Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Lakshmi Balaji, Krishna Balaji Singh, L V K S Bhaska. Genetic polymorphisms of the CYP2E1 gene do not contribute to oral cancer susceptibility in south Indians. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 6. 2012-07-23. PMID:22126492. |
many cyp enzymes function in the liver, but presence of cyp2e1 in the brain is demonstrating its role in both nicotine and ethanol metabolism. |
2012-07-23 |
2023-08-12 |
human |
Zhonghua Shen, Feixiong Cheng, You Xu, Jing Fu, Wen Xiao, Jie Shen, Guixia Liu, Weihua Li, Yun Tan. Investigation of indazole unbinding pathways in CYP2E1 by molecular dynamics simulations. PloS one. vol 7. issue 3. 2012-07-23. PMID:22442693. |
human microsomal cytochrome p450 2e1 (cyp2e1) can oxidize not only low molecular weight xenobiotic compounds such as ethanol, but also many endogenous fatty acids. |
2012-07-23 |
2023-08-12 |
human |
Tao Zeng, Cui-Li Zhang, Fu-Yong Song, Xiu-Lan Zhao, Ke-Qin Xi. Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-α, and CYP2E1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 3-4. 2012-07-16. PMID:22138249. |
in the in vitro study, human normal cell lo2 was exposed to 100 mm ethanol in the presence or absence of go for 24 h. we found that ethanol increased the protein levels of n-srebp-1c and cyp2e1, but decreased the protein levels of ppar-α, which was significantly attenuated by go co-treatment. |
2012-07-16 |
2023-08-12 |
mouse |
Angel León-Buitimea, Lourdes Rodríguez-Fragoso, Fredine T Lauer, Harmony Bowles, Todd A Thompson, Scott W Burchie. Ethanol-induced oxidative stress is associated with EGF receptor phosphorylation in MCF-10A cells overexpressing CYP2E1. Toxicology letters. vol 209. issue 2. 2012-06-04. PMID:22222162. |
cyp2e1 is known to metabolize ethanol and produce reactive oxygen species (ros), including superoxide in epithelial cells. |
2012-06-04 |
2023-08-12 |
human |
Hui Tang, Becky M Sebastian, Armend Axhemi, Xiaocong Chen, Antoinette D Hillian, Donald W Jacobsen, Laura E Nag. Ethanol-induced oxidative stress via the CYP2E1 pathway disrupts adiponectin secretion from adipocytes. Alcoholism, clinical and experimental research. vol 36. issue 2. 2012-05-17. PMID:21895711. |
here, we investigated the role of cytochrome p450 2e1 (cyp2e1) and oxidative stress in the mechanism for impaired adiponectin secretion from adipocytes in response to ethanol. |
2012-05-17 |
2023-08-12 |
Not clear |
Xiaolei Shi, Dan Yao, Chi Che. Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22228769. |
the influence of ethanol on the small molecule metabolome and the role of cyp2e1 in ethanol-induced hepatotoxicity were investigated using liquid chromatography-mass spectrometry (lc-ms)-based metabolomics platform and cyp2e1-null mouse model. |
2012-04-25 |
2023-08-12 |
mouse |
Xiaolei Shi, Dan Yao, Chi Che. Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22228769. |
along with ethyl glucuronide and ethyl sulfate, n-acetyltaurine (nat) was identified as a urinary metabolite that is highly responsive to ethanol exposure and is correlated with the presence of cyp2e1. |
2012-04-25 |
2023-08-12 |
mouse |
C S Ferguson, S Miksys, R Palmour, R F Tyndal. Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 12. 2012-04-09. PMID:21868470. |
independent and combined effects of ethanol self-administration and nicotine treatment on hepatic cyp2e1 in african green monkeys. |
2012-04-09 |
2023-08-12 |
monkey |
C S Ferguson, S Miksys, R Palmour, R F Tyndal. Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 12. 2012-04-09. PMID:21868470. |
this study investigated the induction of hepatic cyp2e1 by ethanol and nicotine, alone and in combination, in a nonhuman primate model. |
2012-04-09 |
2023-08-12 |
monkey |
C S Ferguson, S Miksys, R Palmour, R F Tyndal. Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 12. 2012-04-09. PMID:21868470. |
chlorzoxazone (czn) was used as a probe drug to phenotype in vivo cyp2e1 activity before and after chronic ethanol and/or nicotine exposure. |
2012-04-09 |
2023-08-12 |
monkey |
C S Ferguson, S Miksys, R Palmour, R F Tyndal. Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 12. 2012-04-09. PMID:21868470. |
ethanol and nicotine increased cyp2e1 protein levels and in vitro czn metabolism, with combined exposure to both drugs resulting in the greatest increase. |
2012-04-09 |
2023-08-12 |
monkey |
C S Ferguson, S Miksys, R Palmour, R F Tyndal. Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 12. 2012-04-09. PMID:21868470. |
chronic exposure to ethanol and nicotine induced hepatic cyp2e1 activity and protein levels, particularly when both drugs were used in combination and when ethanol intake was high. |
2012-04-09 |
2023-08-12 |
monkey |
C S Ferguson, S Miksys, R Palmour, R F Tyndal. Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 12. 2012-04-09. PMID:21868470. |
these results have important implications for public health, given the association between elevated cyp2e1 and disease, and the large proportion of individuals who are exposed to ethanol and nicotine, often in combination. |
2012-04-09 |
2023-08-12 |
monkey |
Deanna L Howarth, Mike Passeri, Kirsten C Sadle. Drinks like a fish: using zebrafish to understand alcoholic liver disease. Alcoholism, clinical and experimental research. vol 35. issue 5. 2012-03-07. PMID:21284674. |
exposing 4 dpf zebrafish larvae to 2% ethanol (etoh) for 32 hours achieves ∼80 mm intracellular etoh and upregulation of hepatic cyp2e1, sod, and bip, indicating that etoh is metabolized and provokes oxidative stress. |
2012-03-07 |
2023-08-12 |
zebrafish |
Laetitia Knockaert, Bernard Fromenty, Marie-Anne Robi. Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity. The FEBS journal. vol 278. issue 22. 2011-12-15. PMID:21929725. |
this review will focus on one particular cyp, cyp2e1, which represents a significant source of reactive oxygen species and is involved in the metabolism of small molecule substrates including ethanol, drugs and carcinogens. |
2011-12-15 |
2023-08-12 |
Not clear |
Laetitia Knockaert, Bernard Fromenty, Marie-Anne Robi. Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity. The FEBS journal. vol 278. issue 22. 2011-12-15. PMID:21929725. |
since hepatic cyp2e1 expression is increased in different physiopathological situations such as type 2 diabetes, obesity and ethanol intoxication, the presence of significant levels of this cyp within the mitochondria could have major deleterious effects. |
2011-12-15 |
2023-08-12 |
Not clear |
Becky M Sebastian, Sanjoy Roychowdhury, Hui Tang, Antoinette D Hillian, Ariel E Feldstein, Gregory L Stahl, Kazue Takahashi, Laura E Nag. Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice. The Journal of biological chemistry. vol 286. issue 41. 2011-12-12. PMID:21856753. |
ethanol feeding increased the expression of cyp2e1 in adipocytes, but not stromal vascular cells, in adipose tissue and cyp2e1(-/-) mice were protected from adipose tissue inflammation in response to ethanol. |
2011-12-12 |
2023-08-12 |
mouse |
Becky M Sebastian, Sanjoy Roychowdhury, Hui Tang, Antoinette D Hillian, Ariel E Feldstein, Gregory L Stahl, Kazue Takahashi, Laura E Nag. Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice. The Journal of biological chemistry. vol 286. issue 41. 2011-12-12. PMID:21856753. |
ethanol feeding also increased the number of tunel-positive nuclei in adipose tissue of wild-type mice but not in cyp2e1(-/-) or bid (-/-) mice. |
2011-12-12 |
2023-08-12 |
mouse |
Becky M Sebastian, Sanjoy Roychowdhury, Hui Tang, Antoinette D Hillian, Ariel E Feldstein, Gregory L Stahl, Kazue Takahashi, Laura E Nag. Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice. The Journal of biological chemistry. vol 286. issue 41. 2011-12-12. PMID:21856753. |
in summary, chronic ethanol increases cyp2e1 activity in adipose, leading to bid-mediated apoptosis and activation of complement via c1q, finally resulting in adipose tissue inflammation. |
2011-12-12 |
2023-08-12 |
mouse |
Arthur I Cederbaum, Lili Yang, Xiaodong Wang, Defeng W. CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases. International journal of hepatology. vol 2012. 2011-11-10. PMID:22028977. |
we hypothesize that similar interactions occur as a result of ethanol induction of cyp2e1 and tnfα. |
2011-11-10 |
2023-08-12 |
Not clear |