| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Wang, Yan Kou, Xiaodong Wang, Arthur Cederbaum, Rong Wan. Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. PloS one. vol 9. issue 3. 2015-01-20. PMID:24658151. |
third, k-mean clustering analysis indicated that the cyp2e1 knockout had the reverse effect on ethanol induced oxidative stress and lipid oxidation. |
2015-01-20 |
2023-08-12 |
mouse |
| Yuan Wang, Yan Kou, Xiaodong Wang, Arthur Cederbaum, Rong Wan. Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. PloS one. vol 9. issue 3. 2015-01-20. PMID:24658151. |
more importantly, ipa analysis of proteomic data inferred that the gene expressions of two upstream regulators, nrf2 and pparα, regulated by chronic alcohol feeding and cyp2e1 knockout, are involved in ethanol induced oxidative stress and lipid oxidation. |
2015-01-20 |
2023-08-12 |
mouse |
| Elena Grasselli, Adriana Voci, Ilaria Demori, Rita De Matteis, Andrea D Compalati, Gabriella Gallo, Laura Vergan. Effects of binge ethanol on lipid homeostasis and oxidative stress in a rat model of nonalcoholic fatty liver disease. Journal of physiology and biochemistry. vol 70. issue 2. 2015-01-02. PMID:24481563. |
the data indicate an increased susceptibility of fatty liver to ethanol and suggest that the synergistic effect of diet and ethanol on lipid dysmetabolism might be mediated, at least in part, by ppars and cytochromes cyp4a1 and cyp2e1. |
2015-01-02 |
2023-08-12 |
rat |
| E Kim, J Yang, H Lee, J-R Park, S-H Hong, H-M Woo, S Lee, I B Seo, S-M Ryu, S-J Cho, S-M Park, S-R Yan. Γ-glutamyl transferase as an early and sensitive marker in ethanol-induced liver injury of rats. Transplantation proceedings. vol 46. issue 4. 2015-01-02. PMID:24815155. |
moreover, the cyp2e1 was rapidly reflected to ethanol in rats. |
2015-01-02 |
2023-08-13 |
rat |
| A Holownia, R M Mroz, P Wielgat, P Jakubow, J Jablonski, J Sulek, J J Braszk. Histone acetylation and arachidonic acid cytotoxicity in HepG2 cells overexpressing CYP2E1. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 3. 2014-10-28. PMID:24287576. |
cells grown with ethanol or acetate had increased acetylated histone h3 levels in both cell types and elevated acetylated histone h4 levels in cells overexpressing cyp2e1 but not in naïve cells. |
2014-10-28 |
2023-08-12 |
Not clear |
| A Holownia, R M Mroz, P Wielgat, P Jakubow, J Jablonski, J Sulek, J J Braszk. Histone acetylation and arachidonic acid cytotoxicity in HepG2 cells overexpressing CYP2E1. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 3. 2014-10-28. PMID:24287576. |
in cells overexpressing cyp2e1 grown with ethanol, expression of histone deacetylase 2 was reduced by about 40 %. |
2014-10-28 |
2023-08-12 |
Not clear |
| A Holownia, R M Mroz, P Wielgat, P Jakubow, J Jablonski, J Sulek, J J Braszk. Histone acetylation and arachidonic acid cytotoxicity in HepG2 cells overexpressing CYP2E1. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 3. 2014-10-28. PMID:24287576. |
arachidonic acid altered cell proliferation and was cytotoxic mostly to cells engineered to overexpress cyp2e1 but both effects were significantly lower in cells pretreated with ethanol or acetate. |
2014-10-28 |
2023-08-12 |
Not clear |
| Arthur I Cederbau. Nrf2 and antioxidant defense against CYP2E1 toxicity. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400918. |
induction of cytochrome p450 2e1(cyp2e1) is one of the central pathways by which ethanol generates oxidative stress. |
2014-08-05 |
2023-08-12 |
mouse |
| Arthur I Cederbau. Nrf2 and antioxidant defense against CYP2E1 toxicity. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400918. |
cyp2e1 can be induced by ethanol and several low molecular weight chemicals such as pyrazole. |
2014-08-05 |
2023-08-12 |
mouse |
| Arthur I Cederbau. Nrf2 and antioxidant defense against CYP2E1 toxicity. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400918. |
the chapter discusses biochemical and toxicological effects of cyp2e1 and the effects of nrf2 in modulating these actions of cyp2e1.besides ethanol, cyp2e1 metabolizes and activates many other important toxicological compounds. |
2014-08-05 |
2023-08-12 |
mouse |
| Arthur I Cederbau. Nrf2 and antioxidant defense against CYP2E1 toxicity. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400918. |
ethanol, polyunsaturated fatty acids and iron were toxic to the hepg2 cells which express cyp2e1 (e47 cells) but not control c34hepg2 cells which do not express cyp2e1.toxicity was associated with enhanced oxidant stress and could be prevented by antioxidants and potentiated if glutathione (gsh) was removed. |
2014-08-05 |
2023-08-12 |
mouse |
| Helmut K Seitz, Xiang-Dong Wan. The role of cytochrome P450 2E1 in ethanol-mediated carcinogenesis. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400919. |
the overall induction of cyp2e1 shows interindividual variations and occurs already following a daily ingestion of 40 g of ethanol after 1 week. |
2014-08-05 |
2023-08-12 |
human |
| Helmut K Seitz, Xiang-Dong Wan. The role of cytochrome P450 2E1 in ethanol-mediated carcinogenesis. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400919. |
cyp2e1 induction is associated with an increased metabolism of ethanol resulting in the generation of reactive oxygen species (ros) with direct and indirect carcinogenic action. |
2014-08-05 |
2023-08-12 |
human |
| Helmut K Seitz, Xiang-Dong Wan. The role of cytochrome P450 2E1 in ethanol-mediated carcinogenesis. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400919. |
chlormethiazole inhibits cyp2e1 activity and thus blocks the formation of dna adducts in cell cultures, restores retinoic acids in alcohol fed animals and inhibits chemical induced ethanol mediated hepatocarcinogenesis. |
2014-08-05 |
2023-08-12 |
human |
| Samuel W Frenc. The importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400920. |
the chapter discusses about the critical role of cyp2e1 in ethanol mediated liver injury and its association with nash. |
2014-08-05 |
2023-08-12 |
Not clear |
| Samuel W Frenc. The importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400920. |
ethanol metabolism by cyp2e1 generates hydroxyethyl radicals which promote ethanol hepatotoxicity. |
2014-08-05 |
2023-08-12 |
Not clear |
| Samuel W Frenc. The importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400920. |
greater induction of cyp2e1 and hence greater liver injury occurs with co-administration of ethanol and drugs. |
2014-08-05 |
2023-08-12 |
Not clear |
| Natalia A Osna, Terrence M Donohu. CYP2E1-catalyzed alcohol metabolism: role of oxidant generation in interferon signaling, antigen presentation and autophagy. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400922. |
cytochrome p450 2e1 (cyp2e1) is one of two major enzymes that catalyze ethanol oxidation in the liver. |
2014-08-05 |
2023-08-12 |
Not clear |
| Natalia A Osna, Terrence M Donohu. CYP2E1-catalyzed alcohol metabolism: role of oxidant generation in interferon signaling, antigen presentation and autophagy. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400922. |
cyp2e1 is also unique because it is inducible, as its hepatic content rises after continuous (chronic) ethanol administration, thereby accelerating the rate of ethanol metabolism and affording greater tolerance to heavy alcohol consumption. |
2014-08-05 |
2023-08-12 |
Not clear |
| Claire Heit, Hongbin Dong, Ying Chen, David C Thompson, Richard A Deitrich, Vasilis K Vasilio. The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system. Sub-cellular biochemistry. vol 67. 2014-08-05. PMID:23400924. |
catalase and cytochrome p450 2e1 (cyp2e1) represent the major enzymes in the cns that catalyze ethanol oxidation. |
2014-08-05 |
2023-08-12 |
Not clear |