| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q Chen, M Galleano, A I Cederbau. Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1. The Journal of biological chemistry. vol 272. issue 23. 1997-06-26. PMID:9169410. |
the hep g2-mv2e1-9 cells appear to be a valuable model to study interaction between cyp2e1, polyunsaturated fatty acids, reactive radicals, and the consequence of these interactions on cell viability and to reproduce several of the key features associated with ethanol hepatotoxicity in the intragastric infusion model of ethanol treatment. |
1997-06-26 |
2023-08-12 |
human |
| S W French, M Morimoto, R C Reitz, D Koop, B Klopfenstein, K Estes, P Clot, M Ingelman-Sundberg, E Alban. Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats. The Journal of nutrition. vol 127. issue 5 Suppl. 1997-06-13. PMID:9164261. |
the cyp2e1 inhibitors partially prevented cyp2e1 induction by ethanol and completely blocked lipid peroxidation. |
1997-06-13 |
2023-08-12 |
rat |
| S W French, M Morimoto, R C Reitz, D Koop, B Klopfenstein, K Estes, P Clot, M Ingelman-Sundberg, E Alban. Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats. The Journal of nutrition. vol 127. issue 5 Suppl. 1997-06-13. PMID:9164261. |
lauric acid omega-1 hydroxidation by the liver microsomes in vitro was increased by ethanol and partially blocked by cyp2e1 inhibitors. |
1997-06-13 |
2023-08-12 |
rat |
| S W French, M Morimoto, R C Reitz, D Koop, B Klopfenstein, K Estes, P Clot, M Ingelman-Sundberg, E Alban. Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats. The Journal of nutrition. vol 127. issue 5 Suppl. 1997-06-13. PMID:9164261. |
however, although ethanol feeding increased the total hydroxidation and epoxidation of arachidonic acid, these were not inhibited by cyp2e1 inhibitors. |
1997-06-13 |
2023-08-12 |
rat |
| M X Yang, A I Cederbau. Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1. Archives of biochemistry and biophysics. vol 341. issue 1. 1997-06-03. PMID:9143349. |
cyp2e1 substrates or ligands such as 4-methylpyrazole, ethanol, glycerol, and dimethyl sulfoxide protected cyp2e1 against this rapid degradation, whereas ccl4 accelerated this process. |
1997-06-03 |
2023-08-12 |
human |
| S Kunitoh, S Imaoka, T Hiroi, Y Yabusaki, T Monna, Y Funa. Acetaldehyde as well as ethanol is metabolized by human CYP2E1. The Journal of pharmacology and experimental therapeutics. vol 280. issue 2. 1997-03-17. PMID:9023260. |
acetaldehyde as well as ethanol is metabolized by human cyp2e1. |
1997-03-17 |
2023-08-12 |
human |
| K Iwahashi, K Ameno, H Kinoshita, K Nakamura, R Miyatake, H Suwaki, I Ijiri, Y Ishikawa, Y Ichikawa, T Mendori, K Orin. [The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 31. issue 6. 1997-03-12. PMID:9011144. |
[the ethanol elimination pharmacokinetics--the effects of genotypes of aldh2 and cyp2e1 on the ethanol metabolism]. |
1997-03-12 |
2023-08-12 |
human |
| K Iwahashi, K Ameno, H Kinoshita, K Nakamura, R Miyatake, H Suwaki, I Ijiri, Y Ishikawa, Y Ichikawa, T Mendori, K Orin. [The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 31. issue 6. 1997-03-12. PMID:9011144. |
the effects of the genotypes of cyp2e1, aldh2, adh upon the blood ethanol and acetaldehyde levels were investigated. |
1997-03-12 |
2023-08-12 |
human |
| K Iwahashi, K Ameno, H Kinoshita, K Nakamura, R Miyatake, H Suwaki, Y Ichikawa, I Ijir. CYP2E1, ALDH2 and ADH2 genotypes and blood ethanol elimination kinetics. Clinica chimica acta; international journal of clinical chemistry. vol 255. issue 1. 1997-03-05. PMID:8930415. |
cyp2e1, aldh2 and adh2 genotypes and blood ethanol elimination kinetics. |
1997-03-05 |
2023-08-12 |
Not clear |
| C Nebbia, M Dacasto, L Ceppa, S Bosia, E Burdino, R F Witkamp, G Ugazi. Gender differences in ethanol oxidation and cytochrome P4502E1 content and functions in hepatic microsomes from alcohol-preferring and non-preferring rats. Xenobiotica; the fate of foreign compounds in biological systems. vol 26. issue 11. 1997-02-28. PMID:8948088. |
we have studied the hepatic microsomal metabolism of ethanol (meos), cyp2e1 expression and catalytic activity, and the response to phenobarbital (pb) induction or ccl4 challenge in rats of either sex genetically selected for their preference (p) or aversion (np) for ethanol. |
1997-02-28 |
2023-08-12 |
rat |
| C Nebbia, M Dacasto, L Ceppa, S Bosia, E Burdino, R F Witkamp, G Ugazi. Gender differences in ethanol oxidation and cytochrome P4502E1 content and functions in hepatic microsomes from alcohol-preferring and non-preferring rats. Xenobiotica; the fate of foreign compounds in biological systems. vol 26. issue 11. 1997-02-28. PMID:8948088. |
these results indicate that, in females only, the behavioural trait of ethanol preference is apparently associated not only with higher constitutive levels of cyp2e1 and rate of microsomal metabolism of ethanol but also with altered susceptibility to pb induction. |
1997-02-28 |
2023-08-12 |
rat |
| D Gergel, V Misík, P Riesz, A I Cederbau. Inhibition of rat and human cytochrome P4502E1 catalytic activity and reactive oxygen radical formation by nitric oxide. Archives of biochemistry and biophysics. vol 337. issue 2. 1997-02-24. PMID:9016819. |
cytochrome p4502e1 (cyp2e1) is induced by ethanol and plays an important role in the toxicity of ethanol and other hepatotoxins. |
1997-02-24 |
2023-08-12 |
human |
| D Gergel, V Misík, P Riesz, A I Cederbau. Inhibition of rat and human cytochrome P4502E1 catalytic activity and reactive oxygen radical formation by nitric oxide. Archives of biochemistry and biophysics. vol 337. issue 2. 1997-02-24. PMID:9016819. |
cyp2e1 is also very effective in generating reactive oxygen intermediates such as superoxide radical and h2o2, oxidizing ethanol to the 1-hydroxyethyl radical, and has a high nadph oxidase activity. |
1997-02-24 |
2023-08-12 |
human |
| L Verna, J Whysner, G M William. N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacology & therapeutics. vol 71. issue 1-2. 1997-02-07. PMID:8910949. |
bioactivation is effected by several p450 isozymes including cyp2e1, which is ethanol inducible. |
1997-02-07 |
2023-08-12 |
rat |
| J M Ladero, J A Agúndez, A Rodríguez-Lescure, M Diaz-Rubio, J Beníte. RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma. Gut. vol 39. issue 2. 1997-01-10. PMID:8977352. |
cyp2e1, the coding gene for the ethanol inducible cytochrome p4502e1, is polymorphic at the rsai restriction site in the 5' flanking region. |
1997-01-10 |
2023-08-12 |
Not clear |
| N Tindberg, M Ingelman-Sundber. Expression, catalytic activity, and inducibility of cytochrome P450 2E1 (CYP2E1) in the rat central nervous system. Journal of neurochemistry. vol 67. issue 5. 1996-12-02. PMID:8863515. |
it is concluded that cyp2e1 is expressed and catalytically active in the rat cns, and that cyp2e1 can be induced by a relatively low concentration of ethanol in cortical glial cultures. |
1996-12-02 |
2023-08-12 |
rat |
| D Wu, A I Cederbau. Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. The Journal of biological chemistry. vol 271. issue 39. 1996-11-18. PMID:8798623. |
the effect of ethanol on the viability of a hepg2 cell model which was developed to constitutively express human cyp2e1 was studied in an attempt to establish a linkage between cyp2e1, reactive oxygen intermediates, and ethanol toxicity. |
1996-11-18 |
2023-08-12 |
human |
| D Wu, A I Cederbau. Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. The Journal of biological chemistry. vol 271. issue 39. 1996-11-18. PMID:8798623. |
ethanol was toxic to hepg2 e9 cells, which express cyp2e1, but not to hepg2 mv5 cells, which do not express cyp2e1. |
1996-11-18 |
2023-08-12 |
human |
| D Wu, A I Cederbau. Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. The Journal of biological chemistry. vol 271. issue 39. 1996-11-18. PMID:8798623. |
phorbol 12-myristate 13-acetate, which increases the expression of cyp2e1 in this model, increased the toxicity by ethanol. |
1996-11-18 |
2023-08-12 |
human |
| D Wu, A I Cederbau. Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. The Journal of biological chemistry. vol 271. issue 39. 1996-11-18. PMID:8798623. |
ethanol toxicity was prevented by 4-methylpyrazole and by diallyl sulfide, inhibitors of cyp2e1. |
1996-11-18 |
2023-08-12 |
human |