| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junguo Ma, Yiyi Feng, Siyu Jiang, Xiaoyu L. Altered cellular metabolism of HepG2 cells caused by microcystin-LR. Environmental pollution (Barking, Essex : 1987). vol 225. 2017-06-29. PMID:28336091. |
further research showed that the cyp inducers omeprazole, ethanol, and rifampicin inhibited cell viability, in particular, ethanol, a cyp2e1 inducer, induced ros generation, lipid peroxidation, and apoptosis in hepg2 cells treated with mc-lr. |
2017-06-29 |
2023-08-13 |
human |
| Shufang Na, Jie Li, Huibo Zhang, Yueran Li, Zheqiong Yang, Yanjun Zhong, Guicheng Dong, Jing Yang, Jiang Yu. The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation. Toxicology. vol 385. 2017-06-14. PMID:28385499. |
ethanol, one of the most commonly abused substances throughout history, is a substrate and potent inducer of cytochrome p450 2e1 (cyp2e1). |
2017-06-14 |
2023-08-13 |
rat |
| Shufang Na, Jie Li, Huibo Zhang, Yueran Li, Zheqiong Yang, Yanjun Zhong, Guicheng Dong, Jing Yang, Jiang Yu. The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation. Toxicology. vol 385. 2017-06-14. PMID:28385499. |
our previous study showed that brain cyp2e1 was induced by chronic ethanol treatment and was associated with ethanol-induced neurotoxicity in rats. |
2017-06-14 |
2023-08-13 |
rat |
| Shufang Na, Jie Li, Huibo Zhang, Yueran Li, Zheqiong Yang, Yanjun Zhong, Guicheng Dong, Jing Yang, Jiang Yu. The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation. Toxicology. vol 385. 2017-06-14. PMID:28385499. |
compared with the controls, chronic ethanol treatment (3.0g/kg, i.g., 160days) significantly increased cyp2e1 mrna levels in the rat cortex, but the mrna levels of peroxisome proliferator-activated receptor α (pparα) and the pre- and post-synaptic proteins (synaptophysin, syp, and drebrin1, dbn1) were decreased. |
2017-06-14 |
2023-08-13 |
rat |
| Shufang Na, Jie Li, Huibo Zhang, Yueran Li, Zheqiong Yang, Yanjun Zhong, Guicheng Dong, Jing Yang, Jiang Yu. The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation. Toxicology. vol 385. 2017-06-14. PMID:28385499. |
ethanol treatment dose-dependently induced cyp2e1 mrna expression, and cyp2e1 overexpression exacerbated the ethanol-induced neurotoxicity. |
2017-06-14 |
2023-08-13 |
rat |
| Shufang Na, Jie Li, Huibo Zhang, Yueran Li, Zheqiong Yang, Yanjun Zhong, Guicheng Dong, Jing Yang, Jiang Yu. The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation. Toxicology. vol 385. 2017-06-14. PMID:28385499. |
pretreatment with p38 inhibitor (sb202190) and erk1/2 inhibitor (u0126) attenuated the induction of cyp2e1 mrna and protein levels by ethanol; however, no change was observed with jnk inhibitor pretreatment. |
2017-06-14 |
2023-08-13 |
rat |
| Shufang Na, Jie Li, Huibo Zhang, Yueran Li, Zheqiong Yang, Yanjun Zhong, Guicheng Dong, Jing Yang, Jiang Yu. The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation. Toxicology. vol 385. 2017-06-14. PMID:28385499. |
ethanol exposure or cyp2e1 overexpression significantly decreased pparα, syp, and dbn1 expression as indicated by the data from real-time rt-pcr, western blotting and immunocytochemistry. |
2017-06-14 |
2023-08-13 |
rat |
| Shufang Na, Jie Li, Huibo Zhang, Yueran Li, Zheqiong Yang, Yanjun Zhong, Guicheng Dong, Jing Yang, Jiang Yu. The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation. Toxicology. vol 385. 2017-06-14. PMID:28385499. |
these results suggest that the induction of cyp2e1 by ethanol may be mediated via the p38 and erk1/2 signaling pathways in neurons but not via the jnk pathway. |
2017-06-14 |
2023-08-13 |
rat |
| Zhenhua Ren, Fanmuyi Yang, Xin Wang, Yongchao Wang, Mei Xu, Jacqueline A Frank, Zun-Ji Ke, Zhuo Zhang, Xianglin Shi, Jia Lu. Chronic plus binge ethanol exposure causes more severe pancreatic injury and inflammation. Toxicology and applied pharmacology. vol 308. 2017-05-23. PMID:27538709. |
chronic plus binge ethanol exposure increased the expression of adh1 and cyp2e1. |
2017-05-23 |
2023-08-13 |
mouse |
| Min Ji Bak, Van-Long Truong, Se-Yeon Ko, Xuan Ngan Giang Nguyen, Pajaree Ingkasupart, Mira Jun, Jin Young Shin, Woo-Sik Jeon. Antioxidant and Hepatoprotective Effects of Procyanidins from Wild Grape (Vitis amurensis) Seeds in Ethanol-Induced Cells and Rats. International journal of molecular sciences. vol 17. issue 5. 2017-03-15. PMID:27213339. |
in hepg2 cells, wgp not only diminished the ethanol (etoh, 100 mm)-induced reactive oxygen species (ros) formation and cytochrome p450 2e1 (cyp2e1) expression, but also renovated both the activity and expression of antioxidant enzymes including catalase, superoxide dismutase, and glutathione peroxidase. |
2017-03-15 |
2023-08-13 |
rat |
| Sheng-Lei Yan, Zhi-Hong Wang, Hsiu-Fang Yen, Yi-Ju Lee, Mei-Chin Yi. Reversal of ethanol-induced hepatotoxicity by cinnamic and syringic acids in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 98. issue Pt B. 2017-03-07. PMID:27793734. |
results showed that ethanol stimulated protein expression of cyp2e1, p47 |
2017-03-07 |
2023-08-13 |
mouse |
| Akiko Kojima-Yuasa, Mayu Goto, Eri Yoshikawa, Yuri Morita, Hirotaka Sekiguchi, Keita Sutoh, Koji Usumi, Isao Matsui-Yuas. Protective Effects of Hydrolyzed Nucleoproteins from Salmon Milt against Ethanol-Induced Liver Injury in Rats. Marine drugs. vol 14. issue 12. 2017-03-06. PMID:27999369. |
in this model, cyp2e1 activity in ethanol plus ccl₄-treated rats increased significantly, but dnsm-treatment suppressed the enzyme's activity and reduced intracellular thiobarbituric acid reactive substances (tbars) levels. |
2017-03-06 |
2023-08-13 |
human |
| Meng Wang, Zhaoxiang Zhou, Jian Wang, Xiaoying Zhan. An improved in vitro method for screening toxin and medicine targeting CYP2E1. Environmental toxicology and pharmacology. vol 47. 2017-02-13. PMID:27653210. |
representative cyp2e1 inducers (ethanol and pyrazole) and inhibitors (diallyldisulfide and kaempferol) were applied to evaluate the effectiveness of homogenate-mitochondrial system. |
2017-02-13 |
2023-08-13 |
mouse |
| Meng Wang, Zhaoxiang Zhou, Jian Wang, Xiaoying Zhan. An improved in vitro method for screening toxin and medicine targeting CYP2E1. Environmental toxicology and pharmacology. vol 47. 2017-02-13. PMID:27653210. |
the results showed that in homogenate-mitochondrial method, the protein level and activity of cyp2e1 were increased by ethanol and pyrazole; reduced by diallyldisulfide and kaempferol, and this homogenate-mitochondrial method is convenient with good repeatability and reproducibility in screening chemicals targeting cyp2e1, especially for the inducers. |
2017-02-13 |
2023-08-13 |
mouse |
| Satish Kumar Bedada, Prasad Neerat. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytotherapy research : PTR. vol 30. issue 3. 2016-10-21. PMID:26680654. |
the inhibition of cyp2e1 by rsv may provide a novel approach for minimizing the hepatotoxicity of ethanol. |
2016-10-21 |
2023-08-13 |
human |
| Anayelly López-Islas, Victoria Chagoya-Hazas, Benjamin Pérez-Aguilar, Mayrel Palestino-Domínguez, Verónica Souza, Roxana U Miranda, Leticia Bucio, Luis Enrique Gómez-Quiroz, María-Concepción Gutiérrez-Rui. Cholesterol Enhances the Toxic Effect of Ethanol and Acetaldehyde in Primary Mouse Hepatocytes. Oxidative medicine and cellular longevity. vol 2016. 2016-10-14. PMID:26788255. |
cyp2e1 content increased with hc diet, as well as in those treated with ethanol or acetaldehyde, while the activity of this enzyme determined in microsomes increased in the hc and in all ethanol treated hepatocytes, hc and cw. |
2016-10-14 |
2023-08-13 |
mouse |
| P S S Rao, Santosh Kuma. Chronic Effects of Ethanol and/or Darunavir/Ritonavir on U937 Monocytic Cells: Regulation of Cytochrome P450 and Antioxidant Enzymes, Oxidative Stress, and Cytotoxicity. Alcoholism, clinical and experimental research. vol 40. issue 1. 2016-10-05. PMID:26727525. |
our recent study has shown that acute treatment with ethanol (etoh) increases oxidative stress and cytotoxicity through cytochrome p450 2e1 (cyp2e1)-mediated pathway in u937 monocytic cells. |
2016-10-05 |
2023-08-13 |
Not clear |
| Chiteng Zhang, Yanmei Lai, Guifang Jin, Hansruedi Glatt, Qinzhi Wei, Yungang Li. Human CYP2E1-dependent mutagenicity of mono- and dichlorobiphenyls in Chinese hamster (V79)-derived cells. Chemosphere. vol 144. 2016-08-26. PMID:26547025. |
the effects of each pcb in v79-hcyp2e1-hsult1a1 cells were abolished or reduced in the presence of a cyp2e1 inhibitor (1-aminobenzotriazole), or enhanced by pretreatment of the cells with (cyp2e1-inducing) ethanol, while the genotoxicity was not significantly affected by a sult1 inhibitor (pentachlorophenol). |
2016-08-26 |
2023-08-13 |
human |
| Neelanjana Roy, Debanjali Dasgupta, Indranil Mukhopadhyay, Ankita Chatterjee, Kausik Das, Pradip Bhowmik, Soumyajit Das, Priyadarshi Basu, Amal K Santra, Simanti Datta, Gopal Krishna Dhali, Abhijit Chowdhury, Soma Banerje. Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India. PloS one. vol 11. issue 3. 2016-08-09. PMID:26937962. |
fourteen markers were genotyped within two alcohol metabolism genes [alcohol dehydrogenase (adh) gene clusters (adh1b and adh1c) and aldehyde dehydrogenase (aldh2)], one microsomal ethanol oxidizing enzyme cytochrome p450 (cyp2e1) and three oxidative stress response (osr) genes (mnsod, gstt1 and gstm1) among 490 bengali individuals (322 ald and 168 control) from eastern and north-eastern india and validation was performed in a new cohort of 150 bengali patients including 100 ald and 50 advanced non-alcoholic steatohepatitis (nash). |
2016-08-09 |
2023-08-13 |
Not clear |
| Ewa Florek, Maksymilian Kulza, Wojciech Piekoszewski, Ewa Gomółka, Wojciech Jawień, Artur Teżyk, Marta Napierał. Influence of tobacco smoke exposure on pharmacokinetics of ethyl alcohol in alcohol preferring and non-preferring rats. Pharmacological reports : PR. vol 67. issue 5. 2016-07-06. PMID:26398386. |
tobacco smokes induces cyp1a1, cyp1a2, cyp2a6 isoenzymes, but on the other hand, ethanol activates cyp2e1, which can be important during combined, chronic use of both of them. |
2016-07-06 |
2023-08-13 |
rat |