| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D H Daiker, B K Shipp, H A Schoenfeld, G R Klimpel, G Witz, M T Moslen, J B War. Effect of CYP2E1 induction by ethanol on the immunotoxicity and genotoxicity of extended low-level benzene exposure. Journal of toxicology and environmental health. Part A. vol 59. issue 3. 2000-02-28. PMID:10667633. |
ethanol is a potent inducer of the cytochrome p-450 2e1 (cyp2e1) enzyme, which bioactivates benzene to metabolites with known genotoxicity and immunotoxicity. |
2000-02-28 |
2023-08-12 |
mouse |
| D H Daiker, B K Shipp, H A Schoenfeld, G R Klimpel, G Witz, M T Moslen, J B War. Effect of CYP2E1 induction by ethanol on the immunotoxicity and genotoxicity of extended low-level benzene exposure. Journal of toxicology and environmental health. Part A. vol 59. issue 3. 2000-02-28. PMID:10667633. |
a liquid diet containing 4.1% ethanol was used to induce hepatic cyp2e1 activity by 4-fold in female cd-1 mice. |
2000-02-28 |
2023-08-12 |
mouse |
| D H Daiker, B K Shipp, H A Schoenfeld, G R Klimpel, G Witz, M T Moslen, J B War. Effect of CYP2E1 induction by ethanol on the immunotoxicity and genotoxicity of extended low-level benzene exposure. Journal of toxicology and environmental health. Part A. vol 59. issue 3. 2000-02-28. PMID:10667633. |
this observed absence of immunomodulation by ethanol alone, a potential confounding factor, further validates our previously established murine model of sustained cyp2e1 induction by dietary ethanol. |
2000-02-28 |
2023-08-12 |
mouse |
| Y Nishimura, N Kurata, M Iwase, H Li, H Yasuhar. The effects of organic solvents on trimethadione n-demethylation in rats. Research communications in molecular pathology and pharmacology. vol 104. issue 2. 2000-02-11. PMID:10634315. |
in this study we investigated the effects of organic solvents, such as acetonitrile (an), dimethylsulfoxide (dmso), ethanol (etoh), methanol (meoh), polyethylene glycol (peg) and propylene glycol (pg) on tmo (trimethadione) metabolism, which is mainly mediated by cyp2e1 in the rat. |
2000-02-11 |
2023-08-12 |
rat |
| M J Huentelman, C M Peters, W E Ervine, S M Polutnik, P Johnso. Ethanol has differential effects on rat neuron and thymocyte reactive oxygen species levels and cell viability. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. vol 124. issue 1. 2000-02-04. PMID:10579652. |
these parameters in neurons were relatively unaffected when the cells were incubated with ethanol in the presence of inhibitors of alcohol-oxidizing enzymes, but in thymocytes, the presence of diallyl sulfide (an inhibitor of alcohol-inducible cytochrome p450, cyp2e1) or 4-methylpyrazole (an inhibitor of cyp2e1 and alcohol dehydrogenase) caused decreases in ros production from ethanol. |
2000-02-04 |
2023-08-12 |
rat |
| H Kono, B U Bradford, M Yin, K K Sulik, D R Koop, J M Peters, F J Gonzalez, T McDonald, A Dikalova, M B Kadiiska, R P Mason, R G Thurma. CYP2E1 is not involved in early alcohol-induced liver injury. The American journal of physiology. vol 277. issue 6. 2000-01-20. PMID:10600824. |
female cyp2e1 wild-type (+/+) or -/- mice were given a high-fat liquid diet with either ethanol or isocaloric maltose-dextrin as control continuously for 4 wk. |
2000-01-20 |
2023-08-12 |
mouse |
| H Kono, B U Bradford, M Yin, K K Sulik, D R Koop, J M Peters, F J Gonzalez, T McDonald, A Dikalova, M B Kadiiska, R P Mason, R G Thurma. CYP2E1 is not involved in early alcohol-induced liver injury. The American journal of physiology. vol 277. issue 6. 2000-01-20. PMID:10600824. |
there were also no differences in ethanol elimination rates between cyp2e1 +/+ and -/- mice after acute ethanol administration to naive mice or mice receiving ea for 4 wk. |
2000-01-20 |
2023-08-12 |
mouse |
| H Kono, B U Bradford, M Yin, K K Sulik, D R Koop, J M Peters, F J Gonzalez, T McDonald, A Dikalova, M B Kadiiska, R P Mason, R G Thurma. CYP2E1 is not involved in early alcohol-induced liver injury. The American journal of physiology. vol 277. issue 6. 2000-01-20. PMID:10600824. |
in contrast, mice given ethanol developed mild steatosis, slight inflammation, and necrosis; however, there were no differences between the cyp2e1 +/+ and -/- groups. |
2000-01-20 |
2023-08-12 |
mouse |
| J Gutiérrez-Salinas, L Miranda-Garduño, E Trejo-Izquierdo, M Díaz-Muñoz, S Vidrio, J A Morales-González, R Hernández-Muño. Redox state and energy metabolism during liver regeneration: alterations produced by acute ethanol administration. Biochemical pharmacology. vol 58. issue 11. 1999-12-17. PMID:10571259. |
in addition, proliferating liver promoted decreases in the activity of alcohol dehydrogenase (adh) and of cytochrome p4502e1 (cyp2e1); ethanol treatment prevented the ph-induced diminution of adh activity. |
1999-12-17 |
2023-08-12 |
rat |
| J Román, A Colell, C Blasco, J Caballeria, A Parés, J Rodés, J C Fernández-Chec. Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kappaB. Hepatology (Baltimore, Md.). vol 30. issue 6. 1999-12-16. PMID:10573527. |
the oxidative metabolism of ethanol by the cytochrome p450 2e1 (cyp2e1) has been recognized to contribute to the ethanol-induced deleterious effects through the induction of oxidative stress. |
1999-12-16 |
2023-08-12 |
Not clear |
| J Román, A Colell, C Blasco, J Caballeria, A Parés, J Rodés, J C Fernández-Chec. Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kappaB. Hepatology (Baltimore, Md.). vol 30. issue 6. 1999-12-16. PMID:10573527. |
this study compared the effect of ethanol and acetaldehyde in the induction of oxidative stress and activation of transcription factors nuclear factor-kappab (nf-kappab) and activating protein 1 (ap-1) in hepg2 cells, which do not express cyp2e1, and hepg2 cells transfected with cyp2e1 (e47 cells). |
1999-12-16 |
2023-08-12 |
Not clear |
| J Román, A Colell, C Blasco, J Caballeria, A Parés, J Rodés, J C Fernández-Chec. Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kappaB. Hepatology (Baltimore, Md.). vol 30. issue 6. 1999-12-16. PMID:10573527. |
cyp2e1 is indispensable in the induction of oxidative stress from ethanol, whereas the activation of nf-kappab and ap-1 by acetaldehyde is independent of oxidative stress. |
1999-12-16 |
2023-08-12 |
Not clear |
| S M Lee, T S Cho, D J Kim, Y N Ch. Protective effect of ethanol against acetaminophen-induced hepatotoxicity in mice: role of NADH:quinone reductase. Biochemical pharmacology. vol 58. issue 10. 1999-11-04. PMID:10535745. |
these results suggest that ethanol inhibited not only the microsomal (cyp2e1 mediated) formation of a toxic quinone metabolite from apap, but also accelerated the conversion of the toxic quinone metabolite produced back to apap by stimulating cytoplasmic qr activity. |
1999-11-04 |
2023-08-12 |
mouse |
| X Ponsoda, R Bort, R Jover, M J Gómez-Lechón, J V Castel. Increased toxicity of cocaine on human hepatocytes induced by ethanol: role of GSH. Biochemical pharmacology. vol 58. issue 10. 1999-11-04. PMID:10535748. |
in hepatocytes preincubated for 48 hr with ethanol, neither significant changes in cocaine metabolism nor cytotoxicity were found despite differences in hepatocyte p-nitrophenol hydroxylase (largely cyp2e1 activity). |
1999-11-04 |
2023-08-12 |
human |
| O Niemelä, S Parkkila, M Pasanen, K Viitala, J A Villanueva, C H Halste. Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs. Hepatology (Baltimore, Md.). vol 30. issue 4. 1999-10-20. PMID:10498654. |
to assess possible links between ethanol-induced oxidant stress, expression of hepatic cytochrome p450 (cyp) enzymes, and sex steroid status, we used immunohistochemical methods to compare the generation of protein adducts of acetaldehyde (aa), malondialdehyde (mda), and 4-hydroxynonenal (4-hne) with the amounts of cyp2e1, cyp2a, and cyp3a in the livers of castrated and noncastrated male micropigs fed ethanol for 12 months. |
1999-10-20 |
2023-08-12 |
Not clear |
| Y J Wan, R E Poland, K M Li. Genetic polymorphism of CYP2E1, ADH2, and ALDH2 in Mexican-Americans. Genetic testing. vol 2. issue 1. 1999-10-12. PMID:10464602. |
the cytochrome p450 2e1 (cyp2e1) represents a second enzyme that can metabolize ethanol. |
1999-10-12 |
2023-08-12 |
human |
| Y J Wan, R E Poland, K M Li. Genetic polymorphism of CYP2E1, ADH2, and ALDH2 in Mexican-Americans. Genetic testing. vol 2. issue 1. 1999-10-12. PMID:10464602. |
although normally a minor route of metabolism, its role in chronic alcoholics may be proportionately greater than in nonalcoholics because cyp2e1 is inducible by ethanol. |
1999-10-12 |
2023-08-12 |
human |
| Z Q Gouillon, K Miyamoto, T M Donohue, Y J Wan, B A French, Y Nagao, P Fu, R C Reitz, A Hagbjork, C Yap, Q X Yuan, M Ingelman-Sundberg, S W Frenc. Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway. Frontiers in bioscience : a journal and virtual library. vol 4. 1999-09-16. PMID:10477671. |
the ethanol inducible isoform of cytochrome p450, cyp2e1, may play a role in ethanol-induced liver injury. |
1999-09-16 |
2023-08-12 |
rat |
| C S Liebe. Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review. Alcoholism, clinical and experimental research. vol 23. issue 6. 1999-08-26. PMID:10397283. |
after chronic ethanol consumption, the activity of the microsomal ethanol-oxidizing system (meos) increases, with an associated rise in cytochromes p-450, especially cyp2e1. |
1999-08-26 |
2023-08-12 |
mouse |
| L L Marchand, G R Wilkinson, L R Wilken. Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 8. issue 6. 1999-07-29. PMID:10385138. |
also, the effects in humans of specific dietary factors, other than ethanol, which have been shown in animal and in vitro studies to modulate cyp2e1 activity, are unknown. |
1999-07-29 |
2023-08-12 |
Not clear |