| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claire Heit, Hongbin Dong, Ying Chen, David C Thompson, Richard A Deitrich, Vasilis K Vasilio. The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400924. |
this chapter focuses on the discussion of cyp2e1 in ethanol metabolism in the cns, covering topics including how it is regulated, where it is expressed and how it influences sensitivity to ethanol in the brain. |
2014-08-05 |
2023-08-12 |
Not clear |
| Kamila Balusikova, Jan Kova. Alcohol dehydrogenase and cytochrome P450 2E1 can be induced by long-term exposure to ethanol in cultured liver HEP-G2 cells. In vitro cellular & developmental biology. Animal. vol 49. issue 8. 2014-05-06. PMID:23824954. |
therefore, we tested the effect of long-term exposure to ethanol on the expression and activity of both adh and cyp2e1 in these cells. |
2014-05-06 |
2023-08-12 |
human |
| Kamila Balusikova, Jan Kova. Alcohol dehydrogenase and cytochrome P450 2E1 can be induced by long-term exposure to ethanol in cultured liver HEP-G2 cells. In vitro cellular & developmental biology. Animal. vol 49. issue 8. 2014-05-06. PMID:23824954. |
significantly increased protein expression of adh (about 2.5-fold) as well as cyp2e1 (about 1.6-fold) was found in hep-g2 cells after long-term (12 mo) exposure to ethanol. |
2014-05-06 |
2023-08-12 |
human |
| Orkhontuya Tsedensodnom, Ana M Vacaru, Deanna L Howarth, Chunyue Yin, Kirsten C Sadle. Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease. Disease models & mechanisms. vol 6. issue 5. 2014-04-22. PMID:23798569. |
blocking alcohol dehydrogenase 1 (adh1) and cytochrome p450 2e1 (cyp2e1), the major enzymes that metabolize ethanol, prevented alcohol-induced steatosis and reduced induction of the upr in the liver. |
2014-04-22 |
2023-08-12 |
zebrafish |
| Orkhontuya Tsedensodnom, Ana M Vacaru, Deanna L Howarth, Chunyue Yin, Kirsten C Sadle. Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease. Disease models & mechanisms. vol 6. issue 5. 2014-04-22. PMID:23798569. |
we found that production of reactive oxygen species (ros) increased in larvae exposed to ethanol, whereas inhibition of the zebrafish cyp2e1 homolog or administration of antioxidants reduced ros levels. |
2014-04-22 |
2023-08-12 |
zebrafish |
| Ying Wan, Shuang Jiang, Li-Hua Lian, Ting Bai, Peng-He Cui, Xiao-Ting Sun, Xue-Jun Jin, Yan-Ling Wu, Ji-Xing Na. Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro. International immunopharmacology. vol 17. issue 2. 2014-04-22. PMID:23816536. |
administration of ba or bt significantly decreased cyp2e1 activities and expression of srebp-1caused by ethanol, however, lower dosage of ba or bt showed slight effects on cyp2e1 activity or expression of srebp-1c. |
2014-04-22 |
2023-08-12 |
mouse |
| Ashley N Filiano, Telisha Millender-Swain, Russell Johnson, Martin E Young, Karen L Gamble, Shannon M Baile. Chronic ethanol consumption disrupts the core molecular clock and diurnal rhythms of metabolic genes in the liver without affecting the suprachiasmatic nucleus. PloS one. vol 8. issue 8. 2014-04-15. PMID:23951220. |
ethanol consumption also affected the diurnal oscillations of metabolic genes, including adh1, cpt1a, cyp2e1, pck1, pdk4, ppargc1a, ppargc1b and srebp1c, in the livers of c57bl/6j mice. |
2014-04-15 |
2023-08-12 |
mouse |
| Phillip H Hwang, Lisa Lian, Athanasios I Zavra. Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis. Medical hypotheses. vol 78. issue 2. 2014-04-09. PMID:22100631. |
chronic and high alcohol use has been implicated in the induction of cyp2e1, which oxidizes ethanol to acetaldehyde. |
2014-04-09 |
2023-08-12 |
human |
| Phillip H Hwang, Lisa Lian, Athanasios I Zavra. Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis. Medical hypotheses. vol 78. issue 2. 2014-04-09. PMID:22100631. |
our first hypothesis is that as increased levels of folate lead to higher concentrations of sam, sam antagonizes the expression of cyp2e1, which results in decreased conversion of ethanol into acetaldehyde. |
2014-04-09 |
2023-08-12 |
human |
| Amit Sharma, Kumar Saurabh, Sanjay Yadav, Swatantra K Jain, Devendra Parma. Expression profiling of selected genes of toxication and detoxication pathways in peripheral blood lymphocytes as a biomarker for predicting toxicity of environmental chemicals. International journal of hygiene and environmental health. vol 216. issue 6. 2014-04-08. PMID:23273579. |
similarly, treatment of ethanol increased the expression of cyp2e1 and 3a1 along with transcription factors in pbl. |
2014-04-08 |
2023-08-12 |
rat |
| Yanjun Zhong, Guicheng Dong, Haiguang Luo, Jie Cao, Chang Wang, Jianyuan Wu, Yu-Qi Feng, Jiang Yu. Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:22960445. |
induction of brain cyp2e1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. |
2014-03-28 |
2023-08-12 |
rat |
| Yanjun Zhong, Guicheng Dong, Haiguang Luo, Jie Cao, Chang Wang, Jianyuan Wu, Yu-Qi Feng, Jiang Yu. Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:22960445. |
cytochrome p450 2e1 (cyp2e1) is involved in ethanol metabolism in the brain. |
2014-03-28 |
2023-08-12 |
rat |
| Yanjun Zhong, Guicheng Dong, Haiguang Luo, Jie Cao, Chang Wang, Jianyuan Wu, Yu-Qi Feng, Jiang Yu. Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:22960445. |
this study investigates the role of brain cyp2e1 in the susceptibility of certain brain regions to ethanol neurotoxicity. |
2014-03-28 |
2023-08-12 |
rat |
| Yanjun Zhong, Guicheng Dong, Haiguang Luo, Jie Cao, Chang Wang, Jianyuan Wu, Yu-Qi Feng, Jiang Yu. Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:22960445. |
ethanol markedly increased the levels of cyp2e1 protein, mrna expression, and activity in the hippocampus and cerebellum. |
2014-03-28 |
2023-08-12 |
rat |
| Yanjun Zhong, Guicheng Dong, Haiguang Luo, Jie Cao, Chang Wang, Jianyuan Wu, Yu-Qi Feng, Jiang Yu. Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:22960445. |
cyp2e1 protein and activity were significantly increased by ethanol in the brainstem, with no change in mrna expression. |
2014-03-28 |
2023-08-12 |
rat |
| Yanjun Zhong, Guicheng Dong, Haiguang Luo, Jie Cao, Chang Wang, Jianyuan Wu, Yu-Qi Feng, Jiang Yu. Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:22960445. |
ros levels induced by ethanol paralleled the enhanced cyp2e1 proteins in the hippocampus, granular layer and white matter of cerebellum as well as brainstem. |
2014-03-28 |
2023-08-12 |
rat |
| Yanjun Zhong, Guicheng Dong, Haiguang Luo, Jie Cao, Chang Wang, Jianyuan Wu, Yu-Qi Feng, Jiang Yu. Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:22960445. |
these results suggest that the selective sensitivity of brain regions to ethanol neurodegeneration may be attributed to the regional and cellular-specific induction of cyp2e1 by ethanol. |
2014-03-28 |
2023-08-12 |
rat |
| Dian J Chiang, Sanjoy Roychowdhury, Katelyn Bush, Megan R McMullen, Sorana Pisano, Kathryn Niese, Mitchell A Olman, Michele T Pritchard, Laura E Nag. Adenosine 2A receptor antagonist prevented and reversed liver fibrosis in a mouse model of ethanol-exacerbated liver fibrosis. PloS one. vol 8. issue 7. 2014-02-13. PMID:23874883. |
neither the expression or activity of cyp2e1, required for bio-activation of ccl4, nor ast and alt activity in the plasma were affected by ethanol, indicating that moderate ethanol did not increase the direct hepatotoxicity of ccl4. |
2014-02-13 |
2023-08-12 |
mouse |
| Charmaine S Ferguson, Sharon Miksys, Roberta M Palmour, Rachel F Tyndal. Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys. Neuropharmacology. vol 72. 2014-02-11. PMID:23639433. |
ethanol self-administration and nicotine treatment induce brain levels of cyp2b6 and cyp2e1 in african green monkeys. |
2014-02-11 |
2023-08-12 |
human |
| Charmaine S Ferguson, Sharon Miksys, Roberta M Palmour, Rachel F Tyndal. Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys. Neuropharmacology. vol 72. 2014-02-11. PMID:23639433. |
the objective of this study was to determine the effects of ethanol self-administration and nicotine treatment, alone and in combination, on brain cyp2b6 and cyp2e1 levels in monkeys. |
2014-02-11 |
2023-08-12 |
human |