| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Smith, S C Stamm, J E Riggs, W Stauber, V Harsh, P M Gannett, G Hobbs, M R Mille. Ethanol-mediated CYP1A1/2 induction in rat skeletal muscle tissue. Experimental and molecular pathology. vol 69. issue 3. 2001-01-11. PMID:11115363. |
however, neither skeletal muscle cyp1a1/2 nor cyp2e1 was induced when ethanol diets were administered by a different feeding system. |
2001-01-11 |
2023-08-12 |
rat |
| J F Sinclair, J G Szakacs, S G Wood, H S Walton, J L Bement, F J Gonzalez, E H Jeffery, S A Wrighton, W J Bement, P R Sinclai. Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice. Toxicology and applied pharmacology. vol 168. issue 2. 2000-11-16. PMID:11032766. |
we found that pretreatment of cyp2e1(-/-) mice with ethanol plus isopentanol, the predominant alcohols in alcoholic beverages, for 7 days resulted in micro- and macrovesicular steatosis in the livers of all mice, as well as a dramatic increase in acetaminophen hepatotoxicity. |
2000-11-16 |
2023-08-12 |
mouse |
| J F Sinclair, J G Szakacs, S G Wood, H S Walton, J L Bement, F J Gonzalez, E H Jeffery, S A Wrighton, W J Bement, P R Sinclai. Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice. Toxicology and applied pharmacology. vol 168. issue 2. 2000-11-16. PMID:11032766. |
in cyp2e1(-/-) mice pretreated with ethanol and isopentanol, subsequent exposure to 400 or 600 mg acetaminophen/kg resulted in centrilobular necrosis in all mice with maximal elevation in serum levels of alt. |
2000-11-16 |
2023-08-12 |
mouse |
| J F Sinclair, J G Szakacs, S G Wood, H S Walton, J L Bement, F J Gonzalez, E H Jeffery, S A Wrighton, W J Bement, P R Sinclai. Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice. Toxicology and applied pharmacology. vol 168. issue 2. 2000-11-16. PMID:11032766. |
our findings that a 7-day treatment with ethanol and isopentanol causes extensive hepatic steatosis and increases acetaminophen hepatotoxicity in cyp2e(-/-) mice indicate that cyp2e1 is not essential for either response. |
2000-11-16 |
2023-08-12 |
mouse |
| Z Gouillon, D Lucas, J Li, A L Hagbjork, B A French, P Fu, C Fang, M Ingelman-Sundberg, T M Donohue, S W Frenc. Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 224. issue 4. 2000-09-19. PMID:10964266. |
the cyp2e1 apoprotein levels, which were increased by ethanol feeding, were also increased when chlormethiazole was fed with ethanol. |
2000-09-19 |
2023-08-12 |
rat |
| C Bouchardy, A Hirvonen, C Coutelle, P J Ward, P Dayer, S Benhamo. Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. International journal of cancer. vol 87. issue 5. 2000-08-16. PMID:10925369. |
ethanol is oxidized to acetaldehyde (the suspected carcinogenic agent in alcohol) by alcohol dehydrogenases (adhs) and cytochrome p-4502e1 (cyp2e1), both of which exhibit great inter-individual variability in activity. |
2000-08-16 |
2023-08-12 |
Not clear |
| N Nieto, P Greenwel, S L Friedman, F Zhang, A J Dannenberg, A I Cederbau. Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2. The Journal of biological chemistry. vol 275. issue 26. 2000-08-10. PMID:10770928. |
the ability of ethanol and arachidonic acid (aa), as inducers of oxidative stress and key factors in alcoholic liver disease, to up-regulate alpha 2 collagen type i (col1a2) gene expression was studied in a hepatic stellate cell line overexpressing the ethanol-inducible cytochrome p450 2e1 (cyp2e1) (e5 cells). |
2000-08-10 |
2023-08-12 |
rat |
| N Nieto, P Greenwel, S L Friedman, F Zhang, A J Dannenberg, A I Cederbau. Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2. The Journal of biological chemistry. vol 275. issue 26. 2000-08-10. PMID:10770928. |
a time- and dose-dependent induction in col1a2 mrna by ethanol or aa was observed that was prevented by diallylsulfide, a cyp2e1 inhibitor. |
2000-08-10 |
2023-08-12 |
rat |
| N Nieto, P Greenwel, S L Friedman, F Zhang, A J Dannenberg, A I Cederbau. Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2. The Journal of biological chemistry. vol 275. issue 26. 2000-08-10. PMID:10770928. |
incubation with ns-398, a cox-2 inhibitor, blocked the effect of aa, but not of ethanol, on col1a2 expression suggesting that cyp2e1 activates cox-2 expression, and the oxidation of aa by cox-2 is responsible for the increase in col1a2. |
2000-08-10 |
2023-08-12 |
rat |
| E Yoshihara, K Ameno, K Nakamura, M Ameno, S Itoh, I Ijiri, K Iwahash. The effects of the ALDH2*1/2, CYP2E1 C1/C2 and C/D genotypes on blood ethanol elimination. Drug and chemical toxicology. vol 23. issue 2. 2000-07-28. PMID:10826103. |
the effects of the aldh2*1/2, cyp2e1 c1/c2 and c/d genotypes on blood ethanol elimination. |
2000-07-28 |
2023-08-12 |
human |
| E Yoshihara, K Ameno, K Nakamura, M Ameno, S Itoh, I Ijiri, K Iwahash. The effects of the ALDH2*1/2, CYP2E1 C1/C2 and C/D genotypes on blood ethanol elimination. Drug and chemical toxicology. vol 23. issue 2. 2000-07-28. PMID:10826103. |
the effects of cyp2e1 genotypes on the blood ethanol and acetaldehyde levels were investigated in a pair of japanese volunteers whose adh2, adh3 and aldh2 genotypes were identical but whose cyp2e1 genotypes were different. |
2000-07-28 |
2023-08-12 |
human |
| E Yoshihara, K Ameno, K Nakamura, M Ameno, S Itoh, I Ijiri, K Iwahash. The effects of the ALDH2*1/2, CYP2E1 C1/C2 and C/D genotypes on blood ethanol elimination. Drug and chemical toxicology. vol 23. issue 2. 2000-07-28. PMID:10826103. |
also, the blood ethanol and acetaldehyde concentrations in a volunteer with the c2 and c alleles of cyp2e1 (c1/c2 and c/d) were lower than in one without the c2 and c alleles (c1/c1 and d/d). |
2000-07-28 |
2023-08-12 |
human |
| M Marí, A I Cederbau. CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase. The Journal of biological chemistry. vol 275. issue 20. 2000-06-21. PMID:10748080. |
induction of cyp2e1 (cytochrome p450 2e1) by ethanol appears to be one of the central pathways by which ethanol generates a state of oxidative stress. |
2000-06-21 |
2023-08-12 |
human |
| L F Prescot. Paracetamol, alcohol and the liver. British journal of clinical pharmacology. vol 49. issue 4. 2000-06-21. PMID:10759684. |
in animals, chronic ethanol causes induction of hepatic microsomal enzymes and increases paracetamol hepatotoxicity as expected (ethanol primarily induces cyp2e1 and this isoform is important in the oxidative metabolism of paracetamol). |
2000-06-21 |
2023-08-12 |
Not clear |
| L J Mi, K M Mak, C S Liebe. Attenuation of alcohol-induced apoptosis of hepatocytes in rat livers by polyenylphosphatidylcholine (PPC). Alcoholism, clinical and experimental research. vol 24. issue 2. 2000-05-02. PMID:10698373. |
because polyenylphosphatidylcholine (ppc), a soybean extract rich in polyunsaturated phosphatidylcholines, decreases the induction of ethanol-specific cyp2e1 and opposes oxidative stress, we hypothesized that ppc supplementation may attenuate hepatocyte apoptosis caused by ethanol ingestion. |
2000-05-02 |
2023-08-12 |
rat |
| D Wu, A I Cederbau. Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1. Molecular and cellular biochemistry. vol 204. issue 1-2. 2000-04-11. PMID:10718635. |
ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of cyp2e1. |
2000-04-11 |
2023-08-12 |
rat |
| D Wu, A I Cederbau. Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1. Molecular and cellular biochemistry. vol 204. issue 1-2. 2000-04-11. PMID:10718635. |
ethanol and polyunsaturated fatty acids such as arachidonic acid were shown to be toxic and cause apoptosis in hepg2 cells which express cyp2e1 but not in control hepg2 cell lines. |
2000-04-11 |
2023-08-12 |
rat |
| D Wu, A I Cederbau. Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1. Molecular and cellular biochemistry. vol 204. issue 1-2. 2000-04-11. PMID:10718635. |
rats were treated with pyrazole to increase cyp2e1 levels, hepatocytes were isolated and placed into culture and treated for varying time points with ethanol or arachidonic acid. |
2000-04-11 |
2023-08-12 |
rat |
| D Wu, A I Cederbau. Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1. Molecular and cellular biochemistry. vol 204. issue 1-2. 2000-04-11. PMID:10718635. |
these results extend previous observations found with hepg2 cells expressing cyp2e1 to intact hepatocytes and suggest that release of cytochrome c and activation of caspase 3 play a role in the overall pathway by which cyp2e1 contributes towards the hepatotoxic actions of ethanol and polyunsaturated fatty acids. |
2000-04-11 |
2023-08-12 |
rat |
| D H Daiker, B K Shipp, H A Schoenfeld, G R Klimpel, G Witz, M T Moslen, J B War. Effect of CYP2E1 induction by ethanol on the immunotoxicity and genotoxicity of extended low-level benzene exposure. Journal of toxicology and environmental health. Part A. vol 59. issue 3. 2000-02-28. PMID:10667633. |
effect of cyp2e1 induction by ethanol on the immunotoxicity and genotoxicity of extended low-level benzene exposure. |
2000-02-28 |
2023-08-12 |
mouse |