| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C S Liebe. Aetiology and pathogenesis of alcoholic liver disease. Bailliere's clinical gastroenterology. vol 7. issue 3. 1993-11-26. PMID:8219401. |
in addition to adh, ethanol can be oxidized by liver microsomes: studies over the last twenty years have culminated in the molecular elucidation of the ethanol-inducible cytochrome p450iie1 (cyp2e1) which contributes not only to ethanol metabolism and tolerance, but also to the selective hepatic perivenular toxicity of various xenobiotics. |
1993-11-26 |
2023-08-12 |
Not clear |
| C S Liebe. Aetiology and pathogenesis of alcoholic liver disease. Bailliere's clinical gastroenterology. vol 7. issue 3. 1993-11-26. PMID:8219401. |
their activation by cyp2e1 now provides an understanding for the increased susceptibility of the heavy drinker to the toxicity of industrial solvents, anaesthetic agents, commonly prescribed drugs, 'over the counter' analgesics, chemical carcinogens and even nutritional factors such as vitamin a. ethanol causes not only vitamin a depletion but it also enhances its hepatotoxicity. |
1993-11-26 |
2023-08-12 |
Not clear |
| F J Gonzalez, T Ueno, M Umeno, B J Song, R L Veech, H V Gelboi. Microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome P450, CYP2E1. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1993-10-07. PMID:1845601. |
microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome p450, cyp2e1. |
1993-10-07 |
2023-08-11 |
rat |
| F J Gonzalez, T Ueno, M Umeno, B J Song, R L Veech, H V Gelboi. Microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome P450, CYP2E1. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1993-10-07. PMID:1845601. |
cyp2e1 is solely responsible for microsomal p450-mediated ethanol oxidation activity. |
1993-10-07 |
2023-08-11 |
rat |
| S W French, K Wong, L Jui, E Albano, A L Hagbjork, M Ingelman-Sundber. Effect of ethanol on cytochrome P450 2E1 (CYP2E1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis. Experimental and molecular pathology. vol 58. issue 1. 1993-04-22. PMID:8454037. |
effect of ethanol on cytochrome p450 2e1 (cyp2e1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis. |
1993-04-22 |
2023-08-12 |
rat |
| D L Crankshaw, N D Hine. Hepatic microsomes from beer fed rats contain a cytochrome P-450 metabolic intermediate complex. Biochemical and biophysical research communications. vol 189. issue 2. 1993-01-28. PMID:1472062. |
cytochrome p450 (cyp450) 2e1 (cyp2e1) is induced by pure ethanol following its chronic administration, and commercial alcoholic beverages, whose major constituent is ethanol, are generally assumed to have a similar effect on this isoform of cyp450. |
1993-01-28 |
2023-08-11 |
rat |
| D L Crankshaw, N D Hine. Hepatic microsomes from beer fed rats contain a cytochrome P-450 metabolic intermediate complex. Biochemical and biophysical research communications. vol 189. issue 2. 1993-01-28. PMID:1472062. |
recently, we serendipitously discovered that beer administered to rats for six weeks had only a minimal inductive effect on hepatic microsomal cyp2e1 activity, while rats on 10% ethanol had cyp2e1 levels five-fold greater than controls. |
1993-01-28 |
2023-08-11 |
rat |
| D L Crankshaw, N D Hine. Hepatic microsomes from beer fed rats contain a cytochrome P-450 metabolic intermediate complex. Biochemical and biophysical research communications. vol 189. issue 2. 1993-01-28. PMID:1472062. |
we conclude that beer contains an unidentified component(s) that apparently blocks the typical ethanol induction of cyp2e1 and form an mi complex with cyp450. |
1993-01-28 |
2023-08-11 |
rat |
| H Takahashi, I Johansson, S W French, M Ingelman-Sundber. Effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 (CYP2E1) in the liver of rats chronically fed ethanol. Pharmacology & toxicology. vol 70. issue 5 Pt 1. 1992-07-23. PMID:1608922. |
effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome p450 (cyp2e1) in the liver of rats chronically fed ethanol. |
1992-07-23 |
2023-08-11 |
rat |
| H Takahashi, I Johansson, S W French, M Ingelman-Sundber. Effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 (CYP2E1) in the liver of rats chronically fed ethanol. Pharmacology & toxicology. vol 70. issue 5 Pt 1. 1992-07-23. PMID:1608922. |
we studied the effects of dietary fat composition on the activities of the microsomal ethanol oxidizing system (meos), paranitrophenol hydroxylase (ph) activity and ethanol-inducible cytochrome p450 isozymes (cyp2e1 and cyp2b1) in the liver of rats to determine the role of this ethanol metabolizing pathway in the pathogenesis of alcoholic liver disease (ald). |
1992-07-23 |
2023-08-11 |
rat |
| R Hyland, A Gescher, K Thummel, C Schiller, P Jheeta, K Mynett, A W Smith, J Mrá. Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1. Molecular pharmacology. vol 41. issue 2. 1992-03-27. PMID:1538706. |
pretreatment of rodents with acetone or ethanol induced the rate of metabolism of n-methylformamide and of p-nitrophenol, a known cyp2e1 substrate, but it did not increase aminopyrine n-demethylation. |
1992-03-27 |
2023-08-11 |
mouse |
| R Bühler, K O Lindros, A Nordling, I Johansson, M Ingelman-Sundber. Zonation of cytochrome P450 isozyme expression and induction in rat liver. European journal of biochemistry. vol 204. issue 1. 1992-03-24. PMID:1740154. |
chronic exposure to ethanol caused induction of cyp2e1 in the same cells already being constitutively expressed, whereas cypetoh2 was more induced in the periportal area. |
1992-03-24 |
2023-08-11 |
rat |
| E Dicker, A I Cederbau. Increased oxidation of dimethylnitrosamine in pericentral microsomes after pyrazole induction of cytochrome P-4502E1. Alcoholism, clinical and experimental research. vol 15. issue 6. 1992-03-20. PMID:1686370. |
the oxidation of dmn by both microsomal preparations, as well as the increased rates obtained with the pericentral microsomes, was sensitive to inhibition by carbon monoxide as well as to other cyp2e1 substrates such as ethanol, pyrazole, or 4-methylpyrazole. |
1992-03-20 |
2023-08-11 |
rat |
| P G Forkert, T E Massey, A B Jones, S S Park, H V Gelboin, L M Anderso. Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration. Carcinogenesis. vol 12. issue 12. 1992-01-22. PMID:1747925. |
distribution of cytochrome cyp2e1 in murine liver after ethanol and acetone administration. |
1992-01-22 |
2023-08-11 |
mouse |
| P G Forkert, T E Massey, A B Jones, S S Park, H V Gelboin, L M Anderso. Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration. Carcinogenesis. vol 12. issue 12. 1992-01-22. PMID:1747925. |
the effects of acetone and ethanol administration on cytochrome cyp2e1 in murine liver were investigated. |
1992-01-22 |
2023-08-11 |
mouse |
| P G Forkert, T E Massey, A B Jones, S S Park, H V Gelboin, L M Anderso. Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration. Carcinogenesis. vol 12. issue 12. 1992-01-22. PMID:1747925. |
the results demonstrate that (i) the mouse is a good model for correlative biochemical and histochemical studies of cyp2e1 induction, (ii) in the mouse liver, this p450 is preferentially localized in centrilobular regions constitutively as well as in induced states, (iii) the centrilobular pattern varies under different induction conditions, and (iv) there is a progressive inductive increase in cyp2e1 protein and enzyme activity with chronic ethanol treatment over at least 3 weeks. |
1992-01-22 |
2023-08-11 |
mouse |
| Y Terelius, C Norsten-Höög, T Cronholm, M Ingelman-Sundber. Acetaldehyde as a substrate for ethanol-inducible cytochrome P450 (CYP2E1). Biochemical and biophysical research communications. vol 179. issue 1. 1991-10-02. PMID:1822117. |
the results indicate that cyp2e1 is an aldehyde oxidase and thus metabolizes both ethanol and its primary oxidation product. |
1991-10-02 |
2023-08-11 |
rat |
| I Johansson, E Eliasson, M Ingelman-Sundber. Hormone controlled phosphorylation and degradation of CYP2B1 and CYP2E1 in isolated rat hepatocytes. Biochemical and biophysical research communications. vol 174. issue 1. 1991-02-22. PMID:1989615. |
ethanol (75 mm) completely protected from adrenalin dependent phosphorylation and degradation of cyp2e1, but did not influence cyp2b1 on these parameters. |
1991-02-22 |
2023-08-11 |
human |
| I Johansson, E Eliasson, M Ingelman-Sundber. Hormone controlled phosphorylation and degradation of CYP2B1 and CYP2E1 in isolated rat hepatocytes. Biochemical and biophysical research communications. vol 174. issue 1. 1991-02-22. PMID:1989615. |
examination of para-nitrophenol hydroxylase revealed that ethanol stabilized the catalytically active form of cyp2e1. |
1991-02-22 |
2023-08-11 |
human |