| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C R Lake, L F Major, M G Ziegler, I J Kopi. Increased sympathetic nervous system activity in alcoholic patients treated with disulfiram. The American journal of psychiatry. vol 134. issue 12. 1977-12-29. PMID:920841. |
the authors measured plasma levels of norepinephrine (ne) and dopamine beta-hydroxylase (dbh), pulse rates, and blood pressures of 81 hospitalized alcoholic patients. |
1977-12-29 |
2023-08-11 |
Not clear |
| A Simon, J P Lehner, M Safar, J M Alexandre, Y Weiss, P Millie. [Labile arterial hypertension and sympathetic tonus. Hemodynamic study]. Archives des maladies du coeur et des vaisseaux. vol 69. issue 12. 1977-02-24. PMID:827268. |
cardiac output, cardiopulmonary (cpbv) and total (tbv) blood volumes, vascular reactivity to norepinephrine and dopamine b hydroxylase (dbh) were determined in 41 borderline hypertensives patients in comparison with 28 normal subjects. |
1977-02-24 |
2023-08-11 |
human |
| A Simon, J P Lehner, M Safar, J M Alexandre, Y Weiss, P Millie. [Labile arterial hypertension and sympathetic tonus. Hemodynamic study]. Archives des maladies du coeur et des vaisseaux. vol 69. issue 12. 1977-02-24. PMID:827268. |
the ratio was directly correlated to the pressor-response to norepinephrine (p less than 0.01) and the dbh level (p less than 0.005). |
1977-02-24 |
2023-08-11 |
human |
| J T Shen, W F Ganon. Effect of variations in adrenocortical function on dopamine beta-hydroxylase and norepinephrine in the brain of the rat. The Journal of pharmacology and experimental therapeutics. vol 199. issue 3. 1977-01-29. PMID:994021. |
the effect of adrenalectomy and corticosterone treatment on dopamine beta-hydroxylase (dbh) activity, catecholamine content and norepinephrine formation and metabolism were studied in the hypothalamus and other parts of the brain of male rats. |
1977-01-29 |
2023-08-11 |
rat |
| J T Shen, W F Ganon. Effect of variations in adrenocortical function on dopamine beta-hydroxylase and norepinephrine in the brain of the rat. The Journal of pharmacology and experimental therapeutics. vol 199. issue 3. 1977-01-29. PMID:994021. |
two days after adrenalectomy, there was a decrease in dbh activity in the hypothalamus and the brain stem but no change in norepinephrine or dopamine content. |
1977-01-29 |
2023-08-11 |
rat |
| J T Shen, W F Ganon. Effect of variations in adrenocortical function on dopamine beta-hydroxylase and norepinephrine in the brain of the rat. The Journal of pharmacology and experimental therapeutics. vol 199. issue 3. 1977-01-29. PMID:994021. |
corticosterone in a dose of 100 mg/kg increased dbh activity but decreased hypothalamic norepinephrine and copamine content. |
1977-01-29 |
2023-08-11 |
rat |
| J T Shen, W F Ganon. Effect of variations in adrenocortical function on dopamine beta-hydroxylase and norepinephrine in the brain of the rat. The Journal of pharmacology and experimental therapeutics. vol 199. issue 3. 1977-01-29. PMID:994021. |
the fact that norepinephrine formation and metabolism were increased at the same time that dbh activity in vitro was decreased suggests that dbh is not rate-limiting in adrenergic neurons in the hypothalamus, or that a change in the in vitro activity of the enzyme was not accompanied by a parallel change in its activity in vivo. |
1977-01-29 |
2023-08-11 |
rat |
| K Ogawa, N Yamazaki, T Watanab. Serum dopamine beta-hydroxylase in cardiovascular diseases. Japanese heart journal. vol 17. issue 4. 1976-12-01. PMID:966380. |
dopamine-beta-hydroxylase (dbh), the enzyme responsible for the biosynthesis of norepinephrine from dopamine was assayed in the blood serum of 23 normal adults, 16 patients with congestive heart failure, 19 patients with asymptomatic ischemic heart disease, 4 patients with angina pectoris at rest, 15 patients with essential hypertension, 8 patients with essential hypotension, 5 patients with neurocirculatory asthenia, and 9 normal adults before and after the exercise test. |
1976-12-01 |
2023-08-11 |
Not clear |
| D L Nelson, P B Molinof. Distribution and properties of adrenergic storage vesicles in nerve terminals. The Journal of pharmacology and experimental therapeutics. vol 196. issue 2. 1976-05-10. PMID:1255482. |
the subcellular distribution of adrenergic storage vesicles was determined in rat spleen, heart and superior cervical ganglion and in dog spleen using dopamine-beta-hydroxylase (dbh) as a marker for vesicle membranes and norepinephrine (ne) as a marker for the soluble contents of the storage vesicles. |
1976-05-10 |
2023-08-11 |
rat |
| J L Reid, I J Kopi. The effects of ganglionic blockade, reserpine and vinblastine on plasma catecholamines and dopamine-beta-hydroxylase in the rat. The Journal of pharmacology and experimental therapeutics. vol 193. issue 3. 1975-11-01. PMID:50436. |
in rats, chronic ganglionic blockade induced by repeated doses of chlorisodamine rapidly and profoundly lowered plasma norepinephrine, but plasma dopamine-beta-hydroxylase (dbh) activity, even after 5 days treatment, was not significantly reduced. |
1975-11-01 |
2023-08-11 |
rat |
| L Cubeddu, E Barnes, N Weine. Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. IV. An evaluation of a role for cyclic adenosine monophosphate. The Journal of pharmacology and experimental therapeutics. vol 193. issue 1. 1975-08-22. PMID:166157. |
the effects of several cyclic nucleotide analogs and of phosphodiesterase inhibitors on the release of norepinephrine (ne) and dopamine-beta-hydroxylase activity (dbh) by electrical stimulation were studied in the isolated, perfused cat spleen. |
1975-08-22 |
2023-08-11 |
cat |
| L Cubeddu, N Weine. Nerve stimulation-meditated overflow of norepinephrine and dopamine-beta-hydroxylase. III. Effects of norepinephrine depletion on the alpha presynaptic regulation of release. The Journal of pharmacology and experimental therapeutics. vol 192. issue 1. 1975-07-01. PMID:235629. |
a frequency-dependent increase in the overflow of norepinephrine (ne), 3-h-ne, total 3-h and dopamine-beta-hydroxylase (dbh) activity per nerve impulse was obtained after electrical stimulation of the isolated, perfused cat spleen. |
1975-07-01 |
2023-08-11 |
cat |
| T Ogihara, C A Nugent, S W Shen, S Goldfei. Serum dopamine-beta-hydroxylase activity in parents and children. The Journal of laboratory and clinical medicine. vol 85. issue 4. 1975-06-26. PMID:1120928. |
dopamine-beta-hydroxylase (dbh), an enxyme catalyzing the final step in the synthesis of norepinephrine, is released with norepinephrine on stimulation of the sympathetic nervous system. |
1975-06-26 |
2023-08-11 |
human |
| A G Garcia, S M Kirpeka. On the mechanism of release of norepinephrine from cat spleen slices by sodium deprivation and calcium pretreatment. The Journal of pharmacology and experimental therapeutics. vol 192. issue 2. 1975-06-12. PMID:1117422. |
endogenous norepinephrine (ne) content of cat spleen slices was markedly depleted by incubating them in a sodium-free solution for 2 hours at 37 degrees c. dopamine beta-hydroxylase (dbh) activity was not changed by this treatment. |
1975-06-12 |
2023-08-11 |
cat |
| C D Wise, L Stei. Dopamine-beta-hydroxylase deficits in the brains of schizophrenic patients. Science (New York, N.Y.). vol 181. issue 4097. 1973-09-26. PMID:4719906. |
postmortem brain specimens from 18 schizophrenic patients and 12 normal controls were assayed for dopamine-beta-hydroxylase (dbh), the enzyme responsible for the final step in norepinephrine biosynthesis. |
1973-09-26 |
2023-08-11 |
Not clear |
| R M Weinshilboum, N B Thoa, D G Johnson, I J Kopin, J Axelro. Proportional release of norepinephrine and dopamine- -hydroxylase from sympathetic nerves. Science (New York, N.Y.). vol 174. issue 4016. 1972-03-24. PMID:5135722. |
dopamine-beta-hydroxylase(dbh), the enzyme that catalyzes the conversion of dopamine to norepinephrine, is localized in the vesicles containing catecholamine in sympathetic nerves. |
1972-03-24 |
2023-08-11 |
Not clear |
| R M Weinshilboum, N B Thoa, D G Johnson, I J Kopin, J Axelro. Proportional release of norepinephrine and dopamine- -hydroxylase from sympathetic nerves. Science (New York, N.Y.). vol 174. issue 4016. 1972-03-24. PMID:5135722. |
the amount of dbh released is proportional to the amount of norepinephrine released, and the ratio of norepinephrine to dbh discharged into the incubation medium is similar to that in the soluble portion of the contents of the synaptic vesicles from the vas deferens. |
1972-03-24 |
2023-08-11 |
Not clear |
| R M Weinshilboum, N B Thoa, D G Johnson, I J Kopin, J Axelro. Proportional release of norepinephrine and dopamine- -hydroxylase from sympathetic nerves. Science (New York, N.Y.). vol 174. issue 4016. 1972-03-24. PMID:5135722. |
these data are compatible with the release of the neurotransmitter norepinephrine and dbh from symnpathetic nerves by a process of exocytosis. |
1972-03-24 |
2023-08-11 |
Not clear |