| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying-Huan Lua, Wei-Wah Ong, Hong-Kin Wong, Choy-Hoong Che. Ethanol-induced CYP2E1 Expression is Reduced by Lauric Acid via PI3K Pathway in HepG2 Cells. Tropical life sciences research. vol 31. issue 3. 2020-11-21. PMID:33214856. |
this suggests that ethanol induced cyp2e1 expression by activating pi3k p85 (tyr458) pathway, but not the nfκb p105 (ser933) pathway in hepg2 cells. |
2020-11-21 |
2023-08-13 |
Not clear |
| Natalia Martinez-Gil, Lorena Vidal-Gil, Miguel Flores-Bellver, Rosa Maisto, Javier Sancho-Pelluz, Manuel Diaz-Llopis, Jorge M Barcia, Francisco J Romer. Ethanol-Induced Oxidative Stress Modifies Inflammation and Angiogenesis Biomarkers in Retinal Pigment Epithelial Cells (ARPE-19): Role of CYP2E1 and its Inhibition by Antioxidants. Antioxidants (Basel, Switzerland). vol 9. issue 9. 2020-10-20. PMID:32825644. |
our aim is to clarify the possible implication of cyp2e1 in ethanol (etoh)-induced oxidative stress in rpe alterations. |
2020-10-20 |
2023-08-13 |
Not clear |
| Y -J.Y. Wan, Y Cai, J Li, Q -X. Yuan, B French, F J. Gonzalez, S Frenc. Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice. Hepatology research : the official journal of the Japan Society of Hepatology. vol 19. issue 2. 2020-09-30. PMID:11164737. |
to further analyze the effect of cyp2e1 and ethanol in pparalpha-mediated fatty acid homeostasis, the expression of pparalpha and retinoid x receptor alpha (rxralpha) and their target genes was examined in ethanol fed cyp2e1 deficient mice. |
2020-09-30 |
2023-08-12 |
mouse |
| Y -J.Y. Wan, Y Cai, J Li, Q -X. Yuan, B French, F J. Gonzalez, S Frenc. Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice. Hepatology research : the official journal of the Japan Society of Hepatology. vol 19. issue 2. 2020-09-30. PMID:11164737. |
these data suggest that cyp2e1 and ethanol can regulate pparalpha-mediated fatty acid homeostasis. |
2020-09-30 |
2023-08-12 |
mouse |
| Tomáš Zim. Alcohol Abuse. EJIFCC. vol 29. issue 4. 2020-09-29. PMID:30574039. |
three metabolic pathways of ethanol were describe in human - alcohol dehydrogenase (adh), microsomal ethanol oxidizing system (meos, cyp2e1) and catalase. |
2020-09-29 |
2023-08-13 |
human |
| Kaede Yamasaki, Kazuhiro Sugamoto, Teruaki Arakawa, Kazuo Nishiyama, Masao Yamasak. Chronic intake of high-dose of blueberry leaf extract does not augment the harmful effects of ethanol in rats. PeerJ. vol 7. 2020-09-29. PMID:31211011. |
body weight and food intake decreased, whereas liver aldehyde dehydrogenase (aldh) activity, liver microsomal cytochrome p450 2e1 (cyp2e1) protein and mrna expression, and heme oxygenase 1 (ho-1) mrna expression were upregulated by ethanol intake. |
2020-09-29 |
2023-08-13 |
rat |
| Torsten Diesinger, Vyacheslav Buko, Alfred Lautwein, Radovan Dvorsky, Elena Belonovskaya, Oksana Lukivskaya, Elena Naruta, Siarhei Kirko, Viktor Andreev, Dominik Buckert, Sebastian Bergler, Christian Renz, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Berthold Büchele, Thomas Simmet, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehne. Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis. PloS one. vol 15. issue 7. 2020-09-21. PMID:32701948. |
elevated enzymatic activity of cytochrome p450 2e1 (cyp2e1) is known to be critically responsible for the development of ash due to excessively high levels of reactive oxygen species (ros) during metabolization of ethanol. |
2020-09-21 |
2023-08-13 |
Not clear |
| Keqi Hu, Hang Yu, Zihuan Li, Guifang Jin, Hansi Jia, Meiqi Song, Yungang Li. Human CYP2E1-activated mutagenicity of dioxin-like PCBs 105 and 118-Experimental data consistent with molecular docking results. Toxicology. vol 437. 2020-08-31. PMID:32199159. |
in a human hepatoma (c3a) cell line, pcb 105 and 118 induced micronuclei marginally, while with ethanol pretreatment (to stabilize cyp2e1) both compounds induced micronuclei efficiently, and co-exposure to trans-1,2-dichloroethylene (a selective cyp2e1 inhibitor) led to clearly negative results with both compounds. |
2020-08-31 |
2023-08-13 |
human |
| Fatemeh Sobhanimonfared, Taravat Bamdad, Farzin Roohvan. Cross talk between alcohol-induced oxidative stress and HCV replication. Archives of microbiology. vol 202. issue 7. 2020-08-21. PMID:32448963. |
to evaluate these issues, huh7 cells harboring hcv replicon and cytochrome p450 (cyp2e1) plasmid were exposed to ethanol and mrna expression of beclin-1, interferon-stimulated gene15 (isg15) genes and hcv ns5b for two different times were relatively quantitated. |
2020-08-21 |
2023-08-13 |
Not clear |
| Ramakrishnan Sabitha, Kumari Nishi, Vinoth Prasanna Gunasekaran, Balupillai Agilan, Ernest David, Govindhan Annamalai, Rajamanickam Vinothkumar, Malliga Perumal, Latha Subbiah, Mathan Ganesha. p-Coumaric acid attenuates alcohol exposed hepatic injury through MAPKs, apoptosis and Nrf2 signaling in experimental models. Chemico-biological interactions. vol 321. 2020-03-30. PMID:32151596. |
overall, the ameliorative consequence of pca on ethanol induced oxidative stress and apoptosis was achieved by suppressing the expression of cyp2e1 and overexpressing nrf2 and its target protein ho-1 in rat liver tissue. |
2020-03-30 |
2023-08-13 |
rat |
| Ravindra Babu Pingili, Siva Reddy Challa, A Krishnamanjari Pawar, Vyshnavi Toleti, Tanvija Kodali, Sirisha Koppul. A systematic review on hepatoprotective activity of quercetin against various drugs and toxic agents: Evidence from preclinical studies. Phytotherapy research : PTR. vol 34. issue 1. 2020-03-27. PMID:31617262. |
quercetin exhibited hepatoprotective activity against 2-butoxyethanol, acrylamide, acrylonitrile, aflatoxin b1, aroclor-1254, arsenic, sodium arsenite, azathioprine, cadmium chloride, carbon tetrachloride, chlorpyrifos, cyclosporine a, diazinon, dimethylnitrosamine, doxorubicin, epirubicin, ethanol, fenvalerate, isoniazide, rifampicin, lead acetate, lindane, d-galactosamine, methotrexate, methylmercury, nickel sulfate, paracetamol, perfluorooctanoic acid, polychlorinated biphenyls, pyrrolizidine alkaloid clivorine, rotenone, sodium fluoride, streptazotocin, tert-butyl hydroperoxide, thioacetamide, titanium dioxide, tumor necrosis factor-α, tripterygium glycoside, triptolide, ultraviolet a light, concavalin a, bisphenol, and ischemia-induced hepatotoxicity in various animal models due to its antioxidant, free radical-scavenging,anti-inflammatory, antiapoptotic, and cytochrome p450 2e1 (cyp2e1) inhibitory activities. |
2020-03-27 |
2023-08-13 |
human |
| Alajos Pár, Gabriella Pá. [Alcoholic liver disease: the roles of genetic-epigenetic factors and the effect of abstinence]. Orvosi hetilap. vol 160. issue 14. 2019-10-24. PMID:30931596. |
the p450 cyp2e1 *5 c2, an inducible microsomal oxidase, upregulated by ethanol and by formation of acetaldehyde and reactive oxygen species, increases liver toxicity. |
2019-10-24 |
2023-08-13 |
Not clear |
| Helmut Karl Seitz, Sebastian Muelle. [The role of Cytochrom P4502E1 in Alcoholic Liver Disease and alcohol mediated carcinogenesis]. Zeitschrift fur Gastroenterologie. vol 57. issue 1. 2019-09-11. PMID:30641601. |
oxidative stress, with the generation of reactive oxygen species (ros), develops either in inflammation (alcoholic hepatitis) or during oxidation of ethanol via cytochrome p4502e1 (cyp2e1). |
2019-09-11 |
2023-08-13 |
Not clear |
| Helmut Karl Seitz, Sebastian Muelle. [The role of Cytochrom P4502E1 in Alcoholic Liver Disease and alcohol mediated carcinogenesis]. Zeitschrift fur Gastroenterologie. vol 57. issue 1. 2019-09-11. PMID:30641601. |
cyp2e1 is induced by ethanol, oxidizes ethanol to acetaldehyde, and generates ros during this process. |
2019-09-11 |
2023-08-13 |
Not clear |
| Helmut Karl Seitz, Sebastian Muelle. [The role of Cytochrom P4502E1 in Alcoholic Liver Disease and alcohol mediated carcinogenesis]. Zeitschrift fur Gastroenterologie. vol 57. issue 1. 2019-09-11. PMID:30641601. |
in humans, cyp2e1 is induced following the consumption of 40 grams of ethanol per day after one week. |
2019-09-11 |
2023-08-13 |
Not clear |
| Durr-E-Shahwar Malik, Rhiannon M David, Nigel J Gooderha. Ethanol potentiates the genotoxicity of the food-derived mammary carcinogen PhIP in human estrogen receptor-positive mammary cells: mechanistic support for lifestyle factors (cooked red meat and ethanol) associated with mammary cancer. Archives of toxicology. vol 92. issue 4. 2019-06-26. PMID:29362861. |
ethanol toxicity involves alcohol dehydrogenase metabolism to reactive acetaldehyde, and is also a substrate for cyp2e1, which when uncoupled generates reactive oxygen species (ros) and dna damage. |
2019-06-26 |
2023-08-13 |
human |
| Lin Zhang, Ya-Ping Ji. Toxic effects of combined treatment of 1,2-dichloroethane and ethanol on mouse brain and the related mechanisms. Journal of biochemical and molecular toxicology. vol 33. issue 5. 2019-06-17. PMID:30664321. |
the results suggested that combined exposure to ethanol and 1,2-dce synergistically increased cyp2e1 protein and mrna levels, accelerated the metabolism of ethanol and 1,2-dce in the brain tissue, induced high production of reactive oxygen species (ros), and increased mda levels, thereby damaging the blood-brain barrier and causing obvious pathological changes in brain tissue. |
2019-06-17 |
2023-08-13 |
mouse |
| Teresa Peccerella, Tatjana Arslic-Schmitt, Sebastian Mueller, Kirstin-Berit Linhart, Devanshi Seth, Helmut Bartsch, Helmut K Seit. Chronic Ethanol Consumption and Generation of Etheno-DNA Adducts in Cancer-Prone Tissues. Advances in experimental medicine and biology. vol 1032. 2019-05-31. PMID:30362092. |
a variety of mechanisms may contribute to this carcinogenic effect of alcohol including oxidative stress with the generation of reactive oxygen species (ros), formed via inflammatory pathways or as byproducts of ethanol oxidation through cytochrome p4502e1 (cyp2e1). |
2019-05-31 |
2023-08-13 |
human |
| Teresa Peccerella, Tatjana Arslic-Schmitt, Sebastian Mueller, Kirstin-Berit Linhart, Devanshi Seth, Helmut Bartsch, Helmut K Seit. Chronic Ethanol Consumption and Generation of Etheno-DNA Adducts in Cancer-Prone Tissues. Advances in experimental medicine and biology. vol 1032. 2019-05-31. PMID:30362092. |
etheno-dna adducts are generated in the liver (hepg2) cells over-expressing cyp2e1 when incubated with ethanol;and are inhibited by chlormethiazole. |
2019-05-31 |
2023-08-13 |
human |
| Abdo Mahli, Wolfgang Erwin Thasler, Claus Hellerbran. Establishment of a p-nitrophenol oxidation-based assay for the analysis of CYP2E1 activity in intact hepatocytes in vitro. Toxicology mechanisms and methods. vol 29. issue 3. 2019-05-03. PMID:30380359. |
cyp2e1 metabolizes ethanol and is active in generating reactive oxygen species (ros) and subsequent oxidative stress in the hepatic tissues. |
2019-05-03 |
2023-08-13 |
human |