| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin J J Ronis, Soheila Korourian, Michelle Zipperman, Reza Hakkak, Thomas M Badge. Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition. The Journal of nutrition. vol 134. issue 4. 2004-05-06. PMID:15051845. |
changes in dietary fat composition did not alter ethanol metabolism or cyp2e1 induction, but hepatic cyp4a levels increased markedly in rats fed the saturated fat diet. |
2004-05-06 |
2023-08-12 |
rat |
| Feng Wen, Maher Y Abdalla, Costica Aloman, Jinhua Xiang, Iman M Ahmad, Jose Walewski, Michael L McCormick, Kyle E Brown, Andrea D Branch, Douglas R Spitz, Bradley E Britigan, Warren N Schmid. Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1. Journal of medical virology. vol 72. issue 2. 2004-04-22. PMID:14695664. |
hepatitis c virus (hcv) and hcv core protein are hypothesized to induce hepatic oxidative stress and exacerbate injury caused by other toxins such as ethanol that induce the cytochrome p450 enzyme, cyp2e1. |
2004-04-22 |
2023-08-12 |
Not clear |
| Martin J J Ronis, Reza Hakkak, Sohelia Korourian, Emanuele Albano, Seokjoo Yoon, Magnus Ingelman-Sundberg, Kai O Lindros, Thomas M Badge. Alcoholic liver disease in rats fed ethanol as part of oral or intragastric low-carbohydrate liquid diets. Experimental biology and medicine (Maywood, N.J.). vol 229. issue 4. 2004-04-20. PMID:15044719. |
liver pathology, blood ethanol concentration, serum alanine amino transferase (alt), endotoxin level, hepatic cyp2e1 induction, and cytokine profiles were assessed. |
2004-04-20 |
2023-08-12 |
rat |
| Martin J J Ronis, Reza Hakkak, Sohelia Korourian, Emanuele Albano, Seokjoo Yoon, Magnus Ingelman-Sundberg, Kai O Lindros, Thomas M Badge. Alcoholic liver disease in rats fed ethanol as part of oral or intragastric low-carbohydrate liquid diets. Experimental biology and medicine (Maywood, N.J.). vol 229. issue 4. 2004-04-20. PMID:15044719. |
both oral and intragastric low-carbohydrate ethanol diets resulted in marked steatosis with additional inflammation and necrosis accompanied by significantly increased serum alt, high levels of cyp2e1 expression, and production of auto-antibodies against malondialdehyde and hydroxyethyl free radical protein adducts. |
2004-04-20 |
2023-08-12 |
rat |
| Douglas J Fort, Daniel W McLaughlin, Robert L Rogers, Brody O Buzzar. Evaluation of the developmental toxicities of ethanol, acetaldehyde, and thioacetamide using FETAX. Drug and chemical toxicology. vol 26. issue 1. 2004-04-12. PMID:12643038. |
ethanol also appeared to be bioactivated by cyp2e1. |
2004-04-12 |
2023-08-12 |
Not clear |
| Viola Tamási, Eszter Hazai, Margareta Porsmyr-Palmertz, Magnus Ingelman-Sundberg, László Vereczkey, Katalin Monostor. GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer. Drug metabolism and disposition: the biological fate of chemicals. vol 31. issue 11. 2004-03-15. PMID:14570761. |
hepatocytes in culture showed rapid loss of cyp2e1 enzyme during 72 h. cyp2e1 inducers (ethanol, dimethyl sulfoxide, acetone, isopropanol, pyrazole, and imidazole) were able to prevent the fast decrease of the activities and protein levels of cyp2e1 enzyme. |
2004-03-15 |
2023-08-12 |
human |
| Jian Zhuge, Ye Luo, Ying-Nian Y. Heterologous expression of human cytochrome P450 2E1 in HepG2 cell line. World journal of gastroenterology. vol 9. issue 12. 2004-03-15. PMID:14669323. |
human cytochrome p-450 2e1 (cyp2e1) takes part in the biotransformation of ethanol, acetone, many small-molecule substrates and volatile anesthetics. |
2004-03-15 |
2023-08-12 |
human |
| Hiromasa Ishii, Masayuki Adachi, Jose C Fernández-Checa, Arthur I Cederbaum, Ion V Deaciuc, Amin A Nanj. Role of apoptosis in alcoholic liver injury. Alcoholism, clinical and experimental research. vol 27. issue 7. 2004-03-11. PMID:12878930. |
a. nanji; (2) mitochondria, oxidative stress and apoptosis in alcoholic liver disease, by m. adachi; (3) regulation of cell death by mitochondrial glutathione, by j.c. fernández-checa; (4) toxicity of ethanol in hepg2 cells that express cyp2e1, by a.i. |
2004-03-11 |
2023-08-12 |
Not clear |
| J C Rowlands, L He, T M Badge. Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells. Xenobiotica; the fate of foreign compounds in biological systems. vol 33. issue 4. 2004-02-19. PMID:12745874. |
glucose inhibition of the induction of cyp2e1 mrna expression by ethanol in fgc-4 cells. |
2004-02-19 |
2023-08-12 |
rat |
| J C Rowlands, L He, T M Badge. Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells. Xenobiotica; the fate of foreign compounds in biological systems. vol 33. issue 4. 2004-02-19. PMID:12745874. |
fgc-4 cells grown in a glucose-free media and treated with 1-100 mm ethanol for 24 h exhibited a dose-dependent increase (p < 0.05) in cyp2e1, with maximum mrna steady-state (3.8-fold) or protein (3.1-fold) levels measured at 30 or 100 mm ethanol, respectively. |
2004-02-19 |
2023-08-12 |
rat |
| J C Rowlands, L He, T M Badge. Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells. Xenobiotica; the fate of foreign compounds in biological systems. vol 33. issue 4. 2004-02-19. PMID:12745874. |
in cells treated with 30 mm ethanol, a glucose concentration-dependent inhibition (p < 0.05) of cyp2e1 mrna was observed between 2.5 and 10 mm glucose. |
2004-02-19 |
2023-08-12 |
rat |
| J C Rowlands, L He, T M Badge. Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells. Xenobiotica; the fate of foreign compounds in biological systems. vol 33. issue 4. 2004-02-19. PMID:12745874. |
induction by 30 mm ethanol of cyp2e1 protein was reduced in cells co-treated with 1 mm or greater glucose concentration and complete inhibition was measured with 5 mm glucose co-treatment. |
2004-02-19 |
2023-08-12 |
rat |
| J C Rowlands, L He, T M Badge. Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells. Xenobiotica; the fate of foreign compounds in biological systems. vol 33. issue 4. 2004-02-19. PMID:12745874. |
these data demonstrate that under culture conditions of extremely low carbohydrate concentrations: (1) ethanol treatment of fgc-4 cells results in elevated steady-state levels of cyp2e1 mrna and protein; and (2) glucose inhibits this increase. |
2004-02-19 |
2023-08-12 |
rat |
| J C Rowlands, L He, T M Badge. Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells. Xenobiotica; the fate of foreign compounds in biological systems. vol 33. issue 4. 2004-02-19. PMID:12745874. |
it is concluded that glucose can negatively regulate cyp2e1 expression and could at least partially explain the greater induction of hepatic cyp2e1 in rats fed low carbohydrate ethanol-containing diets compared with high carbohydrate diets at the same ethanol level. |
2004-02-19 |
2023-08-12 |
rat |
| M T Donato, R Klocke, J V Castell, K Stenzel, D Paul, M J Gómez-Lechó. Constitutive and inducible expression of CYP enzymes in immortal hepatocytes derived from SV40 transgenic mice. Xenobiotica; the fate of foreign compounds in biological systems. vol 33. issue 5. 2004-01-29. PMID:12746103. |
3-methylcholanthrene induced cyp1a1/2 (7-ethoxyresorufin o-deethylation); phenobarbital induced cyp2b (7-benzoxyresorufin o-debenzylation), cyp2a4/5 (testosterone 7alpha -hydroxylation) and cyp3a11 (testosterone 6beta -hydroxylation); and rifampicin and dexamethasone induced cyp3a11 activities in the three delta 202 cell lines, whereas only amh-delta 202 cells reproduced to a limited extent the response of cyp2e1 to ethanol observed in hepatocytes. |
2004-01-29 |
2023-08-12 |
mouse |
| S Kato, T Tajiri, N Matsukura, N Matsuda, N Taniai, H Mamada, H Yoshida, T Kiyam, Z Nait. Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. Scandinavian journal of gastroenterology. vol 38. issue 8. 2003-12-16. PMID:12940444. |
cytochrome p450 2e1 (cyp2e1) oxidizes ethanol to form acetaldehyde and aldehyde dehydrogenase 2 (aldh2) detoxifies acetaldehyde, which is carcinogenic in humans, and both alcohol-metabolizing enzymes show the genetic polymorphisms in a japanese population. |
2003-12-16 |
2023-08-12 |
Not clear |
| Lisa A Howard, Sharon Miksys, Ewa Hoffmann, Deborah Mash, Rachel F Tyndal. Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. British journal of pharmacology. vol 138. issue 7. 2003-12-15. PMID:12711639. |
brain cyp2e1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. |
2003-12-15 |
2023-08-12 |
human |
| Lisa A Howard, Sharon Miksys, Ewa Hoffmann, Deborah Mash, Rachel F Tyndal. Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. British journal of pharmacology. vol 138. issue 7. 2003-12-15. PMID:12711639. |
cytochrome p450 2e1 (cyp2e1) metabolizes ethanol and bioactivates tobacco-derived procarcinogens. |
2003-12-15 |
2023-08-12 |
human |
| Lisa A Howard, Sharon Miksys, Ewa Hoffmann, Deborah Mash, Rachel F Tyndal. Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. British journal of pharmacology. vol 138. issue 7. 2003-12-15. PMID:12711639. |
ethanol and nicotine can induce hepatic cyp2e1 and we hypothesized that both centrally active drugs could also induce cyp2e1 within the brain. |
2003-12-15 |
2023-08-12 |
human |
| Lisa A Howard, Sharon Miksys, Ewa Hoffmann, Deborah Mash, Rachel F Tyndal. Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. British journal of pharmacology. vol 138. issue 7. 2003-12-15. PMID:12711639. |
ethanol treatment significantly increased cyp2e1 in olfactory bulbs (1.7-fold), frontal cortex (2.0-fold), hippocampus (1.9-fold) and cerebellum (1.8-fold), while nicotine induced cyp2e1 in olfactory bulbs (2.3-fold), frontal cortex (3.0-fold), olfactory tubercle (3.1-fold), cerebellum (2.5-fold) and brainstem (2.0-fold). |
2003-12-15 |
2023-08-12 |
human |