| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiangzheng Liu, Deqin Kong, Duo Ai, Anqi Xu, Weihua Yu, Zhengwu Peng, Jie Peng, Zhao Wang, Zhao Wang, Rui Liu, Wenli Li, Chunxu Hai, Xiaodi Zhang, Xin Wan. Insulin resistance enhances binge ethanol-induced liver injury through promoting oxidative stress and up-regulation CYP2E1. Life sciences. 2022-06-06. PMID:35662646. |
the activation of cyp2e1 might be also involved in the sensitizing effects of ir on ethanol induced liver injury in mice. |
2022-06-06 |
2023-08-14 |
mouse |
| Hongkun Lin, Xiaoping Guo, Jingjing Liu, Peiyi Liu, Guibin Mei, Hongxia Li, Dan Li, Huimin Chen, Li Chen, Ying Zhao, Chunjie Jiang, Yaqin Yu, Wen Liu, Ping Ya. Improving Lipophagy by Restoring Rab7 Cycle: Protective Effects of Quercetin on Ethanol-Induced Liver Steatosis. Nutrients. vol 14. issue 3. 2022-03-12. PMID:35277017. |
hepg2 cells transfected with cyp2e1 showed similar lipophagy dysfunction when exposed to ethanol, which was blocked when cells were transfected with sirna-rab7 in advance. |
2022-03-12 |
2023-08-13 |
mouse |
| Lin Gao, Jiawei Yuan, Yuhuan Cheng, Mengling Chen, Genhua Zhang, Jihong W. Selenomethionine-Dominated Selenium-Enriched Peanut Protein Ameliorates Alcohol-Induced Liver Disease in Mice by Suppressing Oxidative Stress. Foods (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34945529. |
semet and especially sepp reversed cell viability and cell death, inhibited ethanol induced cyp2e1 activation, decreased reactive oxygen species level, and restored gsh level. |
2021-12-24 |
2023-08-13 |
mouse |
| Meiqi Song, Yujian Wang, Zhihong Chen, Hongbin Gao, Zongying Yang, Hang Yu, Yungang Li. Human CYP enzyme-activated genotoxicity of 2,2',4,4'-tetrabromobiphenyl ether in mammalian cells. Chemosphere. 2021-11-13. PMID:34742755. |
in the human hepatoma (hepg2) cells bde-47 (48 h exposure) was inactive up to 40 μm, however, pretreatment of the cells with ethanol (0.2%, v:v, inducer of cyp2e1) or rifampicin (10 μm, inducer of cyp3a4) led to significant micronuclei formation by bde-47; pretreatment with bisphenol af (100 nm) also potentiated bde-47-induced micronuclei formation (which was blocked by a cyp2e1 inhibitor trans-1,2-dichloroethylene or a cyp3a inhibitor (ketoconazole). |
2021-11-13 |
2023-08-13 |
human |
| Qinyuan Ye, Fuzhi Lian, Pollyanna R G Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K Seitz, Xiang-Dong Wan. Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. Hepatobiliary surgery and nutrition. vol 1. issue 1. 2021-10-21. PMID:23543859. |
ethanol feeding for 1 month with den resulted in significantly increased hepatic cyp2e1 levels and increased nuclear accumulation of nf-κb protein and tnf-α expression, which were associated with increased cyclin d1 expression and p-gst positive altered hepatic foci. |
2021-10-21 |
2023-08-12 |
rat |
| Qinyuan Ye, Fuzhi Lian, Pollyanna R G Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K Seitz, Xiang-Dong Wan. Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. Hepatobiliary surgery and nutrition. vol 1. issue 1. 2021-10-21. PMID:23543859. |
these data demonstrate that the inhibition of ethanol-induced cyp2e1 as a key pathogenic factor can counteract the tumor-promoting action of ethanol by decreasing tnf-α expression, nf-κb activation, and oxidative dna damage as well as restoring normal hepatic levels of retinoic acid in den-treated rats. |
2021-10-21 |
2023-08-12 |
rat |
| Heba Mohamed Ali Labi. Alteration of CYP2E1, DBN1, DNMT1, miRNA-335, miRNA-21, c-Fos and Cox-2 gene expression in prefrontal cortex of rats' offspring submitted to prenatal ethanol exposure during their neurodevelopment and the preventive role of nancocurcumin administration: A histological, ultrastructural and molecular study. Journal of chemical neuroanatomy. vol 113. 2021-10-01. PMID:33657396. |
alteration of cyp2e1, dbn1, dnmt1, mirna-335, mirna-21, c-fos and cox-2 gene expression in prefrontal cortex of rats' offspring submitted to prenatal ethanol exposure during their neurodevelopment and the preventive role of nancocurcumin administration: a histological, ultrastructural and molecular study. |
2021-10-01 |
2023-08-13 |
rat |
| Brisa Rodope Alarcón-Sánchez, Dafne Guerrero-Escalera, Sandra Rosas-Madrigal, Diana Ivette Aparicio-Bautista, Karina Reyes-Gordillo, M Raj Lakshman, Arturo Ortiz-Fernández, Héctor Quezada, Óscar Medina-Contreras, Saúl Villa-Treviño, Julio Isael Pérez-Carreón, Jaime Arellanes-Robled. Nucleoredoxin interaction with flightless-I/actin complex is differentially altered in alcoholic liver disease. Basic & clinical pharmacology & toxicology. vol 127. issue 5. 2021-08-23. PMID:32524749. |
we also showed that ethanol, lps and den synergistically induced liver structural disarrangement, steatosis and inflammatory infiltration accompanied by increased levels of proliferation (ki67), ethanol metabolism (cyp2e1), hepatocarcinogenesis (gstp1) and lps-inducible (myd88 and tlr4) markers. |
2021-08-23 |
2023-08-13 |
mouse |
| Carlos G Penaloza, Mayra Cruz, Gabrielle Germain, Sidra Jabeen, Mohammad Javdan, Richard A Lockshin, Zahra Zaker. Higher sensitivity of female cells to ethanol: methylation of DNA lowers Cyp2e1, generating more ROS. Cell communication and signaling : CCS. vol 18. issue 1. 2021-08-11. PMID:32653010. |
higher sensitivity of female cells to ethanol: methylation of dna lowers cyp2e1, generating more ros. |
2021-08-11 |
2023-08-13 |
mouse |
| Xue Chen, Yunhui Xu, Krista L Denning, Audrey Grigore, Yongke L. PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase. Free radical biology & medicine. vol 169. 2021-06-28. PMID:33892114. |
ethanol is mainly metabolized by alcohol dehydrogenase (adh), cytochrome p450 2e1 (cyp2e1) and catalase. |
2021-06-28 |
2023-08-13 |
mouse |
| Trang Thi Huyen Dang, Jong Won Yu. Cytochrome P450 2E1 (CYP2E1) positively regulates lipid catabolism and induces browning in 3T3-L1 white adipocytes. Life sciences. vol 278. 2021-06-28. PMID:34043994. |
cytochrome p450 2e1 (cyp2e1), a membrane protein which belongs to the cytochrome p450 superfamily, reportedly functions in the xenobiotic metabolism in the body, especially ethanol metabolism. |
2021-06-28 |
2023-08-13 |
Not clear |
| Shipra Bhatt, Vinay Kumar, Ashish Dogra, Probir Kumar Ojha, Priya Wazir, Payare Lal Sangwan, Gurdarshan Singh, Utpal Nand. Amalgamation of Xenobiotica; the fate of foreign compounds in biological systems. vol 51. issue 6. 2021-05-17. PMID:33539218. |
amalgamation of cyp2e1 is directly or indirectly involved in the metabolism of ethanol and endogenous fatty acids but it plays a major role in the bio-activation of toxic substances that produce reactive metabolites leading to hepatotoxicity. |
2021-05-17 |
2023-08-13 |
Not clear |
| Chloé Hugbart, Yann Verres, Brendan Le Daré, Simon Bucher, Elise Vène, Aude Bodin, Vincent Lagente, Bernard Fromenty, Renaud Bouvet, Isabelle Morel, Pascal Loyer, Thomas Gicque. Non-oxidative ethanol metabolism in human hepatic cells in vitro: Involvement of uridine diphospho-glucuronosyltransferase 1A9 in ethylglucuronide production. Toxicology in vitro : an international journal published in association with BIBRA. vol 66. 2021-03-10. PMID:32283135. |
we showed dose- and time-dependent production of ets and etg after ethanol (25 or 50 mm) treatment in culture media of differentiated heparg cells and hh and a significant induction of cyp2e1 mrna expression upon acute ethanol exposure in heparg cells. |
2021-03-10 |
2023-08-13 |
human |
| Nien-Shan Lu, Wan-Chun Chiu, Ya-Ling Chen, Hsiang-Chi Peng, Hitoshi Shirakawa, Suh-Ching Yan. Fish oil up-regulates hepatic autophagy in rats with chronic ethanol consumption. The Journal of nutritional biochemistry. vol 77. 2021-02-24. PMID:31884243. |
after 8 weeks, rats in the e (ethanol diet) group showed the significantly higher plasma aspartate transaminase (ast) and alanine transaminase (alt) activities, protein expression of cytochrome p450 2e1 (cyp2e1), and levels of hepatic inflammatory cytokines. |
2021-02-24 |
2023-08-13 |
rat |
| Neha Attal, Mariel T Sullivan, Cara A Girardi, Kyle J Thompson, Iain H McKillo. Fatty acid binding protein-4 promotes alcohol-dependent hepatosteatosis and hepatocellular carcinoma progression. Translational oncology. vol 14. issue 1. 2021-01-10. PMID:33290990. |
human hcc cells, and hcc cells transfected to express cyp2e1, were exposed to ethanol and analyzed for fabp4 expression, or exposed to rhfabp4 (in the absence/presence of erk, p38-mapk or jnk1/2 inhibitors) and cell proliferation and migration measured. |
2021-01-10 |
2023-08-13 |
mouse |
| Keqi Hu, Lu Cai, Zihuan Li, Hansruedi Glatt, Ming Shi, Yungang Li. Human CYP2E1-dependent mutagenicity of benzene and its hydroxylated metabolites in V79-derived cells: Suppression and enhancement by ethanol pretreatment. Environmental and molecular mutagenesis. vol 61. issue 6. 2020-12-17. PMID:32285472. |
a v79-derived cell line expressing human cyp2e1 and sulfotransferase (sult) 1a1 (v79-hcyp2e1-hsult1a1) pretreated with ethanol (a cyp2e1 stabilizer) was used in the hprt gene mutagenicity assay. |
2020-12-17 |
2023-08-13 |
human |
| Keqi Hu, Lu Cai, Zihuan Li, Hansruedi Glatt, Ming Shi, Yungang Li. Human CYP2E1-dependent mutagenicity of benzene and its hydroxylated metabolites in V79-derived cells: Suppression and enhancement by ethanol pretreatment. Environmental and molecular mutagenesis. vol 61. issue 6. 2020-12-17. PMID:32285472. |
with residual ethanol molecules still being present in cyp2e1 for a period of time after benzene exposure, the acetic acid formed could limit the entrance of benzene, thus inhibit its metabolic activation. |
2020-12-17 |
2023-08-13 |
human |
| Yoo Jeong Lee, Ji Yeon Kim, Dae Yeon Lee, Keon Jae Park, Gyu Hee Kim, Jeong Eun Kim, Gu Seob Roh, Joong Yeon Lim, Seul Koo, Nam Kyoo Lim, Hyun Young Park, Won-Ho Ki. Alcohol consumption before pregnancy causes detrimental fetal development and maternal metabolic disorders. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32572070. |
here, we investigated whether ethanol consumption before pregnancy affects maternal or fetal health and whether pharmacological inhibition of cyp2e1, a major ethanol oxidation enzyme, by 4-methylpyrazole (4-mp) has therapeutic effects. |
2020-12-10 |
2023-08-13 |
mouse |
| Ying-Huan Lua, Wei-Wah Ong, Hong-Kin Wong, Choy-Hoong Che. Ethanol-induced CYP2E1 Expression is Reduced by Lauric Acid via PI3K Pathway in HepG2 Cells. Tropical life sciences research. vol 31. issue 3. 2020-11-21. PMID:33214856. |
cyp2e1 is primarily involved in the microsomal ethanol oxidising system, which generates massive reactive oxygen species (ros) and ultimately leads to oxidative stress and tissue damage. |
2020-11-21 |
2023-08-13 |
Not clear |
| Ying-Huan Lua, Wei-Wah Ong, Hong-Kin Wong, Choy-Hoong Che. Ethanol-induced CYP2E1 Expression is Reduced by Lauric Acid via PI3K Pathway in HepG2 Cells. Tropical life sciences research. vol 31. issue 3. 2020-11-21. PMID:33214856. |
ethanol induced the mrna expression of cyp2e1 significantly, but lauric acid was able to downregulate the induced cyp2e1 expression in a dose-dependent manner. |
2020-11-21 |
2023-08-13 |
Not clear |