| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pat Neafsey, Gary Ginsberg, Dale Hattis, Douglas O Johns, Kathryn Z Guyton, Babasaheb Sonawan. Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity. Journal of toxicology and environmental health. Part B, Critical reviews. vol 12. issue 5-6. 2010-03-17. PMID:20183527. |
part of the reason for conflicting evidence regarding genotype effect on phenotype may be due to the wide variety of exposures such as ethanol or dietary factors and physiological factors including body weight or diabetes that modulate cyp2e1 expression. |
2010-03-17 |
2023-08-12 |
Not clear |
| Jayong Chung, Sudipta Veeramachaneni, Chun Liu, Heather Mernitz, Robert M Russell, Xiang-Dong Wan. Vitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats. Nutrition research (New York, N.Y.). vol 29. issue 9. 2010-02-23. PMID:19854382. |
chronic, excessive ethanol intake can increase retinoic acid (ra) catabolism by inducing cytochrome p450 2e1 (cyp2e1). |
2010-02-23 |
2023-08-12 |
rat |
| Jayong Chung, Sudipta Veeramachaneni, Chun Liu, Heather Mernitz, Robert M Russell, Xiang-Dong Wan. Vitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats. Nutrition research (New York, N.Y.). vol 29. issue 9. 2010-02-23. PMID:19854382. |
the ethanol-fed rats given ve had more than 4-fold higher hepatic ve concentrations than the ethanol-fed rats without ve, but this did not prevent ethanol induction of cyp2e1, lower hepatic retinoid levels, or hepatocellular hyperproliferation. |
2010-02-23 |
2023-08-12 |
rat |
| Carmen Martínez, Segismundo Galván, Elena Garcia-Martin, María I Ramos, Yolanda Gutiérrez-Martín, José A G Agúnde. Variability in ethanol biodisposition in whites is modulated by polymorphisms in the ADH1B and ADH1C genes. Hepatology (Baltimore, Md.). vol 51. issue 2. 2010-02-22. PMID:20101753. |
we analyzed alcohol pharmacokinetics and biodisposition after the administration of 0.5 g/kg ethanol; we measured ethanol effects on reaction time and motor time in response to visual and acoustic signals, and we analyzed 13 single nucleotide polymorphism (snps) in the genes coding for adh1b, adh1c, aldh2, and cyp2e1 in 250 healthy white individuals. |
2010-02-22 |
2023-08-12 |
Not clear |
| Scott Seronello, Chieri Ito, Takaji Wakita, Jinah Cho. Ethanol enhances hepatitis C virus replication through lipid metabolism and elevated NADH/NAD+. The Journal of biological chemistry. vol 285. issue 2. 2010-01-26. PMID:19910460. |
in this study, we use huh7 human hepatoma cells that naturally express comparable levels of cyp2e1 as human liver to demonstrate that ethanol, at subtoxic and physiologically relevant concentrations, enhances complete hcv replication. |
2010-01-26 |
2023-08-12 |
human |
| Scott Seronello, Chieri Ito, Takaji Wakita, Jinah Cho. Ethanol enhances hepatitis C virus replication through lipid metabolism and elevated NADH/NAD+. The Journal of biological chemistry. vol 285. issue 2. 2010-01-26. PMID:19910460. |
the potentiation of hcv replication by ethanol is suppressed by inhibiting cyp2e1 or aldehyde dehydrogenase and requires an elevated nadh/nad(+) ratio. |
2010-01-26 |
2023-08-12 |
human |
| Stephanie M Wang, Rongqian W. The double danger of ethanol and hypoxia: their effects on a hepatoma cell line. International journal of clinical and experimental pathology. vol 2. issue 2. 2010-01-22. PMID:19079654. |
ethanol, alone and in high concentrations, was found to greatly affect cell function as shown by decreased cellular atp levels, increased ldh release, and a downregulated expression of cyp2e1 gene. |
2010-01-22 |
2023-08-12 |
rat |
| Xiaodong Wang, Yongke Lu, Bin Xie, Arthur I Cederbau. Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. Free radical biology & medicine. vol 47. issue 5. 2009-12-07. PMID:19477265. |
chronic ethanol feeding potentiates fas jo2-induced hepatotoxicity: role of cyp2e1 and tnf-alpha and activation of jnk and p38 map kinase. |
2009-12-07 |
2023-08-12 |
mouse |
| Xiaodong Wang, Yongke Lu, Bin Xie, Arthur I Cederbau. Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. Free radical biology & medicine. vol 47. issue 5. 2009-12-07. PMID:19477265. |
we have previously shown that treatment of mice with pyrazole or acute ethanol potentiated fas agonistic jo2 antibody-induced liver injury by a mechanism involving induction of cyp2e1 and elevated oxidative stress. |
2009-12-07 |
2023-08-12 |
mouse |
| Xiaodong Wang, Yongke Lu, Bin Xie, Arthur I Cederbau. Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. Free radical biology & medicine. vol 47. issue 5. 2009-12-07. PMID:19477265. |
wild-type and cyp2e1 knockout mice were fed ethanol or isocaloric dextrose for 4 weeks followed by a single treatment with either saline or jo2. |
2009-12-07 |
2023-08-12 |
mouse |
| Xiaodong Wang, Yongke Lu, Bin Xie, Arthur I Cederbau. Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. Free radical biology & medicine. vol 47. issue 5. 2009-12-07. PMID:19477265. |
the chronic ethanol feeding produced steatosis, elevation of cyp2e1, and oxidative stress in wild-type but not cyp2e1 knockout mice. |
2009-12-07 |
2023-08-12 |
mouse |
| Xiaodong Wang, Yongke Lu, Bin Xie, Arthur I Cederbau. Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. Free radical biology & medicine. vol 47. issue 5. 2009-12-07. PMID:19477265. |
these results show that chronic ethanol feeding enhances fas-induced liver injury by a mechanism associated with induction of cyp2e1, elevated serum tnf-alpha levels, and activation of mapk. |
2009-12-07 |
2023-08-12 |
mouse |
| Arthur Cederbau. Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert opinion on drug metabolism & toxicology. vol 5. issue 10. 2009-11-17. PMID:19671018. |
induction of cyp2e1 is one of the central pathways by which ethanol generates oxidative stress. |
2009-11-17 |
2023-08-12 |
mouse |
| Arthur Cederbau. Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert opinion on drug metabolism & toxicology. vol 5. issue 10. 2009-11-17. PMID:19671018. |
cyp2e1 can be induced by ethanol and several low molecular mass chemicals such as pyrazole. |
2009-11-17 |
2023-08-12 |
mouse |
| Arthur Cederbau. Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert opinion on drug metabolism & toxicology. vol 5. issue 10. 2009-11-17. PMID:19671018. |
besides ethanol, cyp2e1 metabolizes and activates many other toxicologic important compounds. |
2009-11-17 |
2023-08-12 |
mouse |
| Arthur Cederbau. Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert opinion on drug metabolism & toxicology. vol 5. issue 10. 2009-11-17. PMID:19671018. |
ethanol, polyunsaturated fatty acids and iron were toxic to the hepg2 cells, which express cyp2e1 (e47 cells) but not control c34hepg2 cells, which do not express cyp2e1. |
2009-11-17 |
2023-08-12 |
mouse |
| Lucía Hipólito, María J Sánchez-Catalán, Ana Polache, Luis Graner. Induction of brain CYP2E1 changes the effects of ethanol on dopamine release in nucleus accumbens shell. Drug and alcohol dependence. vol 100. issue 1-2. 2009-11-12. PMID:18990514. |
induction of brain cyp2e1 changes the effects of ethanol on dopamine release in nucleus accumbens shell. |
2009-11-12 |
2023-08-12 |
rat |
| Lucía Hipólito, María J Sánchez-Catalán, Ana Polache, Luis Graner. Induction of brain CYP2E1 changes the effects of ethanol on dopamine release in nucleus accumbens shell. Drug and alcohol dependence. vol 100. issue 1-2. 2009-11-12. PMID:18990514. |
cyp2e1 is an important enzyme involved in the brain metabolism of ethanol that can be induced by chronic consumption of alcohol. |
2009-11-12 |
2023-08-12 |
rat |
| Lucía Hipólito, María J Sánchez-Catalán, Ana Polache, Luis Graner. Induction of brain CYP2E1 changes the effects of ethanol on dopamine release in nucleus accumbens shell. Drug and alcohol dependence. vol 100. issue 1-2. 2009-11-12. PMID:18990514. |
in this work, we have started this exploration by analyzing the possible changes in the neurochemical response of the mesolimbic system to ethanol after pharmacological induction of brain cyp2e1. |
2009-11-12 |
2023-08-12 |
rat |
| Lucía Hipólito, María J Sánchez-Catalán, Ana Polache, Luis Graner. Induction of brain CYP2E1 changes the effects of ethanol on dopamine release in nucleus accumbens shell. Drug and alcohol dependence. vol 100. issue 1-2. 2009-11-12. PMID:18990514. |
the results of this study indicate that induction of cyp2e1 changes the response of the mesolimbic system to ethanol in a region-dependent manner. |
2009-11-12 |
2023-08-12 |
rat |