| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Phillip C Usera, Simi Vincent, David Robertso. Human phenotypes and animal knockout models of genetic autonomic disorders. Journal of biomedical science. vol 11. issue 1. 2004-10-14. PMID:14730204. |
dopamine beta-hydroxylase (dbh), the norepinephrine transporter (net), and the vesicular monoamine transporter subtype 2 catalyze intracellular ne biosynthesis, ne reuptake from the synapse, and vesicular transport, respectively. |
2004-10-14 |
2023-08-12 |
mouse |
| John F Cryan, Olivia F O'Leary, Sung-Ha Jin, Julie C Friedland, Ming Ouyang, Bradford R Hirsch, Michelle E Page, Ashutosh Dalvi, Steven A Thomas, Irwin Luck. Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 21. 2004-07-09. PMID:15148402. |
mice unable to synthesize norepinephrine (ne) and epinephrine due to targeted disruption of the dopamine beta-hydroxylase gene, dbh, were used to critically test roles for ne in mediating acute behavioral changes elicited by different classes of antidepressants. |
2004-07-09 |
2023-08-12 |
mouse |
| Patrick Slama, Jean-Luc Boucher, Marius Réglie. Aromatic N-hydroxyguanidines as new reduction cosubstrates for dopamine beta-hydroxylase. Biochemical and biophysical research communications. vol 316. issue 4. 2004-05-21. PMID:15044095. |
conversion of neurotransmitter dopamine into norepinephrine is catalyzed by dopamine beta-hydroxylase (dbh). |
2004-05-21 |
2023-08-12 |
Not clear |
| Jennifer L Rychlik, Vincent Gerbasi, Elaine J Lewi. The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA. The Journal of biological chemistry. vol 278. issue 49. 2004-03-10. PMID:14506227. |
dopamine beta-hydroxylase (dbh) catalyzes the production of norepinephrine, and its expression defines the noradrenergic phenotype. |
2004-03-10 |
2023-08-12 |
Not clear |
| Steven J Swoap, David Weinshenker, Richard D Palmiter, Graham Garbe. Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stress. American journal of physiology. Regulatory, integrative and comparative physiology. vol 286. issue 1. 2004-02-10. PMID:12969876. |
we used mice deficient in dopamine beta-hydroxylase [dbh(-/-)] and their littermate controls [dbh(+/-)] to examine the role of epinephrine (epi) and norepinephrine (ne) in the maintenance of cardiovascular parameters during 7 days of caloric restriction and acute exposure to environmental stress. |
2004-02-10 |
2023-08-12 |
mouse |
| Sajida Hassan, Bao Duong, Kwang-Soo Kim, Michael F Mile. Pharmacogenomic analysis of mechanisms mediating ethanol regulation of dopamine beta-hydroxylase. The Journal of biological chemistry. vol 278. issue 40. 2003-11-06. PMID:12842874. |
dbh catalyzes norepinephrine synthesis, and several studies have suggested a role for norepinephrine in ethanol-mediated behaviors. |
2003-11-06 |
2023-08-12 |
human |
| Haiming Xu, Anthony B Firulli, Xiaotong Zhang, Marthe J Howar. HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a. Developmental biology. vol 262. issue 1. 2003-10-23. PMID:14512028. |
dopamine-beta-hydroxylase (dbh) is the penultimate enzyme required for synthesis of norepinephrine and is thus a noradrenergic cell type-specific marker. |
2003-10-23 |
2023-08-12 |
Not clear |
| Vincent Gerbasi, Svetlana Lutsenko, Elaine J Lewi. A mutation in the ATP7B copper transporter causes reduced dopamine beta-hydroxylase and norepinephrine in mouse adrenal. Neurochemical research. vol 28. issue 6. 2003-07-08. PMID:12718440. |
one cuproprotein, dopamine beta-hydroxylase (dbh) functions in the biosynthesis of norepinephrine and epinephrine, neurohormones in endocrine and nervous tissue. |
2003-07-08 |
2023-08-12 |
mouse |
| Vincent Gerbasi, Svetlana Lutsenko, Elaine J Lewi. A mutation in the ATP7B copper transporter causes reduced dopamine beta-hydroxylase and norepinephrine in mouse adrenal. Neurochemical research. vol 28. issue 6. 2003-07-08. PMID:12718440. |
in addition to the lower level of enzyme, the products of dbh catalytic activity, norepinephrine and epinephrine, are also decreased. |
2003-07-08 |
2023-08-12 |
mouse |
| Suzan Dziennis, Beth A Habecke. Cytokine suppression of dopamine-beta-hydroxylase by extracellular signal-regulated kinase-dependent and -independent pathways. The Journal of biological chemistry. vol 278. issue 18. 2003-06-17. PMID:12609984. |
we used sympathetic neurons and sk-n-be(2)m17 neuroblastoma cells to investigate cdf down-regulation of the norepinephrine synthetic enzyme dopamine-beta-hydroxylase (dbh). |
2003-06-17 |
2023-08-12 |
Not clear |
| C Matson Cannon, R D Palmite. Peptides that regulate food intake: norepinephrine is not required for reduction of feeding induced by cholecystokinin. American journal of physiology. Regulatory, integrative and comparative physiology. vol 284. issue 6. 2003-06-17. PMID:12736175. |
in the present study, we tested the hypothesis that norepinephrine (ne) is necessary for satiety induced by peripheral cck-8 by using mice lacking dopamine beta-hydroxylase (dbh(-/-)), the enzyme responsible for synthesizing ne and epinephrine from dopamine. |
2003-06-17 |
2023-08-12 |
mouse |
| Simi Vincent, David Robertso. The broader view: catecholamine abnormalities. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. vol 12 Suppl 1. 2002-12-20. PMID:12102462. |
norepinephrine (ne), a vital neurotransmitter in both the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (dbh) through the oxidation of dopamine (da) to ne. |
2002-12-20 |
2023-08-12 |
Not clear |
| Emily M Garland, Maureen K Hahn, Terry P Ketch, Nancy R Keller, Chun-Hyung Kim, Kwang-Soo Kim, Italo Biaggioni, John R Shannon, Randy D Blakely, David Robertso. Genetic basis of clinical catecholamine disorders. Annals of the New York Academy of Sciences. vol 971. 2002-12-16. PMID:12438171. |
in 1986, we reported a congenital syndrome of undetectable tissue and circulating levels of norepinephrine and epinephrine, elevated levels of dopamine, and absence of dopamine-beta-hydroxylase (dbh). |
2002-12-16 |
2023-08-12 |
Not clear |
| C A Cornil, J Balthazart, P Motte, L Massotte, V Seuti. Dopamine activates noradrenergic receptors in the preoptic area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 21. 2002-11-25. PMID:12417657. |
two dopamine-beta-hydroxylase (dbh) inhibitors (cysteine and fusaric acid) did not block the da-induced effects, indicating that da is not converted into norepinephrine (ne) to produce its effects. |
2002-11-25 |
2023-08-12 |
Not clear |
| Tatiana Roman, Marcelo Schmitz, Guilherme V Polanczyk, Mariana Eizirik, Luis A Rohde, Mara H Hut. Further evidence for the association between attention-deficit/hyperactivity disorder and the dopamine-beta-hydroxylase gene. American journal of medical genetics. vol 114. issue 2. 2002-07-19. PMID:11857576. |
the dbh gene, the locus that encodes the enzyme dopamine-beta-hydroxylase (dbetah), seems to be an important candidate gene for association studies, since dbetah catalyzes the conversion of dopamine to norepinephrine. |
2002-07-19 |
2023-08-12 |
Not clear |
| Chun-Hyung Kim, Cyrus P Zabetian, Joseph F Cubells, Sonhae Cho, Italo Biaggioni, Bruce M Cohen, David Robertson, Kwang-Soo Ki. Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency. American journal of medical genetics. vol 108. issue 2. 2002-04-03. PMID:11857564. |
norepinephrine (ne), a key neurotransmitter of the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (dbh) that catalyzes oxidation of dopamine (da) to ne. |
2002-04-03 |
2023-08-12 |
human |
| P Szot, D Weinshenker, J M Rho, T W Storey, P A Schwartzkroi. Norepinephrine is required for the anticonvulsant effect of the ketogenic diet. Brain research. Developmental brain research. vol 129. issue 2. 2001-09-27. PMID:11506865. |
to determine if the noradrenergic system has a role in mediating the anticonvulsant action of the kd, dopamine beta-hydroxylase knockout (dbh -/-) mice that lack norepinephrine (ne) and dbh +/- littermates that have normal ne content were fed either a standard rodent chow or the kd. |
2001-09-27 |
2023-08-12 |
mouse |
| N Markoglou, I W Waine. Synthesis and characterization of immobilized dopamine beta-hydroxylase in membrane-bound and solubilized formats. Journal of biochemical and biophysical methods. vol 48. issue 1. 2001-08-02. PMID:11282402. |
dopamine beta-hydroxylase (dbh) catalyzes the beta-hydroxylation of dopamine to norepinephrine. |
2001-08-02 |
2023-08-12 |
Not clear |
| P D Robinson, C K Schutz, F Macciardi, B N White, J J Holde. Genetically determined low maternal serum dopamine beta-hydroxylase levels and the etiology of autism spectrum disorders. American journal of medical genetics. vol 100. issue 1. 2001-07-26. PMID:11337745. |
since previous findings showed that some families with autistic children have a low level of serum dopamine beta-hydroxylase (dbetah), which catalyzes the conversion of dopamine to norepinephrine, we examined the dbh gene as a candidate locus in families with two or more children with autism spectrum disorder using the affected sib-pair method. |
2001-07-26 |
2023-08-12 |
Not clear |
| C Thibault, C Lai, N Wilke, B Duong, M F Olive, S Rahman, H Dong, C W Hodge, D J Lockhart, M F Mile. Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093800. |
ethanol treatment elevated dopamine beta-hydroxylase (dbh, ec 1.14.17.1) mrna and protein levels and increased releasable norepinephrine in sh-sy5y cultures. |
2001-01-18 |
2023-08-12 |
mouse |