| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abdo Mahli, Wolfgang Erwin Thasler, Claus Hellerbran. Establishment of a p-nitrophenol oxidation-based assay for the analysis of CYP2E1 activity in intact hepatocytes in vitro. Toxicology mechanisms and methods. vol 29. issue 3. 2019-05-03. PMID:30380359. |
using hepatoma cells with and without stable cyp2e1 expression and primary human hepatocytes, we established specific methodology to assess cyp2e1 catalytic activity and its induction by ethanol in a small number of cells and in a very short time. |
2019-05-03 |
2023-08-13 |
human |
| S-Q Li, P Wang, D-M Wang, H-J Lu, R-F Li, L-X Duan, S Zhu, S-L Wang, Y-Y Zhang, Y-L Wan. Molecular mechanism for the influence of gender dimorphism on alcoholic liver injury in mice. Human & experimental toxicology. vol 38. issue 1. 2019-03-28. PMID:29792338. |
our study suggested that ethanol treatment induced more expression of hsp27 and hsp70, faster hepatocyte proliferation, higher level of glycogen, and interleukin-6 signaling pathway activation, but less hepatocyte apoptosis and cyp2e1 expression in male mice than female mice, which could be helpful to understand the molecular mechanism for the influence of sex difference on alcoholic liver injury. |
2019-03-28 |
2023-08-13 |
mouse |
| Tung Ming Leung, Yongke L. Alcoholic Liver Disease: from CYP2E1 to CYP2A5. Current molecular pharmacology. vol 10. issue 3. 2019-02-25. PMID:26278389. |
ethanol can induce cyp2e1, an active generator of reactive oxygen species (ros), and cyp2e1 is a contributing factor for alcoholinduced oxidative liver injury. |
2019-02-25 |
2023-08-13 |
mouse |
| Maria Lauda Tomasi, Komal Ramani, Minjung Ryoo, Carla Cossu, Andrea Floris, Ben J Murray, Ainhoa Iglesias-Ara, Ylenia Spissu, Nirmala Mavil. SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 6. 2019-01-15. PMID:29401608. |
cyp2e1 sumoylation was found to be induced by ethanol in vitro and in vivo. |
2019-01-15 |
2023-08-13 |
mouse |
| Bo Zhou, Zhihui Jiang, Xinping Li, Xiaoying Zhan. Kaempferol's Protective Effect on Ethanol-Induced Mouse Primary Hepatocytes Injury Involved in the Synchronous Inhibition of SP1, Hsp70 and CYP2E1. The American journal of Chinese medicine. vol 46. issue 5. 2018-10-22. PMID:29976085. |
after ethanol treatment alone and co-incubation hepatocytes with kaempferol, protein levels of cyp2e1, hsp70, and sp1 were determined in vitro (western blotting and immunofluorescence). |
2018-10-22 |
2023-08-13 |
mouse |
| Bo Zhou, Zhihui Jiang, Xinping Li, Xiaoying Zhan. Kaempferol's Protective Effect on Ethanol-Induced Mouse Primary Hepatocytes Injury Involved in the Synchronous Inhibition of SP1, Hsp70 and CYP2E1. The American journal of Chinese medicine. vol 46. issue 5. 2018-10-22. PMID:29976085. |
in the ethanol-treated hepatocytes, kaempferol decreased protein levels of cyp2e1 in both microsome and mitochondria, cytosolic hsp70 and sp1 in nuclear and cytosol, and the oxidative stress and increased the cell viability compared to those of ethanol group. |
2018-10-22 |
2023-08-13 |
mouse |
| Bo Zhou, Zhihui Jiang, Xinping Li, Xiaoying Zhan. Kaempferol's Protective Effect on Ethanol-Induced Mouse Primary Hepatocytes Injury Involved in the Synchronous Inhibition of SP1, Hsp70 and CYP2E1. The American journal of Chinese medicine. vol 46. issue 5. 2018-10-22. PMID:29976085. |
collectively, our findings propose that the protective mechanism of kaempferol is involved in the synchronous, early and persistent inhibitions of mitochondrial and microsomal cyp2e1, cytosolic hsp70 and nuclear and cytosolic sp1 in mouse primary hepatocytes' injury induced by ethanol. |
2018-10-22 |
2023-08-13 |
mouse |
| Tao Zeng, Cui-Li Zhang, Ning Zhao, Min-Jie Guan, Mo Xiao, Rui Yang, Xiu-Lan Zhao, Li-Hua Yu, Zhen-Ping Zhu, Ke-Qin Xi. Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver. Redox biology. vol 14. 2018-07-11. PMID:28987868. |
ethanol exposure resulted in increased levels of malondialdehyde (mda) and 4-hydroxynonenal (4-hne)-akt adducts, which was significantly inhibited by chlormethiazole (cmz), an efficient cyp2e1 inhibitor. |
2018-07-11 |
2023-08-13 |
mouse |
| Ping He, Yafeng Wu, Jianchao Shun, Yaodong Liang, Mingliang Cheng, Yuping Wan. Baicalin Ameliorates Liver Injury Induced by Chronic plus Binge Ethanol Feeding by Modulating Oxidative Stress and Inflammation via CYP2E1 and NRF2 in Mice. Oxidative medicine and cellular longevity. vol 2017. 2018-05-23. PMID:28951767. |
baicalin ameliorates liver injury induced by chronic plus binge ethanol feeding by modulating oxidative stress and inflammation via cyp2e1 and nrf2 in mice. |
2018-05-23 |
2023-08-13 |
mouse |
| Sarmila Nepali, Hyeon-Hui Ki, Ji-Hyun Lee, Ji-Yun Cha, Young-Mi Lee, Dae-Ki Ki. Triticum aestivum sprout-derived polysaccharide exerts hepatoprotective effects against ethanol-induced liver damage by enhancing the antioxidant system in mice. International journal of molecular medicine. vol 40. issue 4. 2018-05-15. PMID:28849040. |
in addition, tasp significantly inhibited ethanol-induced cytochrome p450 2e1 (cyp2e1) activation, and upregulated the expressions of nuclear factor erythroid 2-related factor 2 (nrf2) and hemeoxygenase-1 (ho-1), and downregulated nadph oxidase genes in ethanol fed mice. |
2018-05-15 |
2023-08-13 |
mouse |
| Hye-Kyung Na, Ja Young Le. Molecular Basis of Alcohol-Related Gastric and Colon Cancer. International journal of molecular sciences. vol 18. issue 6. 2018-03-09. PMID:28538665. |
ethanol is metabolized by alcohol dehydrogenases (adh), catalase or cytochrome p450 2e1 (cyp2e1) to acetaldehyde, which is then further oxidized to acetate by aldehyde dehydrogenase (aldh). |
2018-03-09 |
2023-08-13 |
Not clear |
| B Boussadia, C Ghosh, C Plaud, J M Pascussi, F de Bock, M C Rousset, D Janigro, N March. Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression. Neuroscience. vol 281. 2018-01-26. PMID:25280786. |
when analyzing the effect of drug exposure on cyp2e1 expression we found that, in vivo or in vitro, ethanol increased cyp2e1 levels in the brain and liver. |
2018-01-26 |
2023-08-13 |
mouse |
| Arthur I Cederbau. Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction. Redox biology. vol 2. 2018-01-11. PMID:25454746. |
cyp2e1 metabolizes many toxicologically important compounds including ethanol and is active in generating reactive oxygen species. |
2018-01-11 |
2023-08-13 |
mouse |
| Arthur I Cederbau. Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction. Redox biology. vol 2. 2018-01-11. PMID:25454746. |
since several of the contributions in the common theme series "role of cyp2e1 and oxidative/nitrosative stress in the hepatotoxic actions of alcohol" discuss cyp2e1, this methodology review describes assays on how cyp2e1 catalytic activity and its induction by ethanol and other inducers can be measured using substrate probes such as the oxidation of para-nitrophenol to para-nitrocatechol and the oxidation of ethanol to acetaldehyde. |
2018-01-11 |
2023-08-13 |
mouse |
| Akiko Matsumoto, David Thompson, Ying Chen, Vasilis Vasiliou, Toshihiro Kawamoto, Masayoshi Ichib. Heme oxygenase 1 protects ethanol-administered liver tissue in Aldh2 knockout mice. Alcohol (Fayetteville, N.Y.). vol 52. 2018-01-03. PMID:27139237. |
an anti-oxidative protein, heme oxygenase 1 (ho-1), and an oxidative stress-producing protein, cytochrome p450 2e1 (cyp2e1), were detected at higher levels in aldh2(-/-) mice than in aldh2(+/+) mice, regardless of ethanol treatment. |
2018-01-03 |
2023-08-13 |
mouse |
| Jheneffer Sonara Aguiar Ramos, Alessandro Arruda Alves, Mariana Paiva Lopes, Thays Millena Alves Pedroso, Leandro Prado Felício, Wanessa Fernandes Carvalho, Fernanda Craveiro Franco, Caroline Oliveira Araújo Melo, Macks Wendhell Gonçalves, Thannya Nascimento Soares, Aparecido Divino da Cruz, Daniela de Melo E Silv. DNA damage in peripheral blood lymphocytes and association with polymorphisms in the promoter region of the CYP2E1 gene in alcoholics from Central Brazil. Alcohol (Fayetteville, N.Y.). vol 57. 2018-01-03. PMID:27916141. |
dna damage caused by the accumulation of bio-products generated in the biotransformation of ethanol to acetaldehyde mediated by the cyp2e1 enzyme has been studied. |
2018-01-03 |
2023-08-13 |
Not clear |
| Bruno Christian Koehler, Tatjana Arslic-Schmitt, Theresa Peccerella, Anna-Lena Scherr, Henning Schulze-Bergkamen, Thomas Bruckner, Georg Gdynia, Dirk Jäger, Sebastian Mueller, Helmut Bartsch, Helmut K Seit. Possible Mechanisms of Ethanol-Mediated Colorectal Carcinogenesis: The Role of Cytochrome P4502E1, Etheno-DNA Adducts, and the Anti-Apoptotic Protein Mcl-1. Alcoholism, clinical and experimental research. vol 40. issue 10. 2017-12-19. PMID:27581253. |
the mechanisms by which ethanol (etoh) exerts its carcinogenic effect on the colorectal mucosa are not clear and may include oxidative stress with the action of reactive oxygen species (ros) generated through etoh metabolism via cytochrome p4502e1 (cyp2e1) leading to carcinogenic etheno-dna adducts. |
2017-12-19 |
2023-08-13 |
Not clear |
| Yong Wang, Dianke Yu, William H Tolleson, Li-Rong Yu, Bridgett Green, Linjuan Zeng, Yinting Chen, Si Chen, Zhen Ren, Lei Guo, Weida Tong, Huaijin Guan, Baitang Nin. A systematic evaluation of microRNAs in regulating human hepatic CYP2E1. Biochemical pharmacology. vol 138. 2017-07-26. PMID:28438567. |
cytochrome p450 2e1 (cyp2e1) is an important drug metabolizing enzyme for processing numerous xenobiotics in the liver, including acetaminophen and ethanol. |
2017-07-26 |
2023-08-13 |
human |
| Lu Li, Lu Wang, Rui Song, Guangliang Chen, Yanyan Li. Cytochrome P450 2E1 increases the sensitivity of hepatoma cells to vitamin K2. International journal of oncology. vol 50. issue 5. 2017-07-20. PMID:28339022. |
our results showed that vk2 acted synergistically with ethanol (etoh) to inhibit the viability of smmc-7721 cells, mainly because cytochrome p450 2e1 (cyp2e1) was activated by etoh. |
2017-07-20 |
2023-08-13 |
Not clear |
| Junguo Ma, Yiyi Feng, Siyu Jiang, Xiaoyu L. Altered cellular metabolism of HepG2 cells caused by microcystin-LR. Environmental pollution (Barking, Essex : 1987). vol 225. 2017-06-29. PMID:28336091. |
further research showed that the cyp inducers omeprazole, ethanol, and rifampicin inhibited cell viability, in particular, ethanol, a cyp2e1 inducer, induced ros generation, lipid peroxidation, and apoptosis in hepg2 cells treated with mc-lr. |
2017-06-29 |
2023-08-13 |
human |