| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Goasduff, J F Menez, Y Dreano, F Bertho. CYP1A2 and 2E1 expression in rat liver treated with combined inducers (3-methylcholanthrene and ethanol). Biochemical and biophysical research communications. vol 211. issue 2. 1995-07-24. PMID:7794261. |
the effects of combined ethanol and 3-methylcholanthrene treatment on rat hepatic cytochrome cyp1a2 and cyp2e1 expression were evaluated. |
1995-07-24 |
2023-08-12 |
rat |
| T Goasduff, J F Menez, Y Dreano, F Bertho. CYP1A2 and 2E1 expression in rat liver treated with combined inducers (3-methylcholanthrene and ethanol). Biochemical and biophysical research communications. vol 211. issue 2. 1995-07-24. PMID:7794261. |
treatments involving 3-methylcholanthrene and combined ethanol + 3-methylcholanthrene decreased both cyp2e1 expression at the mrna level (0.6 and 0.4 fold versus controls, respectively) and protein level (0.6 and 0.9 fold versus controls, respectively), while dramatically increasing cyp1a2 expression. |
1995-07-24 |
2023-08-12 |
rat |
| B J Roberts, S E Shoaf, B J Son. Rapid changes in cytochrome P4502E1 (CYP2E1) activity and other P450 isozymes following ethanol withdrawal in rats. Biochemical pharmacology. vol 49. issue 11. 1995-07-14. PMID:7786308. |
rapid changes in cytochrome p4502e1 (cyp2e1) activity and other p450 isozymes following ethanol withdrawal in rats. |
1995-07-14 |
2023-08-12 |
rat |
| M Morimoto, A L Hagbjörk, Y J Wan, P C Fu, P Clot, E Albano, M Ingelman-Sundberg, S W Frenc. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology (Baltimore, Md.). vol 21. issue 6. 1995-06-30. PMID:7768506. |
this study was done to determine if a relationship exists between cyp2e1 induction by ethanol, lipid peroxidation, and liver pathology in experimental alcohol-induced liver disease in the rat. |
1995-06-30 |
2023-08-12 |
rat |
| M Morimoto, A L Hagbjörk, Y J Wan, P C Fu, P Clot, E Albano, M Ingelman-Sundberg, S W Frenc. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology (Baltimore, Md.). vol 21. issue 6. 1995-06-30. PMID:7768506. |
cyp2e1 induction by ethanol was correlated with lipid peroxidation, liver microsomal cyp2e1 hydroxylation of paranitrophenol, and the liver pathology score using the data from the pic-fed rats. |
1995-06-30 |
2023-08-12 |
rat |
| M Morimoto, A L Hagbjörk, Y J Wan, P C Fu, P Clot, E Albano, M Ingelman-Sundberg, S W Frenc. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology (Baltimore, Md.). vol 21. issue 6. 1995-06-30. PMID:7768506. |
microsomal cyp2e1 protein levels induction by ethanol was decreased by pic ingestion. |
1995-06-30 |
2023-08-12 |
rat |
| M Morimoto, A L Hagbjörk, Y J Wan, P C Fu, P Clot, E Albano, M Ingelman-Sundberg, S W Frenc. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology (Baltimore, Md.). vol 21. issue 6. 1995-06-30. PMID:7768506. |
immunohistochemical staining of liver for cyp2e1 protein showed that the lobular distribution of the isozyme changed from the centrilobular to a diffuse pattern, with an increase in the periportal region when the cyp2e1 inhibitors were fed with ethanol, and that this change correlated with the change in the distribution of fat in the lobule. |
1995-06-30 |
2023-08-12 |
rat |
| M Morimoto, A L Hagbjörk, Y J Wan, P C Fu, P Clot, E Albano, M Ingelman-Sundberg, S W Frenc. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology (Baltimore, Md.). vol 21. issue 6. 1995-06-30. PMID:7768506. |
the data support the idea that there is a link between cyp2e1 induction by ethanol and the early phase of ethanol-induced liver injury in this rat model. |
1995-06-30 |
2023-08-12 |
rat |
| B B Rasmussen, J Maënpää, O Pelkonen, S Loft, H E Poulsen, J Lykkesfeldt, K Brøse. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. British journal of clinical pharmacology. vol 39. issue 2. 1995-06-12. PMID:7742153. |
ethanol inhibited the formation of 1,3-dimethyluric acid with k(i) value of 300 microm, a value which is consistent with inhibition of cyp2e1. |
1995-06-12 |
2023-08-12 |
human |
| B B Rasmussen, J Maënpää, O Pelkonen, S Loft, H E Poulsen, J Lykkesfeldt, K Brøse. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. British journal of clinical pharmacology. vol 39. issue 2. 1995-06-12. PMID:7742153. |
ethanol and fluvoxamine both inhibited 8-hydroxylation by about 45% and, in combination, the compounds decreased the formation of 1,3-dimethyluric acid by 90%, indicating that cyp1a2 and cyp2e1 are equally important isoforms for the 8-hydroxylation of theophylline. |
1995-06-12 |
2023-08-12 |
human |
| A D Ross, G Varghese, B Oporto, F J Carmichael, Y Israe. Effect of propylthiouracil treatment on NADPH-cytochrome P450 reductase levels, oxygen consumption and hydroxyl radical formation in liver microsomes from rats fed ethanol or acetone chronically. Biochemical pharmacology. vol 49. issue 7. 1995-06-02. PMID:7741770. |
the present study examined the effect of ptu on hepatic microsomal oxygen consumption and on the activities of nadph-cytochrome p450 reductase (cyp-reductase) and cytochrome p4502e1 (cyp2e1) in rats receiving ethanol or acetone chronically. |
1995-06-02 |
2023-08-12 |
rat |
| A D Ross, G Varghese, B Oporto, F J Carmichael, Y Israe. Effect of propylthiouracil treatment on NADPH-cytochrome P450 reductase levels, oxygen consumption and hydroxyl radical formation in liver microsomes from rats fed ethanol or acetone chronically. Biochemical pharmacology. vol 49. issue 7. 1995-06-02. PMID:7741770. |
microsomal cyp2e1 levels were increased markedly by chronic ethanol administration, while cyp-reductase was affected marginally, but not significantly (p = 0.06). |
1995-06-02 |
2023-08-12 |
rat |
| A D Ross, G Varghese, B Oporto, F J Carmichael, Y Israe. Effect of propylthiouracil treatment on NADPH-cytochrome P450 reductase levels, oxygen consumption and hydroxyl radical formation in liver microsomes from rats fed ethanol or acetone chronically. Biochemical pharmacology. vol 49. issue 7. 1995-06-02. PMID:7741770. |
administration of ptu (25 mg/kg/day) to ethanol- or acetone-fed rats, for 10 and 14 days, respectively, led to a marked reduction in the levels and activity of cyp-reductase, and to a decrease in the rates of microsomal o2 consumption, .oh production and ethanol oxidation, but did not lower the levels of cyp2e1 or the metabolism of the cyp2e1 substrate n,n-nitrosodimethylamine. |
1995-06-02 |
2023-08-12 |
rat |
| Y J Wan, M Morimoto, R G Thurman, H K Bojes, S W Frenc. Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease. Life sciences. vol 56. issue 5. 1995-02-27. PMID:7837930. |
in contrast, the levels of ppar and cyp2e1 mrnas were down- and up-regulated by ethanol in the liver, respectively. |
1995-02-27 |
2023-08-12 |
rat |
| B J Roberts, S E Shoaf, K S Jeong, B J Son. Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochemical and biophysical research communications. vol 205. issue 2. 1995-01-25. PMID:7802633. |
induction of cyp2e1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that cyp2e1 possesses a rapid phase half-life of 6 hours or less. |
1995-01-25 |
2023-08-12 |
rat |
| B J Roberts, S E Shoaf, K S Jeong, B J Son. Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochemical and biophysical research communications. vol 205. issue 2. 1995-01-25. PMID:7802633. |
controversy exists as to whether the induction of cyp2e1 by ethanol occurs via increased protein synthesis or protein stabilization. |
1995-01-25 |
2023-08-12 |
rat |
| B J Roberts, S E Shoaf, K S Jeong, B J Son. Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochemical and biophysical research communications. vol 205. issue 2. 1995-01-25. PMID:7802633. |
to address these issues in vivo, we chronically administered ethanol to rats and determined levels of immunoreactive cyp2e1 in liver, kidney, brain and upper gastro-intestinal tract (gi). |
1995-01-25 |
2023-08-12 |
rat |
| B J Roberts, S E Shoaf, K S Jeong, B J Son. Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochemical and biophysical research communications. vol 205. issue 2. 1995-01-25. PMID:7802633. |
our data shows that chronic ethanol administration induces hepatic (5-6-fold over pair-fed controls) and extra-hepatic cyp2e1, an effect which is strikingly absent 12 hours after ethanol withdrawal. |
1995-01-25 |
2023-08-12 |
rat |
| B J Roberts, S E Shoaf, K S Jeong, B J Son. Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochemical and biophysical research communications. vol 205. issue 2. 1995-01-25. PMID:7802633. |
no changes in cyp2e1 mrna were observed at any time, suggesting these changes are mainly post-translational at a blood ethanol concentration of 0.15% w/v. |
1995-01-25 |
2023-08-12 |
rat |
| B J Roberts, S E Shoaf, K S Jeong, B J Son. Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochemical and biophysical research communications. vol 205. issue 2. 1995-01-25. PMID:7802633. |
our experimental data indicates that cyp2e1 possesses a half-life of 6 hours or less in the liver and is rapidly degraded following the removal of ethanol. |
1995-01-25 |
2023-08-12 |
rat |