| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongming Liu, Guiyu Lou, Chongyi Li, Xiaodong Wang, Arthur I Cederbaum, Lixia Gan, Bin Xi. HBx inhibits CYP2E1 gene expression via downregulating HNF4α in human hepatoma cells. PloS one. vol 9. issue 9. 2015-11-25. PMID:25238230. |
cyp2e1, one of the cytochrome p450 mixed-function oxidases located predominantly in liver, plays a key role in metabolism of xenobiotics including ethanol and procarcinogens. |
2015-11-25 |
2023-08-13 |
mouse |
| Takahiro Minato, Mikihiro Tsutsumi, Mutsumi Tsuchishima, Nobuhiko Hayashi, Takashi Saito, Yasuhiro Matsue, Nobuyuki Toshikuni, Tomiyasu Arisawa, Joseph Georg. Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis. Molecular medicine (Cambridge, Mass.). vol 20. 2015-11-13. PMID:25180626. |
staining for cyp2e1 and 4-nhe demonstrated marked increases in the hepatic tissue of all the groups of oletf rats treated with ethanol compared with olet rats. |
2015-11-13 |
2023-08-13 |
rat |
| Ganna M Shayakhmetova, Larysa B Bondarenko, Valentina M Kovalenko, Volodymyr V Ruscha. CYP2E1 testis expression and alcohol-mediated changes of rat spermatogenesis indices and type I collagen. Arhiv za higijenu rada i toksikologiju. vol 64. issue 2. 2015-09-10. PMID:23819932. |
chronic ethanol consumption caused testicular failure along with an overexpression of cyp2e1 mrna and protein in the testes as well as quantitative changes in type i collagen amino acid contents. |
2015-09-10 |
2023-08-12 |
rat |
| Shivendra D Shukla, Ricardo Restrepo, Philip Fish, Robert W Lim, Jamal A Ibda. Different mechanisms for histone acetylation by ethanol and its metabolite acetate in rat primary hepatocytes. The Journal of pharmacology and experimental therapeutics. vol 354. issue 1. 2015-08-17. PMID:25886906. |
ethanol increased cyp2e1 protein expression but acetate had negligible effect. |
2015-08-17 |
2023-08-13 |
rat |
| Kirsten Linhart, Helmut Bartsch, Helmut K Seit. The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts. Redox biology. vol 3. 2015-08-05. PMID:25462066. |
in the liver cyp2e1 is induced by various compounds including free fatty acids, acetone and ethanol. |
2015-08-05 |
2023-08-13 |
Not clear |
| Kirsten Linhart, Helmut Bartsch, Helmut K Seit. The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts. Redox biology. vol 3. 2015-08-05. PMID:25462066. |
in addition, chronic ethanol ingestion also increases cyp2e1 in the mucosa of the oesophagus and colon. |
2015-08-05 |
2023-08-13 |
Not clear |
| Kirsten Linhart, Helmut Bartsch, Helmut K Seit. The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts. Redox biology. vol 3. 2015-08-05. PMID:25462066. |
since etheno-dna adducts are strong mutagens producing various types of base pair substitution mutations as well as other types of genetic damage, it is strongly believed that they are involved in ethanol mediated carcinogenesis primarily driven by the induction of cyp2e1. |
2015-08-05 |
2023-08-13 |
Not clear |
| A W Jone. Pharmacokinetics of Ethanol - Issues of Forensic Importance. Forensic science review. vol 23. issue 2. 2015-08-05. PMID:26231237. |
a faster rate of ethanol elimination from blood in habituated individuals (alcoholics) is explained by participation of a high km microsomal enzyme (cyp2e1), which is inducible after a period of chronic heavy drinking. |
2015-08-05 |
2023-08-13 |
human |
| Lingtak-Neander Chan, Gail D Anderso. Pharmacokinetic and pharmacodynamic drug interactions with ethanol (alcohol). Clinical pharmacokinetics. vol 53. issue 12. 2015-07-08. PMID:25267448. |
drugs that inhibit adh or cyp2e1 are the most likely theoretical compounds that would lead to a clinically significant pharmacokinetic interaction with ethanol, which include only a limited number of drugs. |
2015-07-08 |
2023-08-13 |
Not clear |
| Do Ik Lee, Seung Tae Kim, Dong Hoon Lee, Jung Min Yu, Su Kil Jang, Seong Soo Jo. Ginsenoside-free molecules from steam-dried ginseng berry promote ethanol metabolism: an alternative choice for an alcohol hangover. Journal of food science. vol 79. issue 7. 2015-05-21. PMID:24962619. |
in this study, we examined whether ginsenoside-free molecules (gfms) from steam-dried ginseng berries promote ethanol metabolism and scavenge free radicals by stimulating primary enzymes (alcohol dehydrogenase, aldehyde dehydrogenase, cyp2e1, and catalase) and antioxidant effects using in vitro and in vivo models. |
2015-05-21 |
2023-08-13 |
mouse |
| Defeng Wu, Arthur I Cederbau. Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. Redox biology. vol 1. 2015-05-13. PMID:24273738. |
cyp2e1 plays a role in the toxicity of ethanol, carcinogens and certain drugs. |
2015-05-13 |
2023-08-12 |
mouse |
| Defeng Wu, Arthur I Cederbau. Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. Redox biology. vol 1. 2015-05-13. PMID:24273738. |
since cyp2e1 plays an important role in the toxicity of ethanol, drugs and carcinogens and is activated under various pathophysiological conditions such as diabetes, nash and obesity, attempts to stimulate autophagy may be beneficial in preventing/lowering cyp2e1/ethanol liver injury. |
2015-05-13 |
2023-08-12 |
mouse |
| Mark A Barnes, Sanjoy Roychowdhury, Laura E Nag. Innate immunity and cell death in alcoholic liver disease: role of cytochrome P4502E1. Redox biology. vol 2. 2015-04-22. PMID:25180169. |
increased expression of cyp2e1 in response to high concentrations of ethanol leads to greater production of cytotoxic ethanol metabolites, which in turn contribute to production of reactive oxygen species, oxidative stress, and ultimately, cell death. |
2015-04-22 |
2023-08-13 |
Not clear |
| Manuela G Neuman, Lawrence Cohen, Samir Zakhari, Radu M Nanau, Sebastian Mueller, Michelle Schneider, Charles Parry, Romina Isip, Helmut K Seit. Alcoholic liver disease: a synopsis of the Charles Lieber's Memorial Symposia 2009-2012. Alcohol and alcoholism (Oxford, Oxfordshire). vol 49. issue 4. 2015-04-15. PMID:24816574. |
the presentations are focused on genetic polymorphisms of ethanol metabolizing enzymes and the role of cytochrome p4502e1 (cyp2e1) in ald. |
2015-04-15 |
2023-08-13 |
human |
| Arthur I Cederbaum, Yongke Lu, Xiaodong Wang, Defeng W. Synergistic toxic interactions between CYP2E1, LPS/TNFα, and JNK/p38 MAP kinase and their implications in alcohol-induced liver injury. Advances in experimental medicine and biology. vol 815. 2015-03-23. PMID:25427906. |
we hypothesize that similar interactions occur as a result of ethanol induction of cyp2e1 and tnfα. |
2015-03-23 |
2023-08-13 |
mouse |
| Claire Heit, Hongbin Dong, Ying Chen, Yatrik M Shah, David C Thompson, Vasilis Vasilio. Transgenic mouse models for alcohol metabolism, toxicity, and cancer. Advances in experimental medicine and biology. vol 815. 2015-03-23. PMID:25427919. |
the primary enzymes involved in ethanol metabolism include alcohol dehydrogenase (adh), cytochrome p450 isoform 2e1, (cyp2e1), catalase (cat), and aldehyde dehydrogenases (aldh). |
2015-03-23 |
2023-08-13 |
mouse |
| Yuan Wang, Yan Kou, Xiaodong Wang, Arthur Cederbaum, Rong Wan. Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. PloS one. vol 9. issue 3. 2015-01-20. PMID:24658151. |
in this study, to obtain an overview of ethanol, cyp2e1 and gender effects on liver injury and gain more insight into the underlying molecular mechanism, mouse liver proteomes were quantitatively analyzed using itraq under eight conditions including mice of different genders, wild type versus cyp2e1 knockout, and normal versus alcohol diet. |
2015-01-20 |
2023-08-12 |
mouse |
| Yuan Wang, Yan Kou, Xiaodong Wang, Arthur Cederbaum, Rong Wan. Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. PloS one. vol 9. issue 3. 2015-01-20. PMID:24658151. |
second, hierarchical clustering analysis showed cyp2e1 knockout played a primary role in the overall differential protein expression compared with ethanol and gender factors. |
2015-01-20 |
2023-08-12 |
mouse |
| Yuan Wang, Yan Kou, Xiaodong Wang, Arthur Cederbaum, Rong Wan. Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. PloS one. vol 9. issue 3. 2015-01-20. PMID:24658151. |
furthermore, pair-wise multiple comparisons have revealed that the only significant expression difference lied in wild-type and cyp2e1 knockout mice both treated with ethanol. |
2015-01-20 |
2023-08-12 |
mouse |
| Yuan Wang, Yan Kou, Xiaodong Wang, Arthur Cederbaum, Rong Wan. Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. PloS one. vol 9. issue 3. 2015-01-20. PMID:24658151. |
third, k-mean clustering analysis indicated that the cyp2e1 knockout had the reverse effect on ethanol induced oxidative stress and lipid oxidation. |
2015-01-20 |
2023-08-12 |
mouse |