| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa A Howard, Sharon Miksys, Ewa Hoffmann, Deborah Mash, Rachel F Tyndal. Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. British journal of pharmacology. vol 138. issue 7. 2003-12-15. PMID:12711639. |
cyp2e1 induction in the brain, by ethanol or nicotine, may influence the central effects of ethanol and the development of nervous tissue pathologies observed in alcoholics and smokers. |
2003-12-15 |
2023-08-12 |
human |
| Irina G Kessova, Ye-Shih Ho, Swan Thung, Arthur I Cederbau. Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase. Hepatology (Baltimore, Md.). vol 38. issue 5. 2003-12-12. PMID:14578852. |
cytochrome p450 2e1 (cyp2e1) activity was elevated about 2-fold by ethanol in sod1(+/+) and sod1(-/-) mice. |
2003-12-12 |
2023-08-12 |
mouse |
| María José Pérez, Arthur I Cederbau. Adenovirus-mediated expression of Cu/Zn- or Mn-superoxide dismutase protects against CYP2E1-dependent toxicity. Hepatology (Baltimore, Md.). vol 38. issue 5. 2003-12-12. PMID:14578853. |
cyp2e1 induction by ethanol is one mechanism by which ethanol creates oxidative stress in the liver. |
2003-12-12 |
2023-08-12 |
Not clear |
| Irina Kessova, Arthur I Cederbau. CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury. Current molecular medicine. vol 3. issue 6. 2003-12-04. PMID:14527082. |
one central pathway appears to be the induction of the cyp2e1 form of cytochrome p450 enzymes by ethanol. |
2003-12-04 |
2023-08-12 |
human |
| Irina Kessova, Arthur I Cederbau. CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury. Current molecular medicine. vol 3. issue 6. 2003-12-04. PMID:14527082. |
cyp2e1 is of interest because of its ability to metabolize and activate many toxicological substrates, including ethanol, to more reactive, toxic products. |
2003-12-04 |
2023-08-12 |
human |
| Thomas M Badger, Martin J J Ronis, Helmut K Seitz, Emanuele Albano, Magnus Ingelman-Sundberg, Charles S Liebe. Alcohol metabolism: role in toxicity and carcinogenesis. Alcoholism, clinical and experimental research. vol 27. issue 2. 2003-12-02. PMID:12605083. |
the presentations were (1) first-pass metabolism of ethanol: basic and clinical aspects, by charles lieber; (2) intracellular cyp2e1 transport, oxidative stress, cytokine release, and ald, by magnus ingelman-sundberg; (3) pulsatile ethanol metabolism in intragastric infusion models: potential role in toxic outcomes, by thomas m. badger and martin j.j. ronis; (4) free radicals, adducts, and autoantibodies resulting from ethanol metabolism: role in ethanol-associated toxicity, by emanuele albano; and (5) gastrointestinal metabolism of ethanol and its possible role in carcinogenesis, by helmut seitz. |
2003-12-02 |
2023-08-12 |
Not clear |
| David R Geter, John W Fournie, Marius H Brouwer, Anthony B DeAngelo, William E Hawkin. p-Nitrophenol and glutathione response in medaka (Oryzias latipes) exposed to MX, a drinking water carcinogen. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 134. issue 3. 2003-12-02. PMID:12643982. |
male medaka exposed for 96 h to the cyp2e1 inducers ethanol and acetone under fasted conditions showed significant increases in pnp-hydroxylation activity. |
2003-12-02 |
2023-08-12 |
Not clear |
| Natalia A Osna, Dahn L Clemens, Terrence M Donohu. Interferon gamma enhances proteasome activity in recombinant Hep G2 cells that express cytochrome P4502E1: modulation by ethanol. Biochemical pharmacology. vol 66. issue 5. 2003-10-06. PMID:12948850. |
we tested the influence of ifngamma on proteasome activity in parental hep g2 cells that do not metabolize ethanol, as well as in recombinant hep g2-derived cells that express either or both alcohol dehydrogenase (adh) and cytochrome p4502e1 (cyp2e1). |
2003-10-06 |
2023-08-12 |
Not clear |
| Marek Waluga, Marek Hartle. [Alcoholic liver disease]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 56. issue 1-2. 2003-09-11. PMID:12901271. |
chronic ethanol consumption does not influence adh activity, but has a profound stimulatory effect on microsomal enzymes, in particular cytochrome cyp2e1. |
2003-09-11 |
2023-08-12 |
Not clear |
| Perrine Hoet, Jean-Pierre Buchet, Christine Sempoux, Vincent Haufroid, Jacques Rahier, Dominique Liso. Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs. Archives of toxicology. vol 76. issue 12. 2003-07-15. PMID:12451447. |
the objectives of these experiments were to investigate (1) whether, like halothane, multiple exposure increases the risk of hcfc-123-induced liver toxicity, and (2) whether ethanol, a potent cyp2e1 inducer, potentiates the liver toxicity of hcfc-123. |
2003-07-15 |
2023-08-12 |
Not clear |
| Perrine Hoet, Jean-Pierre Buchet, Christine Sempoux, Vincent Haufroid, Jacques Rahier, Dominique Liso. Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs. Archives of toxicology. vol 76. issue 12. 2003-07-15. PMID:12451447. |
ethanol consumption produced cyp2e1 induction, increased urinary excretion of both hcfc-123 metabolites (more than 2-fold the rate measured in the non-induced group) and markedly increased the liver toxicity of hcfc-123 as shown by the serum liver enzyme activities (alt 8.5-fold increase, icdh 13-fold increase), and the histopathology. |
2003-07-15 |
2023-08-12 |
Not clear |
| Perrine Hoet, Jean-Pierre Buchet, Christine Sempoux, Vincent Haufroid, Jacques Rahier, Dominique Liso. Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs. Archives of toxicology. vol 76. issue 12. 2003-07-15. PMID:12451447. |
it can be concluded that (1) multiple exposure to hcfc-123 did not increase the liver toxicity of hcfc-123 in this experimental model, and (2) chronic ethanol consumption, known to be cyp2e1 inducer, strongly enhanced the biotransformation of hcfc-123 and its liver toxicity. |
2003-07-15 |
2023-08-12 |
Not clear |
| María José Pérez, Arthur I Cederbau. Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells. Hepatology (Baltimore, Md.). vol 37. issue 6. 2003-06-18. PMID:12774019. |
induction of cyp2e1 is one pathway involved in how ethanol produces oxidative stress. |
2003-06-18 |
2023-08-12 |
rat |
| Kerri A Schoedel, Rachel F Tyndal. Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing CYP2E1 by nicotine: summary and implications. Biochimica et biophysica acta. vol 1619. issue 3. 2003-06-10. PMID:12573488. |
induction of nicotine-metabolizing cyp2b1 by ethanol and ethanol-metabolizing cyp2e1 by nicotine: summary and implications. |
2003-06-10 |
2023-08-12 |
rat |
| Kerri A Schoedel, Rachel F Tyndal. Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing CYP2E1 by nicotine: summary and implications. Biochimica et biophysica acta. vol 1619. issue 3. 2003-06-10. PMID:12573488. |
this review summarizes recent studies published from our laboratory focusing on metabolic aspects of tolerance, which demonstrate that in rat, subchronic, behaviourally relevant doses of ethanol induce hepatic nicotine-metabolizing cytochrome p450 (cyp) 2b1, and that subchronically administered nicotine, at behaviourally relevant doses, induces hepatic ethanol-metabolizing cyp2e1. |
2003-06-10 |
2023-08-12 |
rat |
| Ping Zhao, John T Slatter. Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: implication of potentiated acetaminophen toxicity in alcoholics. Drug metabolism and disposition: the biological fate of chemicals. vol 30. issue 12. 2003-05-13. PMID:12433812. |
chronic ethanol consumption potentiates acetaminophen (apap) hepatotoxicity through enhanced napqi formation via cyp2e1 induction and selective depletion of mitochondrial glutathione. |
2003-05-13 |
2023-08-12 |
rat |
| Ping Zhao, John T Slatter. Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: implication of potentiated acetaminophen toxicity in alcoholics. Drug metabolism and disposition: the biological fate of chemicals. vol 30. issue 12. 2003-05-13. PMID:12433812. |
the highest ethanol-containing diet (36% energy as ethanol) was replaced by control diet for 2, 5, 12, and 17 h. maximal cyp2e1 induction was caused by 36% energy as ethanol diet (2.2-fold, p < 0.05 versus control). |
2003-05-13 |
2023-08-12 |
rat |
| Ping Zhao, John T Slatter. Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: implication of potentiated acetaminophen toxicity in alcoholics. Drug metabolism and disposition: the biological fate of chemicals. vol 30. issue 12. 2003-05-13. PMID:12433812. |
in conclusion, high-dose ethanol potentiated apap hepatotoxicity via cyp2e1 induction and selective mitochondrial gsh depletion. |
2003-05-13 |
2023-08-12 |
rat |
| Dalwoong Choi, Brigitte Leininger-Muller, Young Chul Kim, Pierre Leroy, Gerard Siest, Maria Wellma. Differential role of CYP2E1 binders and isoniazid on CYP2E1 protein modification in NADPH-dependent microsomal oxidative reactions: free radical scavenging ability of isoniazid. Free radical research. vol 36. issue 8. 2003-04-17. PMID:12420748. |
we evaluated the effect of "weak" cyp2e1 binders (ethanol, acetone and glycerol) "tight" cyp2e1 binders (4-methylpyrazole, imidazole, isoniazid and pyridine) and ccl4 (suicide substrate of cyp2e1) on the nadph-dependent production of microsomal reactive oxygen species (ros), lipid peroxidation (lpo), and subsequent modification of microsomal and cyp2e1 proteins. |
2003-04-17 |
2023-08-12 |
rat |
| Dalwoong Choi, Brigitte Leininger-Muller, Young Chul Kim, Pierre Leroy, Gerard Siest, Maria Wellma. Differential role of CYP2E1 binders and isoniazid on CYP2E1 protein modification in NADPH-dependent microsomal oxidative reactions: free radical scavenging ability of isoniazid. Free radical research. vol 36. issue 8. 2003-04-17. PMID:12420748. |
concerning nadph-dependent modification of cyp2e1 protein, all of the tested cyp2e1 binders, except glycerol, prevented this process with a different potency (isoniazid > 4-methylpyrazole = imidazole = pyridine 3 >> acetone > ethanol). |
2003-04-17 |
2023-08-12 |
rat |