| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S P Carpenter, J M Lasker, J L Rauc. Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes. Molecular pharmacology. vol 49. issue 2. 1996-07-03. PMID:8632758. |
collectively, our results indicate that cyp2e1 is present in human fetal liver, that the enzyme is functionally similar to cyp2e1 from adults, and that fetal hepatocyte cyp2e1 is inducible in culture by xenobiotics, including ethanol. |
1996-07-03 |
2023-08-12 |
human |
| S P Carpenter, J M Lasker, J L Rauc. Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes. Molecular pharmacology. vol 49. issue 2. 1996-07-03. PMID:8632758. |
because fetal cyp2e1 mediates ethanol metabolism, the enzyme may play a pivotal role in the local production of acetaldehyde and free radicals, both of which have potential deleterious effects on the developing fetus. |
1996-07-03 |
2023-08-12 |
human |
| D Wu, A I Cederbau. Expression of cytochrome P4502E1 in rat fetal hepatocyte culture. Molecular pharmacology. vol 49. issue 5. 1996-06-19. PMID:8622629. |
the addition of ethanol to the hepatocyte cultures did not have a significant effect on cyp2e1 catalytic oxidation of substrates or cyp2e1 mrna levels. |
1996-06-19 |
2023-08-12 |
human |
| D Wu, A I Cederbau. Expression of cytochrome P4502E1 in rat fetal hepatocyte culture. Molecular pharmacology. vol 49. issue 5. 1996-06-19. PMID:8622629. |
these results suggest that cultures of rat and human fetal hepatocytes may be a valuable model with which to study factors that regulate expression of cyp2e1 and the influence of ethanol and other inducers on expression and stabilization of cyp2e1. |
1996-06-19 |
2023-08-12 |
human |
| Y Amet, F Berthou, S Baird, Y Dreano, J P Bail, J F Mene. Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. Biochemical pharmacology. vol 50. issue 11. 1996-06-06. PMID:8615855. |
the (omega-1)-hydroxylation of lauric acid was inhibited by ethanol (ki = 3.5 mm), acetone (ic50 = 10 mm) dimethylsulfoxide, chlorzoxazone (competitive inhibitors of cyp2e1), diethyldithiocarbamate, and diallylsulfide (both selective mechanism-based inactivators of cyp2e1). |
1996-06-06 |
2023-08-12 |
human |
| J A O'Shaughnessy, L G Sultato. Interaction of ethanol and the organophosphorus insecticide parathion. Biochemical pharmacology. vol 50. issue 11. 1996-06-06. PMID:8615874. |
the presence of ethanol within hepatic microsomal incubations did not alter the p450-dependent formation of paraoxon (activation) and p-nitrophenol (detoxification), although p-nitrophenol levels were increased in the presence of ethanol as a result of inhibition of its biotransformation to 4-nitrocatechol by cyp2e1. |
1996-06-06 |
2023-08-12 |
mouse |
| E Albano, P Clot, M Morimoto, A Tomasi, M Ingelman-Sundberg, S W Frenc. Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology (Baltimore, Md.). vol 23. issue 1. 1996-02-20. PMID:8550035. |
we have previously shown that the treatment with diallyl sulfide (das) and phenylethyl isothiocyanate (pic) of rats receiving ethanol in the alcohol tube-feeding model effectively suppressed the induction of cytochrome p4502e1 (cyp2e1) by ethanol. |
1996-02-20 |
2023-08-12 |
rat |
| E Albano, P Clot, M Morimoto, A Tomasi, M Ingelman-Sundberg, S W Frenc. Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology (Baltimore, Md.). vol 23. issue 1. 1996-02-20. PMID:8550035. |
thus, these results indicated a link between the induction of cyp2e1 by ethanol, the formation of hydroxyethyl radicals and the stimulation of lipid peroxidation. |
1996-02-20 |
2023-08-12 |
rat |
| Y Dai, A I Cederbau. Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line. The Journal of pharmacology and experimental therapeutics. vol 275. issue 3. 1996-02-01. PMID:8531136. |
this increase was completely prevented by 4-methylpyrazole and ethanol indicating its dependence on cyp2e1. |
1996-02-01 |
2023-08-12 |
human |
| R Hakkak, S Korourian, M J Ronis, M Ingelman-Sundberg, T M Badge. Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats. Biochemical pharmacology. vol 51. issue 1. 1996-01-30. PMID:8534269. |
our results indicate that cyp2e1 is present in colonic epithelial cells, and expression of colonic and hepatic microsomal cyp2e1 and cyp2c7 was increased by chronic ethanol intake. |
1996-01-30 |
2023-08-12 |
rat |
| R Hakkak, S Korourian, M J Ronis, M Ingelman-Sundberg, T M Badge. Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats. Biochemical pharmacology. vol 51. issue 1. 1996-01-30. PMID:8534269. |
diet and ethanol differentially regulated cyp2e1 and cyp2c7 in a tissue-specific manner such that the ethanol induced cyp2e1 and cyp2c7 in the colon and liver, and the intragastric diet alone had a tendency to induce these isozymes in the liver and reduce them in the colon. |
1996-01-30 |
2023-08-12 |
rat |
| B J Roberts, B J Song, Y Soh, S S Park, S E Shoa. Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. The Journal of biological chemistry. vol 270. issue 50. 1996-01-26. PMID:8530344. |
ethanol induces cyp2e1 by protein stabilization. |
1996-01-26 |
2023-08-12 |
Not clear |
| B J Roberts, B J Song, Y Soh, S S Park, S E Shoa. Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. The Journal of biological chemistry. vol 270. issue 50. 1996-01-26. PMID:8530344. |
in the present study, we demonstrate that ethanol induces cyp2e1 by protein stabilization in vivo. |
1996-01-26 |
2023-08-12 |
Not clear |
| B J Roberts, B J Song, Y Soh, S S Park, S E Shoa. Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. The Journal of biological chemistry. vol 270. issue 50. 1996-01-26. PMID:8530344. |
at concentrations approximating those found in vivo, ethanol protects cyp2e1 from cytosolic degradation. |
1996-01-26 |
2023-08-12 |
Not clear |
| M Morimoto, R C Reitz, R J Morin, K Nguyen, M Ingelman-Sundberg, S W Frenc. CYP-2E1 inhibitors partially ameliorate the changes in hepatic fatty acid composition induced in rats by chronic administration of ethanol and a high fat diet. The Journal of nutrition. vol 125. issue 12. 1996-01-18. PMID:7500173. |
the objective of this study was to determine if ethanol-induced cytochrome p450 2e1 (cyp2e1) was responsible for the changes in hepatic fatty acids observed in rats fed ethanol intragastrically. |
1996-01-18 |
2023-08-12 |
rat |
| M Morimoto, R C Reitz, R J Morin, K Nguyen, M Ingelman-Sundberg, S W Frenc. CYP-2E1 inhibitors partially ameliorate the changes in hepatic fatty acid composition induced in rats by chronic administration of ethanol and a high fat diet. The Journal of nutrition. vol 125. issue 12. 1996-01-18. PMID:7500173. |
we hypothesized that if cyp2e1 was responsible for these changes then cyp2e1 inhibitors fed with ethanol should prevent the ethanol-induced changes in fatty acids. |
1996-01-18 |
2023-08-12 |
rat |
| M Morimoto, R C Reitz, R J Morin, K Nguyen, M Ingelman-Sundberg, S W Frenc. CYP-2E1 inhibitors partially ameliorate the changes in hepatic fatty acid composition induced in rats by chronic administration of ethanol and a high fat diet. The Journal of nutrition. vol 125. issue 12. 1996-01-18. PMID:7500173. |
we compared the fatty acid composition of the liver in rats fed ethanol alone with that in rats fed ethanol with the cyp2e1 inhibitors, diallyl sulfide and phenethyl isothiocyanate. |
1996-01-18 |
2023-08-12 |
rat |
| M Morimoto, R C Reitz, R J Morin, K Nguyen, M Ingelman-Sundberg, S W Frenc. CYP-2E1 inhibitors partially ameliorate the changes in hepatic fatty acid composition induced in rats by chronic administration of ethanol and a high fat diet. The Journal of nutrition. vol 125. issue 12. 1996-01-18. PMID:7500173. |
ethanol altered the fatty acid composition compared with rats fed ethanol with cyp2e1 inhibitors. |
1996-01-18 |
2023-08-12 |
rat |
| C Montoliu, M Sancho-Tello, I Azorin, M Burgal, S Vallés, J Renau-Piqueras, C Guerr. Ethanol increases cytochrome P4502E1 and induces oxidative stress in astrocytes. Journal of neurochemistry. vol 65. issue 6. 1995-12-15. PMID:7595552. |
we demonstrate the presence of cytochrome p4502e1 (cyp2e1) in astrocytes in primary culture, its induction by ethanol, and the concomitant generation of free radical species. |
1995-12-15 |
2023-08-12 |
Not clear |
| C Montoliu, M Sancho-Tello, I Azorin, M Burgal, S Vallés, J Renau-Piqueras, C Guerr. Ethanol increases cytochrome P4502E1 and induces oxidative stress in astrocytes. Journal of neurochemistry. vol 65. issue 6. 1995-12-15. PMID:7595552. |
addition of 25 mm ethanol to the astrocyte culture medium for 14 days resulted in an increase in the cyp2e1 content, as determined by confocal microscopy and dot blot. |
1995-12-15 |
2023-08-12 |
Not clear |