| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charmaine S Ferguson, Sharon Miksys, Roberta M Palmour, Rachel F Tyndal. Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys. Neuropharmacology. vol 72. 2014-02-11. PMID:23639433. |
immunocytochemistry revealed induction of both cyp2b6 and cyp2e1 protein in certain brain regions and cells within monkey brain as a result of ethanol self-administration, nicotine treatment and combined exposure to both drugs. |
2014-02-11 |
2023-08-12 |
human |
| Charmaine S Ferguson, Sharon Miksys, Roberta M Palmour, Rachel F Tyndal. Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys. Neuropharmacology. vol 72. 2014-02-11. PMID:23639433. |
immunoblotting analyses demonstrated cyp2b6 induction by ethanol in the caudate, putamen and cerebellum (1.5-3.2 fold, p < 0.05), and cyp2e1 induction by nicotine in the frontal cortex and putamen (1.6-2.0 fold, p < 0.05). |
2014-02-11 |
2023-08-12 |
human |
| Charmaine S Ferguson, Sharon Miksys, Roberta M Palmour, Rachel F Tyndal. Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys. Neuropharmacology. vol 72. 2014-02-11. PMID:23639433. |
combined ethanol and nicotine exposure induced cyp2b6 in the caudate, putamen, thalamus and cerebellum (1.4-2.4 fold, p < 0.05), and cyp2e1 in the frontal cortex and putamen (1.5-1.8, p < 0.05). |
2014-02-11 |
2023-08-12 |
human |
| Charmaine S Ferguson, Sharon Miksys, Roberta M Palmour, Rachel F Tyndal. Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys. Neuropharmacology. vol 72. 2014-02-11. PMID:23639433. |
cyp2b6 and cyp2e1 mrna levels were unaffected by ethanol or nicotine exposure. |
2014-02-11 |
2023-08-12 |
human |
| Charmaine S Ferguson, Sharon Miksys, Roberta M Palmour, Rachel F Tyndal. Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys. Neuropharmacology. vol 72. 2014-02-11. PMID:23639433. |
in summary, ethanol and nicotine can induce cyp2b6 and cyp2e1 protein in the primate brain, which could potentially result in altered sensitivity to centrally acting drugs and toxins. |
2014-02-11 |
2023-08-12 |
human |
| Tung-Yuan Shih, Ton-Ho Young, Herng-Sheng Lee, Chung-Bao Hsieh, Oliver Yoa-Pu H. Protective effects of kaempferol on isoniazid- and rifampicin-induced hepatotoxicity. The AAPS journal. vol 15. issue 3. 2014-01-22. PMID:23591749. |
cytochrome p450 2e1 (cyp2e1) metabolizes many toxic substrates, including ethanol, carbon tetrachloride, and inh, which ultimately results in liver injury. |
2014-01-22 |
2023-08-12 |
mouse |
| Jonathan B Ford, Mac T Wayment, Timothy E Albertson, Kelly P Owen, Joshua B Radke, Mark E Sutte. Elimination kinetics of ethanol in a 5-week-old infant and a literature review of infant ethanol pharmacokinetics. Case reports in medicine. vol 2013. 2013-12-25. PMID:24368917. |
primary ethanol metabolism occurs through alcohol dehydrogenase, but minor metabolic pathways such as the p450 enzymes cyp2e1 and cyp1a2 and the enzyme catalase exist. |
2013-12-25 |
2023-08-12 |
Not clear |
| Yuhan Tang, Hongtao Tian, Yanru Shi, Chao Gao, Mingyou Xing, Wei Yang, Wei Bao, Di Wang, Liegang Liu, Ping Ya. Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 20. issue 8-9. 2013-12-24. PMID:23583009. |
our data showed that chronic ethanol over-activated cyp2e1 but suppressed ho-1 with concurrent hepatic oxidative damage, which was partially normalized by quercetin (100mg/kg.bw.). |
2013-12-24 |
2023-08-12 |
human |
| Saikrishna Lakkakula, Rajasekhar Maram, Arasambattu Kannan Munirajan, Ram Mohan Pathapati, Subrahmanyam Bhattaram Visveswara, Bhaskar Vks Lakkakul. Functional PstI/RsaI polymorphisms in the CYP2E1 gene among south Indian populations. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 1. 2013-12-03. PMID:23534720. |
cyp2e1 is inducible by ethanol, acetone, and other low-molecular weight substrates and may mediate development of chemically-mediated cancers. |
2013-12-03 |
2023-08-12 |
human |
| Xiaodong Wang, Defeng Wu, Lili Yang, Lixia Gan, Arthur I Cederbau. Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo. Free radical biology & medicine. vol 63. 2013-11-01. PMID:23669278. |
cyp2e1 plays a role in the mechanisms by which ethanol generates oxidative stress, fatty liver, and liver injury. |
2013-11-01 |
2023-08-12 |
mouse |
| Xiaodong Wang, Defeng Wu, Lili Yang, Lixia Gan, Arthur I Cederbau. Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo. Free radical biology & medicine. vol 63. 2013-11-01. PMID:23669278. |
wild-type (wt), cyp2e1-knock-in (ki), and cyp2e1 knockout (ko) mice were fed ethanol chronically; pair-fed controls received isocaloric dextrose. |
2013-11-01 |
2023-08-12 |
mouse |
| Xiaodong Wang, Defeng Wu, Lili Yang, Lixia Gan, Arthur I Cederbau. Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo. Free radical biology & medicine. vol 63. 2013-11-01. PMID:23669278. |
treatment of hepg2 e47 cells, which express cyp2e1, with ethanol plus arachidonic acid (aa) or ethanol plus buthionine sulfoximine (bso), which depletes glutathione, caused loss of cell viability to a greater extent than in hepg2 c34 cells, which do not express cyp2e1. |
2013-11-01 |
2023-08-12 |
mouse |
| Sumera Karim, Evaggelia Liaskou, Samuel Hadley, Janine Youster, Jeff Faint, David H Adams, Patricia F Lalo. An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 132. issue 1. 2013-08-29. PMID:23300006. |
human pcls demonstrated appropriate upregulation of cyp2e1, adh1α, and adh3 in response to ethanol treatment. |
2013-08-29 |
2023-08-12 |
human |
| M Jin, A Ande, A Kumar, S Kuma. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Cell death & disease. vol 4. 2013-08-23. PMID:23519123. |
cyp2e1 metabolizes ethanol leading to production of reactive oxygen species (ros) and acetaldehyde, which are known to cause not only liver damage but also toxicity to other organs. |
2013-08-23 |
2023-08-12 |
Not clear |
| M Jin, A Ande, A Kumar, S Kuma. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Cell death & disease. vol 4. 2013-08-23. PMID:23519123. |
however, the signaling pathways involved in cyp2e1 regulation by ethanol are not clear, especially in extra-hepatic cells. |
2013-08-23 |
2023-08-12 |
Not clear |
| M Jin, A Ande, A Kumar, S Kuma. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Cell death & disease. vol 4. 2013-08-23. PMID:23519123. |
this study was designed to examine the role of cyp2e1 in ethanol-mediated oxidative stress and cytotoxicity, as well as signaling pathways by which ethanol regulates cyp2e1 in extra-hepatic cells. |
2013-08-23 |
2023-08-12 |
Not clear |
| M Jin, A Ande, A Kumar, S Kuma. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Cell death & disease. vol 4. 2013-08-23. PMID:23519123. |
our results showed that 100 mm ethanol significantly induced oxidative stress, apoptosis, and cell death at 24 h in the svga astrocytic cell line, which was rescued by a cyp2e1 selective inhibitor, diallyl sulfide (das), cyp2e1 sirna, and antioxidants (vitamins c and e). |
2013-08-23 |
2023-08-12 |
Not clear |
| M Jin, A Ande, A Kumar, S Kuma. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Cell death & disease. vol 4. 2013-08-23. PMID:23519123. |
in addition, inhibitors of jnk (sp600125) and sp1 (mithramycin a) completely abrogated induction of cyp2e1 by ethanol in svga astrocytes. |
2013-08-23 |
2023-08-12 |
Not clear |
| Kenjiro Tatematsu, Akihiro Koide, Keiichirou Morimura, Shoji Fukushima, Yukio Mor. The enhancing effect of ethanol on the mutagenic activation of N-nitrosomethylbenzylamine by cytochrome P450 2A in the rat oesophagus. Mutagenesis. vol 28. issue 2. 2013-08-16. PMID:23325793. |
five weeks of treatment with 10% ethanol added to the drinking water or two intragastric treatments with 50% ethanol, both resulted in elevated levels of cyp2e1 (1.5- to 2.3-fold) and mutagenic activities of den, n-nitrosodimethylamine and n-nitrosopyrrolidine in the presence of rat liver s9 (1.5- to 2.4-fold). |
2013-08-16 |
2023-08-12 |
rat |
| Kenjiro Tatematsu, Akihiro Koide, Keiichirou Morimura, Shoji Fukushima, Yukio Mor. The enhancing effect of ethanol on the mutagenic activation of N-nitrosomethylbenzylamine by cytochrome P450 2A in the rat oesophagus. Mutagenesis. vol 28. issue 2. 2013-08-16. PMID:23325793. |
the application of several cyp inhibitors revealed that cyp2a were likely to contribute to the enhancing effect of ethanol on nmba activation in the rat oesophagus and kidney, but that cyp2e1 failed to do so. |
2013-08-16 |
2023-08-12 |
rat |