| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ni-Chung Lee, Yin-Hsiu Chien, Min-Hsiu Hu, Wen-Shin Liu, Pin-Wen Chen, Wei-Hua Wang, Kai-Yuan Tzen, Barry J Byrne, Wuh-Liang Hw. Treatment of congenital neurotransmitter deficiencies by intracerebral ventricular injection of an adeno-associated virus serotype 9 vector. Human gene therapy. vol 25. issue 3. 2014-11-06. PMID:24251946. |
without treatment, 4-week-old ddc(ki) mice exhibited whole-brain homogenate dopamine and serotonin levels of 25% and 15% of normal, respectively. |
2014-11-06 |
2023-08-12 |
mouse |
| Hong-Bin Zhao, Hui Ma, Xiao-Qin Ha, Ping Zheng, Xiao-Yun Li, Ming Zhang, Ju-Zi Dong, Yin-Shu Yan. Salidroside induces rat mesenchymal stem cells to differentiate into dopaminergic neurons. Cell biology international. vol 38. issue 4. 2014-10-30. PMID:24323403. |
the expression of dopamine neurons markers, such as dopamine-beta-hydroxy (dbh), dopa decarboxylase (ddc) and tyrosine hydroxylase (th), was significantly upregulated after treatment with salidroside for 1-12 days. |
2014-10-30 |
2023-08-12 |
rat |
| David Devos, Stéphanie Lejeune, Florence Cormier-Dequaire, Khadija Tahiri, Fanny Charbonnier-Beaupel, Nathalie Rouaix, Alain Duhamel, Bernard Sablonnière, Anne-Marie Bonnet, Cecilia Bonnet, Noel Zahr, Jean Costentin, Marie Vidailhet, Jean-Christophe Corvo. Dopa-decarboxylase gene polymorphisms affect the motor response to L-dopa in Parkinson's disease. Parkinsonism & related disorders. vol 20. issue 2. 2014-09-24. PMID:24216088. |
the major pathway for dopamine synthesis from l-dopa is decarboxylation by aromatic l-amino acid decarboxylase (aaad, encoded by the ddc gene). |
2014-09-24 |
2023-08-12 |
Not clear |
| So Young Park, Dohyoung Kwon, Hyejung Mok, Bong Hyun Chun. Simple and rapid detection of L-Dopa decarboxylase activity using gold nanoparticles. The Analyst. vol 138. issue 11. 2013-12-27. PMID:23596625. |
when l-3,4-dihydroxyphenylalanine (l-dopa) is decarboxylated to dopamine (da) by ddc, da induces the aggregation of aunps, and the color of the aunps changes from red to blue. |
2013-12-27 |
2023-08-12 |
Not clear |
| Bi Zhu, Chuansheng Chen, Robert K Moyzis, Qi Dong, Chunhui Chen, Qinghua He, Jin Li, Jun Li, Xuemei Lei, Chongde Li. The DOPA decarboxylase (DDC) gene is associated with alerting attention. Progress in neuro-psychopharmacology & biological psychiatry. vol 43. 2013-09-19. PMID:23276884. |
dopa decarboxylase (ddc) is involved in the synthesis of dopamine, norepinephrine and serotonin. |
2013-09-19 |
2023-08-12 |
human |
| Riccardo Montioli, Elisa Oppici, Barbara Cellini, Alessandro Roncador, Mirco Dindo, Carla Borri Voltattorn. S250F variant associated with aromatic amino acid decarboxylase deficiency: molecular defects and intracellular rescue by pyridoxine. Human molecular genetics. vol 22. issue 8. 2013-09-03. PMID:23321058. |
dopa or aromatic amino acid decarboxylase (ddc, aadc) is a pyridoxal 5'-phosphate-dependent enzyme that catalyses the production of the neurotransmitters dopamine and serotonin. |
2013-09-03 |
2023-08-12 |
Not clear |
| Theresa K Hodges, Kate L Laskowski, Giuseppe L Squadrito, Maria De Luca, Jeff Leip. Defense traits of larval Drosophila melanogaster exhibit genetically based trade-offs against different species of parasitoids. Evolution; international journal of organic evolution. vol 67. issue 3. 2013-08-30. PMID:23461325. |
we used host larvae with different natural alleles of the gene dopa decarboxylase (ddc), a gene controlling the production of dopamine and known to influence the immune response against parasitoids. |
2013-08-30 |
2023-08-12 |
drosophila_melanogaster |
| Daniel P Czech, Joohyung Lee, Helena Sim, Clare L Parish, Eric Vilain, Vincent R Harle. The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22568433. |
in the human neuroblastoma cell line, m17, sry knockdown resulted in a reduction in th, ddc, dbh and mao-a expression; enzymes which control dopamine synthesis and metabolism. |
2013-08-14 |
2023-08-12 |
human |
| Daniel P Czech, Joohyung Lee, Helena Sim, Clare L Parish, Eric Vilain, Vincent R Harle. The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22568433. |
conversely, sry over-expression increased th, ddc, dbh, d2 r and mao-a levels, accompanied by increased extracellular dopamine levels. |
2013-08-14 |
2023-08-12 |
human |
| Dimitrios Korbakis, Emmanuel G Fragoulis, Andreas Scorila. Quantification and study of the L-DOPA decarboxylase expression in gastric adenocarcinoma cells treated with chemotherapeutic substances. Anti-cancer drugs. vol 24. issue 3. 2013-07-22. PMID:23328075. |
3,4-dihydroxy-l-phenylalanine decarboxylase (ddc) is an enzyme implicated in the biosynthetic pathways of the neurotransmitters dopamine and probably serotonin. |
2013-07-22 |
2023-08-12 |
Not clear |
| Panagiota-Aikaterini Geomela, Christos K Kontos, Ioannis Yiotakis, Emmanuel G Fragoulis, Andreas Scorila. L-DOPA decarboxylase mRNA expression is associated with tumor stage and size in head and neck squamous cell carcinoma: a retrospective cohort study. BMC cancer. vol 12. 2013-07-12. PMID:23083099. |
the ddc gene encodes l-dopa decarboxylase, an enzyme catalyzing the decarboxylation of l-dopa to dopamine. |
2013-07-12 |
2023-08-12 |
Not clear |
| Barbara Cellini, Riccardo Montioli, Elisa Oppici, Carla Borri Voltattorn. Biochemical and computational approaches to improve the clinical treatment of dopa decarboxylase-related diseases: an overview. The open biochemistry journal. vol 6. 2012-12-25. PMID:23264832. |
dopa decarboxylase (ddc) is a pyridoxal 5'-phosphate (plp)-dependent enzyme that by catalyzing the decarboxylation of l-dopa and l-5-hydroxytryptophan produces the neurotransmitters dopamine and serotonin. |
2012-12-25 |
2023-08-12 |
human |
| Ken Sasaki, Syuhei Matsuyama, Ken-Ichi Harano, Takashi Naga. Caste differences in dopamine-related substances and dopamine supply in the brains of honeybees (Apis mellifera L.). General and comparative endocrinology. vol 178. issue 1. 2012-10-31. PMID:22537672. |
the in vitro enzymatic activities of dopa decarboxylase (ddc) during dopamine synthesis in brains were not significantly different between castes. |
2012-10-31 |
2023-08-12 |
Not clear |
| Ken Sasaki, Syuhei Matsuyama, Ken-Ichi Harano, Takashi Naga. Caste differences in dopamine-related substances and dopamine supply in the brains of honeybees (Apis mellifera L.). General and comparative endocrinology. vol 178. issue 1. 2012-10-31. PMID:22537672. |
oral application of dopa to workers led to dopa uptake in the brain and significantly higher dopamine and nada levels in the brain, suggesting that dopamine synthesis could be controlled by the amount of ddc substrate. |
2012-10-31 |
2023-08-12 |
Not clear |
| Ken Sasaki, Syuhei Matsuyama, Ken-Ichi Harano, Takashi Naga. Caste differences in dopamine-related substances and dopamine supply in the brains of honeybees (Apis mellifera L.). General and comparative endocrinology. vol 178. issue 1. 2012-10-31. PMID:22537672. |
these results suggest that the higher levels of brain dopamine in queens compared with workers can be explained by the higher level of ddc substrate, rather than ddc activity in the brain and other tissues of queens as well as exogenous dopamine in the royal jelly. |
2012-10-31 |
2023-08-12 |
Not clear |
| Zhi Zhou, Lingling Wang, Xiaowei Shi, Feng Yue, Mengqiang Wang, Huan Zhang, Linsheng Son. The expression of dopa decarboxylase and dopamine beta hydroxylase and their responding to bacterial challenge during the ontogenesis of scallop Chlamys farreri. Fish & shellfish immunology. vol 33. issue 1. 2012-10-05. PMID:22521420. |
dopa decarboxylase (ddc) and dopamine beta hydroxylase (dbh) is responsible for the synthesis of dopamine and norepinephrine, respectively. |
2012-10-05 |
2023-08-12 |
Not clear |
| Christos Patsis, Vasiliki Glyka, Ioannis Yiotakis, Emmanuel G Fragoulis, Andreas Scorila. l-DOPA Decarboxylase (DDC) Expression Status as a Novel Molecular Tumor Marker for Diagnostic and Prognostic Purposes in Laryngeal Cancer. Translational oncology. vol 5. issue 4. 2012-10-02. PMID:22937181. |
l-dopa decarboxylase (ddc) plays an essential role in the enzymatic synthesis of dopamine and alterations in its gene expression have been reported in several malignancies. |
2012-10-02 |
2023-08-12 |
Not clear |
| Frederick Daidone, Riccardo Montioli, Alessandro Paiardini, Barbara Cellini, Antonio Macchiarulo, Giorgio Giardina, Francesco Bossa, Carla Borri Voltattorn. Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384042. |
dopa decarboxylase (ddc), a pyridoxal 5'-phosphate (plp) enzyme responsible for the biosynthesis of dopamine and serotonin, is involved in parkinson's disease (pd). |
2012-08-27 |
2023-08-12 |
human |
| Sean D Kristjansson, Arpana Agrawal, Christina N Lessov-Schlaggar, Pamela A F Madden, M Lynne Cooper, Kathleen K Bucholz, Kenneth J Sher, Michael T Lynskey, Andrew C Heat. The relationship between rs3779084 in the dopa decarboxylase (DDC) gene and alcohol consumption is mediated by drinking motives in regular smokers. Alcoholism, clinical and experimental research. vol 36. issue 1. 2012-08-24. PMID:21797889. |
this study investigated whether drinking motives mediate the associations between alcohol consumption and 2 single-nucleotide polymorphisms (snps) from genes involved in serotonin (tph2; rs1386496) and dopamine synthesis (ddc; rs3779084). |
2012-08-24 |
2023-08-12 |
Not clear |
| Yusuke Sekine, Shuichi Takagahara, Ryo Hatanaka, Takeshi Watanabe, Haruka Oguchi, Takuya Noguchi, Isao Naguro, Kazuto Kobayashi, Makoto Tsunoda, Takashi Funatsu, Hiroshi Nomura, Takeshi Toyoda, Norio Matsuki, Erina Kuranaga, Masayuki Miura, Kohsuke Takeda, Hidenori Ichij. p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. Journal of cell science. vol 124. issue Pt 17. 2012-02-29. PMID:21878507. |
drosophila tyrosine hydroxylase (th, also known as pale) and dopa decarboxylase (ddc), key enzymes in the dopamine synthesis pathway, underlie the melanin synthesis by providing the melanin precursors dopa and dopamine, respectively. |
2012-02-29 |
2023-08-12 |
drosophila_melanogaster |