| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Calivarathan Latchoumycandane, Mohamad Hanouneh, Laura E Nagy, Thomas M McIntyr. Inflammatory PAF Receptor Signaling Initiates Hedgehog Signaling and Kidney Fibrogenesis During Ethanol Consumption. PloS one. vol 10. issue 12. 2016-06-28. PMID:26720402. |
ethanol catabolism by cyp2e1 in kidney generates local reactive oxygen species that oxidize cellular phospholipids to phospholipid products that activate the platelet-activating factor receptor (ptafr) for inflammatory phospholipids. |
2016-06-28 |
2023-08-13 |
mouse |
| Yongke Lu, Arthur I Cederbau. Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity. Biomolecules. vol 5. issue 4. 2016-06-17. PMID:26501338. |
wild type (wt), cyp2e1 knockout (ko) or cyp2e1 humanized transgenic knockin (ki), mice were fed an ethanol liquid diet or control dextrose diet for four weeks. |
2016-06-17 |
2023-08-13 |
mouse |
| Yongke Lu, Arthur I Cederbau. Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity. Biomolecules. vol 5. issue 4. 2016-06-17. PMID:26501338. |
neither 3-ma nor rapamycin treatment affected cyp2e1 catalytic activity or content or the induction cyp2e1 by ethanol. |
2016-06-17 |
2023-08-13 |
mouse |
| Shivendra D Shukla, Annayya R Aroor, Ricardo Restrepo, Kusum K Kharbanda, Jamal A Ibda. In Vivo Acute on Chronic Ethanol Effects in Liver: A Mouse Model Exhibiting Exacerbated Injury, Altered Metabolic and Epigenetic Responses. Biomolecules. vol 5. issue 4. 2016-06-17. PMID:26610587. |
chronic followed by binge ethanol exacerbated fat accumulation, necrosis, decrease in hepatic sam and sam:sah ratio, increase in adenosine levels, and elevated cyp2e1 levels. |
2016-06-17 |
2023-08-13 |
mouse |
| Calivarathan Latchoumycandane, Laura E Nagy, Thomas M McIntyr. Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption. Free radical biology & medicine. vol 86. 2016-06-03. PMID:26003521. |
cytochrome p450 2e1 (cyp2e1) induction and oxidative metabolism of ethanol in hepatocytes inflame and damage liver. |
2016-06-03 |
2023-08-13 |
mouse |
| Calivarathan Latchoumycandane, Laura E Nagy, Thomas M McIntyr. Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption. Free radical biology & medicine. vol 86. 2016-06-03. PMID:26003521. |
we found that cyp2e1 was induced in kidney tubules of mice chronically ingesting a modified lieber-decarli liquid ethanol diet. |
2016-06-03 |
2023-08-13 |
mouse |
| Calivarathan Latchoumycandane, Laura E Nagy, Thomas M McIntyr. Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption. Free radical biology & medicine. vol 86. 2016-06-03. PMID:26003521. |
we conclude that ethanol catabolism in renal tubules results in a self-perpetuating cycle of cyp2e1 induction, local ptafr ligand formation, and neutrophil infiltration and activation that leads to myeloperoxidase-dependent oxidation and damage to kidney function. |
2016-06-03 |
2023-08-13 |
mouse |
| Masataka Nakano, Takuya Mohri, Tatsuki Fukami, Masataka Takamiya, Yasuhiro Aoki, Howard L McLeod, Miki Nakajim. Single-Nucleotide Polymorphisms in Cytochrome P450 2E1 (CYP2E1) 3'-Untranslated Region Affect the Regulation of CYP2E1 by miR-570. Drug metabolism and disposition: the biological fate of chemicals. vol 43. issue 10. 2016-05-31. PMID:26199425. |
human cytochrome p450 2e1 (cyp2e1) catalyzes the metabolism of numerous xenobiotics, including acetaminophen and ethanol. |
2016-05-31 |
2023-08-13 |
human |
| Ghanim Aljomah, Susan S Baker, Wensheng Liu, Rafal Kozielski, Janet Oluwole, Benita Lupu, Robert D Baker, Lixin Zh. Induction of CYP2E1 in non-alcoholic fatty liver diseases. Experimental and molecular pathology. vol 99. issue 3. 2016-04-19. PMID:26551085. |
in cultured hepg2 cells, ethanol induced the expression of cyp2e1 mrna and protein, but not adh4 or adh6; oleic acid did not induce any of these genes. |
2016-04-19 |
2023-08-13 |
Not clear |
| Haruka Yamashita, Mayu Goto, Isao Matsui-Yuasa, Akiko Kojima-Yuas. Ecklonia cava Polyphenol Has a Protective Effect against Ethanol-Induced Liver Injury in a Cyclic AMP-Dependent Manner. Marine drugs. vol 13. issue 6. 2016-03-03. PMID:26096275. |
the cells were incubated for 0-24 h. in cultured hepatocytes, the ecp treatment with ethanol inhibited cytochrome p450 2e1 (cyp2e1) expression and activity, which is related to the production of ros when large quantities of ethanol are oxidized. |
2016-03-03 |
2023-08-13 |
Not clear |
| Haruka Yamashita, Mayu Goto, Isao Matsui-Yuasa, Akiko Kojima-Yuas. Ecklonia cava Polyphenol Has a Protective Effect against Ethanol-Induced Liver Injury in a Cyclic AMP-Dependent Manner. Marine drugs. vol 13. issue 6. 2016-03-03. PMID:26096275. |
these changes in activities of cyp2e1 and adh were suppressed by treatment with h89, an inhibitor of protein kinase a. ecp treatment with ethanol enhanced cyclic amp concentrations compared with those of control cells. |
2016-03-03 |
2023-08-13 |
Not clear |
| Natalia Martinez-Gil, Miguel Flores-Bellver, Sandra Atienzar-Aroca, Daniel Lopez-Malo, Alba C Urdaneta, Javier Sancho-Pelluz, Cristina Peris-Martínez, Luis Bonet-Ponce, Francisco J Romero, Jorge M Barci. CYP2E1 in the Human Retinal Pigment Epithelium: Expression, Activity, and Induction by Ethanol. Investigative ophthalmology & visual science. vol 56. issue 11. 2016-02-26. PMID:26567798. |
cyp2e1 in the human retinal pigment epithelium: expression, activity, and induction by ethanol. |
2016-02-26 |
2023-08-13 |
human |
| Natalia Martinez-Gil, Miguel Flores-Bellver, Sandra Atienzar-Aroca, Daniel Lopez-Malo, Alba C Urdaneta, Javier Sancho-Pelluz, Cristina Peris-Martínez, Luis Bonet-Ponce, Francisco J Romero, Jorge M Barci. CYP2E1 in the Human Retinal Pigment Epithelium: Expression, Activity, and Induction by Ethanol. Investigative ophthalmology & visual science. vol 56. issue 11. 2016-02-26. PMID:26567798. |
cytochrome p450 2e1 (cyp2e1) is a detoxifying enzyme with particular affinity for ethanol (etoh) expressed in several tissues. |
2016-02-26 |
2023-08-13 |
human |
| Jiangzheng Liu, Xin Wang, Zhengwu Peng, Tao Zhang, Hao Wu, Weihua Yu, Deqing Kong, Ying Liu, Hua Bai, Rui Liu, Xiaodi Zhang, Chunxu Ha. The effects of insulin pre-administration in mice exposed to ethanol: alleviating hepatic oxidative injury through anti-oxidative, anti-apoptotic activities and deteriorating hepatic steatosis through SRBEP-1c activation. International journal of biological sciences. vol 11. issue 5. 2016-01-11. PMID:25892964. |
forth, the modification of ethanol metabolism pathway such as the inhibition of cyp2e1, the activation of aldh might be involved in the anti-oxidative and protective effects exerted by insulin pre-administration against acute ethanol exposure in mice. |
2016-01-11 |
2023-08-13 |
mouse |
| K Iwahashi, H Suwak. Ethanol metabolism, toxicity and genetic polymorphism. Addiction biology. vol 3. issue 3. 2016-01-08. PMID:26734919. |
concerning blood ethanol elimination kinetics, it was reported that the c2 gene of cyp2e1 and the aldh2*1 gene may have greater effects on ethanol and acetaldehyde elimination than the other genotypes, when the blood ethanol level is below 20 m m. |
2016-01-08 |
2023-08-13 |
Not clear |
| Jimena Lavandera, Silvina Ruspini, Alcira Batlle, Ana María Buzale. Cytochrome P450 expression in mouse brain: specific isoenzymes involved in Phase I metabolizing system of porphyrinogenic agents in both microsomes and mitochondria. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 93. issue 1. 2015-12-29. PMID:25386744. |
ethanol also induced cyp2e1 expression in microsomes, although isoflurane provoked opposite effects in mitochondria and microsomes. |
2015-12-29 |
2023-08-13 |
mouse |
| Ellen T McCarthy, Jianping Zhou, Ryan Eckert, David Genochio, Rishi Sharma, Olurinde Oni, Alok De, Tarak Srivastava, Ram Sharma, Virginia J Savin, Mukut Sharm. Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE. Prostaglandins & other lipid mediators. vol 116-117. 2015-12-21. PMID:25447342. |
ethanol at high concentrations altered the actin cytoskeleton, induced cyp2e1, increased superoxide production and inhibited adh gene expression. |
2015-12-21 |
2023-08-13 |
mouse |
| Mary Ann Robledo, Mariana Ordu. Hypothesis of demodicidosis rosacea flushing etiopathogenesis. Medical hypotheses. vol 84. issue 4. 2015-12-03. PMID:25683389. |
as a result, high amounts of acetaldehyde will circulate for longer time in the blood, until the liver cyp2e1(p450) enzyme system finally metabilizes the acetaldehyde, during that period of time the patients will experience a flushing as well as the people with the "asian flushing syndrome" suffer when they drink ethanol. |
2015-12-03 |
2023-08-13 |
human |
| Ileana Hernández, Mayra Domínguez-Pérez, Leticia Bucio, Verónica Souza, Roxana U Miranda, Dahn L Clemens, Luis Enrique Gomez-Quiroz, María Concepción Gutiérrez-Rui. Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 76. 2015-12-01. PMID:25528116. |
vl-17a cells, which express adh and cyp2e1 overloaded with free fatty acids (1 mm of oleic and palmitic acid 2:1) showed an increased oxidative damaged after 24 h free fatty acids treatment when exposed to ethanol (100 mm) for 48 h as a second injury. |
2015-12-01 |
2023-08-13 |
Not clear |
| Ileana Hernández, Mayra Domínguez-Pérez, Leticia Bucio, Verónica Souza, Roxana U Miranda, Dahn L Clemens, Luis Enrique Gomez-Quiroz, María Concepción Gutiérrez-Rui. Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 76. 2015-12-01. PMID:25528116. |
the increased oxidative stress and toxicity in lipid overloaded vl-17a cells subjected to ethanol exposure were accompanied by increases in cyp2e1 protein expression. |
2015-12-01 |
2023-08-13 |
Not clear |