| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Nagats. Genes for human catecholamine-synthesizing enzymes. Neuroscience research. vol 12. issue 2. 1992-02-06. PMID:1684650. |
four enzymes are involved in the biosynthesis of adrenaline: (1) tyrosine 3-mono-oxygenase (tyrosine hydroxylase, th); (2) aromatic l-amino acid decarboxylase (aadc, or dopa decarboxylase, ddc); (3) dopamine beta-mono-oxygenase (dopamine beta-hydroxylase, dbh); and (4) noradrenaline n-methyltransferase (phenylethanolamine n-methyltransferase, pnmt). |
1992-02-06 |
2023-08-11 |
mouse |
| D B Miller, J F Reinhard, A J Daniels, J P O'Callagha. Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium. Journal of neurochemistry. vol 57. issue 2. 1991-08-21. PMID:1649252. |
pretreatment with ddc potentiated the effect of mptp in striatum and resulted in substantially greater dopamine depletion, as well as a more pronounced elevation in gfap. |
1991-08-21 |
2023-08-11 |
mouse |
| D B Miller, J F Reinhard, A J Daniels, J P O'Callagha. Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium. Journal of neurochemistry. vol 57. issue 2. 1991-08-21. PMID:1649252. |
systemically administered mpp+ decreased heart norepinephrine, but did not alter the striatal levels of dopamine or gfap, and pretreatment with ddc did not alter these effects, but did increase lethality. |
1991-08-21 |
2023-08-11 |
mouse |
| A Gjedde, J Reith, S Dyve, G Léger, M Guttman, M Diksic, A Evans, H Kuwabar. Dopa decarboxylase activity of the living human brain. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 7. 1991-05-06. PMID:1688340. |
monoaminergic neurons use dopa decarboxylase (ddc; aromatic-l-amino-acid carboxy-lyase, ec 4.1.1.28) to form dopamine from l-3,4-dihydroxyphenylalanine (l-dopa). |
1991-05-06 |
2023-08-11 |
human |
| A M Vallés, K Whit. Serotonin synthesis and distribution in Drosophila dopa decarboxylase genetic mosaics. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 11. 1990-12-11. PMID:2230952. |
in drosophila, the enzyme dopa decarboxylase (ddc) catalyzes the last step in the biosynthesis of serotonin (5ht) and dopamine. |
1990-12-11 |
2023-08-11 |
drosophila_melanogaster |
| K Hiruma, L M Riddifor. Regulation of dopa decarboxylase gene expression in the larval epidermis of the tobacco hornworm by 20-hydroxyecdysone and juvenile hormone. Developmental biology. vol 138. issue 1. 1990-04-12. PMID:2407577. |
dopa decarboxylase (ddc) which converts dopa to dopamine is important for cuticular melanization and sclerotization in insects. |
1990-04-12 |
2023-08-11 |
drosophila_melanogaster |
| D M Yurek, A Y Deutch, R H Roth, J R Slade. Morphological, neurochemical, and behavioral characterizations associated with the combined treatment of diethyldithiocarbamate and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Brain research. vol 497. issue 2. 1990-01-11. PMID:2573405. |
changes in striatal dopamine (da) neurochemistry, tyrosine hydroxylase immunocytochemistry of da fibers, and behavior following the combined administration of diethyldithiocarbamate (ddc) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to mice were assessed. |
1990-01-11 |
2023-08-11 |
mouse |
| D Di Monte, I Irwin, A Kupsch, S Cooper, L E DeLanney, J W Langsto. Diethyldithiocarbamate and disulfiram inhibit MPP+ and dopamine uptake by striatal synaptosomes. European journal of pharmacology. vol 166. issue 1. 1989-12-01. PMID:2553428. |
diethyldithiocarbamate (ddc) was found to inhibit the uptake of both dopamine and 1-methyl-4-phenyl-pyridinium ion (mpp+, the putative toxic metabolite of the neurotoxicant mptp) by striatal synaptosomes. |
1989-12-01 |
2023-08-11 |
Not clear |
| D Di Monte, I Irwin, A Kupsch, S Cooper, L E DeLanney, J W Langsto. Diethyldithiocarbamate and disulfiram inhibit MPP+ and dopamine uptake by striatal synaptosomes. European journal of pharmacology. vol 166. issue 1. 1989-12-01. PMID:2553428. |
these results suggest that (1) the effect of ddc may be mediated by disulfiram, (2) the uptake of mpp+ and dopamine by striatal synaptosomes is dependent on the redox state of protein thiols, and (3) these protein thiols are located at the outer surface of synaptosomal membranes. |
1989-12-01 |
2023-08-11 |
Not clear |
| T Tanaka, Y Horio, M Taketoshi, I Imamura, M Ando-Yamamoto, K Kangawa, H Matsuo, M Kuroda, H Wad. Molecular cloning and sequencing of a cDNA of rat dopa decarboxylase: partial amino acid homologies with other enzymes synthesizing catecholamines. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 20. 1989-12-01. PMID:2813383. |
a sequence of 58 amino acid residues, including this repeating structure of rat ddc, was found to show homologies with those of rat tyrosine hydroxylase, human dopamine beta-hydroxylase, and bovine phenylethanolamine n-methyltransferase, other mammalian enzymes that synthesize catecholamines. |
1989-12-01 |
2023-08-11 |
human |
| V Budnik, C F Wu, K Whit. Altered branching of serotonin-containing neurons in Drosophila mutants unable to synthesize serotonin and dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 9. issue 8. 1989-09-22. PMID:2570137. |
low but detectable levels of dopamine and 5-ht in the cns are sufficient to prevent the increase in arborization, as indicated by analyses of a temperature-sensitive ddc allele (ddcts2), which has very low dopa decarboxylase activity. |
1989-09-22 |
2023-08-11 |
drosophila_melanogaster |
| V Budnik, L Martin-Morris, K Whit. Perturbed pattern of catecholamine-containing neurons in mutant Drosophila deficient in the enzyme dopa decarboxylase. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 12. 1987-02-10. PMID:3098930. |
these results suggest that in the absence of ddc activity, subsets of normally nonfluorogenic neurons capable of sequestering l-dopa or dopamine accumulate the fluorogenic catecholamine. |
1987-02-10 |
2023-08-11 |
drosophila_melanogaster |
| D W Gietzen, D E Woolle. Sex differences in [3H]-estradiol binding in brain and pituitary after acute dopaminergic treatment. In vivo studies in the rat. Neuroendocrinology. vol 42. issue 4. 1986-05-01. PMID:3008019. |
in order to determine whether or not dopaminergic stimulation might induce sex differences in 3h-e2 binding, male and female gonadectomized-adrenalectomized rats were pretreated either with bromocriptine, a dopamine agonist, or with diethyldithiocarbamate (ddc), an inhibitor of dopamine beta-hydroxylase. |
1986-05-01 |
2023-08-11 |
rat |
| D W Gietzen, D E Woolle. Sex differences in [3H]-estradiol binding in brain and pituitary after acute dopaminergic treatment. In vivo studies in the rat. Neuroendocrinology. vol 42. issue 4. 1986-05-01. PMID:3008019. |
ddc was used in order to increase endogenous release of dopamine. |
1986-05-01 |
2023-08-11 |
rat |
| R Mazumder, T K Das, N M Biswa. Spermatogenesis of rat: effect of central norepinephrine synthesis inhibition by diethyldithiocarbamate. Andrologia. vol 17. issue 4. 1985-11-13. PMID:2996382. |
inhibition of ne synthesis was produced by chronic injection (7 days) of ddc, a dopamine hydroxylase blocker, which decreased brain ne, increased brain da without significantly affecting brain 5-ht. |
1985-11-13 |
2023-08-11 |
human |
| D Sutoo, K San. Modulating effects of biogenic amines on calcium and ethanol-induced sleeping time. Alcohol (Fayetteville, N.Y.). vol 1. issue 2. 1985-10-03. PMID:6537217. |
p-chlorophenylalanine (pcpa, 300 mg/kg), alpha-methyltyrosine (alpha mpt, 100 mg/kg) and diethyldithiocarbamate (ddc, 250 mg/kg) were administered intraperitoneally (ip) to mice to reduce the levels of serotonin (5-ht), dopamine (da) and norepinephrine (ne) respectively in the brain. |
1985-10-03 |
2023-08-12 |
mouse |
| K Hiruma, L M Riddifor. Hormonal regulation of dopa decarboxylase during a larval molt. Developmental biology. vol 110. issue 2. 1985-08-27. PMID:4018412. |
cuticular sclerotization in insects requires dopamine derivatives and thus the presence of dopa decarboxylase (ddc), the enzyme which converts dopa to dopamine. |
1985-08-27 |
2023-08-11 |
Not clear |
| B L Tempel, M S Livingstone, W G Quin. Mutations in the dopa decarboxylase gene affect learning in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. vol 81. issue 11. 1984-07-24. PMID:6427773. |
dopa decarboxylase (ddc) mutations affect synthesis of two of these, dopamine and serotonin. |
1984-07-24 |
2023-08-12 |
drosophila_melanogaster |
| T L Johnson, C O Knowle. Influence of formamidines on biogenic amine levels in rat brain and plasma. General pharmacology. vol 14. issue 6. 1984-03-21. PMID:6662341. |
at 1 hr following s.c. injection, cdf (200 mg/kg) caused a reduction in levels of norepinephrine (ne), 5-hydroxytryptamine (5-ht), and tyramine (trm), an increase in dopamine (da), and no change in levels of beta-phenethylamine (pea) in samples of whole rat brain, whereas dmc (100 mg/kg) and ddc (25 mg/kg) effected reductions of brain levels of ne, 5-ht, trm, and pea with no change in da. |
1984-03-21 |
2023-08-12 |
rat |
| M S Livingstone, B L Tempe. Genetic dissection of monoamine neurotransmitter synthesis in Drosophila. Nature. vol 303. issue 5912. 1983-06-17. PMID:6133219. |
in contrast, dopa decarboxylase (ddc) mutations decreased dopamine and serotonin synthesis but did not affect octopamine synthesis. |
1983-06-17 |
2023-08-12 |
drosophila_melanogaster |