| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E A Stephens, J A Taylor, N Kaplan, C H Yang, L L Hsieh, G W Lucier, D A Bel. Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese. Pharmacogenetics. vol 4. issue 4. 1995-01-10. PMID:7987402. |
human cytochrome p4502e1 (cyp2e1) is inducible by ethanol and is involved in metabolism of many known carcinogens including n-nitrosodimethylamine, butadiene, benzene, and carbon tetrachloride. |
1995-01-10 |
2023-08-12 |
human |
| Y Amet, F Berthou, T Goasduff, J P Salaun, L Le Breton, J F Mene. Evidence that cytochrome P450 2E1 is involved in the (omega-1)-hydroxylation of lauric acid in rat liver microsomes. Biochemical and biophysical research communications. vol 203. issue 2. 1994-10-18. PMID:8093035. |
the present study examined changes in hepatic cyp2e1 content and (omega-1)-hydroxylation of lauric acid in rats treated with pyridine, pyrazole, acetone, ethanol and 3-methylcholanthrene. |
1994-10-18 |
2023-08-12 |
rat |
| K Iwahashi, R Miyatake, H Suwaki, H Kinoshita, K Ameno, I Ijiri, Y Ishikawa, Y Matsu. [Blood ethanol levels and the CTP2E1 C2 allele]. Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence. vol 29. issue 3. 1994-10-04. PMID:8080402. |
the effect of cyp2e1 upon the blood ethanol level was investigated. |
1994-10-04 |
2023-08-12 |
human |
| K Iwahashi, R Miyatake, H Suwaki, H Kinoshita, K Ameno, I Ijiri, Y Ishikawa, Y Matsu. [Blood ethanol levels and the CTP2E1 C2 allele]. Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence. vol 29. issue 3. 1994-10-04. PMID:8080402. |
beta 60 (0.28 mg/ml/hr) of the blood ethanol concentration-time curve in one with the cyp2e1 c2 allele was higher than that (0.25 mg/ml/hr) in the other with no c2 allele. |
1994-10-04 |
2023-08-12 |
human |
| K Iwahashi, R Miyatake, H Suwaki, H Kinoshita, K Ameno, I Ijiri, Y Ishikawa, Y Matsu. [Blood ethanol levels and the CTP2E1 C2 allele]. Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence. vol 29. issue 3. 1994-10-04. PMID:8080402. |
it is possible that the c2 allele may correspond to the higher cyp2e1 activity of ethanol metabolism. |
1994-10-04 |
2023-08-12 |
human |
| T Nakajima, R S Wang, E Elovaara, F J Gonzalez, H V Gelboin, H Vainio, T Aoyam. CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively. Biochemical pharmacology. vol 48. issue 4. 1994-09-30. PMID:8080435. |
these results suggest that (1) at least four p450s, cyp2c11/6, cyp2e1, cyp2b1/2 and cyp1a1/2, contribute to the metabolism of styrene, (2) cyp2c11/6, which probably corresponds to cyp2c11, is the major form of p450 responsible for the metabolism in untreated rat liver microsomes, and also in those treated with ethanol. |
1994-09-30 |
2023-08-12 |
rat |
| V A Eagling, J L Howe, M J Barry, D J Bac. The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochemical pharmacology. vol 48. issue 2. 1994-09-06. PMID:8053924. |
pre-treatment of rats with beta-naphthoflavone and ethanol (cyp1a and cyp2e1 inducers, respectively) had no effect on amt formation. |
1994-09-06 |
2023-08-12 |
human |
| M Ingelman-Sundberg, I Johansson, I Persson, M Oscarson, Y Hu, L Bertilsson, M L Dahl, F Sjöqvis. Genetic polymorphism of cytochrome P450. Functional consequences and possible relationship to disease and alcohol toxicity. EXS. vol 71. 1994-08-12. PMID:8032151. |
ethanol-inducible cytochrome p450 2e1 (cyp2e1) oxidizes ethanol and acetaldehyde, in addition to over 80 toxicologically important xenobiotics. |
1994-08-12 |
2023-08-12 |
human |
| A Buard, P H Beaune, A Renier, M C Jaurand, J Bignon, P Lauren. Expression of cytochrome P450 in rat pleural mesothelial cells in secondary cultures. Journal of cellular physiology. vol 160. issue 1. 1994-08-04. PMID:8021296. |
cyp2e1 apoprotein was constitutively expressed in cultured rpmc, and markedly increased by 170 mm ethanol, and 0.1 microm or 1 microm dexamethasone treatments. |
1994-08-04 |
2023-08-12 |
rat |
| A Buard, P H Beaune, A Renier, M C Jaurand, J Bignon, P Lauren. Expression of cytochrome P450 in rat pleural mesothelial cells in secondary cultures. Journal of cellular physiology. vol 160. issue 1. 1994-08-04. PMID:8021296. |
unexpectedly, whereas the amount cyp2e1 mrna was not modified by ethanol treatment, dexamethasone has a marked inductive effect on cyp2e1 mrna level. |
1994-08-04 |
2023-08-12 |
rat |
| Y Hu, V Mishin, I Johansson, C von Bahr, A Cross, M J Ronis, T M Badger, M Ingelman-Sundber. Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:8014872. |
in the present investigation we have evaluated the effects of a drug used for treatment of ethanol withdrawal states, chloromethiazole (cmz), on cyp2e1 expression in rat liver. |
1994-07-26 |
2023-08-12 |
rat |
| S Kunitoh, T Tanaka, S Imaoka, Y Funae, Y Monn. Contribution of cytochrome P450s to MEOS (microsomal ethanol-oxidizing system): a specific and sensitive assay of MEOS activity by HPLC with fluorescence labeling. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1B. 1994-07-21. PMID:8003131. |
the km value of cyp2e1 for ethanol oxidation was 9.48 mm, similar to that of hepatic microsomes from rats treated with ethanol. |
1994-07-21 |
2023-08-12 |
rat |
| S Kunitoh, T Tanaka, S Imaoka, Y Funae, Y Monn. Contribution of cytochrome P450s to MEOS (microsomal ethanol-oxidizing system): a specific and sensitive assay of MEOS activity by HPLC with fluorescence labeling. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1B. 1994-07-21. PMID:8003131. |
the km value of cyp1a2 was higher than that of cyp2e1, indicating the cyp1a2 with lower affinity for ethanol compared with cyp2e1. |
1994-07-21 |
2023-08-12 |
rat |
| S Kunitoh, T Tanaka, S Imaoka, Y Funae, Y Monn. Contribution of cytochrome P450s to MEOS (microsomal ethanol-oxidizing system): a specific and sensitive assay of MEOS activity by HPLC with fluorescence labeling. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1B. 1994-07-21. PMID:8003131. |
from the results of an inhibition study with antibodies, cyp2e1 was found to be a main contributor to meos induced by ethanol in rats, but cyp1a2 was considered to play an important role for meos when cyp2e1 was not induced. |
1994-07-21 |
2023-08-12 |
rat |
| D A Burke, D J Wedd, D Herriott, M K Bayliss, D J Spalding, P Wilco. Evaluation of pyrazole and ethanol induced S9 fraction in bacterial mutagenicity testing. Mutagenesis. vol 9. issue 1. 1994-07-08. PMID:8208127. |
s9 fractions were prepared from rats pre-treated with pyrazole or ethanol (inducers of cyp2e1) and then used in the ames test (or pre-incubation modification) with urethane, acetaminophen, aniline, benzene, procarbazine and n-nitrosopyrrolidine. |
1994-07-08 |
2023-08-12 |
rat |
| D A Burke, D J Wedd, D Herriott, M K Bayliss, D J Spalding, P Wilco. Evaluation of pyrazole and ethanol induced S9 fraction in bacterial mutagenicity testing. Mutagenesis. vol 9. issue 1. 1994-07-08. PMID:8208127. |
both pyrazole and ethanol induced s9 were superior to pb/beta-nf-s9 and uninduced-s9 for the activation of n-nitrosopyrrolidine, a known cyp2e1 substrate. |
1994-07-08 |
2023-08-12 |
rat |
| R D White, M E Hahn, W L Lockhart, J J Stegema. Catalytic and immunochemical characterization of hepatic microsomal cytochromes P450 in beluga whale (Delphinapterus leucas). Toxicology and applied pharmacology. vol 126. issue 1. 1994-06-10. PMID:8184432. |
antibodies to ethanol and ketone-inducible rat cyp2e1 reacted with two proteins in beluga liver microsomes. |
1994-06-10 |
2023-08-12 |
rat |
| H Tainaka, T Naito, N Murayama, Y Yamazoe, R Kat. Modulation of ethanol-mediated CYP2E1 induction by clofibrate and L-carnitine in rat liver. Biological & pharmaceutical bulletin. vol 16. issue 12. 1994-04-21. PMID:8130774. |
the administration of ethanol in the diet (containing 21% calories as ethanol, given for 3 weeks) increased levels of hepatic cyp2e1 protein (1.9-fold that of untreated controls) and mrna (2.1-fold). |
1994-04-21 |
2023-08-12 |
rat |
| M Ingelman-Sundberg, I Johansson, H Yin, Y Terelius, E Eliasson, P Clot, E Alban. Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease. Alcohol (Fayetteville, N.Y.). vol 10. issue 6. 1994-04-14. PMID:8123198. |
in the tsukamoto-french model, ethanol causes an important 10-20-fold induction of ethanol-inducible cytochrome p4502e1 (cyp2e1), mediated through enzyme stabilization and increased rate of gene transcription. |
1994-04-14 |
2023-08-12 |
rat |
| T M Badger, M J Ronis, M Ingelman-Sundberg, R Hakka. Pulsatile blood alcohol and CYP2E1 induction during chronic alcohol infusions in rats. Alcohol (Fayetteville, N.Y.). vol 10. issue 6. 1994-04-14. PMID:8123199. |
we propose that the pulsatile bacs are caused by an ethanol concentration-dependent regulation of an ethanol metabolizing system, perhaps cyp2e1. |
1994-04-14 |
2023-08-12 |
rat |