| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Hawi, D Foley, A Kirley, M McCarron, M Fitzgerald, M Gil. Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population. Molecular psychiatry. vol 6. issue 4. 2001-09-06. PMID:11443526. |
dopa decarboxylase (ddc) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and l-5 hydroxytryptophan to serotonin. |
2001-09-06 |
2023-08-12 |
Not clear |
| P B Koch, B Behnecke, M Weigmann-Lenz, R H Ffrench-Constan. Insect pigmentation: activities of beta-alanyldopamine synthase in wing color patterns of wild-type and melanic mutant swallowtail butterfly Papilio glaucus. Pigment cell research. vol 13 Suppl 8. 2001-04-19. PMID:11041358. |
from earlier studies we know that dopamine produced from dopa by the enzyme dopadecarboxylase (ddc), is a precursor of both black melanin and also of n-beta-alanyldopamine (nbad) in yellow papiliochrome synthesis. |
2001-04-19 |
2023-08-12 |
Not clear |
| D M McGrew, I Irwin, J W Langsto. Ethylenebisdithiocarbamate enhances MPTP-induced striatal dopamine depletion in mice. Neurotoxicology. vol 21. issue 3. 2000-11-07. PMID:10894120. |
diethyldithiocarbamate (ddc) has been shown to enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced striatal dopamine depletion in mice. |
2000-11-07 |
2023-08-12 |
mouse |
| D M McGrew, I Irwin, J W Langsto. Ethylenebisdithiocarbamate enhances MPTP-induced striatal dopamine depletion in mice. Neurotoxicology. vol 21. issue 3. 2000-11-07. PMID:10894120. |
consistent with previous reports, ddc produced statistically significant enhancement in mptp-induced striatal dopamine depletion. |
2000-11-07 |
2023-08-12 |
mouse |
| A Fisher, M S Star. Opposite effects of glutamate antagonists and antiparkinsonian drugs on the activities of DOPA decarboxylase and 5-HTP decarboxylase in the rat brain. Brain research. vol 868. issue 2. 2000-08-18. PMID:10854579. |
it is concluded that glutamate exerts a differential physiological influence on the biosynthesis of dopamine and 5-ht in the brain, by tonically suppressing ddc and tonically stimulating 5-htpdc. |
2000-08-18 |
2023-08-12 |
rat |
| A D Børglum, T G Bruun, T E Kjeldsen, H Ewald, O Mors, G Kirov, C Russ, B Freeman, D A Collier, T A Krus. Two novel variants in the DOPA decarboxylase gene: association with bipolar affective disorder. Molecular psychiatry. vol 4. issue 6. 2000-01-03. PMID:10578236. |
dopa decarboxylase (ddc), also known as aromatic l-amino acid decarboxylase (aadc), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin. |
2000-01-03 |
2023-08-12 |
Not clear |
| T L Walters, I Irwin, K Delfani, J W Langston, A M Janso. Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP. Experimental neurology. vol 156. issue 1. 1999-04-21. PMID:10192777. |
however, when animals were pretreated with ddc (400 mg/kg ip), the same dose of mptp resulted in a 50% loss of neurons in the substantia nigra pars compacta, as well as a 70% reduction in striatal dopamine (da). |
1999-04-21 |
2023-08-12 |
mouse |
| T L Walters, I Irwin, K Delfani, J W Langston, A M Janso. Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP. Experimental neurology. vol 156. issue 1. 1999-04-21. PMID:10192777. |
as expected, animals receiving ddc alone did not show any dopamine depletion nor nigral neuronal loss. |
1999-04-21 |
2023-08-12 |
mouse |
| T D Mantzouridis, E G Fragouli. Two different cDNAs code for L-DOPA decarboxylase in the white prepuparium and eclosion developmental stages of the insect Ceratitis capitata1. Biochimica et biophysica acta. vol 1443. issue 1-2. 1999-02-04. PMID:9838157. |
in insects the dopa decarboxylase gene (ddc) is expressed in the epidermis where dopamine derivatives promote cuticle sclerotization and the central nervous system participating in the synthesis of serotonin and dopamine. |
1999-02-04 |
2023-08-12 |
Not clear |
| M Bertoldi, P Dominici, P S Moore, B Maras, C B Voltattorn. Reaction of dopa decarboxylase with alpha-methyldopa leads to an oxidative deamination producing 3,4-dihydroxyphenylacetone, an active site directed affinity label. Biochemistry. vol 37. issue 18. 1998-06-08. PMID:9572873. |
271, 23954-23959], the conversion of dopamine (da) into 3,4-dihydroxyphenylacetaldehyde and ammonia catalyzed by ddc is accompanied by irreversible loss of decarboxylase activity. |
1998-06-08 |
2023-08-12 |
Not clear |
| P Cumming, A Ase, H Kuwabara, A Gjedd. [3H]DOPA formed from [3H]tyrosine in living rat brain is not committed to dopamine synthesis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 18. issue 5. 1998-06-04. PMID:9591841. |
tyrosine hydroxylase of catecholamine neurons catalyzes the synthesis of 3,4-dihydroxphenylalanine (dopa), which is subsequently metabolized to dopamine by dopa decarboxylase (ddc). |
1998-06-04 |
2023-08-12 |
rat |
| P Cumming, A Ase, H Kuwabara, A Gjedd. [3H]DOPA formed from [3H]tyrosine in living rat brain is not committed to dopamine synthesis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 18. issue 5. 1998-06-04. PMID:9591841. |
the rate constant for the clearance of dopa from brain (0.06 min(-1)) and earlier estimates of the rate constant of ddc activity in striatum (0.26 min(-1)) together predict that 80% of dopa formed in normal rat striatum normally is available for dopamine synthesis. |
1998-06-04 |
2023-08-12 |
rat |
| I Y Rauschenbach, M J Sukhanova, L V Shumnaya, N E Gruntenko, L G Grenback, T M Khlebodarova, N A Chentsov. Role of DOPA decarboxylase and N-acetyl transferase in regulation of dopamine content in Drosophila virilis under normal and heat stress conditions. Insect biochemistry and molecular biology. vol 27. issue 8-9. 1998-03-02. PMID:9443373. |
activity levels of dopa decarboxylase (ddc), an enzyme responsible for dopamine (da) synthesis, and of n-acetyl transferase (nat), an enzyme responsible for its degradation, were studied under normal and stress conditions in two lines of drosophila virilis which are in contrast concerning their da content under normal conditions and its alterations under stress. |
1998-03-02 |
2023-08-12 |
drosophila_melanogaster |
| P Cumming, A Ase, C Laliberté, H Kuwabara, A Gjedd. In vivo regulation of DOPA decarboxylase by dopamine receptors in rat brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 17. issue 11. 1997-12-24. PMID:9390657. |
to test the hypothesis that dopamine (da) receptors influence cerebral dopa-decarboxylase (ddc) activity in vivo, we used hplc to measure the kinetics of the cerebral uptake and metabolism of [3h]dopa in carbidopa-treated rats, and in rats also treated acutely with a da receptor antagonist (flupenthixol, 2 mg/kg, intraperitoneally) or a da receptor agonist (apomorphine, 200 microg/g, subcutaneously). |
1997-12-24 |
2023-08-12 |
human |
| K Murakami, S F Akana, M F Dallma. Dopamine-beta-hydroxylase activity is necessary for hypothalamo-pituitary-adrenal (HPA) responses to ether, and stress-induced facilitation of subsequent HPA responses to acute ether emerges as HPA responses are inhibited by increasing corticosterone (B). Journal of neuroendocrinology. vol 9. issue 8. 1997-10-10. PMID:9283048. |
to determine a role of norepinephrine (ne) in stress-induced hpa function, young male rats were treated with diethyldithiocarbamide (ddc) which inhibits dopamine-beta-hydroxylase, the enzyme that synthesizes ne from dopamine (da). |
1997-10-10 |
2023-08-12 |
rat |
| L V Shumnaia, M Zh Sukhanova, N E Gruntenko, L G Grenbék, T M Khlebodarova, I Iu Raushenbak. [Genetic analysis of differences in dopa decarboxylase activity between two Drosophila virilis lines differing in dopamine content]. Genetika. vol 33. issue 3. 1997-08-05. PMID:9244765. |
activity of dopa decarboxylase (ddc) in two drosophila virilis lines differing in dopamine (da) content was investigated. |
1997-08-05 |
2023-08-12 |
drosophila_melanogaster |
| T Brannan, A Prikhojan, M D Yah. An in vivo comparison of the capacity of striatal versus extrastriatal brain regions to form dopamine from exogenously administered L-dopa. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 11. 1997-04-17. PMID:9013415. |
we used the technique of cerebral microdialysis to monitor the metabolism of exogenously administered l-dopa and compared dopamine and dopamine metabolite formation in the striatum (a site containing abundant dopamine nerve terminals and dopa-decarboxylase (ddc) activity) versus the cerebellum and occipital cortex (sites with limited dopaminergic innervation and ddc activity). |
1997-04-17 |
2023-08-12 |
Not clear |
| T Brannan, A Prikhojan, M D Yah. An in vivo comparison of the capacity of striatal versus extrastriatal brain regions to form dopamine from exogenously administered L-dopa. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 11. 1997-04-17. PMID:9013415. |
we conclude that brain areas with marked reductions in dopamine nerve terminals and ddc activity have a diminished capacity to synthesize dopamine and also lack storage mechanisms to protect the newly synthesized dopamine from degradative metabolism. |
1997-04-17 |
2023-08-12 |
Not clear |
| H Ewald, O Mors, H Eiberg, T Flint, T A Krus. No evidence of linkage between manic depressive illness and the dopa decarboxylase gene or nearby region on chromosome 7p. Psychiatric genetics. vol 5. issue 4. 1996-10-11. PMID:8750358. |
dopa decarboxylase (ddc) is involved directly in the synthesis of dopamine and serotonin and indirectly in the synthesis of noradrenaline. |
1996-10-11 |
2023-08-12 |
Not clear |
| D Wang, J L Marsh, F J Ayal. Evolutionary changes in the expression pattern of a developmentally essential gene in three Drosophila species. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 14. 1996-08-29. PMID:8692952. |
in drosophila, they have evolved nonoverlapping functions, including the production of distinct types of cuticle, and for ddc, the production of the neurotransmitters, dopamine and serotonin. |
1996-08-29 |
2023-08-12 |
drosophila_melanogaster |