| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongke Lu, Jian Zhuge, Defeng Wu, Arthur I Cederbau. Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 2. 2011-04-28. PMID:21051534. |
the possibility that induction of cyp2e1 is permissive for the induction of cyp2a5 may reflect a new contribution by cyp2e1 to the actions of ethanol. |
2011-04-28 |
2023-08-12 |
mouse |
| Fawzia Bardag-Gorce, Joan Oliva, Andrew Lin, Jun Li, Barbara A French, Samuel W Frenc. Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. Experimental and molecular pathology. vol 90. issue 1. 2011-02-11. PMID:21036165. |
oxidative stress occurs in the liver of rats fed with alcohol chronically due to ethanol metabolism by cyp2e1, causing liver injury. |
2011-02-11 |
2023-08-12 |
rat |
| Gunda Millonig, Ying Wang, Nils Homann, Friederike Bernhardt, Hua Qin, Sebastian Mueller, Helmut Bartsch, Helmut K Seit. Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions. International journal of cancer. vol 128. issue 3. 2011-01-14. PMID:20715111. |
ethanol exerts its carcinogenic effect in the liver among others via the induction of cytochrome p450 2e1 (cyp2e1) and the generation of carcinogenic etheno-dna adducts. |
2011-01-14 |
2023-08-12 |
human |
| Gunda Millonig, Ying Wang, Nils Homann, Friederike Bernhardt, Hua Qin, Sebastian Mueller, Helmut Bartsch, Helmut K Seit. Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions. International journal of cancer. vol 128. issue 3. 2011-01-14. PMID:20715111. |
our data demonstrate for the first time an induction of cyp2e1 in the esophageal mucosa by ethanol in a dose dependent manner in man and may explain, at least in part, the generation of carcinogenic dna lesions in this target organ. |
2011-01-14 |
2023-08-12 |
human |
| Hsu-Sheng Yu, Tsunehiro Oyama, Toyohi Isse, Kyoko Kitagawa, Thi-Thu-Phuong Pham, Masayuki Tanaka, Toshihiro Kawamot. Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. Chemico-biological interactions. vol 188. issue 3. 2010-12-21. PMID:20813101. |
ingested ethanol is mainly oxidized by the enzymes alcohol dehydrogenase (adh), cytochrome p-450 2e1 (cyp2e1), and catalase to form acetaldehyde, which is subsequently oxidized by aldehyde dehydrogenase 2 (aldh2) to produce acetate. |
2010-12-21 |
2023-08-12 |
human |
| Fawzia Bardag-Gorce, Joan Oliva, Wesley Wong, Stephanie Fong, Jun Li, Barbara A French, Samuel W Frenc. S-adenosylmethionine decreases the peak blood alcohol levels 3 h after an acute bolus of ethanol by inducing alcohol metabolizing enzymes in the liver. Experimental and molecular pathology. vol 89. issue 3. 2010-12-15. PMID:20828554. |
the ethanol elimination rate is regulated by alcohol metabolizing enzymes, primarily alcohol dehydrogenase (adh1), acetaldehyde dehydrogenase (aldh), and cytochrome p450 (cyp2e1). |
2010-12-15 |
2023-08-12 |
Not clear |
| Defeng Wu, Xiaodong Wang, Richard Zhou, Arthur Cederbau. CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells. Biochemical and biophysical research communications. vol 402. issue 1. 2010-12-08. PMID:20932821. |
we evaluated the ability of cyp2e1 to modulate the effects of ethanol on lipid accumulation and autophagy in vitro. |
2010-12-08 |
2023-08-12 |
Not clear |
| Defeng Wu, Xiaodong Wang, Richard Zhou, Arthur Cederbau. CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells. Biochemical and biophysical research communications. vol 402. issue 1. 2010-12-08. PMID:20932821. |
the e47 hepg2 cell which expresses cyp2e1 was treated with ethanol at 50, 100 and 150mm for 4 or 5days. |
2010-12-08 |
2023-08-12 |
Not clear |
| Defeng Wu, Xiaodong Wang, Richard Zhou, Arthur Cederbau. CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells. Biochemical and biophysical research communications. vol 402. issue 1. 2010-12-08. PMID:20932821. |
ethanol induced cyp2e1 activity and oxidative stress in e47 cells compared with c34 cells. |
2010-12-08 |
2023-08-12 |
Not clear |
| Zeliha Kayaaltı, Tülin Söylemezoğl. Distribution of ADH1B, ALDH2, CYP2E1 *6, and CYP2E1 *7B genotypes in Turkish population. Alcohol (Fayetteville, N.Y.). vol 44. issue 5. 2010-11-24. PMID:20598484. |
the most well-known metabolic pathways from ethanol to acetaldehyde include alcohol dehydrogenase (adh) and the microsomal ethanol oxidizing system that involves cytochrome p450 2e1 (cyp2e1). |
2010-11-24 |
2023-08-12 |
Not clear |
| Alan Wayne Jone. Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework. Forensic science international. vol 200. issue 1-3. 2010-10-29. PMID:20304569. |
in alcoholics during detoxification, because activity of microsomal enzyme (cyp2e1) is boosted, the ethanol elimination rate might be 25-35 mg/100ml/h. |
2010-10-29 |
2023-08-12 |
human |
| Seema Bansal, Chuan-Peng Liu, Naresh B V Sepuri, Hindupur K Anandatheerthavarada, Venkatesh Selvaraj, Jan Hoek, Ginger L Milne, F Peter Guengerich, Narayan G Avadhan. Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress. The Journal of biological chemistry. vol 285. issue 32. 2010-09-20. PMID:20529841. |
notably, expression of mt++ cyp2e1 protein in yeast cells caused more severe mitochondrial dna damage and respiratory deficiency than the wild type or er+ proteins as tested by the inability of cells to grow on glycerol or ethanol. |
2010-09-20 |
2023-08-12 |
rat |
| Chunshu Hao, Wei Liu, Xiaofei Luan, Yang Li, Haiyan Gui, Yan Peng, Jianping Shen, Gang Hu, Jian Yan. Aquaporin-4 knockout enhances astrocyte toxicity induced by 1-methyl-4-phenylpyridinium ion and lipopolysaccharide via increasing the expression of cytochrome P4502E1. Toxicology letters. vol 198. issue 2. 2010-09-10. PMID:20615459. |
notably, aqp4 knockout enhanced the up-regulation of the expression of cyp2e1 in astrocytes exposed to mpp(+), lps and ethanol. |
2010-09-10 |
2023-08-12 |
Not clear |
| Alan Wayne Jone. Role of CYP2E1 in the metabolism of ethanol in patients with liver cirrhosis. Scandinavian journal of gastroenterology. vol 45. issue 3. 2010-07-22. PMID:19900053. |
role of cyp2e1 in the metabolism of ethanol in patients with liver cirrhosis. |
2010-07-22 |
2023-08-12 |
Not clear |
| Sanjoy Roychowdhury, Megan R McMullen, Michele T Pritchard, Wei Li, Robert G Salomon, Laura E Nag. Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice. Free radical biology & medicine. vol 47. issue 11. 2010-06-21. PMID:19616618. |
pathological markers of ethanol-induced hepatic injury including serum alanine aminotransferase, hepatic triglyceride, and cyp2e1 were elevated in response to ethanol feeding. |
2010-06-21 |
2023-08-12 |
mouse |
| Amy J Hewitt, Kevin R Walker, Susan M Kobus, Margo Poklewska-Koziell, James N Reynolds, James F Brie. Differential effects of chronic ethanol exposure on cytochrome P450 2E1 and the hypothalamic-pituitary-adrenal axis in the maternal-fetal unit of the guinea pig. Neurotoxicology and teratology. vol 32. issue 2. 2010-06-15. PMID:20006703. |
this study tested the hypothesis that chronic ethanol exposure (cee), via chronic maternal ethanol administration, increases cytochrome p450 2e1 (cyp2e1) expression and alters hypothalamic-pituitary-adrenal (hpa) axis activity in the maternal-fetal unit during the third-trimester-equivalent of gestation. |
2010-06-15 |
2023-08-12 |
Not clear |
| Martin J Ronis, Soheila Korourian, Michael L Blackburn, Jamie Badeaux, Thomas M Badge. The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat. Alcohol (Fayetteville, N.Y.). vol 44. issue 2. 2010-05-13. PMID:20116195. |
the present study examined the effects of selective inhibition of the cytochrome p450 enzyme cyp2e1 compared with the inhibition of overall ethanol metabolism on the development of alcoholic steatohepatitis. |
2010-05-13 |
2023-08-12 |
rat |
| Martin J Ronis, Soheila Korourian, Michael L Blackburn, Jamie Badeaux, Thomas M Badge. The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat. Alcohol (Fayetteville, N.Y.). vol 44. issue 2. 2010-05-13. PMID:20116195. |
ethanol metabolism by cyp2e1 may be linked in part to triglyceride accumulation, to induction of tnf-alpha, and to chemokine production. |
2010-05-13 |
2023-08-12 |
rat |
| Pat Neafsey, Gary Ginsberg, Dale Hattis, Douglas O Johns, Kathryn Z Guyton, Babasaheb Sonawan. Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity. Journal of toxicology and environmental health. Part B, Critical reviews. vol 12. issue 5-6. 2010-03-17. PMID:20183527. |
cyp2e1 is also one of the enzymes that metabolizes ethanol to acetaldehyde, and is induced by recent ethanol ingestion. |
2010-03-17 |
2023-08-12 |
Not clear |
| Pat Neafsey, Gary Ginsberg, Dale Hattis, Douglas O Johns, Kathryn Z Guyton, Babasaheb Sonawan. Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity. Journal of toxicology and environmental health. Part B, Critical reviews. vol 12. issue 5-6. 2010-03-17. PMID:20183527. |
genetic polymorphisms in cyp2e1 were identified and linked to altered susceptibility to hepatic cirrhosis induced by ethanol and esophageal and other cancers in some epidemiological studies. |
2010-03-17 |
2023-08-12 |
Not clear |