| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Dupont, D Lucas, P Clot, C Ménez, E Alban. Cytochrome P4502E1 inducibility and hydroxyethyl radical formation among alcoholics. Journal of hepatology. vol 28. issue 4. 1998-06-18. PMID:9566824. |
animal studies have shown that the induction of cytochrome p4502e1 (cyp2e1) modulates oxidative damage induced by ethanol. |
1998-06-18 |
2023-08-12 |
Not clear |
| U Klotz, E Ammo. Clinical and toxicological consequences of the inductive potential of ethanol. European journal of clinical pharmacology. vol 54. issue 1. 1998-06-11. PMID:9591923. |
ethanol is consumed worldwide in tremendous amounts and is an effective inducer of hepatic drug metabolism, especially involving pathways accomplished by the cyp2e1 isoform of the cytochrome p-450 (cyp) superfamily. |
1998-06-11 |
2023-08-12 |
Not clear |
| C Fang, K O Lindros, T M Badger, M J Ronis, M Ingelman-Sundber. Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole. Hepatology (Baltimore, Md.). vol 27. issue 5. 1998-05-19. PMID:9581684. |
chronic ethanol treatment significantly increased the expression of cyp2e1, microsomal p-nitrophenol hydroxylase activity (indicative for cyp2e1 enzyme activity), and the expression of transforming growth factor beta1 (tgf-beta1), tumor necrosis factor alpha (tnf-alpha), and interleukin (il)-1beta (1.4- to 4.6-fold). |
1998-05-19 |
2023-08-12 |
rat |
| I D Norton, M V Apte, P S Haber, G W McCaughan, R C Pirola, J S Wilso. Cytochrome P4502E1 is present in rat pancreas and is induced by chronic ethanol administration. Gut. vol 42. issue 3. 1998-05-14. PMID:9577353. |
in the liver, cytochrome p4502e1 (cyp2e1, the inducible ethanol metabolising enzyme) is one of the proposed pathways by which ethanol induces oxidative stress. |
1998-05-14 |
2023-08-12 |
rat |
| M J Ronis, J Huang, V Longo, N Tindberg, M Ingelman-Sundberg, T M Badge. Expression and distribution of cytochrome P450 enzymes in male rat kidney: effects of ethanol, acetone and dietary conditions. Biochemical pharmacology. vol 55. issue 2. 1998-02-18. PMID:9448734. |
in the chronic 35-day ethanol exposure experiment, cyp2e1 apoprotein was also elevated 6-fold and this was found to be accompanied by a significant 3-fold increase in cyp2e1 mrna. |
1998-02-18 |
2023-08-12 |
rat |
| M J Ronis, J Huang, V Longo, N Tindberg, M Ingelman-Sundberg, T M Badge. Expression and distribution of cytochrome P450 enzymes in male rat kidney: effects of ethanol, acetone and dietary conditions. Biochemical pharmacology. vol 55. issue 2. 1998-02-18. PMID:9448734. |
thus, acetone induced a variety of renal cytochrome p450 forms in addition to cyp2e1, while ethanol appeared to be a much more specific renal cyp2e1 inducer. |
1998-02-18 |
2023-08-12 |
rat |
| M J Ronis, J Huang, V Longo, N Tindberg, M Ingelman-Sundberg, T M Badge. Expression and distribution of cytochrome P450 enzymes in male rat kidney: effects of ethanol, acetone and dietary conditions. Biochemical pharmacology. vol 55. issue 2. 1998-02-18. PMID:9448734. |
furthermore, as reported in the liver, acetone and ethanol appeared to induce cyp2e1 in the kidney by different mechanisms. |
1998-02-18 |
2023-08-12 |
rat |
| N Rizzo, E Hispard, S Dolbeault, S Dally, R Leverge, C Girr. Impact of long-term ethanol consumption on CYP1A2 activity. Clinical pharmacology and therapeutics. vol 62. issue 5. 1997-12-18. PMID:9390106. |
ethanol is a well-known inducer of cyp2e1; whether or not it is an inducer of other cytochromes has not been investigated systematically. |
1997-12-18 |
2023-08-12 |
human |
| M Lechevrel, C P Wil. Absence of a differential induction of cytochrome P450 2E1 by different alcoholic beverages in rats: implications for the aetiology of human oesophageal cancer. Archives of toxicology. vol 71. issue 11. 1997-12-04. PMID:9363842. |
however, there were no significant differences in the level of cyp2e1 protein or enzymatic activity between the different alcoholic beverages at the same ethanol concentration. |
1997-12-04 |
2023-08-12 |
human |
| M Lechevrel, C P Wil. Absence of a differential induction of cytochrome P450 2E1 by different alcoholic beverages in rats: implications for the aetiology of human oesophageal cancer. Archives of toxicology. vol 71. issue 11. 1997-12-04. PMID:9363842. |
these data show that induction of cyp2e1 with acute alcohol treatment is predominantly determined by the ethanol content of the beverage. |
1997-12-04 |
2023-08-12 |
human |
| Y Amet, A Zerilli, T Goasduff, Y Dréano, F Bertho. Noninvolvement of CYP2E1 in the (omega-1)-hydroxylation of fatty acids in rat kidney microsomes. Biochemical pharmacology. vol 54. issue 8. 1997-11-21. PMID:9354595. |
pyrazole, acetone, and ethanol are known to induce cytochrome p450 2e1 (cyp2e1) and fatty acid (omega-1)-hydroxylation in rat liver microsomes. |
1997-11-21 |
2023-08-12 |
human |
| Y Amet, A Zerilli, T Goasduff, Y Dréano, F Bertho. Noninvolvement of CYP2E1 in the (omega-1)-hydroxylation of fatty acids in rat kidney microsomes. Biochemical pharmacology. vol 54. issue 8. 1997-11-21. PMID:9354595. |
chemical inhibitions using either cyp2e1 competitive inhibitors (such as chlorzoxazone, dmso, and ethanol) or p450 mechanism-based inhibitors (such as diethyldithiocarbamate and 17-octadecynoic acid) led to a partial inhibition of the hydroxylations. |
1997-11-21 |
2023-08-12 |
human |
| K H Lee, B Y Kwak, J H Kim, S K Yoo, S K Yum, H S Jeon. Genetic polymorphism of cytochrome P-4502E1 and mitochondrial aldehyde dehydrogenase in a Korean population. Alcoholism, clinical and experimental research. vol 21. issue 6. 1997-11-04. PMID:9309300. |
cytochrome p-4502e1 (cyp2e1), a liver microsomal enzyme, also metabolizes acetaldehyde and ethanol. |
1997-11-04 |
2023-08-12 |
Not clear |
| S P Carpenter, D D Savage, E D Schultz, J L Rauc. Ethanol-mediated transplacental induction of CYP2E1 in fetal rat liver. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262372. |
we examined the potential for the widely consumed xenobiotic ethanol to transplacentally induce fetal rat cyp2e1. |
1997-09-11 |
2023-08-12 |
rat |
| S P Carpenter, D D Savage, E D Schultz, J L Rauc. Ethanol-mediated transplacental induction of CYP2E1 in fetal rat liver. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262372. |
collectively, fetuses exposed to a 5% ethanol diet throughout gestation exhibited transplacental induction of an hepatic cyp2e1 that may possess different catalytic properties from the analogous adult enzyme. |
1997-09-11 |
2023-08-12 |
rat |
| A Zhukov, M Ingelman-Sundber. Selective fast degradation of cytochrome P-450 2E1 in serum-deprived hepatoma cells by a mechanism sensitive to inhibitors of vesicular transport. European journal of biochemistry. vol 247. issue 1. 1997-08-21. PMID:9249006. |
the effect of serum withdrawal was specific for cyp2e1 since (a) no concomitant fast degradation of cyp2b1 and nadph-cytochrome p-450 reductase was observed and (b) the cyp2e1 ligands ethanol and imidazole prevented the fast degradation of the enzyme. |
1997-08-21 |
2023-08-12 |
Not clear |
| M X Yang, A I Cederbau. Glycerol increases content and activity of human cytochrome P-4502E1 in a transduced HepG2 cell line by protein stabilization. Alcoholism, clinical and experimental research. vol 21. issue 2. 1997-07-22. PMID:9113273. |
stabilization of cyp2e1 protein by glycerol was not additive or synergistic with the increase of cyp2e1 by ethanol or 4-methylpyrazole, suggesting that all three agents elevate cyp2e1 by a similar type of mechanism in this model. |
1997-07-22 |
2023-08-12 |
human |
| D R Koop, B Klopfenstein, Y Iimuro, R G Thurma. Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Molecular pharmacology. vol 51. issue 6. 1997-07-14. PMID:9187260. |
however, in the ethanol and gdcl3-treated animals, there was no significant decrease in the induction of cyp2e1. |
1997-07-14 |
2023-08-12 |
rat |
| D R Koop, B Klopfenstein, Y Iimuro, R G Thurma. Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Molecular pharmacology. vol 51. issue 6. 1997-07-14. PMID:9187260. |
cyp2e1 was elevated approximately 5-fold, as estimated by immunoblot analysis, and rates of p-nitrophenol and chlorzoxazone hydroxylation were elevated 3- to 4-fold in ethanol + gdcl3-treated rats. |
1997-07-14 |
2023-08-12 |
rat |
| D R Koop, B Klopfenstein, Y Iimuro, R G Thurma. Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Molecular pharmacology. vol 51. issue 6. 1997-07-14. PMID:9187260. |
thus, these results clearly dissociate the induction of cyp2e1 by intragastric infusion of ethanol from the generation of early alcohol-induced liver disease. |
1997-07-14 |
2023-08-12 |
rat |