| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H N Sabbah, W C Stanley, V G Sharov, T Mishima, M Tanimura, C R Benedict, S Hegde, S Goldstei. Effects of dopamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Circulation. vol 102. issue 16. 2000-10-31. PMID:11034950. |
inhibition of dopamine beta-hydroxylase (dbh) results in a decrease in norepinephrine synthesis. |
2000-10-31 |
2023-08-12 |
Not clear |
| B A Pappas, T Nguyen, B Brownlee, D Tanasoiu, T Fortin, N Sherre. Ectopic noradrenergic hyperinnervation does not functionally compensate for neonatal forebrain acetylcholine lesion. Brain research. vol 867. issue 1-2. 2000-08-04. PMID:10837801. |
the 6-ohda treatment abolished hippocampal and cortical dopamine-beta-hydroxylase (dbh) ir terminals, indicating the absence of normal norepinephrine (ne) innervation. |
2000-08-04 |
2023-08-12 |
rat |
| S S Hegde, K F Frida. Dopamine-beta-hydroxylase inhibition: a novel sympatho-modulatory approach for the treatment of congestive heart failure. Current pharmaceutical design. vol 4. issue 6. 1999-05-07. PMID:10197057. |
an alternative strategy for directly modulating sympathetic nerve function is to inhibit the biosynthesis of norepinephrine (ne) via inhibition of dopamine-beta-hydroxylase (dbh), the enzyme which catalyzes the conversion of dopamine (da) to ne in sympathetic nerves. |
1999-05-07 |
2023-08-12 |
Not clear |
| C H Kim, H S Kim, J F Cubells, K S Ki. A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene. The Journal of biological chemistry. vol 274. issue 10. 1999-03-30. PMID:10037744. |
net is expressed only in neuronal tissues that synthesize and secrete norepinephrine and in most cases is co-expressed with the norepinephrine-synthetic enzyme dopamine beta-hydroxylase (dbh). |
1999-03-30 |
2023-08-12 |
human |
| A Mayerhofer, G D Smith, M Danilchik, J E Levine, D P Wolf, G A Dissen, S R Ojed. Oocytes are a source of catecholamines in the primate ovary: evidence for a cell-cell regulatory loop. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 18. 1998-09-28. PMID:9724817. |
we now show that the primate ovary expresses both the genes encoding th and dopamine beta-hydroxylase (dbh), the key enzymes in norepinephrine (ne) biosynthesis. |
1998-09-28 |
2023-08-12 |
human |
| S A Thomas, B T Marck, R D Palmiter, A M Matsumot. Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase. Journal of neurochemistry. vol 70. issue 6. 1998-06-05. PMID:9603211. |
mice with a targeted disruption of the dopamine beta-hydroxylase (dbh) gene are unable to synthesize norepinephrine (ne) and epinephrine. |
1998-06-05 |
2023-08-12 |
mouse |
| S A Thomas, R D Palmite. Impaired maternal behavior in mice lacking norepinephrine and epinephrine. Cell. vol 91. issue 5. 1997-12-29. PMID:9393852. |
the roles of norepinephrine (ne) and epinephrine in behavior were investigated by targeted disruption of the dopamine beta-hydroxylase (dbh) gene, thereby eliminating these compounds in vivo. |
1997-12-29 |
2023-08-12 |
mouse |
| C W Berridge, T L Stratford, S L Foote, A E Kelle. Distribution of dopamine beta-hydroxylase-like immunoreactive fibers within the shell subregion of the nucleus accumbens. Synapse (New York, N.Y.). vol 27. issue 3. 1997-11-26. PMID:9329158. |
coronal sections of rat brain were processed to visualize immunoreactivity for the norepinephrine synthetic enzyme dopamine beta-hydroxylase (dbh), a specific marker for noradrenergic processes. |
1997-11-26 |
2023-08-12 |
rat |
| S A Thomas, R D Palmite. Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory. Behavioral neuroscience. vol 111. issue 3. 1997-08-12. PMID:9189272. |
mice unable to synthesize norepinephrine (ne) were created by targeted disruption of the dopamine beta-hydroxylase (dbh) gene. |
1997-08-12 |
2023-08-12 |
mouse |
| O Hwang, S Y Park, K S Ki. Protein kinase A coordinately regulates both basal expression and cyclic AMP-mediated induction of three catecholamine-synthesizing enzyme genes. Journal of neurochemistry. vol 68. issue 6. 1997-06-17. PMID:9166715. |
in the presence of 40 microm h-89, mrna levels of th, dbh, and pnmt were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. at 20 microm, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%. |
1997-06-17 |
2023-08-12 |
cattle |
| J M Zhang, J Dix, C J Langtimm-Sedlak, T Trusk, B Schroeder, R Hoffmann, A D Strosberg, J W Winslow, M Sieber-Blu. Neurotrophin-3- and norepinephrine-mediated adrenergic differentiation and the inhibitory action of desipramine and cocaine. Journal of neurobiology. vol 32. issue 3. 1997-06-12. PMID:9058320. |
taken together, our data indicate that nt-3 is involved in the appearance of the ne transporter (net) during embryonic development; internalized ne directly or indirectly increases adrenergic differentiation as measured by immunoreactivity of the adrenergic biosynthetic enzyme dbh; and norepinephrine uptake inhibitors have treatogenic potential. |
1997-06-12 |
2023-08-12 |
Not clear |
| J Wei, C N Ramchand, A E Clark, G P Hemming. A study of enzymes involved in catecholamine metabolism in parents of patients with schizophrenia. Schizophrenia research. vol 19. issue 1. 1997-05-12. PMID:9147493. |
the concentrations of serum homovanillic acid (hva), norepinephrine (ne), tyrosine (tyr), phenylalanine (phe) and tryptophan (trp), and the activities of serum dopamine-beta-hydroxylase (dbh), platelet monoamine oxidase (mao), and erythrocyte catechol-o-methyl transferase (comt) were measured in 68 healthy parents who had schizophrenic offspring. |
1997-05-12 |
2023-08-12 |
Not clear |
| K Meszaros, E Lenzinger, T Füreder, K Hornik, U Willinger, T Stompe, A M Heiden, E Resinger, N Fathi, E Gerhard, K Fuchs, E Miller-Reiter, V Pfersmann, W Sieghart, H N Aschauer, S Kaspe. Schizophrenia and the dopamine-beta-hydroxylase gene: results of a linkage and association study. Psychiatric genetics. vol 6. issue 1. 1996-10-31. PMID:8925253. |
dbh catalyzes the synthesis of norepinephrine from dopamine in noradrenergic neurons. |
1996-10-31 |
2023-08-12 |
Not clear |
| H Ewald, O Mors, T Flint, H Eiberg, T A Krus. Linkage analysis between manic depressive illness and the dopamine beta-hydroxylase gene. Psychiatric genetics. vol 4. issue 3. 1995-05-23. PMID:7719704. |
dbh is required for conversion of dopamine to norepinephrine, the third step in catecholamine biosynthesis. |
1995-05-23 |
2023-08-12 |
Not clear |
| K Kobayashi, S Morita, H Sawada, T Mizuguchi, K Yamada, I Nagatsu, K Fujita, R J Kreitman, I Pastan, T Nagats. Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 4. 1995-03-20. PMID:7862648. |
this was accompanied by a dramatic loss of dbh-containing neurons and a significant decrease in dbh activity and norepinephrine levels in various regions of the brain. |
1995-03-20 |
2023-08-12 |
mouse |
| J Shaskus, E Zellmer, E J Lewi. A negative regulatory element in the rat dopamine beta-hydroxylase gene contributes to the cell type specificity of expression. Journal of neurochemistry. vol 64. issue 1. 1995-01-24. PMID:7798950. |
dopamine beta-hydroxylase (dbh) catalyzes the synthesis of the neurohormone norepinephrine and is expressed only in noradrenergic and adrenergic cells of the nervous and endocrine systems. |
1995-01-24 |
2023-08-12 |
rat |
| K Kobayashi, S Morita, T Mizuguchi, H Sawada, K Yamada, I Nagatsu, K Fujita, T Nagats. Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice. The Journal of biological chemistry. vol 269. issue 47. 1994-12-28. PMID:7961964. |
dopamine beta-hydroxylase (dbh; ec 1.14.17.1) catalyzes the production of the neurotransmitter and hormone norepinephrine in the third step of the catecholamine biosynthesis pathway. |
1994-12-28 |
2023-08-12 |
mouse |
| K Kobayashi, S Morita, T Mizuguchi, H Sawada, K Yamada, I Nagatsu, K Fujita, T Nagats. Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice. The Journal of biological chemistry. vol 269. issue 47. 1994-12-28. PMID:7961964. |
however, in these transgenics the steady-state levels of norepinephrine and epinephrine were normally maintained without the acceleration of the catecholamine turnover rate, suggesting that there are some regulatory mechanisms to preserve a constant rate of norepinephrine synthesis in spite of the increased amount of dbh protein. |
1994-12-28 |
2023-08-12 |
mouse |
| K Kobayashi, S Morita, T Mizuguchi, H Sawada, K Yamada, I Nagatsu, K Fujita, T Nagats. Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice. The Journal of biological chemistry. vol 269. issue 47. 1994-12-28. PMID:7961964. |
these transgenic mice with the minigene construct provide one approach to study the mechanisms underlying biogenesis of the dbh polypeptide and regulation of norepinephrine synthesis. |
1994-12-28 |
2023-08-12 |
mouse |
| K S Kim, H Ishiguro, C Tinti, J Wagner, T H Jo. The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 11 Pt 2. 1994-12-02. PMID:7525897. |
dopamine beta-hydroxylase (dbh) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine. |
1994-12-02 |
2023-08-12 |
human |