| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuka Morikawa, Fabien D'Autréaux, Michael D Gershon, Peter Cserjes. Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Developmental biology. vol 307. issue 1. 2007-09-10. PMID:17531968. |
to determine whether hand2 regulates noradrenergic differentiation, the levels of the norepinephrine biosynthetic enzymes, tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) was examined. |
2007-09-10 |
2023-08-12 |
mouse |
| James E Faber, Caroline L Szymeczek, Susanna Cotecchia, Steven A Thomas, Akito Tanoue, Gozoh Tsujimoto, Hua Zhan. Alpha1-adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension. American journal of physiology. Heart and circulatory physiology. vol 292. issue 5. 2007-06-27. PMID:17220188. |
mice genetically deficient in norepinephrine and epinephrine production [dopamine beta-hydroxylase(-/-) (dbh(-/-))] or alpha(1)-ars were examined for alterations in ph, cardiac hypertrophy, and vascular remodeling after 21 days exposure to normobaric 0.1 inspired oxygen fraction (fi(o(2))). |
2007-06-27 |
2023-08-12 |
mouse |
| C A Paladini, M J Beckstead, D Weinshenke. Electrophysiological properties of catecholaminergic neurons in the norepinephrine-deficient mouse. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17156935. |
to determine how norepinephrine affects the basic physiological properties of catecholaminergic neurons, brain slices containing the substantia nigra pars compacta and locus coeruleus were studied with cell-attached and whole-cell recordings in control and dopamine beta-hydroxylase knockout (dbh -/-) mice that lack norepinephrine. |
2007-04-11 |
2023-08-12 |
mouse |
| C A Paladini, M J Beckstead, D Weinshenke. Electrophysiological properties of catecholaminergic neurons in the norepinephrine-deficient mouse. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17156935. |
normal alpha-2 mediated outward currents were restored in dbh -/- slices after pre-incubation with norepinephrine. |
2007-04-11 |
2023-08-12 |
mouse |
| Christopher P Smith, Sheena Sharma, Jena J Steinl. Age-related changes in sympathetic neurotransmission in rat retina and choroid. Experimental eye research. vol 84. issue 1. 2007-02-26. PMID:17074321. |
decreased expression of dbh with age in the retina could lead to reduced production of norepinephrine, potentially resulting in an increase of beta1-adrenergic receptor expression due to denervation supersensitivity. |
2007-02-26 |
2023-08-12 |
rat |
| M D Köhnke, W Kolb, A M Köhnke, U Lutz, S Schick, A Batr. DBH*444G/A polymorphism of the dopamine-beta-hydroxylase gene is associated with alcoholism but not with severe alcohol withdrawal symptoms. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 7. 2007-01-05. PMID:16252068. |
as the enzyme dopamine-beta-hydroxylase (dbetah) converts dopamine to norepinephrine and both transmitters seem to be involved in the pathology of alcoholism and severe alcohol withdrawal symptoms, the gene encoding dbetah (dbh) was applied to explore the genetic background of alcoholism and severe withdrawal symptoms. |
2007-01-05 |
2023-08-12 |
human |
| Brooke N Bourdélat-Parks, George M Anderson, Zoe R Donaldson, Jay M Weiss, Robert W Bonsall, Milburn S Emery, L Cameron Liles, David Weinshenke. Effects of dopamine beta-hydroxylase genotype and disulfiram inhibition on catecholamine homeostasis in mice. Psychopharmacology. vol 183. issue 1. 2006-12-12. PMID:16163519. |
dopamine beta-hydroxylase (dbh) converts dopamine (da) to norepinephrine (ne), thus playing a critical role in catecholamine metabolism. |
2006-12-12 |
2023-08-12 |
mouse |
| Jesse R Schank, Rossella Ventura, Stefano Puglisi-Allegra, Antonio Alcaro, Charlene D Cole, L Cameron Liles, Philip Seeman, David Weinshenke. Dopamine beta-hydroxylase knockout mice have alterations in dopamine signaling and are hypersensitive to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16395294. |
we used da beta-hydroxylase (dbh) knockout (dbh-/-) mice that lack norepinephrine (ne) to determine the consequences of chronic ne deficiency on midbrain da neuron function in vivo. |
2006-11-01 |
2023-08-12 |
mouse |
| Jeff D Sanders, Patricia Szot, David Weinshenker, H Kevin Happe, David B Bylund, L Charles Murri. Analysis of brain adrenergic receptors in dopamine-beta-hydroxylase knockout mice. Brain research. vol 1109. issue 1. 2006-10-31. PMID:16854392. |
the biosynthesis of norepinephrine occurs through a multi-enzymatic pathway that includes the enzyme dopamine-beta-hydroxylase (dbh). |
2006-10-31 |
2023-08-12 |
mouse |
| Jeff D Sanders, Patricia Szot, David Weinshenker, H Kevin Happe, David B Bylund, L Charles Murri. Analysis of brain adrenergic receptors in dopamine-beta-hydroxylase knockout mice. Brain research. vol 1109. issue 1. 2006-10-31. PMID:16854392. |
mice with a homozygous deletion of dbh (dbh-/-) have a selective and complete absence of norepinephrine. |
2006-10-31 |
2023-08-12 |
mouse |
| Jeff D Sanders, Patricia Szot, David Weinshenker, H Kevin Happe, David B Bylund, L Charles Murri. Analysis of brain adrenergic receptors in dopamine-beta-hydroxylase knockout mice. Brain research. vol 1109. issue 1. 2006-10-31. PMID:16854392. |
the purpose of this study was to assess the expression of alpha-1, alpha-2 and beta adrenergic receptors (alpha1-ar, alpha2-ar and beta-ar) in the postnatal absence of norepinephrine by comparing noradrenergic receptors in dbh-/- mice with those in dbh heterozygotes (dbh+/-), which have normal levels of norepinephrine throughout life. |
2006-10-31 |
2023-08-12 |
mouse |
| Fatih Ozbay, Karen G Wigg, Eda Tahir Turanli, Phil Asherson, Yanki Yazgan, Paul Sandor, Cathy L Bar. Analysis of the dopamine beta hydroxylase gene in Gilles de la Tourette syndrome. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 6. 2006-10-18. PMID:16838359. |
dopamine-beta-hydroxylase (dbh) is the key enzyme in the conversion of dopamine to norepinephrine and the alleles of several polymorphisms of the dbh gene are correlated with individual variation in serum levels of the enzyme. |
2006-10-18 |
2023-08-12 |
Not clear |
| Patricia Patterson-Buckendahl, Lucia Kubovcakova, Olga Krizanova, Larissa A Pohorecky, Richard Kvetnansk. Ethanol consumption increases rat stress hormones and adrenomedullary gene expression. Alcohol (Fayetteville, N.Y.). vol 37. issue 3. 2006-09-01. PMID:16713504. |
plasma epinephrine (epi); norepinephrine (ne); corticosterone (cort); prolactin (prl); adrenomedullary gene expression of catecholamine biosynthetic enzymes tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), and phenylethanolamine-n-methyl transferase (pnmt); and th protein levels were measured. |
2006-09-01 |
2023-08-12 |
human |
| C Depondt, H R Cock, D G Healy, M W Burley, D Weinshenker, N W Wood, D B Goldstein, S M Sisodiy. The -1021C->T DBH gene variant is not associated with epilepsy or antiepileptic drug response. Neurology. vol 63. issue 8. 2006-01-18. PMID:15505174. |
dopamine beta-hydroxylase (dbh) catalyzes the conversion of dopamine to norepinephrine (ne). |
2006-01-18 |
2023-08-12 |
Not clear |
| Marlene M Hsieh, George Lupas, Jennifer Rychlik, Suzan Dziennis, Beth A Habecker, Elaine J Lewi. ERK1/2 is a negative regulator of homeodomain protein Arix/Phox2a. Journal of neurochemistry. vol 94. issue 6. 2005-10-27. PMID:16156742. |
treatment of sympathetic neurons with the mek1 inhibitor, pd98059, results in an elevation of mrnas encoding noradrenergic proteins, dopamine beta-hydroxylase (dbh) and norepinephrine transporter (net), but not tyrosine hydroyxlase (th). |
2005-10-27 |
2023-08-12 |
Not clear |
| Meng-Yang Zhu, Wei-Ping Wang, Abiye H Iyo, Gregory A Ordway, Kwang-Soo Ki. Age-associated changes in mRNA levels of Phox2, norepinephrine transporter and dopamine beta-hydroxylase in the locus coeruleus and adrenal glands of rats. Journal of neurochemistry. vol 94. issue 3. 2005-09-19. PMID:16033425. |
age-related changes in the gene expression of the transcription factors, phox2a and 2b, and two marker proteins, norepinephrine transporter (net) and dopamine beta-hydroxylase (dbh), of noradrenergic neurons were characterized in the locus coeruleus (lc) and adrenal glands using in situ hybridization. |
2005-09-19 |
2023-08-12 |
rat |
| Michiko Abe, Zhihong Wu, Miyuki Yamamoto, Jing Ji Jin, Yasuharu Tabara, Masaki Mogi, Katsuhiko Kohara, Tetsuro Miki, Jun Nakur. Association of dopamine beta-hydroxylase polymorphism with hypertension through interaction with fasting plasma glucose in Japanese. Hypertension research : official journal of the Japanese Society of Hypertension. vol 28. issue 3. 2005-09-06. PMID:16097364. |
dopamine-beta-hydroxylase (dbh) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. |
2005-09-06 |
2023-08-12 |
Not clear |
| Bryan Hudson, Sue Ritte. Hindbrain catecholamine neurons mediate consummatory responses to glucoprivation. Physiology & behavior. vol 82. issue 2-3. 2005-02-17. PMID:15276785. |
previous work using the retrogradely transported immunotoxin, saporin (sap) conjugated to a monoclonal antibody against dopamine-beta-hydroxylase (dbh; dsap), to selectively lesion norepinephrine (ne) and epinephrine (e) neurons projecting to the medial hypothalamus, demonstrated the essential role of these neurons for appetitive ingestive responses to glucoprivation. |
2005-02-17 |
2023-08-12 |
rat |
| Claire Matson Cannon, Luna Abdallah, Laurence H Tecott, Matthew J During, Richard D Palmite. Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry mice. Neuron. vol 44. issue 3. 2005-01-18. PMID:15504330. |
by contrast, amph-induced hypophagia in response to the same dose of amph is not blunted in mice lacking the ability to make norepinephrine and epinephrine (dbh(-/-)), dopamine d(2) receptors (d2r(-/-)), dopamine d(1) receptors (d1r(-/-)), serotonin 2c receptors (htr2c(-/y)), neuropeptide y (npy(-/-)), and in mice with compromised melanocortin signaling (a(y)). |
2005-01-18 |
2023-08-12 |
mouse |
| J Deinum, A H van den Meiracker, F Boomsma, F J van Ittersum, R A Wevers, J W M Lender. [From gene to disease; dopamine-beta-hydroxylase deficiency and orthostatic hypotension]. Nederlands tijdschrift voor geneeskunde. vol 148. issue 36. 2004-11-09. PMID:15495941. |
the dbh gene encodes dopamine-beta-hydroxylase (dbetah), the enzyme that catalyses the formation of norepinephrine from dopamine. |
2004-11-09 |
2023-08-12 |
Not clear |