| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong-Dae Kim, Tsunehiro Oyama, Toyohi Isse, Heon Kim, Toshihiro Kawamot. Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot study. Archives of toxicology. vol 79. issue 4. 2005-09-21. PMID:15654606. |
these results suggest that cyp2e1, 2b1/2 and 4b1 play some role in ethanol metabolism and that aldh2-deficient individuals may have higher levels of cyp2e1, 2b1/2 and 4b1 enzymes compared to aldh2 wild-type individuals. |
2005-09-21 |
2023-08-12 |
mouse |
| Youqing Xu, Maria A Leo, Charles S Liebe. DLPC attenuates alcohol-induced cytotoxicity in HepG2 cells expressing CYP2E1. Alcohol and alcoholism (Oxford, Oxfordshire). vol 40. issue 3. 2005-08-11. PMID:15753073. |
alcoholic liver injury was shown to result largely from oxidative stress generated by ethanol metabolism via cytochrome p4502e1 (cyp2e1). |
2005-08-11 |
2023-08-12 |
Not clear |
| Farah Esfandiari, Jesus A Villanueva, Donna H Wong, Samuel W French, Charles H Halste. Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. American journal of physiology. Gastrointestinal and liver physiology. vol 289. issue 1. 2005-08-02. PMID:15705656. |
the effects of ethanol feeding or folate-deficient diets, singly or in combination, on cytochrome p-450 2e1 (cyp2e1) and signal pathways for apoptosis and steatosis were analyzed using microarray, real-time pcr, and immunoblotting techniques. |
2005-08-02 |
2023-08-12 |
Not clear |
| Farah Esfandiari, Jesus A Villanueva, Donna H Wong, Samuel W French, Charles H Halste. Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. American journal of physiology. Gastrointestinal and liver physiology. vol 289. issue 1. 2005-08-02. PMID:15705656. |
liver cyp2e1 and the endoplasmic reticulum stress signals glucose-regulated protein 78 (grp78), caspase 12, and sterol regulatory element binding protein-1c (srebp-1c) were each activated in pigs fed folate-deficient or ethanol diets singly or in combination. |
2005-08-02 |
2023-08-12 |
Not clear |
| Farah Esfandiari, Jesus A Villanueva, Donna H Wong, Samuel W French, Charles H Halste. Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. American journal of physiology. Gastrointestinal and liver physiology. vol 289. issue 1. 2005-08-02. PMID:15705656. |
the induction of abnormal hepatic methionine metabolism through the combination of ethanol feeding with folate deficiency is associated with the activation of cyp2e1 and enhances endoplasmic reticulum stress signals that promote steatosis and apoptosis. |
2005-08-02 |
2023-08-12 |
Not clear |
| Aparajita Dey, Alok Dhawan, Prahlad Kishore Seth, Devendra Parma. Evidence for cytochrome P450 2E1 catalytic activity and expression in rat blood lymphocytes. Life sciences. vol 77. issue 10. 2005-08-02. PMID:15890371. |
rt-pcr studies have shown that as observed in liver, acute treatment of ethanol (single oral dose of 0.8 ml/kg b.wt, i.p), resulted in increase in the mrna expression of cyp2e1 in freshly isolated rat blood lymphocytes. |
2005-08-02 |
2023-08-12 |
rat |
| Aparajita Dey, Alok Dhawan, Prahlad Kishore Seth, Devendra Parma. Evidence for cytochrome P450 2E1 catalytic activity and expression in rat blood lymphocytes. Life sciences. vol 77. issue 10. 2005-08-02. PMID:15890371. |
similar to that seen in liver, pretreatment of ethanol was found to produce an increase in the cyp2e1 isoenzyme in the blood lymphocytes. |
2005-08-02 |
2023-08-12 |
rat |
| Qi Cao, Ki M Mak, Charles S Liebe. Cytochrome P4502E1 primes macrophages to increase TNF-alpha production in response to lipopolysaccharide. American journal of physiology. Gastrointestinal and liver physiology. vol 289. issue 1. 2005-08-02. PMID:15961886. |
because cytochrome p4502e1 (cyp2e1) is upregulated in kupffer cells after ethanol, we hypothesized that this effect primes kupffer cells, sensitizing them to increase tnf-alpha production in response to lps. |
2005-08-02 |
2023-08-12 |
Not clear |
| Qi Cao, Ki M Mak, Charles S Liebe. Cytochrome P4502E1 primes macrophages to increase TNF-alpha production in response to lipopolysaccharide. American journal of physiology. Gastrointestinal and liver physiology. vol 289. issue 1. 2005-08-02. PMID:15961886. |
accordingly, cyp2e1 priming could explain the sensitization of kupffer cells to lps activation by ethanol, a critical early step in alcoholic liver disease. |
2005-08-02 |
2023-08-12 |
Not clear |
| Mamatha Garige, Maokai Gong, Manjunath N Rao, Yili Zhang, M Raj Lakshma. Mechanism of action of ethanol in the down-regulation of Gal(beta)1, 4GlcNAc alpha2,6-sialyltransferase messenger RNA in human liver cell lines. Metabolism: clinical and experimental. vol 54. issue 6. 2005-07-28. PMID:15931606. |
we now mimic these actions of ethanol using ( a ) human liver hepg2 cells stably transfected with ethanol-inducible human cytochrome p4502e1 (cyp2e1 cells), or ( b ) with high alcohol dehydrogenase (had cells) but not in wild-type hepg2 cells lacking either of the above 2 enzymes as models. |
2005-07-28 |
2023-08-12 |
human |
| Mamatha Garige, Maokai Gong, Manjunath N Rao, Yili Zhang, M Raj Lakshma. Mechanism of action of ethanol in the down-regulation of Gal(beta)1, 4GlcNAc alpha2,6-sialyltransferase messenger RNA in human liver cell lines. Metabolism: clinical and experimental. vol 54. issue 6. 2005-07-28. PMID:15931606. |
incubation of these cells for 72 hours with 100 mmol/l ethanol caused decreases (up to 76%, p < .05) of 2,6-st mrna levels in cyp2e1 and had cells but not in the wild type. |
2005-07-28 |
2023-08-12 |
human |
| Natalie Lassen, Tia Estey, Robert L Tanguay, Aglaia Pappa, Mark J Reimers, Vasilis Vasilio. Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2. Drug metabolism and disposition: the biological fate of chemicals. vol 33. issue 5. 2005-07-27. PMID:15703303. |
ethanol is metabolized to acetaldehyde mainly by the alcohol dehydrogenase pathway and, to a lesser extent, through microsomal oxidation (cyp2e1) and the catalase-h(2)o(2) system. |
2005-07-27 |
2023-08-12 |
human |
| Charles S Liebe. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol (Fayetteville, N.Y.). vol 34. issue 1. 2005-06-09. PMID:15670660. |
liver disease in the alcoholic is due not only to malnutrition but also to ethanol's hepatotoxicity linked to its metabolism by means of the alcohol dehydrogenase and cytochrome p450 2e1 (cyp2e1) pathways and the resulting production of toxic acetaldehyde. |
2005-06-09 |
2023-08-12 |
rat |
| Charles S Liebe. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol (Fayetteville, N.Y.). vol 34. issue 1. 2005-06-09. PMID:15670660. |
furthermore, cyp2e1 activity is inducible by its substrates, not only ethanol but also fatty acids. |
2005-06-09 |
2023-08-12 |
rat |
| Fawzia Bardag-Gorce, Jun Li, Barbara A French, Samuel W Frenc. The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal. Experimental and molecular pathology. vol 78. issue 2. 2005-05-16. PMID:15713435. |
to correlate the loss of proteasomal activity with cyp2e1 induction, ethanol was fed intragastrically for 1, 3, 7, and 15 days. |
2005-05-16 |
2023-08-12 |
rat |
| Fawzia Bardag-Gorce, Jun Li, Barbara A French, Samuel W Frenc. The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal. Experimental and molecular pathology. vol 78. issue 2. 2005-05-16. PMID:15713435. |
the maximum induction of cyp2e1 (3.5-fold) occurred after 15 days of ethanol feeding. |
2005-05-16 |
2023-08-12 |
rat |
| Fawzia Bardag-Gorce, Jun Li, Barbara A French, Samuel W Frenc. The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal. Experimental and molecular pathology. vol 78. issue 2. 2005-05-16. PMID:15713435. |
when ethanol was given to rats for 1 month, cyp2e1 was significantly induced, and the proteasomal activity was significantly decreased. |
2005-05-16 |
2023-08-12 |
rat |
| Fawzia Bardag-Gorce, Jun Li, Barbara A French, Samuel W Frenc. The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal. Experimental and molecular pathology. vol 78. issue 2. 2005-05-16. PMID:15713435. |
these results indicate that proteasomal activity was not directly affected by ethanol or cyp2e1 induction. |
2005-05-16 |
2023-08-12 |
rat |
| Judy L Raucy, Jerome Lasker, Kazuaki Ozaki, Veronica Zolet. Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology. vol 79. issue 2. 2005-05-05. PMID:15056802. |
regulation of cyp2e1 by ethanol and palmitic acid and cyp4a11 by clofibrate in primary cultures of human hepatocytes. |
2005-05-05 |
2023-08-12 |
human |
| Judy L Raucy, Jerome Lasker, Kazuaki Ozaki, Veronica Zolet. Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology. vol 79. issue 2. 2005-05-05. PMID:15056802. |
ethanol significantly (p < 0.05) increased expression of cyp2e1 mrna by 216 +/- 32% of control, but did not alter cyp4a11 mrna accumulation (145 +/- 22% of control). |
2005-05-05 |
2023-08-12 |
human |