in the striatum of 10 patients with idiopathic parkinson's disease (pd) and 23 patients with dominantly inherited olivopontocerebellar atrophy (opca). |
1995-04-13 |
2023-08-12 |
human |
| X H Zhong, J W Haycock, K Shannak, Y Robitaille, J Fratkin, A H Koeppen, O Hornykiewicz, S J Kis. Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 1. 1995-04-13. PMID:7885342. |
both th and ddc protein levels were significantly lower than those of the controls in the striatum of all of the patients with pd and in the subgroup of patients with opca having severely depleted dopamine. |
1995-04-13 |
2023-08-12 |
human |
| X H Zhong, J W Haycock, K Shannak, Y Robitaille, J Fratkin, A H Koeppen, O Hornykiewicz, S J Kis. Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 1. 1995-04-13. PMID:7885342. |
in contradistinction, th but not ddc protein levels were reduced in those patients with opca having moderately reduced dopamine levels. |
1995-04-13 |
2023-08-12 |
human |
| X H Zhong, J W Haycock, K Shannak, Y Robitaille, J Fratkin, A H Koeppen, O Hornykiewicz, S J Kis. Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 1. 1995-04-13. PMID:7885342. |
this suggests that in the early stage of nigrostriatal dopamine neurone degeneration, ddc levels may be less susceptible to neurodegenerative influences than is th synthesis or, alternatively, ddc synthesis may be more aggressively upregulated. |
1995-04-13 |
2023-08-12 |
human |
| M J Lundell, J Hirs. Temporal and spatial development of serotonin and dopamine neurons in the Drosophila CNS. Developmental biology. vol 165. issue 2. 1994-11-29. PMID:7958407. |
we present a high-resolution profile of the temporal and spatial immunoreactivity for dopamine and serotonin in the drosophila embryonic cns and the expression pattern of two enzymes important in their biosynthesis, dopa decarboxylase (ddc) and tyrosine hydroxylase (th). |
1994-11-29 |
2023-08-12 |
drosophila_melanogaster |
| M J Lundell, J Hirs. Temporal and spatial development of serotonin and dopamine neurons in the Drosophila CNS. Developmental biology. vol 165. issue 2. 1994-11-29. PMID:7958407. |
ddc performs the final catalytic step in the synthesis of both biogenic amines and th is the rate-limiting enzymatic step in the synthesis of dopamine. |
1994-11-29 |
2023-08-12 |
drosophila_melanogaster |
| M J Lundell, J Hirs. Temporal and spatial development of serotonin and dopamine neurons in the Drosophila CNS. Developmental biology. vol 165. issue 2. 1994-11-29. PMID:7958407. |
despite low levels of ddc, both dopamine and serotonin are first detected at the earliest stages of ddc expression. |
1994-11-29 |
2023-08-12 |
drosophila_melanogaster |
| K Kim, B J Lee, B N Cho, S S Kang, W S Choi, S D Park, C C Lee, W K Cho, W Wuttk. Blockade of noradrenergic neurotransmission with diethyldithiocarbamic acid decreases the mRNA level of gonadotropin-releasing hormone in the hypothalamus of ovariectomized, steroid-treated prepubertal rats. Neuroendocrinology. vol 59. issue 6. 1994-10-13. PMID:8084377. |
in order to determine whether noradrenergic neurotransmission is involved in the stimulatory effect of p on gnrh gene expression, diethyldithiocarbamic acid (ddc, 500 mg/kg), a dopamine beta-hydroxylase inhibitor was administered i.p. |
1994-10-13 |
2023-08-12 |
rat |
| K Kim, B J Lee, B N Cho, S S Kang, W S Choi, S D Park, C C Lee, W K Cho, W Wuttk. Blockade of noradrenergic neurotransmission with diethyldithiocarbamic acid decreases the mRNA level of gonadotropin-releasing hormone in the hypothalamus of ovariectomized, steroid-treated prepubertal rats. Neuroendocrinology. vol 59. issue 6. 1994-10-13. PMID:8084377. |
a single injection of p into ovx + e primed rats augmented norepinephrine (ne) content, while the administration of ddc effectively blocked the p-induced increase in ne content, along with the increase in dopamine content. |
1994-10-13 |
2023-08-12 |
rat |
| A Zuddas, F Fascetti, G U Corsini, M P Piccard. In brown Norway rats, MPP+ is accumulated in the nigrostriatal dopaminergic terminals but it is not neurotoxic: a model of natural resistance to MPTP toxicity. Experimental neurology. vol 127. issue 1. 1994-07-07. PMID:8200437. |
in mice, ddc prolonged the striatal exposure to mpp+, potentiated the mptp-induced acute syndrome, and enhanced the mptp-induced striatal dopamine depletion. |
1994-07-07 |
2023-08-12 |
mouse |
| A Zuddas, F Fascetti, G U Corsini, M P Piccard. In brown Norway rats, MPP+ is accumulated in the nigrostriatal dopaminergic terminals but it is not neurotoxic: a model of natural resistance to MPTP toxicity. Experimental neurology. vol 127. issue 1. 1994-07-07. PMID:8200437. |
in rats, ddc potentiated the mptp-induced acute syndrome, but no changes in the striatal dopamine were observed after either mptp or ddc + mptp administration. |
1994-07-07 |
2023-08-12 |
mouse |
| A Zuddas, F Fascetti, G U Corsini, M P Piccard. In brown Norway rats, MPP+ is accumulated in the nigrostriatal dopaminergic terminals but it is not neurotoxic: a model of natural resistance to MPTP toxicity. Experimental neurology. vol 127. issue 1. 1994-07-07. PMID:8200437. |
when mptp alone or ddc + mptp was administered to rats unilaterally lesioned with 6-hydroxy dopamine (6-oh-da), the levels of mpp+ measured in the intact striatum were significantly higher than those found in the 6-oh-da-lesioned striatum. |
1994-07-07 |
2023-08-12 |
mouse |
| M J Lundell, J Hirs. The zfh-2 gene product is a potential regulator of neuron-specific dopa decarboxylase gene expression in Drosophila. Developmental biology. vol 154. issue 1. 1992-12-02. PMID:1426635. |
the in vivo profile of zfh-2 in the larval cns shows intriguing overlap with ddc in specific serotonin and dopamine neurons. |
1992-12-02 |
2023-08-11 |
human |
| P R Buckland, M C O'Donovan, P McGuffi. Changes in dopa decarboxylase mRNA but not tyrosine hydroxylase mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1357712. |
these results indicate that ddc may be more important than th in the long term regulation of dopamine production. |
1992-11-25 |
2023-08-11 |
rat |
| K Inoue, T Kudo, Y Kishimot. The production mechanism of amniotic fluid dopamine in rats. Asia-Oceania journal of obstetrics and gynaecology. vol 17. issue 4. 1992-04-20. PMID:1801681. |
these results suggest that fetal plasma l-dopa may be converted to dopamine by fetal kidney ddc, and that the dopamine is voided into the amniotic cavity in fetal urine. |
1992-04-20 |
2023-08-11 |
rat |