| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arthur I Cederbau. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. Journal of gastroenterology and hepatology. vol 21 Suppl 3. 2007-05-29. PMID:16958665. |
induction of cytochrome p450 2e1 (cyp2e1) is a central pathway by which ethanol generates oxidative stress. |
2007-05-29 |
2023-08-12 |
mouse |
| Arthur I Cederbau. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. Journal of gastroenterology and hepatology. vol 21 Suppl 3. 2007-05-29. PMID:16958665. |
toxicity of these agents is enhanced by ethanol, due to induction of cyp2e1. |
2007-05-29 |
2023-08-12 |
mouse |
| Arthur I Cederbau. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. Journal of gastroenterology and hepatology. vol 21 Suppl 3. 2007-05-29. PMID:16958665. |
ethanol, polyunsaturated fatty acids and iron were toxic to the hepg2 cells that express cyp2e1 (e47 cells) but not control hepg2 cells. |
2007-05-29 |
2023-08-12 |
mouse |
| Xiaodong Wang, Arthur I Cederbau. Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways. Free radical biology & medicine. vol 42. issue 7. 2007-05-10. PMID:17349925. |
this study evaluated whether acute ethanol pretreatment potentiates fas-mediated liver injury and if oxidative stress and cyp2e1 play a role in any enhanced hepatotoxicity. |
2007-05-10 |
2023-08-12 |
mouse |
| Xiaodong Wang, Arthur I Cederbau. Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways. Free radical biology & medicine. vol 42. issue 7. 2007-05-10. PMID:17349925. |
cyp2e1 catalytic activity and protein were increased 2-fold by the acute ethanol pretreatment. |
2007-05-10 |
2023-08-12 |
mouse |
| Xiaodong Wang, Arthur I Cederbau. Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways. Free radical biology & medicine. vol 42. issue 7. 2007-05-10. PMID:17349925. |
the enhanced hepatotoxicity of jo2 plus ethanol and the elevated oxidative stress and tnf levels were lower in cyp2e1 knockout mice compared to wild-type mice expressing cyp2e1 but higher than saline controls. |
2007-05-10 |
2023-08-12 |
mouse |
| Simonetta Gemma, Susanna Vichi, Emanuela Testa. Metabolic and genetic factors contributing to alcohol induced effects and fetal alcohol syndrome. Neuroscience and biobehavioral reviews. vol 31. issue 2. 2007-04-17. PMID:16908065. |
the involvement of genetics as a one risk factor in fas has been suggested by animal models and by molecular epidemiological studies on different populations, bearing allelic variants for those enzymes, such as adh e cyp2e1, involved in ethanol metabolism. |
2007-04-17 |
2023-08-12 |
Not clear |
| Frank J Gonzale. The 2006 Bernard B. Brodie Award Lecture. Cyp2e1. Drug metabolism and disposition: the biological fate of chemicals. vol 35. issue 1. 2007-03-13. PMID:17020953. |
subsequent studies revealed that activation of acetaminophen to an active metabolite is primarily carried out by cyp2e1, an ethanol-inducible cytochrome p450 that was first suggested by characterization of the microsomal ethanol oxidation system. |
2007-03-13 |
2023-08-12 |
Not clear |
| Jian Zhuge, Arthur I Cederbau. Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1. Free radical biology & medicine. vol 41. issue 7. 2007-02-16. PMID:16962935. |
ethanol treatment causes an increase in expression of tgf-beta1 and cyp2e1 in the centrilobular area. |
2007-02-16 |
2023-08-12 |
human |
| Fawzia Bardag-Gorce, Barbara A French, Li Nan, Helen Song, Sheila Khanh Nguyen, Holly Yong, Jennifer Dede, Samuel W Frenc. CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. Experimental and molecular pathology. vol 81. issue 3. 2007-01-24. PMID:17034788. |
cyp2e1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (mallory body-like) formation. |
2007-01-24 |
2023-08-12 |
human |
| Fawzia Bardag-Gorce, Barbara A French, Li Nan, Helen Song, Sheila Khanh Nguyen, Holly Yong, Jennifer Dede, Samuel W Frenc. CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. Experimental and molecular pathology. vol 81. issue 3. 2007-01-24. PMID:17034788. |
hepg2 cells transduced to over express cyp2e1 (e47) and control hepg2 cells (c34) were first treated with arachidonic acid, then fe-nat, and finally with ethanol. |
2007-01-24 |
2023-08-12 |
human |
| Fawzia Bardag-Gorce, Barbara A French, Li Nan, Helen Song, Sheila Khanh Nguyen, Holly Yong, Jennifer Dede, Samuel W Frenc. CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. Experimental and molecular pathology. vol 81. issue 3. 2007-01-24. PMID:17034788. |
these results indicate that the ethanol induced cyp2e1 generates oxidative stress that is responsible for the decrease in proteasome activity. |
2007-01-24 |
2023-08-12 |
human |
| Emanuele Alban. Alcohol, oxidative stress and free radical damage. The Proceedings of the Nutrition Society. vol 65. issue 3. 2007-01-23. PMID:16923312. |
furthermore, hydroxyethyl free radicals (her) are also generated during ethanol metabolism by cyp2e1. |
2007-01-23 |
2023-08-12 |
Not clear |
| Natalia A Osna, Ronda L White, Sandra Todero, Benita L McVicker, Geoffrey M Thiele, Dahn L Clemens, Dean J Tuma, Terrence M Donohu. Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells. Hepatology (Baltimore, Md.). vol 45. issue 1. 2007-01-23. PMID:17187415. |
ethanol exposure to vl-17a cells increased cyp2e1 and decreased proteasome peptidase activities. |
2007-01-23 |
2023-08-12 |
Not clear |
| S Hamitouche, J Poupon, Y Dreano, Y Amet, D Luca. Ethanol oxidation into acetaldehyde by 16 recombinant human cytochrome P450 isoforms: role of CYP2C isoforms in human liver microsomes. Toxicology letters. vol 167. issue 3. 2007-01-04. PMID:17084997. |
the significant correlation found between ethanol oxidation and cyp2e1, cyp3a4 and cyp1a2 catalytic activities in a panel of human liver microsomes confirmed the strong implication of these cyps in ethanol metabolism. |
2007-01-04 |
2023-08-12 |
human |
| S Hamitouche, J Poupon, Y Dreano, Y Amet, D Luca. Ethanol oxidation into acetaldehyde by 16 recombinant human cytochrome P450 isoforms: role of CYP2C isoforms in human liver microsomes. Toxicology letters. vol 167. issue 3. 2007-01-04. PMID:17084997. |
tienilic acid (100 microm) and ticlopidine (20 microm), mechanism-based inhibitors of cyp2c9 and cyp2c19, respectively, decreased ethanol oxidation by 8+/-1.2% and 7.6+/-1.6% in human liver microsomal samples while selective inhibitors of cyp2e1 (dedtc 100 microm), cyp3a4 (tao 50 microm) and cyp1a2 (furafylline 25 microm) decreased it by 11.9+/-2.1%, 19.8+/-1.9% and 16.3+/-3.9%, respectively. |
2007-01-04 |
2023-08-12 |
human |
| Anna M Lee, Jiang Yue, Rachel F Tyndal. In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: induction by chronic nicotine treatment. Drug metabolism and disposition: the biological fate of chemicals. vol 34. issue 9. 2006-12-04. PMID:16763012. |
thus, nicotine exposure may affect the metabolism of cyp2e1 substrates such as acetaminophen, ethanol, and benzene. |
2006-12-04 |
2023-08-12 |
monkey |
| Hai Wu, Ping Cai, Dahn L Clemens, Thomas R Jerrells, G A Shakeel Ansari, Bhupendra S Kaphali. Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: role of nonoxidative metabolism. Toxicology and applied pharmacology. vol 216. issue 2. 2006-11-07. PMID:16806343. |
hepatic microsomal cytochrome p450 (cyp2e1), induced in chronic alcohol abuse, is also reported to oxidize ethanol. |
2006-11-07 |
2023-08-12 |
rat |
| Hai Wu, Ping Cai, Dahn L Clemens, Thomas R Jerrells, G A Shakeel Ansari, Bhupendra S Kaphali. Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: role of nonoxidative metabolism. Toxicology and applied pharmacology. vol 216. issue 2. 2006-11-07. PMID:16806343. |
these results suggest that adh-catalyzed oxidative metabolism of ethanol is the major mechanism of its disposition, regardless of cyp2e1 overexpression. |
2006-11-07 |
2023-08-12 |
rat |
| Hai Wu, Ping Cai, Dahn L Clemens, Thomas R Jerrells, G A Shakeel Ansari, Bhupendra S Kaphali. Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: role of nonoxidative metabolism. Toxicology and applied pharmacology. vol 216. issue 2. 2006-11-07. PMID:16806343. |
on the other hand, diminished adh activity facilitates nonoxidative metabolism of ethanol to faees as found in e47 cells, regardless of cyp2e1 overexpression. |
2006-11-07 |
2023-08-12 |
rat |