| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vasilis Vasiliou, Thomas L Ziegler, Pequita Bludeau, Dennis R Petersen, Frank J Gonzalez, Richard A Deitric. CYP2E1 and catalase influence ethanol sensitivity in the central nervous system. Pharmacogenetics and genomics. vol 16. issue 1. 2006-03-02. PMID:16344722. |
cyp2e1 and catalase influence ethanol sensitivity in the central nervous system. |
2006-03-02 |
2023-08-12 |
Not clear |
| Vasilis Vasiliou, Thomas L Ziegler, Pequita Bludeau, Dennis R Petersen, Frank J Gonzalez, Richard A Deitric. CYP2E1 and catalase influence ethanol sensitivity in the central nervous system. Pharmacogenetics and genomics. vol 16. issue 1. 2006-03-02. PMID:16344722. |
ethanol is metabolized to acetaldehyde mainly by the alcohol dehydrogenase pathway (adhs) and, to a lesser extent, by microsomal oxidization (cyp2e1) and the catalase-h2o2 system. |
2006-03-02 |
2023-08-12 |
Not clear |
| Yoshihiro Morishima, Hwei-Ming Peng, Hsia-lien Lin, Paul F Hollenberg, Roger K Sunahara, Yoichi Osawa, William B Prat. Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. Biochemistry. vol 44. issue 49. 2006-02-21. PMID:16331994. |
alcohol-inducible cytochrome p450 2e1 (cyp2e1) has the most rapid turnover of any member of this large family of membrane-bound oxygenases, and its degradation rate is altered profoundly by various substrates, such as ethanol and ccl(4). |
2006-02-21 |
2023-08-12 |
human |
| Yoshihiro Morishima, Hwei-Ming Peng, Hsia-lien Lin, Paul F Hollenberg, Roger K Sunahara, Yoichi Osawa, William B Prat. Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. Biochemistry. vol 44. issue 49. 2006-02-21. PMID:16331994. |
our observations lead to a general model of how substrates, such as ethanol, can regulate the interaction of cyp2e1 with the chaperones hsp90 and hsp70 to profoundly alter enzyme turnover. |
2006-02-21 |
2023-08-12 |
human |
| C S Liebe. Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years. Roczniki Akademii Medycznej w Bialymstoku (1995). vol 50. 2006-01-31. PMID:16363067. |
the activity of its main enzyme, cytochrome p4502e1 (cyp2e1), and its gene are increased by chronic consumption, resulting in metabolic tolerance to ethanol. |
2006-01-31 |
2023-08-12 |
Not clear |
| C S Liebe. Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years. Roczniki Akademii Medycznej w Bialymstoku (1995). vol 50. 2006-01-31. PMID:16363067. |
similarly dilinoleoylphosphatidylcholine (dlpc), ppc's main component, also partially opposes the increase in cyp2e1 by ethanol. |
2006-01-31 |
2023-08-12 |
Not clear |
| b' Tom\\xc3\\xa1s Zima, Marta Kalousov\\xc3\\xa. Oxidative stress and signal transduction pathways in alcoholic liver disease. Alcoholism, clinical and experimental research. vol 29. issue 11 Suppl. 2006-01-26. PMID:16344594.' |
ethanol, its metabolites arising during its metabolic degradation as well as novel compounds formed via ethanol induced oxidative stress, especially during the action of the ethanol inducible microsomal cytochrome cyp2e1, may apart from direct damage to biological structures affect signal transduction pathways thus modulating and potentiating damage. |
2006-01-26 |
2023-08-12 |
Not clear |
| Pengfei Gong, Arthur I Cederbau. Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology (Baltimore, Md.). vol 43. issue 1. 2006-01-24. PMID:16374848. |
induction of cyp2e1 by ethanol is one pathway through which ethanol generates oxidative stress. |
2006-01-24 |
2023-08-12 |
mouse |
| Marie-Anne Robin, Ingrid Sauvage, Thomas Grandperret, Véronique Descatoire, Dominique Pessayre, Bernard Froment. Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes. FEBS letters. vol 579. issue 30. 2006-01-23. PMID:16337197. |
in this study, we asked whether ethanol, a known inducer of microsomal cyp2e1, could also increase cyp2e1 within mitochondria. |
2006-01-23 |
2023-08-12 |
mouse |
| Marie-Anne Robin, Ingrid Sauvage, Thomas Grandperret, Véronique Descatoire, Dominique Pessayre, Bernard Froment. Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes. FEBS letters. vol 579. issue 30. 2006-01-23. PMID:16337197. |
our findings indicated that ethanol increased microsomal and mitochondrial cyp2e1 in cultured rat hepatocytes and in the liver of lean mice. |
2006-01-23 |
2023-08-12 |
mouse |
| Marie-Anne Robin, Ingrid Sauvage, Thomas Grandperret, Véronique Descatoire, Dominique Pessayre, Bernard Froment. Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes. FEBS letters. vol 579. issue 30. 2006-01-23. PMID:16337197. |
in contrast, in leptin-deficient obese mice, ethanol administration did not increase mitochondrial cyp2e1, nor it depleted mitochondrial glutathione, suggesting that leptin deficiency hampers mitochondrial targeting of cyp2e1. |
2006-01-23 |
2023-08-12 |
mouse |
| Marie-Anne Robin, Ingrid Sauvage, Thomas Grandperret, Véronique Descatoire, Dominique Pessayre, Bernard Froment. Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes. FEBS letters. vol 579. issue 30. 2006-01-23. PMID:16337197. |
thus, ethanol intoxication increases cyp2e1 not only in the endoplasmic reticulum but also in mitochondria, thus favouring oxidative stress in these compartments. |
2006-01-23 |
2023-08-12 |
mouse |
| Raj Lakshman, Arthur I Cederbaum, Jan B Hoek, Masahiro Konishi, Dennis Koop, Terrence M Donoh. Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. Alcoholism, clinical and experimental research. vol 29. issue 9. 2005-12-22. PMID:16205373. |
the presentations were (1) ethanol regulates 2,6-sialyltransferase (2,6-st) gene expression posttranscriptionally by the interaction of a cytosolic binding protein with 2,6-st mrna in cyp2e1- and adh-transfected hepg2 cells, by raj lakshman; (2) nature versus nurture: hepg2-e47 cells as a tool to investigate mechanisms of ethanol-mediated potentiation of cell killing, by jan b. hoek; (3) ethanol up-regulates profibrogenic connective tissue growth factor gene expression in hepg2 cells via cytochrome p-450 2e1-mediated ethanol oxidation, by masahiro konishi; (4) role of calcium and calcium-activated enzymes in cyp2e1-dependent toxicity, by arthur i cederbaum; (5) the use of cell lines to characterize the role of cyp2e1 in the metabolism of farnesol, by dennis koop; and (6) studies with hepg2 cells that express the two major ethanol-metabolizing enzymes, by terrence m. donohue. |
2005-12-22 |
2023-08-12 |
human |
| Jakub Jabloński, Adam Hołownia, Ewa Jabłońska, Janina Moniuszko-Jakoniuk, Jan Braszko, Jolanta Iwanowska, Magda Marcińczy. The effect of ethanol and nitric oxide on the N-nitrosodimethylamine formation in HepG2 cells overexpressing CYP2E1. Human & experimental toxicology. vol 24. issue 9. 2005-12-22. PMID:16235733. |
the effect of ethanol and nitric oxide on the n-nitrosodimethylamine formation in hepg2 cells overexpressing cyp2e1. |
2005-12-22 |
2023-08-12 |
Not clear |
| Natalia A Osna, Dahn L Clemens, Terrence M Donohu. Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells. Hepatology (Baltimore, Md.). vol 42. issue 5. 2005-12-09. PMID:16250053. |
we previously showed that ifngamma signal transduction was suppressed by ethanol in recombinant hepg2 cells (vl-17a cells), which express alcohol dehydrogenase (adh) and cyp2e1. |
2005-12-09 |
2023-08-12 |
Not clear |
| Natalia A Osna, Dahn L Clemens, Terrence M Donohu. Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells. Hepatology (Baltimore, Md.). vol 42. issue 5. 2005-12-09. PMID:16250053. |
when cells expressing either adh (va-13 cells) or cyp2e1 (e-47 cells) were exposed to ethanol, both adh- and cyp2e1-generated products reduced stat1 phosphorylation. |
2005-12-09 |
2023-08-12 |
Not clear |
| Yasuyuki Sadzuka, Chieko Inoue, Saho Hirooka, Tomomi Sugiyama, Keizo Umegaki, Takashi Sonob. Effects of theanine on alcohol metabolism and hepatic toxicity. Biological & pharmaceutical bulletin. vol 28. issue 9. 2005-10-28. PMID:16141543. |
since the elevation of cytochrome p450 (cyp) 2e1 activity was controlled in the theanine-combined groups, it was considered that these disorders attributable to cyp2e1 in ethanol long-term uptake might be avoidable by theanine. |
2005-10-28 |
2023-08-12 |
mouse |
| Yong-Dae Kim, Tsunehiro Oyama, Toyohi Isse, Heon Kim, Toshihiro Kawamot. Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot study. Archives of toxicology. vol 79. issue 4. 2005-09-21. PMID:15654606. |
using ethanol exposure, the protein expression levels of cyp2e1, 2b1/2 and 4b1 in aldh2 +/+ mice were increased by factors of 2.61, 1.88 and 2.01 compared with aldh2 +/+ mice that were not exposed to ethanol, respectively. |
2005-09-21 |
2023-08-12 |
mouse |
| Yong-Dae Kim, Tsunehiro Oyama, Toyohi Isse, Heon Kim, Toshihiro Kawamot. Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot study. Archives of toxicology. vol 79. issue 4. 2005-09-21. PMID:15654606. |
on the other hand, in the aldh2 -/- mice, cyp2e1, 2b1/2 and 4b1 protein expression levels after ethanol treatment were shown to be 1.99, 1.05 and 1.33 greater than those of aldh2 -/- control mice, respectively. |
2005-09-21 |
2023-08-12 |
mouse |
| Yong-Dae Kim, Tsunehiro Oyama, Toyohi Isse, Heon Kim, Toshihiro Kawamot. Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot study. Archives of toxicology. vol 79. issue 4. 2005-09-21. PMID:15654606. |
we also found an interesting fact in the present study; the aldh2 -/- mice were shown to have higher cyp2e1 (by a factor of 4.19), 2b1/2 (by a factor of 2.89) and 4b1 (by a factor of 1.53) protein expression levels than aldh2 +/+ mice despite the lack of ethanol treatment. |
2005-09-21 |
2023-08-12 |
mouse |