| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karthikeyan Chandrasekaran, Kavitha Swaminathan, S Mathan Kumar, Suvro Chatterjee, Dahn L Clemens, Aparajita De. Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes--alcohol dehydrogenase and Cytochrome P450 2E1. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 4. 2011-08-18. PMID:21414402. |
chronic ethanol exposure of vl-17a cells resulted in 1.1- to 2.5-fold increased levels of adh and cyp2e1. |
2011-08-18 |
2023-08-12 |
human |
| Joan Oliva, Fawzia Bardag-Gorce, Brittany Tillman, Samuel W Frenc. Protective effect of quercetin, EGCG, catechin and betaine against oxidative stress induced by ethanol in vitro. Experimental and molecular pathology. vol 90. issue 3. 2011-07-19. PMID:21352821. |
hepg2 cells overexpressing cyp2e1 were subjected to arachidonic acid, iron and 100mm ethanol with or without the antioxidant agent. |
2011-07-19 |
2023-08-12 |
Not clear |
| Joan Oliva, Fawzia Bardag-Gorce, Brittany Tillman, Samuel W Frenc. Protective effect of quercetin, EGCG, catechin and betaine against oxidative stress induced by ethanol in vitro. Experimental and molecular pathology. vol 90. issue 3. 2011-07-19. PMID:21352821. |
catechin prevented cyp2e1 induction by ethanol. |
2011-07-19 |
2023-08-12 |
Not clear |
| Mario Comporti, Cinzia Signorini, Silvia Leoncini, Concetta Gardi, Lucia Ciccoli, Anna Giardini, Daniela Vecchio, Beatrice Arezzin. Ethanol-induced oxidative stress: basic knowledge. Genes & nutrition. vol 5. issue 2. 2011-07-14. PMID:20606811. |
the cytochrome p(450) isoform (cyp2e1) specifically involved in ethanol oxidation is discussed. |
2011-07-14 |
2023-08-12 |
Not clear |
| Sarah M Denucci, Ming Tong, Lisa Longato, Margot Lawton, Mashiko Setshedi, Rolf I Carlson, Jack R Wands, Suzanne M de la Mont. Rat strain differences in susceptibility to alcohol-induced chronic liver injury and hepatic insulin resistance. Gastroenterology research and practice. vol 2010. 2011-07-14. PMID:20814553. |
ethanol feeding in fs rats only reduced il-6, aldh1-3, cyp2e1, and gapdh expression in liver. |
2011-07-14 |
2023-08-12 |
rat |
| Amy Webb, Penelope A Lind, Jelger Kalmijn, Heidi S Feiler, Tom L Smith, Marc A Schuckit, Kirk Wilhelmse. The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis. Alcoholism, clinical and experimental research. vol 35. issue 1. 2011-06-23. PMID:20958328. |
cyp2e1, a gene known for its involvement with ethanol metabolism, maps to this region. |
2011-06-23 |
2023-08-12 |
Not clear |
| Laetitia Knockaert, Véronique Descatoire, Nathalie Vadrot, Bernard Fromenty, Marie-Anne Robi. Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 2. 2011-06-08. PMID:21130154. |
mitochondrial cyp2e1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen. |
2011-06-08 |
2023-08-12 |
Not clear |
| Laetitia Knockaert, Véronique Descatoire, Nathalie Vadrot, Bernard Fromenty, Marie-Anne Robi. Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 2. 2011-06-08. PMID:21130154. |
the aim of our study was to investigate the role of mitochondrial cyp2e1 in the toxicity of acetaminophen and ethanol. |
2011-06-08 |
2023-08-12 |
Not clear |
| Laetitia Knockaert, Véronique Descatoire, Nathalie Vadrot, Bernard Fromenty, Marie-Anne Robi. Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 2. 2011-06-08. PMID:21130154. |
our results indicated that when acetaminophen or ethanol were used as cyp2e1 substrates, the exclusive localization of cyp2e1 within mitochondria was sufficient to induce reactive oxygen species overproduction, depletion of reduced glutathione, increased expression of mitochondrial hsp70, mitochondrial dysfunction and cytotoxicity. |
2011-06-08 |
2023-08-12 |
Not clear |
| Yongke Lu, Defeng Wu, Xiaodong Wang, Stephen C Ward, Arthur I Cederbau. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free radical biology & medicine. vol 49. issue 9. 2011-05-17. PMID:20692331. |
there is a need to develop oral models of significant liver injury and to evaluate the possible role of cyp2e1 in ethanol actions in such models. |
2011-05-17 |
2023-08-12 |
mouse |
| Yongke Lu, Defeng Wu, Xiaodong Wang, Stephen C Ward, Arthur I Cederbau. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free radical biology & medicine. vol 49. issue 9. 2011-05-17. PMID:20692331. |
wt mice and the cyp2e1 ko and ki mice (both provided by dr. f. gonzalez, national cancer institute) were fed a high-fat lieber-decarli ethanol liquid diet for 3weeks; pair-fed controls received dextrose. |
2011-05-17 |
2023-08-12 |
mouse |
| Yongke Lu, Defeng Wu, Xiaodong Wang, Stephen C Ward, Arthur I Cederbau. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free radical biology & medicine. vol 49. issue 9. 2011-05-17. PMID:20692331. |
moreover, it is the human cyp2e1 that restores these effects of ethanol, which suggests that results for fatty liver and oxidant stress from rodent models of ethanol intake and mouse cyp2e1 can be extrapolated to human models of ethanol intake and to human cyp2e1. |
2011-05-17 |
2023-08-12 |
mouse |
| Soo Han Bae, Su Haeng Sung, Eun Jung Cho, Se Kyoung Lee, Hye Eun Lee, Hyun Ae Woo, Dae-Yeul Yu, In Sup Kil, Sue Goo Rhe. Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver. Hepatology (Baltimore, Md.). vol 53. issue 3. 2011-05-12. PMID:21319188. |
ethanol consumption induces the accumulation of cytochrome p450 2e1 (cyp2e1), a major contributor to ethanol-induced ros production in the liver. |
2011-05-12 |
2023-08-12 |
mouse |
| Yongke Lu, Jian Zhuge, Defeng Wu, Arthur I Cederbau. Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 2. 2011-04-28. PMID:21051534. |
ethanol induction of cyp2a5: permissive role for cyp2e1. |
2011-04-28 |
2023-08-12 |
mouse |
| Yongke Lu, Jian Zhuge, Defeng Wu, Arthur I Cederbau. Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 2. 2011-04-28. PMID:21051534. |
we evaluated whether ethanol can elevate cyp2a5 and whether cyp2e1 plays a role in the ethanol induction of cyp2a5. |
2011-04-28 |
2023-08-12 |
mouse |
| Yongke Lu, Jian Zhuge, Defeng Wu, Arthur I Cederbau. Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 2. 2011-04-28. PMID:21051534. |
wild-type (wt), cyp2e1 knockout (ko), and cyp2e1 knockin (ki) mice were fed ethanol for 3 weeks. |
2011-04-28 |
2023-08-12 |
mouse |
| Yongke Lu, Jian Zhuge, Defeng Wu, Arthur I Cederbau. Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 2. 2011-04-28. PMID:21051534. |
ethanol increased cyp2e1 and cyp2a5 protein and activity in wt mice but not in the ko mice. |
2011-04-28 |
2023-08-12 |
mouse |
| Yongke Lu, Jian Zhuge, Defeng Wu, Arthur I Cederbau. Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 2. 2011-04-28. PMID:21051534. |
ethanol induction of cyp2a5 occurred only after cyp2e1 was first induced. |
2011-04-28 |
2023-08-12 |
mouse |
| Yongke Lu, Jian Zhuge, Defeng Wu, Arthur I Cederbau. Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 2. 2011-04-28. PMID:21051534. |
induction of cyp2a5 by ethanol is potentiated by the induction of cyp2e1. |
2011-04-28 |
2023-08-12 |
mouse |
| Yongke Lu, Jian Zhuge, Defeng Wu, Arthur I Cederbau. Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 2. 2011-04-28. PMID:21051534. |
we speculate that ethanol induction of cyp2e1 followed by increases in reactive oxygen species and activation of nrf2 are important steps in the mechanism by which ethanol induces cyp2a5. |
2011-04-28 |
2023-08-12 |
mouse |