| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jean-Pierre Desager, Jean-Luc Golnez, Charlotte De Buck, Yves Horsman. Watercress has no Importance for the elimination of ethanol by CYP2E1 inhibition. Pharmacology & toxicology. vol 91. issue 3. 2003-02-25. PMID:12427108. |
watercress has no importance for the elimination of ethanol by cyp2e1 inhibition. |
2003-02-25 |
2023-08-12 |
human |
| Jean-Pierre Desager, Jean-Luc Golnez, Charlotte De Buck, Yves Horsman. Watercress has no Importance for the elimination of ethanol by CYP2E1 inhibition. Pharmacology & toxicology. vol 91. issue 3. 2003-02-25. PMID:12427108. |
since ethanol and its metabolite, acetaldehyde, are cyp2e1 substrates, the influence of watercress on ethanol and acetaldehyde was investigated in healthy human volunteers. |
2003-02-25 |
2023-08-12 |
human |
| Y Yamada, F Sun, I Tsuritani, R Hond. Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers. Journal of human hypertension. vol 16. issue 7. 2003-01-03. PMID:12080432. |
orientals have unique genetic polymorphisms in ethanol metabolizing enzymes, such as alcohol dehydrogenase-2 (adh2), aldehyde dehydrogenase-2 (aldh2) and cytochrome p450-2e1 (cyp2e1). |
2003-01-03 |
2023-08-12 |
human |
| Yukio Mori, Akihiro Koide, Yoshinori Kobayashi, Keiichirou Morimura, Masahiro Kaneko, Shoji Fukushim. Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver. Mutagenesis. vol 17. issue 3. 2002-12-06. PMID:11971997. |
immunoblot analyses of microsomal cyp proteins revealed induction of cyp2e1 (approximately 2-fold), but not cyp2b1/2, 1a1/2 or 3a2, by treatment with 10% ethanol in the drinking water for 2 weeks. |
2002-12-06 |
2023-08-12 |
rat |
| Yukio Mori, Akihiro Koide, Yoshinori Kobayashi, Keiichirou Morimura, Masahiro Kaneko, Shoji Fukushim. Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver. Mutagenesis. vol 17. issue 3. 2002-12-06. PMID:11971997. |
these results demonstrate that ethanol exerts an enhancing effect on mutagenic activation by cyp2e1 of dmn, den and npyr, but does not affect that of nmba and the other carcinogens by cyp2b1/2, 1a1/2 and 3a2 and udpgt1a1, 1a6 and 2b1 activities. |
2002-12-06 |
2023-08-12 |
rat |
| A J MacDonald, A Rostami-Hodjegan, G T Tucker, D A Linken. Analysis of solvent central nervous system toxicity and ethanol interactions using a human population physiologically based kinetic and dynamic model. Regulatory toxicology and pharmacology : RTP. vol 35. issue 2 Pt 1. 2002-11-14. PMID:12052002. |
pbpk models of inhaled m-xylene and orally ingested ethanol were developed and combined by a competitive enzyme (cyp2e1) inhibition model. |
2002-11-14 |
2023-08-12 |
human |
| Ping Zhao, Thomas F Kalhorn, John T Slatter. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Hepatology (Baltimore, Md.). vol 36. issue 2. 2002-08-27. PMID:12143040. |
ethanol induced cyp2e1 in both the 10-day and 6-week groups by approximately 2-fold. |
2002-08-27 |
2023-08-12 |
rat |
| Ping Zhao, Thomas F Kalhorn, John T Slatter. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Hepatology (Baltimore, Md.). vol 36. issue 2. 2002-08-27. PMID:12143040. |
partial inhibition of napqi formation by cyp2e1 inhibitor diethyldithiocarbamate to that of pair-fed controls abolished apap toxicity in the 10-day ethanol group only. |
2002-08-27 |
2023-08-12 |
rat |
| Ping Zhao, Thomas F Kalhorn, John T Slatter. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Hepatology (Baltimore, Md.). vol 36. issue 2. 2002-08-27. PMID:12143040. |
in conclusion, 10-day ethanol feeding enhances apap toxicity through cyp2e1 induction, whereas 6-week ethanol feeding potentiates apap hepatotoxicity by inducing cyp2e1 and selectively depleting mitochondrial gsh. |
2002-08-27 |
2023-08-12 |
rat |
| Kengathevy Morgan, Samuel W French, Timothy R Morga. Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage. Hepatology (Baltimore, Md.). vol 36. issue 1. 2002-07-23. PMID:12085356. |
hepatic metabolism of ethanol by cytochrome p450 2e1 (cyp2e1) is believed to contribute to alcoholic liver damage. |
2002-07-23 |
2023-08-12 |
mouse |
| Barry H Rumac. Acetaminophen hepatotoxicity: the first 35 years. Journal of toxicology. Clinical toxicology. vol 40. issue 1. 2002-05-30. PMID:11990202. |
the role of diet and ethanol induction and inhibition on cyp2e1, the enzyme of greatest interest for acetaminophen is multifaceted. |
2002-05-30 |
2023-08-12 |
Not clear |
| Carl M Oneta, Charles S Lieber, JunJie Li, Sigmund Rüttimann, Beat Schmid, Jürg Lattmann, Alan S Rosman, Helmut K Seit. Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase. Journal of hepatology. vol 36. issue 1. 2002-05-01. PMID:11804663. |
chronic ethanol consumption results in the induction of hepatic cytochrome p4502e1 (cyp2e1) in man, which is believed to play an important role in the pathogenesis of alcoholic liver disease. |
2002-05-01 |
2023-08-12 |
Not clear |
| Montserrat Marí, Jingxiang Bai, Arthur I Cederbau. Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1. The Journal of pharmacology and experimental therapeutics. vol 301. issue 1. 2002-04-18. PMID:11907164. |
induction of cytochrome p450 cyp2e1 by ethanol appears to be one of the mechanisms by which ethanol creates a state of oxidative stress. |
2002-04-18 |
2023-08-12 |
Not clear |
| D M Runge, T W Stock, T Lehmann, C Taege, U Bernauer, D B Stolz, S Hofmann, H Fot. Expression of cytochrome P450 2E1 in normal human bronchial epithelial cells and activation by ethanol in culture. Archives of toxicology. vol 75. issue 6. 2002-04-03. PMID:11570691. |
serum-free primary cultures of human bronchial epithelial cells and freshly isolated samples of human bronchial epithelium were used to investigate basal expression of the cytochrome p450 enzyme cyp2e1 and its activation or induction by ethanol in bronchial epithelial cells. |
2002-04-03 |
2023-08-12 |
human |
| D M Runge, T W Stock, T Lehmann, C Taege, U Bernauer, D B Stolz, S Hofmann, H Fot. Expression of cytochrome P450 2E1 in normal human bronchial epithelial cells and activation by ethanol in culture. Archives of toxicology. vol 75. issue 6. 2002-04-03. PMID:11570691. |
in short-term cultured isolated bronchial epithelium, ethanol treatment increased cyp2e1 activity by up to 5-fold within 4 days but with inter-individual differences. |
2002-04-03 |
2023-08-12 |
human |
| D M Runge, T W Stock, T Lehmann, C Taege, U Bernauer, D B Stolz, S Hofmann, H Fot. Expression of cytochrome P450 2E1 in normal human bronchial epithelial cells and activation by ethanol in culture. Archives of toxicology. vol 75. issue 6. 2002-04-03. PMID:11570691. |
in cells up to 4 weeks in culture, cyp2e1 activity remained inducible by a single dose of ethanol. |
2002-04-03 |
2023-08-12 |
human |
| A I Cederbaum, D Wu, M Mari, J Ba. CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free radical biology & medicine. vol 31. issue 12. 2002-03-22. PMID:11744327. |
induction of cyp2e1 by ethanol is one of the central pathways by which ethanol generates a state of oxidative stress in hepatocytes. |
2002-03-22 |
2023-08-12 |
Not clear |
| A I Cederbaum, D Wu, M Mari, J Ba. CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free radical biology & medicine. vol 31. issue 12. 2002-03-22. PMID:11744327. |
to study the biochemical and toxicological actions of cyp2e1, our laboratory established hepg2 cell lines which constitutively overexpress cyp2e1 and characterized these cells with respect to ethanol toxicity. |
2002-03-22 |
2023-08-12 |
Not clear |
| J W Yang, J S Shin, J J Lee, H I Chang, C W Ki. In vitro model using mouse hepatocytes for study of alcohol stress. Bioscience, biotechnology, and biochemistry. vol 65. issue 7. 2002-03-01. PMID:11515535. |
the expression of cytochrome p450 2e1 (cyp2e1), phase i enzyme was examined in response to ethanol and allyl alcohol. |
2002-03-01 |
2023-08-12 |
mouse |
| J W Yang, J S Shin, J J Lee, H I Chang, C W Ki. In vitro model using mouse hepatocytes for study of alcohol stress. Bioscience, biotechnology, and biochemistry. vol 65. issue 7. 2002-03-01. PMID:11515535. |
these results on cyp2e1 induction demonstrate that primary mouse hepatocytes, when using ethanol and allyl alcohol as substrates and in insulin-free medium, provide a suitable system for the studies of the role of cyp2e1 in xenobiotic metabolism and toxicity. |
2002-03-01 |
2023-08-12 |
mouse |