| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Lytton, A Helander, Z Q Zhang-Gouillon, K Stokkeland, R Bordone, S Aricò, E Albano, S W French, M Ingelman-Sundber. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Molecular pharmacology. vol 55. issue 2. 1999-03-11. PMID:9927612. |
to further investigate autoantibodies against cytochrome p-450s during alcohol abuse, sera of rats chronically treated with ethanol in the total enteral nutrition model and sera from alcoholics with or without alcohol liver disease and from control subjects were analyzed by enzyme-linked immunosorbent assay and western blotting for the presence of igg against rat and human cyp2e1, rat cyp3a1, and human cyp3a4. |
1999-03-11 |
2023-08-12 |
human |
| S D Lytton, A Helander, Z Q Zhang-Gouillon, K Stokkeland, R Bordone, S Aricò, E Albano, S W French, M Ingelman-Sundber. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Molecular pharmacology. vol 55. issue 2. 1999-03-11. PMID:9927612. |
a time-dependent appearance of igg against rat cyp3a1 and cyp2e1 was evident during chronic ethanol feeding of rats. |
1999-03-11 |
2023-08-12 |
human |
| P Stawowy, R Bonnet, H Rommelspache. The high-affinity binding of [3H]norharman ([3H]beta-carboline) to the ethanol-inducible cytochrome P450 2E1 in rat liver. Biochemical pharmacology. vol 57. issue 5. 1999-02-19. PMID:9952314. |
it was displaceable by ethanol (ki 14.25 microm), indicating that norharman and ethanol bind to the same binding site on cyp2e1. |
1999-02-19 |
2023-08-12 |
human |
| H Tsukada, P Y Wang, T Kaneko, Y Wang, M Nakano, A Sat. Dietary carbohydrate intake plays an important role in preventing alcoholic fatty liver in the rat. Journal of hepatology. vol 29. issue 5. 1999-02-10. PMID:9833908. |
dietary carbohydrate intake during ethanol ingestion augments the induction of hepatic cytochrome p450 2e1 (cyp2e1) by ethanol. |
1999-02-10 |
2023-08-12 |
rat |
| Y Amet, F Adas, A A Nanj. Fatty acid omega- and (omega-1)-hydroxylation in experimental alcoholic liver disease: relationship to different dietary fatty acids. Alcoholism, clinical and experimental research. vol 22. issue 7. 1999-02-04. PMID:9802534. |
ethanol induction of cyp2e1 was related to the concentration of polyunsaturated fatty acids in the diet; induction of cyp4a by ethanol was seen in all groups. |
1999-02-04 |
2023-08-12 |
rat |
| P Y Wang, T Kaneko, Y Wang, A Sat. Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats. Hepatology (Baltimore, Md.). vol 29. issue 1. 1999-02-03. PMID:9862862. |
the ethanol increased the hepatic microsomal cyp2e1 level and the rate of dimethylnitrosamine (dmn) demethylation. |
1999-02-03 |
2023-08-12 |
rat |
| P Y Wang, T Kaneko, Y Wang, A Sat. Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats. Hepatology (Baltimore, Md.). vol 29. issue 1. 1999-02-03. PMID:9862862. |
the 40- or 80-mg/100 g acarbose diet, which alone increased the cyp2e1 level and the rate of dmn demethylation, augmented the enzyme induction by ethanol. |
1999-02-03 |
2023-08-12 |
rat |
| P Y Wang, T Kaneko, Y Wang, A Sat. Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats. Hepatology (Baltimore, Md.). vol 29. issue 1. 1999-02-03. PMID:9862862. |
our study demonstrated that high doses of acarbose, alone or in combination with ethanol, can potentiate ccl4 and ap hepatotoxicity in rats by inducing hepatic cyp2e1. |
1999-02-03 |
2023-08-12 |
rat |
| K Sakurai, A I Cederbau. Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1. Molecular pharmacology. vol 54. issue 6. 1999-01-12. PMID:9855631. |
ethanol increases the content of cytochrome p450 2e1 (cyp2e1), which generates reactive oxygen species, and transition metals such as iron are powerful catalysts of hydroxyl radical formation and lipid peroxidation. |
1999-01-12 |
2023-08-12 |
Not clear |
| K Sakurai, A I Cederbau. Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1. Molecular pharmacology. vol 54. issue 6. 1999-01-12. PMID:9855631. |
experiments were carried out to attempt to link cyp2e1, iron, and oxidative stress as a potential mechanism by which iron increases ethanol toxicity. |
1999-01-12 |
2023-08-12 |
Not clear |
| D G McCarver, R Byun, R N Hines, M Hichme, W Wegene. A genetic polymorphism in the regulatory sequences of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake. Toxicology and applied pharmacology. vol 152. issue 1. 1998-11-20. PMID:9772223. |
a genetic polymorphism in the regulatory sequences of human cyp2e1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake. |
1998-11-20 |
2023-08-12 |
human |
| D G McCarver, R Byun, R N Hines, M Hichme, W Wegene. A genetic polymorphism in the regulatory sequences of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake. Toxicology and applied pharmacology. vol 152. issue 1. 1998-11-20. PMID:9772223. |
the presence of the insertion mutation was associated with greater cyp2e1 metabolic ability, but only among individuals who either were obese or had recently consumed ethanol (p < 0.01, both). |
1998-11-20 |
2023-08-12 |
human |
| J Grove, A S Brown, A K Daly, M F Bassendine, O F James, C P Da. The RsaI polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol dehydrogenase genotype. Pharmacogenetics. vol 8. issue 4. 1998-11-13. PMID:9731720. |
this risk appears to be particularly manifest in individuals carrying the adh3*2 allele, presumably reflecting increased metabolism of ethanol by cyp2e1. |
1998-11-13 |
2023-08-12 |
Not clear |
| A I Cederbau. Ethanol-related cytotoxicity catalyzed by CYP2E1-dependent generation of reactive oxygen intermediates in transduced HepG2 cells. BioFactors (Oxford, England). vol 8. issue 1-2. 1998-10-26. PMID:9699015. |
to establish direct linkage between the ethanol-inducible cytochrome p450, cyp2e1, ethanol hepatotoxicity, and lipid peroxidation, a hepg2 cell line which expresses human cyp2e1 was established by retroviral infection. |
1998-10-26 |
2023-08-12 |
human |
| A I Cederbau. Ethanol-related cytotoxicity catalyzed by CYP2E1-dependent generation of reactive oxygen intermediates in transduced HepG2 cells. BioFactors (Oxford, England). vol 8. issue 1-2. 1998-10-26. PMID:9699015. |
ethanol produced a time-and concentration-dependent cytotoxicity to hepg2 cells expressing the cyp2e1 but not to control cells. |
1998-10-26 |
2023-08-12 |
human |
| A I Cederbau. Ethanol-related cytotoxicity catalyzed by CYP2E1-dependent generation of reactive oxygen intermediates in transduced HepG2 cells. BioFactors (Oxford, England). vol 8. issue 1-2. 1998-10-26. PMID:9699015. |
the ethanol toxicity was prevented by inhibitors of cyp2e1 and antioxidants. |
1998-10-26 |
2023-08-12 |
human |
| K V Ramana, K K Kohl. Gene regulation of cytochrome P450--an overview. Indian journal of experimental biology. vol 36. issue 5. 1998-09-15. PMID:9717460. |
ethanol regulates the expression of cyp2e1 by posttranslational stabilization making it resistant to the proteolytic digestion. |
1998-09-15 |
2023-08-12 |
Not clear |
| F Adas, F Berthou, D Picart, P Lozac'h, F Beaugé, Y Ame. Involvement of cytochrome P450 2E1 in the (omega-1)-hydroxylation of oleic acid in human and rat liver microsomes. Journal of lipid research. vol 39. issue 6. 1998-08-28. PMID:9643352. |
after treatment of rats with ethanol or clofibrate, inducers of cyp2e1 and cyp4a, respectively, the hydroxylations of oleic acid were shown to be less inducible than those of lauric acid. |
1998-08-28 |
2023-08-12 |
human |
| R K Felten, D B DeNicola, G P Carlso. Minimal effects of acrylonitrile on pulmonary and hepatic cell injury enzymes in rats with induced cytochrome P450. Drug and chemical toxicology. vol 21. issue 2. 1998-08-05. PMID:9598299. |
five agents, phenobarbital, beta-naphthoflavone, pyridine, ethanol, and acetone, were administered prior to an as inducers of cyp2b, cyp1a, and cyp2e1. |
1998-08-05 |
2023-08-12 |
human |
| Y Amet, D Lucas, Z Q Zhang-Gouillon, S W Frenc. P-450-dependent metabolism of lauric acid in alcoholic liver disease: comparison between rat liver and kidney microsomes. Alcoholism, clinical and experimental research. vol 22. issue 2. 1998-07-20. PMID:9581653. |
chemical inhibitions using cyp2e1 competitive inhibitors (such as chlorzoxazone and ethanol) led to a nonsignificant inhibition of the renal (omega-1)-hydroxylation of lauric acid. |
1998-07-20 |
2023-08-12 |
human |