| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Comoglio, A Tomasi, S Malandrino, G Poli, E Alban. Scavenging effect of silipide, a new silybin-phospholipid complex, on ethanol-derived free radicals. Biochemical pharmacology. vol 50. issue 8. 1995-12-14. PMID:7488251. |
this effect is not due to an interference with the metabolism of ethanol by cyp2e1, but is rather related to the capacity of the silybin molecule to scavenge hydroxyethyl radicals. |
1995-12-14 |
2023-08-12 |
rat |
| W A Schmalix, M Barrenscheen, R Landsiedel, C Janzowski, G Eisenbrand, F Gonzalez, E Eliasson, M Ingelman-Sundberg, M Perchermeier, H Grei. Stable expression of human cytochrome P450 2E1 in V79 Chinese hamster cells. European journal of pharmacology. vol 293. issue 2. 1995-12-04. PMID:7589226. |
cyp2e1 content and activity was increased upon cultivation in the presence of ethanol indicating a substrate mediated stabilization effect. |
1995-12-04 |
2023-08-12 |
human |
| K O Lindros, T Badger, M Ronis, M Ingelman-Sundberg, M Koivusal. Phenethyl isothiocyanate, a new dietary liver aldehyde dehydrogenase inhibitor. The Journal of pharmacology and experimental therapeutics. vol 275. issue 1. 1995-11-21. PMID:7562599. |
we administered peitc to rats treated chronically with ethanol for 38 days by means of total enteral nutrition model to inhibit cyp2e1. |
1995-11-21 |
2023-08-12 |
rat |
| A Zerilli, D Lucas, Y Amet, F Beauge, A Volant, H H Floch, F Berthou, J F Mene. Cytochrome P-450 2E1 in rat liver, kidney and lung microsomes after chronic administration of ethanol either orally or by inhalation. Alcohol and alcoholism (Oxford, Oxfordshire). vol 30. issue 3. 1995-11-20. PMID:7545990. |
in this study, microsomal cytochrome p-450 2e1 (cyp2e1) contents and activities were tested in liver, kidney and lung from wistar rats after the following treatments (1) oral administration of a 10% ethanol solution for 4 weeks; (2) pair fed controls; (3) oral administration of a 5% acetone solution for 1 week; (4) inhalation of ethanol vapour for 4 weeks. |
1995-11-20 |
2023-08-12 |
rat |
| V E Kostrubsky, S C Strom, S G Wood, S A Wrighton, P R Sinclair, J F Sinclai. Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes. Archives of biochemistry and biophysics. vol 322. issue 2. 1995-11-06. PMID:7574728. |
in primary cultures of human hepatocytes prepared from three separate livers, ethanol increased both cyp3a and cyp2e1, as detected immunochemically. |
1995-11-06 |
2023-08-12 |
human |
| Y Hu, M Ingelman-Sundberg, K O Lindro. Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation. Biochemical pharmacology. vol 50. issue 2. 1995-09-01. PMID:7632158. |
in contrast to most other cyp forms, which are ligand-activated at the transcriptional level, ethanol induction of cyp2e1 has been found to be post-translational. |
1995-09-01 |
2023-08-12 |
rat |
| Y Hu, M Ingelman-Sundberg, K O Lindro. Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation. Biochemical pharmacology. vol 50. issue 2. 1995-09-01. PMID:7632158. |
however, transcriptional activation of the cyp2e1 gene was recently described in fed animals maintained at very high ethanol levels. |
1995-09-01 |
2023-08-12 |
rat |
| Y Hu, M Ingelman-Sundberg, K O Lindro. Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation. Biochemical pharmacology. vol 50. issue 2. 1995-09-01. PMID:7632158. |
by comparison, the amount of cyp2e1 mrna, as assayed both by northern blot and slot blot, was significantly increased (5- to 6-fold) by ethanol only in fasted rats; this increase was smaller than that observed after fasting alone (8- to 9-fold). |
1995-09-01 |
2023-08-12 |
rat |
| Y Hu, M Ingelman-Sundberg, K O Lindro. Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation. Biochemical pharmacology. vol 50. issue 2. 1995-09-01. PMID:7632158. |
thus no evidence was obtained for an increased pretranslational cyp2e1 gene expression as a consequence of the continuous presence of ethanol at intoxicating levels for 3 days. |
1995-09-01 |
2023-08-12 |
rat |
| Y Hu, M Ingelman-Sundberg, K O Lindro. Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation. Biochemical pharmacology. vol 50. issue 2. 1995-09-01. PMID:7632158. |
our results indicate that transcriptional activation of cyp2e1 requires the long-term presence of highly intoxicating ethanol levels. |
1995-09-01 |
2023-08-12 |
rat |
| H R Ha, J Chen, A U Freiburghaus, F Follat. Metabolism of theophylline by cDNA-expressed human cytochromes P-450. British journal of clinical pharmacology. vol 39. issue 3. 1995-08-28. PMID:7619675. |
the data suggest also that not only tobacco smoking but also chronic alcohol intake may influence theophylline elimination in man as ethanol induces cyp2e1. |
1995-08-28 |
2023-08-12 |
human |
| T M Badger, M J Ronis, M Ingelman-Sundberg, R Hakka. Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions. European journal of biochemistry. vol 230. issue 3. 1995-08-10. PMID:7601153. |
continuous, long-term intragastric infusions of ethanol leads to a two-step induction of hepatic cytochrome p450 2e1 (cyp2e1) that is correlated with blood ethanol concentrations (becs) and urine alcohol concentrations (uecs). |
1995-08-10 |
2023-08-12 |
rat |
| T M Badger, M J Ronis, M Ingelman-Sundberg, R Hakka. Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions. European journal of biochemistry. vol 230. issue 3. 1995-08-10. PMID:7601153. |
in the present study, rats were treated with ethanol (levels reaching 13 g.kg-1.day-1) for 38 days in the presence of compounds reported to block cyp2e1 activity or expression, to study the possible involvement of cyp2e1 in the pulsatile becs. |
1995-08-10 |
2023-08-12 |
rat |
| T M Badger, M J Ronis, M Ingelman-Sundberg, R Hakka. Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions. European journal of biochemistry. vol 230. issue 3. 1995-08-10. PMID:7601153. |
hepatic microsomal metabolism of carbon tetrachloride and p-nitrophenol, as well as mean cyp2e1 apoprotein levels, were significantly greater (p < or = 0.05) in ethanol-treated rats than in control rats, whereas rats treated with das, cmz or pet had significantly (p < or = 0.05) reduced p-nitrophenol and carbon tetrachloride metabolism and lower cyp2e1 apoprotein levels compared to those of ethanol controls. |
1995-08-10 |
2023-08-12 |
rat |
| T M Badger, M J Ronis, M Ingelman-Sundberg, R Hakka. Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions. European journal of biochemistry. vol 230. issue 3. 1995-08-10. PMID:7601153. |
none of the putative cyp2e1 blockers altered the pulsatile nature of ethanol in urine. |
1995-08-10 |
2023-08-12 |
rat |
| K Iwahashi, R Miyatake, K Nakamura, H Suwaki, H Kinoshita, K Ameno, I Ijiri, Y Ishikawa, H Yoneyama, T Mendor. [The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism]. Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence. vol 30. issue 2. 1995-08-01. PMID:7598661. |
[the ethanol elimination pharmacokinetics--the effects of genotypes of aldh2 and cyp2e1 on the ethanol metabolism]. |
1995-08-01 |
2023-08-12 |
human |
| K Iwahashi, R Miyatake, K Nakamura, H Suwaki, H Kinoshita, K Ameno, I Ijiri, Y Ishikawa, H Yoneyama, T Mendor. [The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism]. Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence. vol 30. issue 2. 1995-08-01. PMID:7598661. |
the effect of cyp2e1 upon the blood ethanol level was investigated. |
1995-08-01 |
2023-08-12 |
human |
| K Iwahashi, R Miyatake, K Nakamura, H Suwaki, H Kinoshita, K Ameno, I Ijiri, Y Ishikawa, H Yoneyama, T Mendor. [The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism]. Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence. vol 30. issue 2. 1995-08-01. PMID:7598661. |
the predicting 95% confidence bounds determined on regression analysis of these data suggested that after venous injection of ethanol, the blood ethanol concentration in a volunteer normal homozygous for cyp2e1 (c1/c1) is higher than that heterozygous (c1/c2). |
1995-08-01 |
2023-08-12 |
human |
| K Iwahashi, R Miyatake, K Nakamura, H Suwaki, H Kinoshita, K Ameno, I Ijiri, Y Ishikawa, H Yoneyama, T Mendor. [The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism]. Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence. vol 30. issue 2. 1995-08-01. PMID:7598661. |
and beta 60 (the blood ethanol concentration-time curve) of the subject heterozygous for cyp2e1 (c1/c2) was higher than that normal homozygous (c1/c1). |
1995-08-01 |
2023-08-12 |
human |
| K Iwahashi, R Miyatake, K Nakamura, H Suwaki, H Kinoshita, K Ameno, I Ijiri, Y Ishikawa, H Yoneyama, T Mendor. [The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism]. Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence. vol 30. issue 2. 1995-08-01. PMID:7598661. |
it is possible that the c2 allele corresponding to the higher cyp2e1 activity may affect the ethanol metabolism. |
1995-08-01 |
2023-08-12 |
human |