| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Conde de la Rosa, H Moshage, N Niet. [Hepatocyte oxidant stress and alcoholic liver disease]. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. vol 100. issue 3. 2008-09-17. PMID:18416641. |
many pathways have been suggested to play a role on how ethanol induces a state of "oxidative stress", including redox-state changes, acetaldehyde production, damage to the mitochondria, membrane injury, apoptosis, ethanol-induced hypoxia, effects on the immune system and altered cytokine production, increased endotoxin levels and activation of kupffer cells, mobilization of iron, changes in the antioxidant defense, particularly mitochondrial glutathione (gsh), one electron oxidation of ethanol to 1-hydroxy-ethyl radical, and induction of cyp2e1. |
2008-09-17 |
2023-08-12 |
Not clear |
| Gerardo Gómez-Moreno, Javier Guardia, Antonio Cutand. Interaction of paracetamol in chronic alcoholic patients. Importance for odontologists. Medicina oral, patologia oral y cirugia bucal. vol 13. issue 4. 2008-09-15. PMID:18379447. |
ethanol is also detoxified by cyp2e1, which is an inducer of ethanol such that chronic ingestion increases the level of this enzyme. |
2008-09-15 |
2023-08-12 |
Not clear |
| Xiaodong Wang, Arthur I Cederbau. S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice. Archives of biochemistry and biophysics. vol 477. issue 1. 2008-09-10. PMID:18482574. |
the ethanol plus jo2 treatment increased activity and content of cyp2e1, inos content and tnf-alpha levels; these increases were blunted by sam. |
2008-09-10 |
2023-08-12 |
mouse |
| Xiaodong Wang, Arthur I Cederbau. S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice. Archives of biochemistry and biophysics. vol 477. issue 1. 2008-09-10. PMID:18482574. |
sam also protected against the elevated oxidative and nitrosative stress found after ethanol plus jo2, likely due to the decreases in cyp2e1, inos and tnf-alpha. |
2008-09-10 |
2023-08-12 |
mouse |
| Xiaodong Wang, Arthur I Cederbau. S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice. Archives of biochemistry and biophysics. vol 477. issue 1. 2008-09-10. PMID:18482574. |
it is suggested that sam protects against the ethanol plus jo2 toxicity by restoring hepatic sam levels, preventing the increase in inos, cyp2e1 and tnf-alpha and there by lowering the elevated oxidative/nitrosative stress and activation of the jnk signal pathway, ultimately preventing mitochondrial damage. |
2008-09-10 |
2023-08-12 |
mouse |
| M José Sánchez-Catalán, Lucía Hipólito, Consuelo Guerri, Luis Granero, Ana Polach. Distribution and differential induction of CYP2E1 by ethanol and acetone in the mesocorticolimbic system of rat. Alcohol and alcoholism (Oxford, Oxfordshire). vol 43. issue 4. 2008-08-14. PMID:18326880. |
distribution and differential induction of cyp2e1 by ethanol and acetone in the mesocorticolimbic system of rat. |
2008-08-14 |
2023-08-12 |
rat |
| Yongke Lu, Jian Zhuge, Xiaodong Wang, Jingxiang Bai, Arthur I Cederbau. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology (Baltimore, Md.). vol 47. issue 5. 2008-08-01. PMID:18393316. |
cyp2e1 was induced by ethanol in wild-type mice, and oxidative stress induced by ethanol was higher in wild-type mice than in cyp2e1-knockout mice. |
2008-08-01 |
2023-08-12 |
mouse |
| Yongke Lu, Jian Zhuge, Xiaodong Wang, Jingxiang Bai, Arthur I Cederbau. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology (Baltimore, Md.). vol 47. issue 5. 2008-08-01. PMID:18393316. |
chlormethiazole, an inhibitor of cyp2e1, lowered macrovesicular fat accumulation, inhibited oxidative stress, and up-regulated pparalpha protein level in wild-type mice fed ethanol. |
2008-08-01 |
2023-08-12 |
mouse |
| Yongke Lu, Jian Zhuge, Xiaodong Wang, Jingxiang Bai, Arthur I Cederbau. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology (Baltimore, Md.). vol 47. issue 5. 2008-08-01. PMID:18393316. |
these results indicate that cyp2e1 contributes to experimental alcoholic fatty liver in this model and suggest that cyp2e1-derived oxidative stress may inhibit oxidation of fatty acids by preventing up-regulation of pparalpha by ethanol, resulting in fatty liver. |
2008-08-01 |
2023-08-12 |
mouse |
| Evelyn Lamy, Yvonne Völkel, Peter H Roos, Fekadu Kassie, Volker Mersch-Sunderman. Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion. International journal of hygiene and environmental health. vol 211. issue 1-2. 2008-06-24. PMID:17660004. |
ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent hepg2 cells by cyp2e1 induction and glutathione depletion. |
2008-06-24 |
2023-08-12 |
human |
| Evelyn Lamy, Yvonne Völkel, Peter H Roos, Fekadu Kassie, Volker Mersch-Sunderman. Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion. International journal of hygiene and environmental health. vol 211. issue 1-2. 2008-06-24. PMID:17660004. |
in conclusion, both the ethanol-mediated induction of cyp2e1 and the depletion of gsh provide a mechanistic explanation for the over-additive effects of ethanol and aa. |
2008-06-24 |
2023-08-12 |
human |
| Wen-hu Liu, Te-chung Liu, Mei-chin Yi. Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 46. issue 5. 2008-06-05. PMID:18222027. |
ethanol treatment increased malondialdehyde (mda) level, decreased glutathione (gsh) content and catalase and glutathione peroxidase (gpx) activities, and increased cytochrome p450 2e1 (cyp2e1) activity in liver (p<0.05). |
2008-06-05 |
2023-08-12 |
mouse |
| Defeng Wu, Arthur I Cederbau. Development and properties of HepG2 cells that constitutively express CYP2E1. Methods in molecular biology (Clifton, N.J.). vol 447. 2008-05-15. PMID:18369917. |
cyp2e1, a member of the cytochrome p450 family, is induced by ethanol. |
2008-05-15 |
2023-08-12 |
human |
| Defeng Wu, Arthur I Cederbau. Development and properties of HepG2 cells that constitutively express CYP2E1. Methods in molecular biology (Clifton, N.J.). vol 447. 2008-05-15. PMID:18369917. |
induction of cyp2e1 plays an important role in ethanol-induced oxidant stress and ethanol toxicity. |
2008-05-15 |
2023-08-12 |
human |
| Defeng Wu, Arthur I Cederbau. Development and properties of HepG2 cells that constitutively express CYP2E1. Methods in molecular biology (Clifton, N.J.). vol 447. 2008-05-15. PMID:18369917. |
these cells displayed elevated oxidative stress, loss of mitochondrial function and loss of viability when challenged with prooxidants such as ethanol, polyunsaturated fatty acids (pufa) such as arachidonic acid, iron, or when depleted of the critical antioxidant glutathione, as compared with control hepg2 cells which do not express cyp2e1. |
2008-05-15 |
2023-08-12 |
human |
| Takayuki Uchimoto, Sakae Itoga, Masahiko Nezu, Masahiko Sunaga, Takeshi Tomonaga, Fumio Nomur. Role of the genetic polymorphisms in the 5'-flanking region for transcriptional regulation of the human CYP2E1 gene. Alcoholism, clinical and experimental research. vol 31. issue 1 Suppl. 2008-04-24. PMID:17331164. |
difference in susceptibility in enzyme induction of the cyp2e1 by environmental factors such as ethanol may be associated with the risk of these diseases. |
2008-04-24 |
2023-08-12 |
human |
| Yongke Lu, Arthur I Cederbau. CYP2E1 and oxidative liver injury by alcohol. Free radical biology & medicine. vol 44. issue 5. 2008-04-24. PMID:18078827. |
one central pathway seems to be the induction of cytochrome p450 2e1 (cyp2e1) by ethanol. |
2008-04-24 |
2023-08-12 |
mouse |
| Yongke Lu, Arthur I Cederbau. CYP2E1 and oxidative liver injury by alcohol. Free radical biology & medicine. vol 44. issue 5. 2008-04-24. PMID:18078827. |
cyp2e1 metabolizes and activates many toxicological substrates, including ethanol, to more reactive, toxic products. |
2008-04-24 |
2023-08-12 |
mouse |
| Jun-Won Yun, Young-Kyung Kim, Byoung-Seok Lee, Chae-Wook Kim, Jin-Sook Hyun, Joo-Hyun Baik, Jung-Ju Kim, Bae-Hwan Ki. Effect of dietary epigallocatechin-3-gallate on cytochrome P450 2E1-dependent alcoholic liver damage: enhancement of fatty acid oxidation. Bioscience, biotechnology, and biochemistry. vol 71. issue 12. 2008-04-07. PMID:18071271. |
ethanol treatment significantly elevated hepatic cyp2e1 expression while simultaneously reducing hepatic phospho-acetyl coa carboxylase (p-acc) and carnitine palmitoyl-transferase 1 (cpt-1) levels. |
2008-04-07 |
2023-08-12 |
Not clear |
| Jun-Won Yun, Young-Kyung Kim, Byoung-Seok Lee, Chae-Wook Kim, Jin-Sook Hyun, Joo-Hyun Baik, Jung-Ju Kim, Bae-Hwan Ki. Effect of dietary epigallocatechin-3-gallate on cytochrome P450 2E1-dependent alcoholic liver damage: enhancement of fatty acid oxidation. Bioscience, biotechnology, and biochemistry. vol 71. issue 12. 2008-04-07. PMID:18071271. |
while egcg markedly reversed the effect of ethanol on hepatic p-acc and cpt-1 levels, it had no effect on the ethanol-induced elevation in cyp2e1 expression. |
2008-04-07 |
2023-08-12 |
Not clear |