| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nidhi Kapoor, Aditya B Pant, Alok Dhawan, Uppendra N Dwievedi, Yogendra K Gupta, Prahlad K Seth, Devendra Parma. Differences in sensitivity of cultured rat brain neuronal and glial cytochrome P450 2E1 to ethanol. Life sciences. vol 79. issue 16. 2006-11-06. PMID:16737717. |
the present study was initiated to investigate the expression and catalytic activity of the constitutive and inducible forms of cyp2e1, the major ethanol inducible cyp, in cultured rat brain neuronal and glial cells. |
2006-11-06 |
2023-08-12 |
rat |
| A Rossini, S Soares Lima, D C M Rapozo, M Faria, R M Albano, L F Ribeiro Pint. CYP2A6 and CYP2E1 polymorphisms in a Brazilian population living in Rio de Janeiro. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 39. issue 2. 2006-10-31. PMID:16470306. |
cyp2e1 metabolizes ethanol and other low-molecular weight compounds and can also activate nitrosamines. |
2006-10-31 |
2023-08-12 |
human |
| Sanjay Yadav, Alok Dhawan, Ram L Singh, Prahlad K Seth, Devendra Parma. Expression of constitutive and inducible cytochrome P450 2E1 in rat brain. Molecular and cellular biochemistry. vol 286. issue 1-2. 2006-10-19. PMID:16652227. |
like liver, pretreatment with cyp2e1 inducers such as ethanol or pyrazole or acetone significantly increased the activity of brain microsomal ndma-d. |
2006-10-19 |
2023-08-12 |
rat |
| Sanjay Yadav, Alok Dhawan, Ram L Singh, Prahlad K Seth, Devendra Parma. Expression of constitutive and inducible cytochrome P450 2E1 in rat brain. Molecular and cellular biochemistry. vol 286. issue 1-2. 2006-10-19. PMID:16652227. |
kinetic studies also showed an increase in the vmax and affinity (km) of the substrate towards the brain enzyme due to increased expression of cyp2e1 in microsomes of brain isolated from ethanol pretreated rats. |
2006-10-19 |
2023-08-12 |
rat |
| Sanjay Yadav, Alok Dhawan, Ram L Singh, Prahlad K Seth, Devendra Parma. Expression of constitutive and inducible cytochrome P450 2E1 in rat brain. Molecular and cellular biochemistry. vol 286. issue 1-2. 2006-10-19. PMID:16652227. |
furthermore, several fold increase in the mrna expression and activity of cyp2e1 in cerebellum and hippocampus while a relatively small increase in the olfactory lobes and no significant change in other brain regions following ethanol pretreatment have indicated that cyp2e1 induction maybe involved in selective sensitivity of these brain areas to ethanol induced free radical damage and neuronal degeneration. |
2006-10-19 |
2023-08-12 |
rat |
| Simonetta Gemma, Susanna Vichi, Emanuela Testa. Individual susceptibility and alcohol effects:biochemical and genetic aspects. Annali dell'Istituto superiore di sanita. vol 42. issue 1. 2006-10-12. PMID:16801720. |
the hepatic enzymatic systems involved in ethanol metabolism are alcohol dehydrogenase (adh), aldehyde dehydrogenase (aldh) and microsomal p4502e1 (cyp2e1). |
2006-10-12 |
2023-08-12 |
Not clear |
| Simonetta Gemma, Susanna Vichi, Emanuela Testa. Individual susceptibility and alcohol effects:biochemical and genetic aspects. Annali dell'Istituto superiore di sanita. vol 42. issue 1. 2006-10-12. PMID:16801720. |
about 10% of moderate quantities of ethanol is metabolised by cyp2e1; the percentage increases when adh is saturated. |
2006-10-12 |
2023-08-12 |
Not clear |
| Arthur I Cederbau. CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury. The Mount Sinai journal of medicine, New York. vol 73. issue 4. 2006-10-10. PMID:16878272. |
one central pathway appears to be the induction of the cyp2e1 form of cytochrome p450 enzymes by ethanol. |
2006-10-10 |
2023-08-12 |
human |
| Arthur I Cederbau. CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury. The Mount Sinai journal of medicine, New York. vol 73. issue 4. 2006-10-10. PMID:16878272. |
cyp2e1 is of interest because of its ability to metabolize and activate many toxicological substrates, including ethanol, to more reactive toxic products. |
2006-10-10 |
2023-08-12 |
human |
| Courtney R Plumlee, Catherine A Lazaro, Nelson Fausto, Stephen J Polya. Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells. Virology journal. vol 2. 2006-09-18. PMID:16324217. |
these effects of alcohol occurred independently of i) alcohol metabolism via adh and cyp2e1, and ii) cytotoxic or cytostatic effects of ethanol. |
2006-09-18 |
2023-08-12 |
human |
| Jose M Jimenez-Lopez, Arthur I Cederbau. CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury. Expert opinion on drug metabolism & toxicology. vol 1. issue 4. 2006-08-16. PMID:16863432. |
one central pathway appears to be the induction, by ethanol, of the cyp2e1 form of cytochrome p450 enzymes. |
2006-08-16 |
2023-08-12 |
Not clear |
| Jose M Jimenez-Lopez, Arthur I Cederbau. CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury. Expert opinion on drug metabolism & toxicology. vol 1. issue 4. 2006-08-16. PMID:16863432. |
cyp2e1 is of interest because it metabolises and activates many toxicological substrates, including ethanol, to more reactive products. |
2006-08-16 |
2023-08-12 |
Not clear |
| Masashi Shimada, Liegang Liu, Natascha Nussler, Sven Jonas, Jan M Langrehr, Toshihisa Ogawa, Michio Kaminishi, Peter Neuhaus, Andreas K Nussle. Human hepatocytes are protected from ethanol-induced cytotoxicity by DADS via CYP2E1 inhibition. Toxicology letters. vol 163. issue 3. 2006-05-12. PMID:16356668. |
we found a clear dose-dependent response between ethanol and cyp2e1 activity. |
2006-05-12 |
2023-08-12 |
human |
| Jingxiang Bai, Arthur I Cederbau. Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione. The Journal of biological chemistry. vol 281. issue 8. 2006-05-04. PMID:16380384. |
induction of cyp2e1 by ethanol is one mechanism by which ethanol causes oxidative stress and alcohol liver disease. |
2006-05-04 |
2023-08-12 |
human |
| Jingxiang Bai, Arthur I Cederbau. Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione. The Journal of biological chemistry. vol 281. issue 8. 2006-05-04. PMID:16380384. |
the accumulation of cyp2e1 in hepatic mitochondria induced by ethanol consumption might play an important role in alcohol liver disease. |
2006-05-04 |
2023-08-12 |
human |
| Terrence M Donohue, Natalia A Osna, Dahn L Clemen. Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity. The international journal of biochemistry & cell biology. vol 38. issue 1. 2006-04-20. PMID:16181800. |
because ethanol consumption causes a decline in hepatic protein catabolism, we examined the influence of ethanol exposure on proteasome activity in hepg2, vl-17a, e-47 (cyp2e1(+)) and va-13 (adh(+)) cells. |
2006-04-20 |
2023-08-12 |
human |
| Terrence M Donohue, Natalia A Osna, Dahn L Clemen. Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity. The international journal of biochemistry & cell biology. vol 38. issue 1. 2006-04-20. PMID:16181800. |
we conclude that recombinant vl-17a cells, which express both adh and cyp2e1 exhibit hepatocyte-like characteristics in response to ethanol. |
2006-04-20 |
2023-08-12 |
human |
| Terrence M Donohue, Natalia A Osna, Dahn L Clemen. Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity. The international journal of biochemistry & cell biology. vol 38. issue 1. 2006-04-20. PMID:16181800. |
furthermore, the metabolism of ethanol by these cells via adh and cyp2e1 is sufficient to bring about an inhibition of proteasome activity that may lead to apoptotic cell death. |
2006-04-20 |
2023-08-12 |
human |
| Hitoshi Ishikawa, Yu Miyatsu, Kazuo Kurihara, Kazuhito Yokoyam. Gene-environmental interactions between alcohol-drinking behavior and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes. Mutation research. vol 594. issue 1-2. 2006-03-28. PMID:16126235. |
ethanol is converted to acetaldehyde by alcohol dehydrogenase (adh), cytochrome p4502e1 (cyp2e1) and catalase. |
2006-03-28 |
2023-08-12 |
human |
| Jian Zhuge, Arthur I Cederbau. Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1. Free radical biology & medicine. vol 40. issue 1. 2006-03-16. PMID:16337880. |
cyp2e1 plays an important role in toxicity of many chemicals and ethanol and produces oxidant stress. |
2006-03-16 |
2023-08-12 |
human |