| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenjiro Tatematsu, Akihiro Koide, Keiichirou Morimura, Shoji Fukushima, Yukio Mor. The enhancing effect of ethanol on the mutagenic activation of N-nitrosomethylbenzylamine by cytochrome P450 2A in the rat oesophagus. Mutagenesis. vol 28. issue 2. 2013-08-16. PMID:23325793. |
these results showed that the enhancing effect of ethanol on nmba-induced oesophageal carcinogenesis could be attributed to an increase in the metabolic activation of nmba by oesophageal cyp2a during the initiation phase, and that this occurred independently of cyp2e1. |
2013-08-16 |
2023-08-12 |
rat |
| Bo Young Min, Nam Young Kim, Eun Sun Jang, Cheol Min Shin, Sang Hyup Lee, Young Soo Park, Jin-Hyeok Hwang, Sook-Hyang Jeong, Nayoung Kim, Dong Ho Lee, Jin-Wook Ki. Ethanol potentiates hepatitis B virus replication through oxidative stress-dependent and -independent transcriptional activation. Biochemical and biophysical research communications. vol 431. issue 1. 2013-08-02. PMID:23274499. |
ethanol did not induce oxidative stress in hepad38 cells with minimal expression of cyp2e1. |
2013-08-02 |
2023-08-12 |
human |
| Bo Young Min, Nam Young Kim, Eun Sun Jang, Cheol Min Shin, Sang Hyup Lee, Young Soo Park, Jin-Hyeok Hwang, Sook-Hyang Jeong, Nayoung Kim, Dong Ho Lee, Jin-Wook Ki. Ethanol potentiates hepatitis B virus replication through oxidative stress-dependent and -independent transcriptional activation. Biochemical and biophysical research communications. vol 431. issue 1. 2013-08-02. PMID:23274499. |
however, over-expression of cyp2e1 induced oxidative stress and amplified transcriptional activation of hbv by ethanol. |
2013-08-02 |
2023-08-12 |
human |
| Paul G Thomes, Rebecca A Ehlers, Casey S Trambly, Dahn L Clemens, Howard S Fox, Dean J Tuma, Terrence M Donohu. Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells. Autophagy. vol 9. issue 1. 2013-07-15. PMID:23090141. |
the ethanol-elicited rise in lc3-ii was dependent on ethanol dose, was seen only in cells that expressed alcohol dehydrogenase (adh) and was augmented in cells that coexpressed cytochrome cyp2e1 (p450 2e1). |
2013-07-15 |
2023-08-12 |
Not clear |
| Kazuhiro Tokuda, Yukitoshi Izumi, Charles F Zorumsk. Locally-generated acetaldehyde is involved in ethanol-mediated LTP inhibition in the hippocampus. Neuroscience letters. vol 537. 2013-07-09. PMID:23352848. |
however, sodium azide, a catalase inhibitor, and allyl sulfide, an inhibitor of cytochrome p450 2e1 (cyp2e1), failed to overcome ltp inhibition by 60mm ethanol. |
2013-07-09 |
2023-08-12 |
rat |
| Sanjoy Roychowdhury, Megan R McMullen, Sorana G Pisano, Xiuli Liu, Laura E Nag. Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. Hepatology (Baltimore, Md.). vol 57. issue 5. 2013-07-05. PMID:23319235. |
chronic ethanol feeding failed to induce rip3 in the livers of cytochrome p450 2e1 (cyp2e1)-deficient mice, indicating cyp2e1-mediated ethanol metabolism is critical for rip3 expression in response to ethanol feeding. |
2013-07-05 |
2023-08-12 |
mouse |
| Amit Sharma, Kumar Saurabh, Sanjay Yadav, Swatantra K Jain, Devendra Parma. Ethanol induced induction of cytochrome P450 2E1 and activation of mitogen activated protein kinases in peripheral blood lymphocytes. Xenobiotica; the fate of foreign compounds in biological systems. vol 42. issue 4. 2013-06-24. PMID:21999510. |
the present data demonstrating similarities in the induction of cyp2e1 and lipid peroxidation and activation of map kinases in blood lymphocytes with liver after acute or chronic exposure of ethanol have suggested that blood lymphocytes could be used to monitor ethanol induced cyp2e1 induction and associated oxidative stress in liver. |
2013-06-24 |
2023-08-12 |
rat |
| Laura E Martikainen, Minna Rahnasto-Rilla, Silvie Neshybova, Maija Lahtela-Kakkonen, Hannu Raunio, Risto O Juvone. Interactions of inhibitor molecules with the human CYP2E1 enzyme active site. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 47. issue 5. 2013-04-30. PMID:23069620. |
cyp2e1 is an important enzyme oxidizing ethanol as well as several drugs and other xenobiotics in the human liver. |
2013-04-30 |
2023-08-12 |
human |
| Volodymyr O Kitam, Oksana V Maksymchuk, Mykola O Chashchy. The possible mechanisms of CYP2E1 interactions with HSP90 and the influence of ethanol on them. BMC structural biology. vol 12. 2013-03-22. PMID:23241420. |
the possible mechanisms of cyp2e1 interactions with hsp90 and the influence of ethanol on them. |
2013-03-22 |
2023-08-12 |
Not clear |
| Rong-Huai Zhang, Jian-Yuan Gao, Hai-Tao Guo, Glenda I Scott, Anna R Eason, Xiao-Ming Wang, Jun Re. Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis. Biochimica et biophysica acta. vol 1832. issue 1. 2013-03-04. PMID:22967841. |
ethanol led to elevated levels of cyp2e1, inos and phospholamban, decreased levels of ho-1 and na(+)ca(2+) exchanger, cardiac contractile and intracellular ca(2+) defects, cardiac fibrosis, overt o(2)(-) production, and apoptosis accompanied with increased phosphorylation of jnk and ask-1, the effects were significantly attenuated or ablated by diallyl sulfide. |
2013-03-04 |
2023-08-12 |
mouse |
| Rong-Huai Zhang, Jian-Yuan Gao, Hai-Tao Guo, Glenda I Scott, Anna R Eason, Xiao-Ming Wang, Jun Re. Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis. Biochimica et biophysica acta. vol 1832. issue 1. 2013-03-04. PMID:22967841. |
taken together, these findings suggest that ethanol metabolism through cyp2e1 may contribute to the pathogenesis of alcoholic cardiomyopathy including myocardial contractile dysfunction, oxidative stress and apoptosis, possibly through activation of jnk and ask-1 signaling. |
2013-03-04 |
2023-08-12 |
mouse |
| Yongke Lu, Xu Hannah Zhang, Arthur I Cederbau. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 2. 2013-01-25. PMID:22552773. |
chronic ethanol consumption was previously shown to induce cyp2a5 in mice, and this induction of cyp2a5 by ethanol was cyp2e1 dependent. |
2013-01-25 |
2023-08-12 |
mouse |
| Yongke Lu, Xu Hannah Zhang, Arthur I Cederbau. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 2. 2013-01-25. PMID:22552773. |
cyp2e1 was induced by chronic ethanol consumption to the same degree in wild-type (wt) mice and cyp2a5 knockout (cyp2a5 (-/-)) mice, suggesting that unlike the cyp2e1-dependent ethanol induction of cyp2a5, ethanol induction of cyp2e1 is not cyp2a5 dependent. |
2013-01-25 |
2023-08-12 |
mouse |
| Yongke Lu, Xu Hannah Zhang, Arthur I Cederbau. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 2. 2013-01-25. PMID:22552773. |
microsomal ethanol oxidation was about 25% lower in cyp2a5 (-/-) mice compared with that in wt mice, suggesting that cyp2a5 can oxidize ethanol although to a lesser extent than cyp2e1 does. |
2013-01-25 |
2023-08-12 |
mouse |
| Yongke Lu, Xu Hannah Zhang, Arthur I Cederbau. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 2. 2013-01-25. PMID:22552773. |
cyp2a5 was induced by short-term ethanol consumption in human cyp2e1 transgenic knockin (cyp2e1 (-/-) ki) mice but not in cyp2e1 knockout (cyp2e1 (-/-)) mice. |
2013-01-25 |
2023-08-12 |
mouse |
| Yongke Lu, Xu Hannah Zhang, Arthur I Cederbau. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 2. 2013-01-25. PMID:22552773. |
the redox-sensitive transcription factor nuclear factor-erythroid 2-related factor 2 (nrf2) was also induced by acute ethanol in cyp2e1 (-/-) ki mice but not in cyp2e1 (-/-) mice. |
2013-01-25 |
2023-08-12 |
mouse |
| Yongke Lu, Xu Hannah Zhang, Arthur I Cederbau. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 2. 2013-01-25. PMID:22552773. |
ethanol induction of cyp2a5 in nrf2 knockout (nrf2 (-/-)) mice was lower compared with that in wt mice, whereas cyp2e1 induction by ethanol was comparable in wt and nrf2 (-/-) mice. |
2013-01-25 |
2023-08-12 |
mouse |
| Yongke Lu, Xu Hannah Zhang, Arthur I Cederbau. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 2. 2013-01-25. PMID:22552773. |
antioxidants (n-acetyl-cysteine and vitamin c), which blocked oxidative stress induced by chronic ethanol in wt mice and acute ethanol in cyp2e1 (-/-) ki mice, also blunted the induction of cyp2a5 and nrf2 by ethanol but not the induction of cyp2e1 by ethanol. |
2013-01-25 |
2023-08-12 |
mouse |
| Yongke Lu, Xu Hannah Zhang, Arthur I Cederbau. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 2. 2013-01-25. PMID:22552773. |
these results suggest that oxidative stress induced by ethanol via induction of cyp2e1 upregulates nrf2 activity, which in turn regulates ethanol induction of cyp2a5. |
2013-01-25 |
2023-08-12 |
mouse |
| Defeng Wu, Xiaodong Wang, Richard Zhou, Lili Yang, Arthur I Cederbau. Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. Free radical biology & medicine. vol 53. issue 6. 2013-01-16. PMID:22819980. |
the goal of the current study was to evaluate whether cyp2e1 plays a role in binge-ethanol induced steatosis and if autophagy impacts cyp2e1-mediated hepatotoxicity, oxidative stress and fatty liver formation produced by ethanol. |
2013-01-16 |
2023-08-12 |
mouse |