| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arthur I Cederbaum, Yongke Lu, Defeng W. Role of oxidative stress in alcohol-induced liver injury. Archives of toxicology. vol 83. issue 6. 2009-08-31. PMID:19448996. |
special emphasis is placed on cyp2e1, which is induced by alcohol and is reactive in metabolizing and activating many hepatotoxins, including ethanol, to reactive products, and in generating ros. |
2009-08-31 |
2023-08-12 |
Not clear |
| Ying Wang, Gunda Millonig, Jagadeesan Nair, Eleonora Patsenker, Felix Stickel, Sebastian Mueller, Helmut Bartsch, Helmut K Seit. Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. Hepatology (Baltimore, Md.). vol 50. issue 2. 2009-08-21. PMID:19489076. |
to further assess the role of cyp2e1 in the formation of etheno-dna adducts, hepg2 cells stably transfected with human cyp2e1 were exposed to ethanol with or without chlormethiazole (cmz), a specific cyp2e1 inhibitor. |
2009-08-21 |
2023-08-12 |
human |
| Angelica Butura, Kerstin Nilsson, Kengathevy Morgan, Timothy R Morgan, Samuel W French, Inger Johansson, Ina Schuppe-Koistinen, Magnus Ingelman-Sundber. The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model. Journal of hepatology. vol 50. issue 3. 2009-07-29. PMID:19157621. |
cyp2e1 metabolizes ethanol, generates reactive oxygen species, and is suggested to be important for development of alcoholic liver disease. |
2009-07-29 |
2023-08-12 |
mouse |
| Angelica Butura, Kerstin Nilsson, Kengathevy Morgan, Timothy R Morgan, Samuel W French, Inger Johansson, Ina Schuppe-Koistinen, Magnus Ingelman-Sundber. The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model. Journal of hepatology. vol 50. issue 3. 2009-07-29. PMID:19157621. |
the present study aims to evaluate the role of cyp2e1 in combination with ethanol for development of alcoholic liver disease using mice transgenic for the human cyp2e1 gene. |
2009-07-29 |
2023-08-12 |
mouse |
| James R Roede, David J Orlicky, Aron B Fisher, Dennis R Peterse. Overexpression of peroxiredoxin 6 does not prevent ethanol-mediated oxidative stress and may play a role in hepatic lipid accumulation. The Journal of pharmacology and experimental therapeutics. vol 330. issue 1. 2009-07-27. PMID:19386791. |
after 9 weeks of ethanol consumption, all backgrounds exhibited elevations of plasma alanine aminotransferase activity, hepatosteatosis, cyp2e1 induction, and lipid peroxidation; however, hepatic triglyceride accumulation seemed to be exacerbated in ethanol-fed tg mice. |
2009-07-27 |
2023-08-12 |
mouse |
| Anwar Jamal Khan, Munindra Ruwali, Gourdas Choudhuri, Neeraj Mathur, Qayyum Husain, Devendra Parma. Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis. Mutation research. vol 664. issue 1-2. 2009-07-24. PMID:19428381. |
the association of polymorphism in cytochrome p450 2e1 (cyp2e1), the major microsomal ethanol metabolizing enzyme and its interaction with genes, involved in detoxification of reactive oxygen species, such as glutathione-s-transferases m1 (gstm1) and alcohol intake, gamma-aminobutyric acid receptor gamma2 (gabrg2) was studied with the risk to alcoholic cirrhosis in a case-control study. |
2009-07-24 |
2023-08-12 |
Not clear |
| Jiang Yue, Jibran Khokhar, Sharon Miksys, Rachel F Tyndal. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. European journal of pharmacology. vol 609. issue 1-3. 2009-07-13. PMID:19285975. |
differential induction of ethanol-metabolizing cyp2e1 and nicotine-metabolizing cyp2b1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. |
2009-07-13 |
2023-08-12 |
rat |
| Jiang Yue, Jibran Khokhar, Sharon Miksys, Rachel F Tyndal. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. European journal of pharmacology. vol 609. issue 1-3. 2009-07-13. PMID:19285975. |
cyp2e1 was increased 1.7, 1.8, and 1.4 fold by the three doses of nicotine alone (p<0.02-0.21); cyp2e1 levels were increased by voluntary ethanol intake alone and a further 2.4, 2.2, and 1.8 fold by 0.4, 0.8, and 1.2 mg/kg nicotine respectively versus saline pretreatment (p<0.002-0.06). |
2009-07-13 |
2023-08-12 |
rat |
| Jiang Yue, Jibran Khokhar, Sharon Miksys, Rachel F Tyndal. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. European journal of pharmacology. vol 609. issue 1-3. 2009-07-13. PMID:19285975. |
chronic nicotine increased voluntary ethanol intake thereby enhancing cyp2e1 and cyp2b1/2 levels. |
2009-07-13 |
2023-08-12 |
rat |
| Shannon M Bailey, Sudheer K Mantena, Telisha Millender-Swain, Yavuz Cakir, Nirag C Jhala, David Chhieng, Kent E Pinkerton, Scott W Ballinge. Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE(-/-) mouse: implications for a "multihit" hypothesis of fatty liver disease. Free radical biology & medicine. vol 46. issue 7. 2009-06-18. PMID:19280709. |
exposure to ethanol + ets induced the largest increase in cyp2e1 and inos protein, as well as increased 3-nitrotyrosine, mtdna damage, and decreased cytochrome c oxidase protein, compared to all other groups. |
2009-06-18 |
2023-08-12 |
mouse |
| Mercè Correa, Cristina Viaggi, Miguel A Escrig, María Pascual, Consuelo Guerri, Francesca Vaglini, Carlos M G Aragon, Giovanni U Corsin. Ethanol intake and ethanol-induced locomotion and locomotor sensitization in Cyp2e1 knockout mice. Pharmacogenetics and genomics. vol 19. issue 3. 2009-05-18. PMID:19177030. |
ethanol intake and ethanol-induced locomotion and locomotor sensitization in cyp2e1 knockout mice. |
2009-05-18 |
2023-08-12 |
mouse |
| Oxana Doroshyenko, Uwe Fuhr, Daria Kunz, Dorothee Frank, Martina Kinzig, Alexander Jetter, Yvonne Reith, Andreas Lazar, Dirk Taubert, Julia Kirchheiner, Matthias Baum, Gerhard Eisenbrand, Franz-Ingo Berger, Daniel Bertow, Albrecht Berkessel, Fritz Sörgel, Edgar Schömig, Dorota Tomalik-Schart. In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 18. issue 2. 2009-04-16. PMID:19190172. |
participants ingested self-prepared potato chips containing acrylamide (1 mg) without comedication, after cyp2e1 inhibition (500 mg disulfiram, single dose) or induction (48 g/d ethanol for 1 week), and were phenotyped for cyp2e1 with chlorzoxazone (250 mg, single dose). |
2009-04-16 |
2023-08-12 |
human |
| O V Maksymchuk, V I Bobyk, L L Sydoryk, M O Chashchy. [Influence of long-term combined gamma-radiation and ethanol on cytochrome P450 2E1 expression in the mice liver]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). vol 80. issue 5. 2009-04-06. PMID:19248623. |
the chronic ethanol intake induced cyp2e1 protein expression but not increased cyp2e1 mrna level. |
2009-04-06 |
2023-08-12 |
mouse |
| O V Maksymchuk, V I Bobyk, L L Sydoryk, M O Chashchy. [Influence of long-term combined gamma-radiation and ethanol on cytochrome P450 2E1 expression in the mice liver]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). vol 80. issue 5. 2009-04-06. PMID:19248623. |
the first week of continuous combined influence of ethanol and gamma-irradiation was characterized by the increase of cyp2e1 protein level, that was back to normal on second week. |
2009-04-06 |
2023-08-12 |
mouse |
| Michael J Passeri, Ayca Cinaroglu, Chuan Gao, Kirsten C Sadle. Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology (Baltimore, Md.). vol 49. issue 2. 2009-03-12. PMID:19127516. |
exposing 4 dpf zebrafish larvae to 2% ethanol (etoh) for 32 hours achieves approximately 80 mm intracellular etoh and up-regulation of hepatic cyp2e1, sod, and bip, indicating that etoh is metabolized and provokes oxidant stress. |
2009-03-12 |
2023-08-12 |
zebrafish |
| James Haorah, Servio H Ramirez, Nicholas Floreani, Santhi Gorantla, Brenda Morsey, Yuri Persidsk. Mechanism of alcohol-induced oxidative stress and neuronal injury. Free radical biology & medicine. vol 45. issue 11. 2009-02-03. PMID:18845238. |
here, we present the evidence that metabolism of ethanol in primary human neurons by alcohol dehydrogenase (adh) or cytochrome p450-2e1 (cyp2e1) generates reactive oxygen species (ros) and nitric oxide (no) via induction of nadph/xanthine oxidase (nox/xox) and nitric oxide synthase (nos) in human neurons. |
2009-02-03 |
2023-08-12 |
human |
| Erin M McCartney, Ljiljana Semendric, Karla J Helbig, Susan Hinze, Brett Jones, Steven A Weinman, Michael R Bear. Alcohol metabolism increases the replication of hepatitis C virus and attenuates the antiviral action of interferon. The Journal of infectious diseases. vol 198. issue 12. 2009-01-16. PMID:18956976. |
to determine the effect that alcohol metabolism has on hcv replication and the antiviral action of interferon (ifn), huh-7 cells that harbor hcv replication and metabolize ethanol via the introduced expression of cytochrome p450 2e1 (cyp2e1) were treated with ethanol and ifn-alpha. |
2009-01-16 |
2023-08-12 |
Not clear |
| Defeng Wu, Arthur I Cederbau. Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicology and applied pharmacology. vol 207. issue 2 Suppl. 2008-10-01. PMID:16019049. |
induction of cyp2e1 by ethanol is one of the central pathways by which ethanol generates a state of oxidative stress in hepatocytes. |
2008-10-01 |
2023-08-12 |
Not clear |
| Defeng Wu, Arthur I Cederbau. Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicology and applied pharmacology. vol 207. issue 2 Suppl. 2008-10-01. PMID:16019049. |
to study the biochemical and toxicological actions of cyp2e1, our laboratory established hepg2 cell lines which constitutively overexpress cyp2e1 and characterized these cells with respect to ethanol toxicity. |
2008-10-01 |
2023-08-12 |
Not clear |
| Alan Wayne Jone. Ultra-rapid rate of ethanol elimination from blood in drunken drivers with extremely high blood-alcohol concentrations. International journal of legal medicine. vol 122. issue 2. 2008-09-25. PMID:17572905. |
the mechanism accounting for more rapid metabolism is probably related to induction of the microsomal enzyme (cyp2e1) pathway for ethanol oxidation, as one consequence of continuous heavy drinking. |
2008-09-25 |
2023-08-12 |
Not clear |