| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Defeng Wu, Xiaodong Wang, Richard Zhou, Lili Yang, Arthur I Cederbau. Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. Free radical biology & medicine. vol 53. issue 6. 2013-01-16. PMID:22819980. |
wild type (wt), cyp2e1 knockin (ki) and cyp2e1 knockout (ko) mice were gavaged with 3g/kg body wt ethanol twice a day for four days. |
2013-01-16 |
2023-08-12 |
mouse |
| Defeng Wu, Xiaodong Wang, Richard Zhou, Lili Yang, Arthur I Cederbau. Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. Free radical biology & medicine. vol 53. issue 6. 2013-01-16. PMID:22819980. |
inhibition of macroautophagy by administration of 3-methyladenine enhanced the binge ethanol hepatotoxicity, steatosis and oxidant stress in cyp2e1 ki, but not cyp2e1 ko mice. |
2013-01-16 |
2023-08-12 |
mouse |
| Defeng Wu, Xiaodong Wang, Richard Zhou, Lili Yang, Arthur I Cederbau. Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. Free radical biology & medicine. vol 53. issue 6. 2013-01-16. PMID:22819980. |
treatment of hepg2 e47 cells which express cyp2e1 with 100mm ethanol for 8 days increased fat accumulation and oxidant stress but decreased autophagy. |
2013-01-16 |
2023-08-12 |
mouse |
| Defeng Wu, Xiaodong Wang, Richard Zhou, Lili Yang, Arthur I Cederbau. Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. Free radical biology & medicine. vol 53. issue 6. 2013-01-16. PMID:22819980. |
ethanol had no effect on these reactions in hepg2 c34 cells which do not express cyp2e1. |
2013-01-16 |
2023-08-12 |
mouse |
| Defeng Wu, Xiaodong Wang, Richard Zhou, Lili Yang, Arthur I Cederbau. Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. Free radical biology & medicine. vol 53. issue 6. 2013-01-16. PMID:22819980. |
the antioxidant n-acetylcysteine, and cyp2e1 inhibitor chlormethiazole blunted these effects of ethanol. |
2013-01-16 |
2023-08-12 |
mouse |
| Defeng Wu, Xiaodong Wang, Richard Zhou, Lili Yang, Arthur I Cederbau. Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. Free radical biology & medicine. vol 53. issue 6. 2013-01-16. PMID:22819980. |
inhibition of autophagy promotes binge ethanol induced hepatotoxicity, steatosis and oxidant stress via cyp2e1. |
2013-01-16 |
2023-08-12 |
mouse |
| Arthur I Cederbau. CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment. Drug metabolism and drug interactions. vol 27. issue 3. 2012-11-20. PMID:23104821. |
cyp2e1 potentiates toxicity in obesity and after chronic ethanol treatment. |
2012-11-20 |
2023-08-12 |
mouse |
| Arthur I Cederbau. CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment. Drug metabolism and drug interactions. vol 27. issue 3. 2012-11-20. PMID:23104821. |
ethanol produced fatty liver and oxidant stress in wt mice; these effects were blunted in the cyp2e1 ko mice but restored in the cyp2e1 ki mice. |
2012-11-20 |
2023-08-12 |
mouse |
| Mengyao Jin, Anil Kumar, Santosh Kuma. Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway. PloS one. vol 7. issue 4. 2012-11-19. PMID:22530035. |
our results showed that 100 mm ethanol significantly induced cyp2a6 mrna and protein (~150%) and increased ros formation, and induction of gene expression and ros were both completely blocked by treatment with either a cyp2e1 inhibitor (diallyl sulfide) or an antioxidant (vitamin c). |
2012-11-19 |
2023-08-12 |
Not clear |
| Ligia A Azzalis, Fernando L A Fonseca, Karin A Simon, Fernanda Schindler, Leandro Giavarotti, Hugo P Monteiro, Luis A Videla, Virgínia B C Junqueir. Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet. Drug and chemical toxicology. vol 35. issue 3. 2012-10-22. PMID:22288377. |
effects of ethanol on cyp2e1 levels and related oxidative stress using a standard balanced diet. |
2012-10-22 |
2023-08-12 |
rat |
| Ligia A Azzalis, Fernando L A Fonseca, Karin A Simon, Fernanda Schindler, Leandro Giavarotti, Hugo P Monteiro, Luis A Videla, Virgínia B C Junqueir. Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet. Drug and chemical toxicology. vol 35. issue 3. 2012-10-22. PMID:22288377. |
this study describes the effects of ethanol treatment on cyp2e1 levels and its relationship with oxidative stress using a balanced standard diet to avoid low or high carbohydrate consumption. |
2012-10-22 |
2023-08-12 |
rat |
| Ligia A Azzalis, Fernando L A Fonseca, Karin A Simon, Fernanda Schindler, Leandro Giavarotti, Hugo P Monteiro, Luis A Videla, Virgínia B C Junqueir. Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet. Drug and chemical toxicology. vol 35. issue 3. 2012-10-22. PMID:22288377. |
the results have shown that ethanol administration was associated with cyp2e1 induction and stabilization without related oxidative stress. |
2012-10-22 |
2023-08-12 |
rat |
| Irene Catanzaro, Flores Naselli, Marghereth Saverini, Antonio Giacalone, Giuseppe Montalto, Fabio Caradonn. Cytochrome P450 2E1 variable number tandem repeat polymorphisms and health risks: a genotype-phenotype study in cancers associated with drinking and/or smoking. Molecular medicine reports. vol 6. issue 2. 2012-10-16. PMID:22614694. |
cytochrome p450 2e1 (cyp2e1) is one of the main enzymes involved in the oxidation of ethanol and in the transformation of a number of potentially dangerous compounds. |
2012-10-16 |
2023-08-12 |
human |
| M Jurima-Romet, H S Huan. Comparison of the cytotoxicity of ACE inhibitors and effects of cytochrome P-450 and glutathione modulation in primary rat hepatocyte cultures. Toxicology in vitro : an international journal published in association with BIBRA. vol 8. issue 4. 2012-10-02. PMID:20692951. |
induction with phenobarbital (cyp2b), beta-naphthoflavone (cyp1a) or ethanol (cyp2e1) did not influence the cytotoxicity of any of the ace inhibitors. |
2012-10-02 |
2023-08-12 |
rat |
| Lakshmi Balaji, Krishna Balaji Singh, L V K S Bhaska. Genetic polymorphisms of the CYP2E1 gene do not contribute to oral cancer susceptibility in south Indians. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 6. 2012-07-23. PMID:22126492. |
many cyp enzymes function in the liver, but presence of cyp2e1 in the brain is demonstrating its role in both nicotine and ethanol metabolism. |
2012-07-23 |
2023-08-12 |
human |
| Zhonghua Shen, Feixiong Cheng, You Xu, Jing Fu, Wen Xiao, Jie Shen, Guixia Liu, Weihua Li, Yun Tan. Investigation of indazole unbinding pathways in CYP2E1 by molecular dynamics simulations. PloS one. vol 7. issue 3. 2012-07-23. PMID:22442693. |
human microsomal cytochrome p450 2e1 (cyp2e1) can oxidize not only low molecular weight xenobiotic compounds such as ethanol, but also many endogenous fatty acids. |
2012-07-23 |
2023-08-12 |
human |
| Tao Zeng, Cui-Li Zhang, Fu-Yong Song, Xiu-Lan Zhao, Ke-Qin Xi. Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-α, and CYP2E1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 3-4. 2012-07-16. PMID:22138249. |
in the in vitro study, human normal cell lo2 was exposed to 100 mm ethanol in the presence or absence of go for 24 h. we found that ethanol increased the protein levels of n-srebp-1c and cyp2e1, but decreased the protein levels of ppar-α, which was significantly attenuated by go co-treatment. |
2012-07-16 |
2023-08-12 |
mouse |
| Angel León-Buitimea, Lourdes Rodríguez-Fragoso, Fredine T Lauer, Harmony Bowles, Todd A Thompson, Scott W Burchie. Ethanol-induced oxidative stress is associated with EGF receptor phosphorylation in MCF-10A cells overexpressing CYP2E1. Toxicology letters. vol 209. issue 2. 2012-06-04. PMID:22222162. |
cyp2e1 is known to metabolize ethanol and produce reactive oxygen species (ros), including superoxide in epithelial cells. |
2012-06-04 |
2023-08-12 |
human |
| Hui Tang, Becky M Sebastian, Armend Axhemi, Xiaocong Chen, Antoinette D Hillian, Donald W Jacobsen, Laura E Nag. Ethanol-induced oxidative stress via the CYP2E1 pathway disrupts adiponectin secretion from adipocytes. Alcoholism, clinical and experimental research. vol 36. issue 2. 2012-05-17. PMID:21895711. |
here, we investigated the role of cytochrome p450 2e1 (cyp2e1) and oxidative stress in the mechanism for impaired adiponectin secretion from adipocytes in response to ethanol. |
2012-05-17 |
2023-08-12 |
Not clear |
| Xiaolei Shi, Dan Yao, Chi Che. Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22228769. |
the influence of ethanol on the small molecule metabolome and the role of cyp2e1 in ethanol-induced hepatotoxicity were investigated using liquid chromatography-mass spectrometry (lc-ms)-based metabolomics platform and cyp2e1-null mouse model. |
2012-04-25 |
2023-08-12 |
mouse |