| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M F Blouquit, A Geloën, H Koubi, D Edwards, D Gripoi. Decreased norepinephrine turnover rate in the brown adipose tissue of pre-obese fa/fa Zucker rats. Journal of developmental physiology. vol 19. issue 6. 1994-12-02. PMID:7963300. |
norepinephrine (ne) content and turnover rate, and the activity of dopamine-beta-hydroxylase (dbh) were measured in the brown adipose tissue (bat) of developing zucker rats of the three genotypes: fa/fa and fa/fa (with a lean phenotype) and fa/fa (phenotypically obese). |
1994-12-02 |
2023-08-12 |
rat |
| P Martin, M Ohno, S B Southerland, R B Mailman, K Suzuk. Heterotypic sprouting of serotonergic forebrain fibers in the brindled mottled mutant mouse. Brain research. Developmental brain research. vol 77. issue 2. 1994-06-09. PMID:8174230. |
one role for copper is as a cofactor for dopamine-beta-hydroxylase (dbh), the enzyme that converts dopamine to norepinephrine (ne). |
1994-06-09 |
2023-08-12 |
mouse |
| C Y Chai, S Y Chen, S D Wang, C J Tseng, R H Lin, S P Mao, H T Horng, J C Liu, J S Ku. Precollicular decerebration reduces the pressor responses evoked by stimulation of rostral pons but not medulla in cats. Journal of the autonomic nervous system. vol 46. issue 1-2. 1994-04-01. PMID:7907100. |
the pressor areas of the vlm and dm were dbh positive, indicating the presence of norepinephrine, while the dftg-pvg and ftl were not. |
1994-04-01 |
2023-08-12 |
Not clear |
| S Berrard, N Faucon Biguet, L Houhou, A Lamouroux, J Malle. Retinoic acid induces cholinergic differentiation of cultured newborn rat sympathetic neurons. Journal of neuroscience research. vol 35. issue 4. 1993-09-30. PMID:8103115. |
concomitantly, ra reduced the specific activities of two catecholamine synthetic enzymes, tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) and the level of norepinephrine (ne). |
1993-09-30 |
2023-08-12 |
rat |
| H Ishiguro, K T Kim, T H Joh, K S Ki. Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region. The Journal of biological chemistry. vol 268. issue 24. 1993-09-16. PMID:7688735. |
dopamine beta-hydroxylase (dbh), the enzyme catalyzing the conversion of dopamine to norepinephrine, is specifically expressed in adrenergic and noradrenergic neurons in the central nervous system. |
1993-09-16 |
2023-08-12 |
human |
| S Morita, K Kobayashi, T Mizuguchi, K Yamada, I Nagatsu, K Titani, K Fujita, H Hidaka, T Nagats. The 5'-flanking region of the human dopamine beta-hydroxylase gene promotes neuron subtype-specific gene expression in the central nervous system of transgenic mice. Brain research. Molecular brain research. vol 17. issue 3-4. 1993-07-15. PMID:8510498. |
dopamine beta-hydroxylase (dbh, ec 1.14.17.1) catalyzes the conversion of dopamine to norepinephrine, the third step of catecholamine biosynthesis. |
1993-07-15 |
2023-08-12 |
mouse |
| A McMahon, E L Sabba. Regulation of expression of dopamine beta-hydroxylase in PC12 cells by glucocorticoids and cyclic AMP analogues. Journal of neurochemistry. vol 59. issue 6. 1992-12-22. PMID:1359011. |
in this study we have found that in pc12 cells, the mrna levels of dopamine beta-hydroxylase (dbh), the enzyme that catalyzes the formation of norepinephrine from dopamine, can be regulated by glucocorticoids and cyclic amp (camp) analogues. |
1992-12-22 |
2023-08-11 |
rat |
| J H Tulen, A J Man in 't Veld, M R Dzoljic, K Mechelse, P Molema. Sleeping with and without norepinephrine: effects of metoclopramide and D,L-threo-3,4-dihydroxyphenylserine on sleep in dopamine beta-hydroxylase deficiency. Sleep. vol 14. issue 1. 1992-06-04. PMID:1811317. |
these data indicate that in patients with dbh deficiency norepinephrine is not essential for the development of a normal sleep/wake pattern but may have a facilitatory role in the generation of rem sleep. |
1992-06-04 |
2023-08-11 |
Not clear |
| K Kobayashi, T Sasaoka, S Morita, I Nagatsu, A Iguchi, Y Kurosawa, K Fujita, T Nomura, M Kimura, M Katsuk. Genetic alteration of catecholamine specificity in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 5. 1992-04-07. PMID:1542654. |
human pnmt transcripts and immunoreactivity were mainly detected in norepinephrine neurons in brain and sympathetic ganglion as well as in norepinephrine-producing cells in adrenal medulla of transgenic mice, indicating that the human dbh gene promoter of 4 kilobases is sufficient to direct expression of the gene in norepinephrine-producing cells. |
1992-04-07 |
2023-08-11 |
mouse |
| A Biegon, S Fieldus. Reduced tyrosine hydroxylase immunoreactivity in locus coeruleus of suicide victims. Synapse (New York, N.Y.). vol 10. issue 1. 1992-03-24. PMID:1346945. |
antibodies against tyrosine hydroxylase (th, the rate-limiting enzyme in norepinephrine synthesis) and dopamine beta-hydroxylase (dbh, the last enzyme in the synthesis) were used for immunohistochemical staining of human brain locus coeruleus sections, obtained postmortem from suicide victims and matched controls. |
1992-03-24 |
2023-08-11 |
human |
| E H Mercer, G W Hoyle, R P Kapur, R L Brinster, R D Palmite. The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron. vol 7. issue 5. 1992-01-14. PMID:1742021. |
dopamine beta-hydroxylase (dbh) catalyzes the final step in the biosynthesis of norepinephrine, the principal classic neurotransmitter of peripheral sympathetic neurons. |
1992-01-14 |
2023-08-11 |
mouse |
| N H Jurkiewicz, A Jurkiewicz, A G Garci. Reinnervation of the transplanted vas deferens: differential recovery of various biochemical and pharmacological parameters. Journal of neural transmission. General section. vol 85. issue 2. 1991-12-17. PMID:1930879. |
after about 5 months, a regeneration of autonomic nerves was clearly shown: first, by a complete recovery of neuronal uptake, indicated by: a) potentiation by cocaine of epinephrine (epi) dose-response curves (t = 1.47 +/- 0.25, controls (c) = 1.50 +/- 0.14 log units); b) reversion to normal levels of pd2 values for norepinephrine (ne) and epi (t = 6.6 +/- 0.1; 7.0 +/- 0.1, and c = 6.4 +/- 0.1; 6.9 +/- 0.1, respectively); second, a partial restoration of nerve terminals, and corresponding pools of ne, which was seen through histofluorescence and was indicated by a percent increase of: a) ne content, 47% (t = 3.8 +/- 0.8, c = 8.5 +/- 0.7 micrograms/g); b) dopamine-beta-hydroxylase (dbh) activity, 37% (t = 136 +/- 80, c = 364 +/- 15 nmol(hr.g); c) release of ne by 57 mm-potassium, 23% (t = 33.0 +/- 12.0, c = 147 +/- 14 ng/g. |
1991-12-17 |
2023-08-11 |
rat |
| D Schuback, P Kramer, L Ozelius, G Holmgren, L Forsgren, M Kyllerman, J Wahlström, C M Craft, T Nygaard, M Bri. Dopamine beta-hydroxylase gene excluded in four subtypes of hereditary dystonia. Human genetics. vol 87. issue 3. 1991-09-12. PMID:1677923. |
dopamine beta-hydroxylase (dbh), the enzyme that converts dopamine to norepinephrine, has been implicated in dystonia because of increased serum levels of dbh in some patients, the influence of catecholaminergic drugs on the human phenotypes, and altered norepinephrine levels in several brain regions in dystonia patients and in genetically dystonic rodents. |
1991-09-12 |
2023-08-11 |
human |
| D Robertson, V Haile, S E Perry, R M Robertson, J A Phillips, I Biaggion. Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension (Dallas, Tex. : 1979). vol 18. issue 1. 1991-09-03. PMID:1677640. |
dopamine beta-hydroxylase (dbh) deficiency is a genetic disorder in which affected patients cannot synthesize norepinephrine, epinephrine, and octopamine in either the central nervous system or the peripheral autonomic neurons. |
1991-09-03 |
2023-08-11 |
Not clear |
| N Borghini, Y Dalmaz, L Peyri. Effect of guanethidine on dopamine in small intensely fluorescent cells of the superior cervical ganglion of the rat. Journal of the autonomic nervous system. vol 32. issue 1. 1991-06-04. PMID:1673696. |
the guanethidine effect was assessed in the ganglion using biochemistry of dopamine and norepinephrine and immunocytochemistry of tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh). |
1991-06-04 |
2023-08-11 |
rat |
| S D Wang, M E Goldberger, M Murra. Plasticity of spinal systems after unilateral lumbosacral dorsal rhizotomy in the adult rat. The Journal of comparative neurology. vol 304. issue 4. 1991-05-13. PMID:1707425. |
application of immunocytochemical methods to visualize tachykinins (predominantly substance p magnitude of sp), serotonin (5-ht), and dopamine b-hydroxylase (dbh), the synthesizing enzyme for norepinephrine, permits us to compare the response of sp systems in rat and cat spinal cord and to examine the response of two descending systems, serotoninergic and noradrenergic, to deafferentation. |
1991-05-13 |
2023-08-11 |
rat |
| P K Ganguly, S L Lee, G Waghra. Modulation of cardiac beta-adrenergic receptors by dopamine beta-hydroxylase. Biochimica et biophysica acta. vol 1055. issue 2. 1991-01-03. PMID:2173628. |
since dbh is coreleased with norepinephrine, these results indicate that a functional coupling of the putative beta-adrenergic receptor with dbh may exist in cardiac muscle. |
1991-01-03 |
2023-08-11 |
Not clear |
| H J Wu, R J Parmer, A H Koop, D J Rozansky, D T O'Conno. Molecular cloning, structure, and expression of dopamine-beta-hydroxylase from bovine adrenal medulla. Journal of neurochemistry. vol 55. issue 1. 1990-07-20. PMID:1693949. |
dopamine-beta-hydroxylase (dbh), the enzyme that catalyzes the conversion of dopamine to norepinephrine, remains the topic of many unanswered questions. |
1990-07-20 |
2023-08-11 |
human |
| J C Lauterborn, C E Riba. Differences in dopamine beta-hydroxylase immunoreactivity between the brains of genetically epilepsy-prone and Sprague-Dawley rats. Epilepsy research. vol 4. issue 3. 1990-03-06. PMID:2612490. |
in this study, the immunocytochemical localization of dopamine beta-hydroxylase (dbh), the synthesizing enzyme for norepinephrine, was compared between gepr-9s and sd rats. |
1990-03-06 |
2023-08-11 |
rat |
| T Sato, S Minami, N Igarashi, K Miyagaw. Suppression of norepinephrine secretion by dopamine in children with neuroblastoma: evidence for precursor inhibition in catecholamine pathway. Endocrinologia japonica. vol 36. issue 4. 1989-12-28. PMID:2583066. |
one patient showed an inverse correlation between da and norepinephrine (ne) excretion; a decrease in da was associated with an increase in ne and plasma da-beta-hydroxylase (dbh) activity. |
1989-12-28 |
2023-08-11 |
Not clear |