| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Riccardo Montioli, Giacomo Janson, Alessandro Paiardini, Mariarita Bertoldi, Carla Borri Voltattorn. Heterozygosis in aromatic amino acid decarboxylase deficiency: Evidence for a positive interallelic complementation between R347Q and R358H mutations. IUBMB life. vol 70. issue 3. 2019-01-30. PMID:29356298. |
aromatic amino acid or dopa decarboxylase (aadc or ddc) is a homodimeric pyridoxal 5'-phosphate (plp) enzyme responsible for the generation of the neurotransmitters dopamine and serotonin. |
2019-01-30 |
2023-08-13 |
human |
| Esfandiar Azadmarzabadi, Arvin Haghighatfard, Alireza Mohammad. Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 18. issue 3. 2018-08-01. PMID:29423959. |
here, we aimed to describe the association between comprehensive psychological characteristics and messenger rna levels of dopamine receptor d1 (drd1), dopamine receptor d2 (drd2), dopamine receptor d3 (drd3), dopamine receptor d4 (drd4), dopamine receptor d5 (drd5), comt, dopamine beta-hydroxylase (dbh), tyrosine hydroxylase (th), monoamine oxidase a (maom), dopa decarboxylase (ddc), dopamine transporter (dat), serotonin transporter (5-htt), brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf) genes based on peripheral blood samples from 400 subjects who react differently to major life event stressors. |
2018-08-01 |
2023-08-13 |
human |
| Xiaoxue Gao, Jinting Liu, Pingyuan Gong, Junhui Wang, Wan Fang, Hongming Yan, Lusha Zhu, Xiaolin Zho. Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making. Social cognitive and affective neuroscience. vol 12. issue 9. 2018-05-24. PMID:28431168. |
more importantly, we demonstrated that the genetic variations of the aromatic-l-amino-acid decarboxylase (ddc) gene, which is involved in the synthesis of both dopamine and serotonin, contributed to individual differences in the susceptibility to framing. |
2018-05-24 |
2023-08-13 |
human |
| Liping Huang, Minzhen Deng, Sheng Zhang, Shiyao Lu, Xuehong Gui, Yongqi Fan. β-asarone and levodopa coadministration increases striatal levels of dopamine and levodopa and improves behavioral competence in Parkinson's rat by enhancing dopa decarboxylase activity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-15. PMID:28787702. |
neurotransmitters, dopa decarboxylase (ddc), tyrosine hydroxylase (th), catechol-o-methyltransferase (comt), monoamine oxidase b (mao-b) and dopamine transporter (dat) levels were detected. |
2018-05-15 |
2023-08-13 |
rat |
| Daniel P Eisenberg, Philip D Kohn, Catherine E Hegarty, Angela M Ianni, Bhaskar Kolachana, Michael D Gregory, Joseph C Masdeu, Karen F Berma. Common Variation in the DOPA Decarboxylase (DDC) Gene and Human Striatal DDC Activity In Vivo. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:26924680. |
the synthesis of multiple amine neurotransmitters, such as dopamine, norepinephrine, serotonin, and trace amines, relies in part on dopa decarboxylase (ddc, aadc), an enzyme that is required for normative neural operations. |
2018-01-09 |
2023-08-13 |
human |
| Francisca Sanchez-Jiménez, Almudena Pino-Ángeles, Rocio Rodríguez-López, María Morales, José Luis Urdiale. Structural and functional analogies and differences between histidine decarboxylase and aromatic l-amino acid decarboxylase molecular networks: Biomedical implications. Pharmacological research. vol 114. 2017-12-26. PMID:27769832. |
human histidine decarboxylase (hdc) and dopa decarboxilase (ddc) are highly homologous enzymes responsible for the synthesis of biogenic amines (ba) like histamine, and serotonin and dopamine, respectively. |
2017-12-26 |
2023-08-13 |
human |
| Arunangshu Das, Anita Verma, Krishna J Mukherje. Synthesis of dopamine in E. coli using plasmid-based expression system and its marked effect on host growth profiles. Preparative biochemistry & biotechnology. vol 47. issue 8. 2017-11-20. PMID:28430025. |
we report the synthesis of dopamine by extending the aromatic amino acid pathway of escherichia coli dh5α by the expression of 4-hydroxyphenylacetate-3-hydrolase (hpabc) from e. coli and an engineered dopa decarboxylase (ddc) from pig kidney cell. |
2017-11-20 |
2023-08-13 |
Not clear |
| b' Thomas R Lemonds, Jin Liu, Aleksandar Popadi\\xc4\\x8. The contribution of the melanin pathway to overall body pigmentation during ontogenesis of Periplaneta americana. Insect science. vol 23. issue 4. 2017-04-27. PMID:27158782.' |
in addition, the ddc rnai results reveal that it is dopamine melanin, not dopa melanin, acts as the main contributor in this process. |
2017-04-27 |
2023-08-13 |
Not clear |
| Dai Tsukioka, Susumu Izumi, Takeshi Adach. Cloning and expression analysis of a novel tissue-specific dopa decarboxylase mRNA splicing variant in Bombyx mori. Bioscience, biotechnology, and biochemistry. vol 81. issue 3. 2017-03-06. PMID:27869544. |
dopa decarboxylase (ddc) protein is involved in the synthesis of dopamine and serotonin. |
2017-03-06 |
2023-08-13 |
drosophila_melanogaster |
| Hong Yu, Jun Liu, Aiping Yang, Guohui Yang, Wenjun Yang, Heyue Lei, Jianjun Quan, Zengyu Zhan. Lack of Association Between Polymorphisms in Dopa Decarboxylase and Dopamine Receptor-1 Genes With Childhood Autism in Chinese Han Population. Journal of child neurology. vol 31. issue 5. 2016-12-13. PMID:26337060. |
this study is to determine the association of single-nucleotide polymorphisms in dopa decarboxylase (ddc) and dopamine receptor-1 (drd1) genes with childhood autism, in a chinese han population. |
2016-12-13 |
2023-08-13 |
Not clear |
| Emmanuel I Papadopoulos, Constantina Petraki, Alkiviadis Gregorakis, Eleni Chra, Emmanuel G Fragoulis, Andreas Scorila. L-DOPA decarboxylase mRNA levels provide high diagnostic accuracy and discrimination between clear cell and non-clear cell subtypes in renal cell carcinoma. Clinical biochemistry. vol 48. issue 9. 2016-02-24. PMID:25721989. |
l-dopa decarboxylase (ddc) is the gene encoding the enzyme that catalyzes the biosynthesis of dopamine in humans. |
2016-02-24 |
2023-08-13 |
Not clear |
| Wei Zhang, Sungwon Kim, Robert Settlage, Wyatt McMahon, Lindsay H Sumners, Paul B Siegel, Benjamin J Dorshorst, Mark A Cline, Elizabeth R Gilber. Hypothalamic differences in expression of genes involved in monoamine synthesis and signaling pathways after insulin injection in chickens from lines selected for high and low body weight. Neurogenetics. vol 16. issue 2. 2015-11-25. PMID:25582322. |
there was greater expression of genes, mainly tyrosine hydroxylase (th), l-aromatic amino acid decarboxylase (ddc), and vesicular monoamine transporter (vmat), involved in serotonin and dopamine biosynthesis and signaling in lws than in hws vehicle-injected chickens. |
2015-11-25 |
2023-08-13 |
chicken |
| Caroline Moreau, Sayah Meguig, Jean-Christophe Corvol, Julien Labreuche, Francis Vasseur, Alain Duhamel, Arnaud Delval, Thomas Bardyn, Jean-Christophe Devedjian, Nathalie Rouaix, Gregory Petyt, Christine Brefel-Courbon, Fabienne Ory-Magne, Dominique Guehl, Alexandre Eusebio, Valérie Fraix, Pierre-Jean Saulnier, Ouhaid Lagha-Boukbiza, Frank Durif, Mirela Faighel, Caroline Giordana, Sophie Drapier, David Maltête, Christine Tranchant, Jean-Luc Houeto, Bettina Debû, Jean-Philippe Azulay, François Tison, Alain Destée, Marie Vidailhet, Olivier Rascol, Kathy Dujardin, Luc Defebvre, Régis Bordet, Bernard Sablonnière, David Devo. Polymorphism of the dopamine transporter type 1 gene modifies the treatment response in Parkinson's disease. Brain : a journal of neurology. vol 138. issue Pt 5. 2015-07-17. PMID:25805645. |
patients were screened for variants of genes involved in dopamine metabolism: rs28363170 and rs3836790 polymorphisms in the slc6a3 gene, rs921451 and rs3837091 in the ddc gene (encoding the aromatic l-amino acid decarboxylase involved in the synthesis of dopamine from l-dopa), rs1799836 in the maob gene (coding for monoamine oxidase b) and rs4680 in the comt gene (coding for catechol-o-methyltransferase). |
2015-07-17 |
2023-08-13 |
human |
| Jie Ren, Yuanyuan Zhang, Huizi Jin, Jing Yu, Yueyang Zhou, Fang Wu, Weidong Zhan. Novel inhibitors of human DOPA decarboxylase extracted from Euonymus glabra Roxb. ACS chemical biology. vol 9. issue 4. 2015-07-01. PMID:24471650. |
dopamine, a biogenic amine with important biological functions, is produced from l-dopa by dopa decarboxylase (ddc). |
2015-07-01 |
2023-08-12 |
human |
| Jie Ren, Yuanyuan Zhang, Huizi Jin, Jing Yu, Yueyang Zhou, Fang Wu, Weidong Zhan. Novel inhibitors of human DOPA decarboxylase extracted from Euonymus glabra Roxb. ACS chemical biology. vol 9. issue 4. 2015-07-01. PMID:24471650. |
ddc is a potential target to modulate the production of dopamine in several pathological states. |
2015-07-01 |
2023-08-12 |
human |
| Riccardo Montioli, Mirco Dindo, Alejandro Giorgetti, Stefano Piccoli, Barbara Cellini, Carla Borri Voltattorn. A comprehensive picture of the mutations associated with aromatic amino acid decarboxylase deficiency: from molecular mechanisms to therapy implications. Human molecular genetics. vol 23. issue 20. 2015-06-03. PMID:24865461. |
dopa decarboxylase (ddc), or aromatic amino acid decarboxylase (aadc), is a pyridoxal 5'-phosphate enzyme responsible for the production of the neurotransmitters dopamine and serotonin. |
2015-06-03 |
2023-08-13 |
Not clear |
| Emmanuel I Papadopoulos, Emmanuel G Fragoulis, Andreas Scorila. Human L-DOPA decarboxylase mRNA is a target of miR-145: A prediction to validation workflow. Gene. vol 554. issue 2. 2015-02-17. PMID:25445287. |
l-dopa decarboxylase (ddc) is a multiply-regulated gene which encodes the enzyme that catalyzes the biosynthesis of dopamine in humans. |
2015-02-17 |
2023-08-13 |
human |
| b' Jin Liu, Thomas R Lemonds, Aleksandar Popadi\\xc4\\x8. The genetic control of aposematic black pigmentation in hemimetabolous insects: insights from Oncopeltus fasciatus. Evolution & development. vol 16. issue 5. 2015-01-02. PMID:25124093.' |
the results of the ddc rnai are particularly informative because they reveal that it is dopamine melanin, not dopa melanin, which is the predominant component of black pigments in oncopeltus. |
2015-01-02 |
2023-08-13 |
Not clear |
| Hortensia Alonso-Navarro, Felix Javier Jimenez-Jimenez, Elena Garcia-Martin, Jose A G Agunde. Genomic and pharmacogenomic biomarkers of Parkinson's disease. Current drug metabolism. vol 15. issue 2. 2014-11-24. PMID:24694231. |
nor did polymorphisms in genes related to dopamine or serotonin drd, dat, th, ddc, dbh, mao, comt, slc6a4, mtr, mthfr, oxidative stress noq1, noq2, mephx, hfe, gpx, cat, mnsod, hfe, ho-1, ho-2, nfe2l2, keap1, inflammatory processes, ils, tnf, act, nos, hnmt, abp1, hrhs, trophic and growth factors bdnf, fgf, or mitochondrial metabolism and function. |
2014-11-24 |
2023-08-13 |
cat |
| Ni-Chung Lee, Yin-Hsiu Chien, Min-Hsiu Hu, Wen-Shin Liu, Pin-Wen Chen, Wei-Hua Wang, Kai-Yuan Tzen, Barry J Byrne, Wuh-Liang Hw. Treatment of congenital neurotransmitter deficiencies by intracerebral ventricular injection of an adeno-associated virus serotype 9 vector. Human gene therapy. vol 25. issue 3. 2014-11-06. PMID:24251946. |
in this study, we performed gene therapy to treat knock-in mice with dopamine and serotonin deficiencies caused by a mutation in the aromatic l-amino acid decarboxylase (aadc) gene (ddc(ki) mice). |
2014-11-06 |
2023-08-12 |
mouse |