| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyland C Gonzalez, Kelly R Misare, Tsultrim T Mendenhall, Bethany J Wolf, Patrick J Mulholland, Kacy L Gordon, Jessica H Hartma. Transgenic expression of human cytochrome P450 2E1 in C. elegans and rat PC-12 cells sensitizes to ethanol-induced locomotor and mitochondrial effects. Biochemical and biophysical research communications. vol 734. 2024-10-02. PMID:39357336. |
ethanol toxicity is mainly driven by the metabolite acetaldehyde, which is generated through three pathways: alcohol dehydrogenase (adh2), catalase (cat), and cytochrome p450 2e1 (cyp2e1). |
2024-10-02 |
2024-10-05 |
human |
| Hyland C Gonzalez, Kelly R Misare, Tsultrim T Mendenhall, Bethany J Wolf, Patrick J Mulholland, Kacy L Gordon, Jessica H Hartma. Transgenic expression of human cytochrome P450 2E1 in C. elegans and rat PC-12 cells sensitizes to ethanol-induced locomotor and mitochondrial effects. Biochemical and biophysical research communications. vol 734. 2024-10-02. PMID:39357336. |
adh2, while the main ethanol clearance pathway in the liver, is not expressed in the mammalian brain, resulting in cat and cyp2e1 driving local metabolism of ethanol in the central nervous system. |
2024-10-02 |
2024-10-05 |
human |
| Hyland C Gonzalez, Kelly R Misare, Tsultrim T Mendenhall, Bethany J Wolf, Patrick J Mulholland, Kacy L Gordon, Jessica H Hartma. Transgenic expression of human cytochrome P450 2E1 in C. elegans and rat PC-12 cells sensitizes to ethanol-induced locomotor and mitochondrial effects. Biochemical and biophysical research communications. vol 734. 2024-10-02. PMID:39357336. |
to answer this question, we generated transgenic caenorhabditis elegans roundworms expressing human cyp2e1 in the mitochondria, endoplasmic reticulum, or both and exposed them to ethanol. |
2024-10-02 |
2024-10-05 |
human |
| Hyland C Gonzalez, Kelly R Misare, Tsultrim T Mendenhall, Bethany J Wolf, Patrick J Mulholland, Kacy L Gordon, Jessica H Hartma. Transgenic expression of human cytochrome P450 2E1 in C. elegans and rat PC-12 cells sensitizes to ethanol-induced locomotor and mitochondrial effects. Biochemical and biophysical research communications. vol 734. 2024-10-02. PMID:39357336. |
cyp2e1 expression, regardless of organellar targeting, reduced mitochondrial respiration in response to ethanol. |
2024-10-02 |
2024-10-05 |
human |
| Hyland C Gonzalez, Kelly R Misare, Tsultrim T Mendenhall, Bethany J Wolf, Patrick J Mulholland, Kacy L Gordon, Jessica H Hartma. Transgenic expression of human cytochrome P450 2E1 in C. elegans and rat PC-12 cells sensitizes to ethanol-induced locomotor and mitochondrial effects. Biochemical and biophysical research communications. vol 734. 2024-10-02. PMID:39357336. |
together, these findings suggest that subcellular localization of cyp2e1 impacts behavioral effects of ethanol and should be further studied in the mammalian central nervous system. |
2024-10-02 |
2024-10-05 |
human |
| Hongkun Lin, Xiaoping Guo, Jingjing Liu, Li Chen, Huimin Chen, Ying Zhao, Hongxia Li, Shuang Rong, Ping Ya. Refining the Rab7-V1G1 axis to mitigate iron deposition: protective effects of quercetin in alcoholic liver disease. The Journal of nutritional biochemistry. 2024-09-16. PMID:39284533. |
additionally, hepg2 cells, after transfection with the cyp2e1 plasmid, were incubated with ethanol and/or quercetin. |
2024-09-16 |
2024-09-19 |
mouse |
| Wei Jiang, Min Zhang, Rui Cao, Xinghao Wang, Youbo Zu. Different ethanol exposure durations affect cytochrome P450 2E1-mediated sevoflurane metabolism in rat liver. BMC anesthesiology. vol 24. issue 1. 2024-09-11. PMID:39256673. |
it has been reported that ethanol exposure can upregulate the protein expression and enzyme activity of cytochrome p450 2e1 (cyp2e1). |
2024-09-11 |
2024-09-13 |
rat |
| Qing-Xiang Zheng, Qing-Lin Liu, Wen-Na Sun, Xin-Yu Jiang, Tao Zen. Biphasic effects of ethanol consumption on N,N-dimethylformamide-induced liver injury in mice. Toxicology. vol 506. 2024-06-26. PMID:38924947. |
notably, cytochrome p4502e1 (cyp2e1) protein level and activity in mouse livers were not significantly affected by ethanol per se in the two models. |
2024-06-26 |
2024-06-29 |
mouse |
| Hyejin Mun, Sungyul Lee, Suyoung Choi, Ji-Hoon Jeong, Seungbeom Ko, Yoo Lim Chun, Benjamin Deaton, Clay T Yeager, Audrey Boyette, Juliana Palmera, London Newman, Ping Zhou, Soona Shin, Dong-Chan Kim, Cari A Sagum, Mark T Bedford, Young-Kook Kim, Jaeyul Kwon, Junyang Jung, Jeong Ho Chang, Je-Hyun Yoo. Targeting of CYP2E1 by miRNAs in alcohol-induced intestine injury. Molecules and cells. 2024-06-20. PMID:38901530. |
ethanol (etoh)-inducible cytochrome p450-2e1 (cyp2e1), a key enzyme in etoh metabolism, promotes alcohol-induced hepatic steatosis and inflammatory liver disease, at least in part by mediating changes in intestinal permeability. |
2024-06-20 |
2024-06-23 |
Not clear |
| David Strischewski, Amira Kalmar, Paul C Guest, Henrik Dobrowolny, Gabriela Meyer-Lotz, Conrad J Schiffner, Wolfgang Jordan, Ulf J Müller, Katrin Borucki, Michael Böttcher, Borna Relja, Johann Steine. Naturalistic comparison of clomethiazole and Diazepam treatment in alcohol withdrawal: effects on oxidative stress, inflammatory cytokines and hepatic biomarkers. European archives of psychiatry and clinical neuroscience. 2024-06-08. PMID:38851655. |
ethanol is metabolized by alcohol dehydrogenase to acetaldehyde and induces cytochrome p450 2e1 (cyp2e1), which generates reactive oxygen species that cause inflammatory liver damage. |
2024-06-08 |
2024-06-11 |
Not clear |
| Weiwen Lai, Shipeng Zhou, Yan Bai, Qishi Che, Hua Cao, Jiao Guo, Zhengquan S. Glucosamine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress and inflammation. Current research in food science. vol 8. 2024-02-29. PMID:38420347. |
further mechanisms suggest that glc can inhibit the expression of ethanol metabolism enzyme cytochrome p4502e1 (cyp2e1), activate the antioxidant pathway keap1/nrf2/ho-1, down-regulate the phosphorylation of mapk and nf-κb signaling pathways, and thus reduce the expression of tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β) and interleukin-6 (il-6). |
2024-02-29 |
2024-03-02 |
mouse |
| Karli R LeFort, Wiramon Rungratanawanich, Byoung-Joon Son. Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-12. PMID:38214802. |
while the ethanol-inducible cytochrome p450-2e1 (cyp2e1) is mainly responsible for oxidizing binge alcohol via the microsomal ethanol oxidizing system, it is also responsible for metabolizing many xenobiotics, including pollutants, chemicals, drugs, and specific diets abundant in n-6 fatty acids, into toxic metabolites in many organs, including the liver, causing pathological insults through organelles such as mitochondria and endoplasmic reticula. |
2024-01-12 |
2024-01-14 |
Not clear |
| Jinhan Yang, Lin Zhang, Tong Wang, Jiajia Zhang, Mingyue Li, Xiaoxia Jin, Xiaoqiong Tan, Gaoyang Wang, Fenghong Zhao, Yaping Ji. Synergistic effects of combined treatment of 1,2-dichloroethane and high-dose ethanol on liver damage in mice and the related mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-05-07. PMID:37150348. |
in the current study, we further investigated the effects of combined treatment with 1,2-dce and high dose ethanol on liver and the mechanisms since both of them can be metabolized by cyp2e1 in the liver. |
2023-05-07 |
2023-08-14 |
mouse |
| Jinhan Yang, Lin Zhang, Tong Wang, Jiajia Zhang, Mingyue Li, Xiaoxia Jin, Xiaoqiong Tan, Gaoyang Wang, Fenghong Zhao, Yaping Ji. Synergistic effects of combined treatment of 1,2-dichloroethane and high-dose ethanol on liver damage in mice and the related mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-05-07. PMID:37150348. |
first, combined treatment of mice with 1,2-dce and high-dose ethanol could synergistically upregulate both protein and mrna levels of cyp2e1, which might aggravate liver damage through cyp2e1-mediated oxidative stress. |
2023-05-07 |
2023-08-14 |
mouse |
| Chuyun Yan, Wanting Hu, Jinqi Tu, Jinyao Li, Qionglin Liang, Shuxin Ha. Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease. Journal of translational medicine. vol 21. issue 1. 2023-05-04. PMID:37143126. |
many metabolic enzymes, including alcohol dehydrogenases such as adh, cyp2e1, and catacetaldehyde dehydrogenases aldhsand nonoxidative metabolizing enzymes such as sult, ugt, and faees, are involved in the metabolism of ethanol, the main component in alcoholic beverages. |
2023-05-04 |
2023-08-14 |
Not clear |
| Paul G Thomes, Gage Rensch, Carol A Casey, Terrence M Donohu. Ethanol Exposure to Ethanol-Oxidizing HEPG2 Cells Induces Intracellular Protein Aggregation. Cells. vol 12. issue 7. 2023-04-13. PMID:37048086. |
here, we sought to verify whether inhibition of proteasome activity by ethanol exposure enhances protein aggregate formation in vl-17a cells, which are recombinant, ethanol-oxidizing hepg2 cells that express both alcohol dehydrogenase (adh) and cytochrome p450 2e1 (cyp2e1). |
2023-04-13 |
2023-08-14 |
Not clear |
| Dhara Patel, Pooja Rathaur, Kirti Parwani, Farhin Patel, Dixa Sharma, Kaid Johar, Palash Manda. In vitro, in vivo, and in silico analysis of synbiotics as preventive interventions for lipid metabolism in ethanol-induced adipose tissue injury. Lipids in health and disease. vol 22. issue 1. 2023-04-13. PMID:37055787. |
in support of the morphological changes, quantitative real-time pcr demonstrated overexpression of adiponectin and downregulation of leptin, resistin, pparγ, cyp2e1, inos, il-6, and tnf-α after administration of synbiotics compared to the ethanol group. |
2023-04-13 |
2023-08-14 |
rat |
| Bernice Asiedu, Busisani Wiseman Lembede, Monica Gomes, Abe Kasonga, Pilani Nkomozepi, Trevor Tapiwa Nyakudya, Eliton Chivand. Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models. Metabolites. vol 13. issue 2. 2023-02-25. PMID:36837786. |
mean daily ethanol intake, which ranged from 10 to 14.5 g/kg body mass/day, resulted in significant cyp2e1 elevation ( |
2023-02-25 |
2023-08-14 |
rat |
| Jeevan B Gc, Christopher T Szlenk, Ayobami Diyaolu, Peter Obi, Haiyang Wei, Xutong Shi, K Michael Gibson, Senthil Natesan, Jean-Baptiste Roulle. Allosteric Modulation of α1β3γ2 GABA Biophysical journal. 2023-02-01. PMID:36721367. |
it is the natural substrate of alcohol dehydrogenase and a substrate for cyp2e1, two enzymes implicated in ethanol metabolism. |
2023-02-01 |
2023-08-14 |
human |
| Nicolas Hohmann, Fabian Schröder, Bernardo Moreira, Haidong Teng, Jürgen Burhenne, Thomas Bruckner, Sebastian Mueller, Walter E Haefeli, Helmut K Seit. Effect of Clomethiazole Vs. Clorazepate on Hepatic Fat and Serum Transaminase Activities in Alcohol-Associated Liver Disease: Results from a Randomized, Controlled Phase II Clinical Trial. Alcohol and alcoholism (Oxford, Oxfordshire). 2022-12-23. PMID:36562601. |
one important source of ros is microsomal ethanol metabolism catalyzed by cytochrome p450 2e1 (cyp2e1), which is induced by chronic ethanol consumption. |
2022-12-23 |
2023-08-14 |
Not clear |