| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Judy L Raucy, Jerome Lasker, Kazuaki Ozaki, Veronica Zolet. Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology. vol 79. issue 2. 2005-05-05. PMID:15056802. |
in contrast, hepatocytes exposed to ethanol exhibited only a slight elevation in cyp2e1 protein (122 +/- 13% of control) and a negligible effect on cyp4a11 protein. |
2005-05-05 |
2023-08-12 |
human |
| Judy L Raucy, Jerome Lasker, Kazuaki Ozaki, Veronica Zolet. Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology. vol 79. issue 2. 2005-05-05. PMID:15056802. |
the lack of induction of cyp2e1 protein by ethanol in human hepatocytes indicates that for certain p450 enzymes, isolated hepatocytes may not be an adequate tool for predicting in vivo responses. |
2005-05-05 |
2023-08-12 |
human |
| Andres A Caro, Arthur I Cederbau. Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochemical pharmacology. vol 69. issue 7. 2005-04-22. PMID:15763544. |
however, sam inhibited the catalytic activity of cyp2e1 with typical substrates such as p-nitrophenol, ethanol, and dimethylnitrosamine, with an ic(50) around 1.5-5mm. |
2005-04-22 |
2023-08-12 |
human |
| Andres A Caro, Arthur I Cederbau. Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochemical pharmacology. vol 69. issue 7. 2005-04-22. PMID:15763544. |
since the k(i) for sam inhibition of cyp2e1 activity is relatively high, inhibition of cyp2e1 activity is not likely to play a major role in the ability of sam to protect against the hepatotoxicity produced by toxins requiring metabolic activation by cyp2e1 such as acetaminophen, ethanol, carbon tetrachloride, thioacetamide and carcinogens. |
2005-04-22 |
2023-08-12 |
human |
| Soo-Kyung Suh, Brian L Hood, Bong-Jo Kim, Thomas P Conrads, Timothy D Veenstra, Byoung J Son. Identification of oxidized mitochondrial proteins in alcohol-exposed human hepatoma cells and mouse liver. Proteomics. vol 4. issue 11. 2005-04-13. PMID:15449375. |
human hepatoma hepg2 cells with transduced cyp2e1 (e47 cells) were used as a model to generate ros through cyp2e1-mediated ethanol metabolism. |
2005-04-13 |
2023-08-12 |
mouse |
| Jose M Jimenez-Lopez, Arthur I Cederbau. Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells. The Journal of pharmacology and experimental therapeutics. vol 312. issue 3. 2005-04-05. PMID:15494549. |
hepatic induction of cyp2e1 is a major pathway involved in oxidative stress and damage caused by chronic ethanol consumption; cyp2e1 also promotes the activation of a variety of hepatotoxins to reactive intermediates. |
2005-04-05 |
2023-08-12 |
Not clear |
| Charles S Liebe. The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role. Drug metabolism reviews. vol 36. issue 3-4. 2005-04-01. PMID:15554233. |
after chronic ethanol consumption, the activity of the meos increases, with an associated rise in cytochrome p450, especially cyp2e1, most conclusively shown in alcohol dehydrogenase negative deer mice. |
2005-04-01 |
2023-08-12 |
mouse |
| Charles S Liebe. The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role. Drug metabolism reviews. vol 36. issue 3-4. 2005-04-01. PMID:15554233. |
cyp2e1 has also a physiologic role which comprises gluconeogenesis from ketones, oxidation of fatty acids, and detoxification of xenobiotics other than ethanol. |
2005-04-01 |
2023-08-12 |
mouse |
| Frank J Gonzale. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutation research. vol 569. issue 1-2. 2005-03-03. PMID:15603755. |
cyp2e1 is induced by alcohol and the primary p450 that carries out ethanol oxidation that can lead to the production of activated oxygen species and oxidative stress that elevate erk1/2 phosphorylation through egrf/c-raf signaling. |
2005-03-03 |
2023-08-12 |
mouse |
| Kristina K Wolf, Sheryl G Wood, Jenna L Bement, Peter R Sinclair, Steven A Wrighton, Elizabeth Jeffery, Frank J Gonzalez, Jacqueline F Sinclai. Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice. Drug metabolism and disposition: the biological fate of chemicals. vol 32. issue 7. 2005-01-31. PMID:15205381. |
treatment with a combination of ethanol and isopentanol resulted in induction of cyp3a proteins in wild-type and cyp2e1(-/-) mice, as well as cyp2e1 protein in wild-type mice. |
2005-01-31 |
2023-08-12 |
mouse |
| James Haorah, David Heilman, Casey Diekmann, Natalia Osna, Terrence M Donohue, Anuja Ghorpade, Yuri Persidsk. Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease. Cellular immunology. vol 229. issue 2. 2004-11-23. PMID:15474528. |
to investigate the mechanisms underlying these functional changes, we measured pr and cyp2e1 activities [an ethanol (etoh) metabolizing enzyme] and reactive oxygen species (ros) in human monocyte-derived macrophages (mdm) following hiv-1 infection and etoh treatment. |
2004-11-23 |
2023-08-12 |
human |
| Laura E Nag. Molecular aspects of alcohol metabolism: transcription factors involved in early ethanol-induced liver injury. Annual review of nutrition. vol 24. 2004-11-01. PMID:15189113. |
however, upon continued exposure to ethanol, the progression of liver injury involves ethanol metabolism via cyp2e1 and consequent oxidant stress, as well as potential direct effects of ethanol on membrane proteins that are independent of ethanol metabolism. |
2004-11-01 |
2023-08-12 |
Not clear |
| Bogusława Pietrzak, Elzbieta Czarneck. Influence of felbamate on selected central effects of ethanol in experimental animals. Acta poloniae pharmaceutica. vol 61. issue 3. 2004-10-26. PMID:15481247. |
these interactions may be of pharmacodynamic character, but pharmacokinetic nature cannot be excluded, felbamate and ethanol are substrates for the cytochrome cyp2e1. |
2004-10-26 |
2023-08-12 |
mouse |
| Jose M Jimenez-Lopez, Arthur I Cederbau. Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity. Free radical biology & medicine. vol 36. issue 3. 2004-10-14. PMID:15036355. |
chronic ethanol consumption causes oxidative damage in the liver, and induction of cytochrome p450 2e1 (cyp2e1) is one pathway involved in oxidative stress produced by ethanol. |
2004-10-14 |
2023-08-12 |
Not clear |
| R J E Laheij, M Verlaan, M G H Van Oijen, M S De Doelder, C A J Dejong, J B M J Janse. Gastrointestinal symptoms and ethanol metabolism in alcoholics. Digestive diseases and sciences. vol 49. issue 6. 2004-09-03. PMID:15309892. |
the aim of this study was to determine whether genetic polymorphism in alcohol dehydrogenase 3 (adh3) and cytochrome p450 2e1 (cyp2e1), important first-pass enzymes in the metabolism of ethanol, predispose to the development of gastrointestinal symptoms in alcoholics, blood samples were obtained from 92 adult alcoholics admitted for detoxification. |
2004-09-03 |
2023-08-12 |
human |
| Fuyumi Isayama, Matthias Froh, Blair U Bradford, Stephen E McKim, Maria B Kadiiska, Henry D Connor, Ronald P Mason, Dennis R Koop, Michael D Wheeler, Gavin E Artee. The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice. Free radical biology & medicine. vol 35. issue 12. 2004-08-09. PMID:14680680. |
however, there was no difference in liver pathology and radical formation between wild-type and cyp2e1 knockout mice fed ethanol. |
2004-08-09 |
2023-08-12 |
mouse |
| Courtney S Schaffert, Sandra L Todero, Benita L McVicker, Pamela L Tuma, Michael F Sorrell, Dean J Tum. WIF-B cells as a model for alcohol-induced hepatocyte injury. Biochemical pharmacology. vol 67. issue 11. 2004-06-21. PMID:15135311. |
initial studies revealed wif-b cells exhibited alcohol dehydrogenase (adh) activity, expressed cytochrome p4502e1 (cyp2e1), and efficiently metabolized ethanol in culture. |
2004-06-21 |
2023-08-12 |
Not clear |
| H Tapiero, D M Townsend, K D Te. The role of carotenoids in the prevention of human pathologies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 58. issue 2. 2004-06-16. PMID:14992791. |
chronic ethanol consumption significantly increases hydrogen peroxide and decreases mitochondrial glutathione (gsh) in cells overexpressing cyp2e1. |
2004-06-16 |
2023-08-12 |
human |
| Andres A Caro, Arthur I Cederbau. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annual review of pharmacology and toxicology. vol 44. 2004-05-13. PMID:14744237. |
ethanol, polyunsaturated fatty acids, and iron were found to be cytotoxic in hepg2 cells that overexpress cyp2e1. |
2004-05-13 |
2023-08-12 |
human |
| Diane J Lees Murdock, Jacqueline Clarke, Peter R Flatt, Yvonne A Barnett, Christopher R Barnet. Role of CYP2E1 in ketone-stimulated insulin release in pancreatic B-cells. Biochemical pharmacology. vol 67. issue 5. 2004-05-07. PMID:15104240. |
cultivation of cyp2e1 expressing brin bd11h2e1 and ins-1h2e1 cells in 40 mm ethanol increased the rate of p-nitrophenol hydroxylation (0.968 +/- 0.09 nmol/min/mg microsomal protein, p < 0.001 and 0.846 +/- 0.103 nmol/min/mg microsomal protein, p < 0.001, respectively) providing further evidence that the heterologous protein is inducible. |
2004-05-07 |
2023-08-12 |
human |